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| 1 | Progress in the mechanism and targeted drug therapy for COPD显示文摘Chronic obstructive pulmonary disease(COPD)is emphysema and/or chronic bronchitis characterised by long-term breathing problems and poor airflow.The prevalence of COPD has increased over the last decade and the drugs most commonly used to treat it,such as glucocorticoids and bronchodilators,have significant therapeutic effects;however,they also cause side effects,including infection and immunosuppression.Here we reviewed the pathogenesis and progression of COPD and elaborated on the effects and mechanisms of newly developed molecular targeted COPD therapeutic drugs.Among these new drugs,we focussed on thioredoxin(Trx).Trx effectively prevents the progression of COPD by regulating redox status and protease/anti-protease balance,blocking the NF-κB and MAPK signalling pathways,suppressing the activation and migration of inflammatory cells and the production of cytokines,inhibiting the synthesis and the activation of adhesion factors and growth factors,and controlling the cAMP-PKA and PI3K/Akt signalling pathways.The mechanism by which Trx affects COPD is different from glucocorticoid-based mechanisms which regulate the inflammatory reaction in association with suppressing immune responses.In addition,Trx also improves the insensitivity of COPD to steroids by inhibiting the production and internalisation of macrophage migration inhibitory factor(MIF).Taken together,these findings suggest that Trx may be the ideal drug for treating COPD. | Cuixue Wang Jiedong Zhou Jinquan Wang Shujing Li Atsushi Fukunaga Junji Yodoi Hai Tian | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 8 |
| 2 | Treatment of nonalcoholic steatohepatitis with vitamins E and C: a pilot study显示文摘 | Miwa Kawanaka Mitsuhiko Suehiro Gotaro Yamada Jun Nakamura Keisuke Hino Ken Nishino Junji Yodoi Hajime Nakamura Hirofumi Kawamoto Takahito Oka Noriyo Urata Daisuke Goto | 2013 | 2013 (defa)2013，，： | 2 |
| 3 | Nanoceria and thioredoxin regulate a common antioxidative gene network in tubby mice 显示文摘 | Cai X Yodoi J Seal SF | 2014 | Adv Exp MedBiol2014，801，： | 1 |
| 4 | Persistent oxidative stress in cancer显示文摘 | Shinya Toyokuni Keisei Okamoto Junji Yodoi Hiroshi Hiai | 1995 | FEBS Letters1995，，1： | 1 |
| 5 | Redox control of cell death 显示文摘 | Ueda S Masutani H Nakamura H Tanaka T Ueno M Yodoi J | 2002 | Antioxid Redox Signal2002，4，3： | 1 |
| 6 | Lipid pemxidation and pemxynitrite in retinal ischemia- reperfusion injury显示文摘 | Shibuki H Katai N Yodoi J | 2000 | Invest Ophthalmol VisSci2000，41，11： | 1 |
| 7 | The role of thioredoxin in the aging process:Involvement of oxidative stress 显示文摘 | Yoshida T Oka S Masutani H Nakamura H Yodoi J | 2003 | Antioxid Redox Signal2003，5，5： | 1 |
| 8 | Overexpression of thioredoxin prevents thioacetamide-induced hepatic fibrosis in mice显示文摘 | Hiroaki Okuyama Hajime Nakamura Yasuyuki Shimahara Naoki Uyama Yong-Won Kwon Norifumi Kawada Yoshio Yamaoka Junji Yodoi | 2004 | Journal of Hepatology2004，，1： | 1 |
| 9 | Cytopro- tectiye effect of thioredoxin against retinal photic injury in mice 显示文摘 | Tanito M Masutani H Nakamura H Ohira A Yodoi J | 2002 | Invest Ophthalmol Vis Sci2002，43，4： | 1 |
| 10 | Isolation and Characterization of Polysacchs ride-Producing Baetriafrom Kefir Grains显示文摘 | Haruludo yodoi | 1990 | Dairy sci1990，73，： | 1 |
| 11 | Thioredoxin super- family and thioredoxin-inducing agents 显示文摘 | Hirota K Nakamura H Masutani H Yodoi J | 2002 | Ann N Y Acad Sci2002，957，： | 1 |
| 12 | Redox imbal- ance and its control in HIV infection, Antinxid显示文摘 | NAKAMURA H MASUTANI H YODOI J | 2002 | Redox Signal2002，4，3： | 1 |
| 13 | Oxidative stress induces adult T cell leukemia derived factor/thioredoxin in the rat retina 显示文摘 | Ohira A Honda O Gauntt CD Yamamoto M Hori K Masutani H Yodoi J Honda Y | 1994 | Lab Invest1994，70，2： | 1 |
| 14 | Induction of human thioredoxin in cultured human retinal pigment epithelial cells through cyclic AMP-dependent pathway; involvement in the cytoprotective activity of prostaglandin E 1 显示文摘 | Yamamoto M Sato N Tajima H Furuke K Ohira A Honda Y Yodoi J | 1997 | Exp Eye Res1997，65，5： | 1 |
| 15 | Lipid peroxidation and peroxynitrite in retinal ischemia-reperfusion injury显示文摘 | Shibuki H Katai N Yodoi J | 2000 | Invest Ophthalmol Vis Sci2000，41，11： | 1 |
| 16 | Presistent oxidative stress in cancer显示文摘 | Toyokuni S Okamom K Yodoi J | 1995 | FEBS Lett1995，358，： | 1 |
| 17 | Foxp3 regulatory T cells play a protective role in angiotensin II-induced aortic aneurysm formation in mice 显示文摘 | Yodoi K Yamashita T Sasaki N | 2015 | Hypertension2015，65，4： | 1 |
| 18 | The thioredoxin system in retro- viral infection and apoptosis显示文摘 | Masutani H Ueda S Yodoi J | 2005 | Cell Death Differ2005，12，8： | 1 |
| 19 | Redox regulation of cellular activation 显示文摘 | Nakamura H Nakamura K Yodoi J | 1997 | Annu Rev Immunol1997，15，： | 1 |
| 20 | Cytoprotective effect of thioredoxin against retinal photic injury in mice 显示文摘 | Tanito M Masutani H Nakamura H Ohira A Yodoi J | 2002 | Invest Ophthalmol Vis Sci2002，43，4： | 1 |
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