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| 1 | Corrosion behavior of Mg-Y alloy in NaCl aqueous solution | Xin Zhang a,b,c,Kui Zhang a,Xia Deng a,Hongwei Li b,c,Yongjun Li a,Minglong Ma a,Ning Li b,c,Yanlong Wang b,c a State Key Laboratory for Fabrication and Processing of Nonferrous Metals,Beijing General Research Institute for Nonferrous Metals,Beijing 100088,China b Beijing Engineering Research Center for Advanced Manufacturing and Evaluation of Special Vehicle Parts,Beijing 100072,China c Center of Technology,Beijing North Vehicle Group Corporation,Beijing 100072,China | 2012 | Progress in Natural Science:Materials International2012，22，2： | 7 |
| 2 | It is safe to use transdermal glyceryl trinitrate to lower blood pressure in patients with acute ischaemic stroke with carotid stenosis显示文摘Background There is concern that blood pressure(BP)lowering in acute stroke may compromise cerebral perfusion and worsen outcome in the presence of carotid stenosis.We assessed the effect of glyceryl trinitrate(GTN)in patients with carotid stenosis using data from the Efficacy of Nitric Oxide in Stroke(ENOS)Trial.Methods ENOS randomised 4011 patients with acute stroke and raised systolic BP(140-220 mm Hg)to transdermal GTN or no GTN within 48 hours of onset.Those on prestroke antihypertensives were also randomised to stop or continue their medication for 7 days.The primary outcome was the modified Rankin Scale(mRS)at day 90.Ipsilateral carotid stenosis was split:<30%;30-<50%;50-<70%;≥70%.Data are ORs with 95%CIs adjusted for baseline prognostic factors.results 2023(60.5%)ischaemic stroke participants had carotid imaging.As compared with<30%,≥70%ipsilateral stenosis was associated with an unfavourable shift in mRS(worse outcome)at 90 days(OR 1.88,95%CI 1.44 to 2.44,p<0.001).Those with≥70%stenosis who received GTN versus no GTN had a favourable shift in mRS(OR 0.56,95%CI 0.34 to 0.93,p=0.024).In those with 50-<70%stenosis,continuing versus stopping prestroke antihypertensives was associated with worse disability,mood,quality of life and cognition at 90 days.Clinical outcomes did not differ across bilateral stenosis groups.Conclusions Following ischaemic stroke,severe ipsilateral carotid stenosis is associated with worse functional outcome at 90 days.GTN appears safe in ipsilateral or bilateral carotid stenosis,and might improve outcome in severe ipsilateral carotid stenosis. | Jason P Appleton Lisa J Woodhouse Andrew Belcher Daniel Bereczki Eivind Berge Valeria Caso Hui Meng Chang Hanne K Christensen Ronan Collins John Gommans Ann C Laska George Ntaios Serefnur Ozturk Gillian M Sare Szabolcs Szatmari Yongjun Wang Joanna M Wardlaw Nikola Sprigg Philip M Bath for the ENOS investigators | 2019 | Stroke & Vascular Neurology2019，4，1： | 6 |
| 3 | Tenecteplase Reperfusion therapy in Acute ischaemic Cerebrovascular Events-Ⅱ (TRACE Ⅱ): rationale and design显示文摘Background and purpose Tenecteplase(TNK)is a promising agent for treatment of acute ischaemic stroke(AIS).We hypothesised that recombinant human TNK tissue-type plasminogen activator(rhTNK-tPA)is non-inferior to rt-PA in achieving excellent functional outcome at 90 days,when administered within 4.5 hours of ischaemic stroke onset.Methods and design Tenecteplase Reperfusion therapy in Acute ischemic Cerebrovascular Events(TRACE)is a phase Ⅲ,multicentre,prospective,randomised,open-label,blinded-end point non-inferiority study.Patients eligible for intravenous thrombolysis therapy are randomised to rhTNK-tPA 0.25 mg/kg(single bolus)to a maximum of 25 mg or rt-PA 0.9 mg/kg(10%bolus+90%infusion/1 hour)to a maximum of 90 mg.Medications considered necessary for the patient’s health may be given at the discretion of the investigator during 90-day follow-up.Study outcomes The primary study outcome is excellent functional outcome defined as modified Rankin Scale(mRS)0–1 at 90 days.Secondary efficacy outcomes include favourable functional outcome defined as mRS≤2 at 90 days,ordinal distribution of mRS and major neurological improvement on the National Institutes of Health Stroke Scale.Safety outcomes are symptomatic intracranial haemorrhage within 36 hours and death from any cause.Discussion There is no completed registration study of TNK in AIS worldwide.TRACE Ⅱ strives to provide evidence for a new drug application for rhTNK-tPA in AIS within 4.5 hours through a well-designed and rigorously executed randomised trial in China. | Shuya Li Bruce C V Campbell Lee H Schwamm Marc Fisher Mark Parsons Hao Li Yuesong Pan Yongjun Wang | 2022 | Stroke & Vascular Neurology2022，7，1： | 2 |
| 4 | Autophagy promotes tumor cell survival and restricts necrosis, inflammation, and tumorigenesis显示文摘 | Kurt Degenhardt Robin Mathew Brian Beaudoin Kevin Bray Diana Anderson Guanghua Chen Chandreyee Mukherjee Yufang Shi Céline Gélinas Yongjun Fan Deirdre A. Nelson Shengkan Jin Eileen White | 2006 | Cancer Cell2006，，1： | 2 |
| 5 | Electrical pro- perties of SnO2-ZnO-Nb2O3 varistor system显示文摘 | Yongjun W Jinfeng W Hongcun C | 2000 | J Phys D: Appl Phys2000，33，： | 1 |
| 6 | A Critical Role of the PINCH-Integrin-linked Kinase Interaction in the Regulation of Cell Shape Change and migration显示文摘 | Yongjun Z Lida G Ka C | 2002 | J Biol Chem2002，277，： | 1 |
| 7 | A critical role of the PINCH integrin linked kinase interaction in the regulation of cell shape change and migration显示文摘 | Yongjun Z Lida G Ka C | 2002 | J Biol Chem2002，277，7： | 1 |
| 8 | Atorvastatin suppresses glio- ma invasion and migration by reducing microglial MT1 MMP ex- pression 显示文摘 | Yongjun Y Shuyun H Lei C | 2013 | J Neuroimmunol2013，260，12： | 1 |
| 9 | 显示文摘 | Leng Yongjun Hwa C S Khor K | 2003 | Journal of Power Sources2003，117，： | 1 |
| 10 | Ef- ficient harmonic filter allocation in an industrial distri- bution system显示文摘 | Stone P E C Wang J ingjiang Shin Yongjune | 2012 | IEEE Transactions on Industrial E- lectronics2012，59，2： | 1 |
| 11 | Dietal vitamin C requirement and its effects on tissue antioxidant capacity of juvenile largemouth bass, Micropterus salmoides 显示文摘 | Yongjun C Ruimin Y Yongjian L | 2015 | Aquaculture2015，435，： | 1 |
| 12 | Atorvastatin suppresses glioma invasion andmigration by reducing microglial MT1-MMP expression 显示文摘 | Yongjun Y Shuyun H Lei C | 2013 | J Neuroimmunol2013，260，1： | 1 |
| 13 | Applications of non evaporable getterpumpinvacuummetrology显示文摘 | Detian L Yongjun C | 2011 | Vacuum2011，85，7： | 1 |
| 14 | Atorvastatin suppresses glio- ma invasion and migration by reducing microglial MT1-MMP ex- pression 显示文摘 | Yongjun Y Shuyun H Lei C | 2013 | J Neuroimmuno2013，260，12： | 1 |
| 15 | Full parallax view- ing-angle enhanced computer-generated holographic 3D display sys- tem using integral lens array显示文摘 | KYONGS1K C JOOHWAN K YONGJUN L | 2005 | Optics Express2005，13，10： | 1 |
| 16 | Temporal trends and rural-urban disparities in cerebrovascular risk factors,in-hospital management and outcomes in ischaemic strokes in China from 2005 to 2015:a nationwide serial cross-sectional survey显示文摘Background Stroke is the leading cause of mortality in China,with limited evidence of in-hospital burden obtained from nationwide surveys.We aimed to monitor and track the temporal trends and rural-urban disparities in cerebrovascular risk factors,management and outcomes from 2005 to 2015.Methods We used a two-stage random sampling survey to create a nationally representative sample of patients admitted for ischaemic stroke in 2005,2010 and 2015.We sampled participating hospitals with an economic-geographical region-stratified random-sampling approach first and then obtained patients with a systematic sampling approach.We weighed our survey data to estimate the national-level results and assess changes from 2005 to 2015.Results We analysed 28277 ischaemic stroke admissions from 189 participating hospitals.From 2005 to 2015,the estimated national hospital admission rate for ischaemic stroke per 100000 people increased(from 75.9 to 402.7,Ptrend<0.001),and the prevalence of risk factors,including hypertension,diabetes,dyslipidaemia and current smoking,increased.The composite score of diagnostic tests for stroke aetiology assessment(from 0.22 to 0.36,Ptrend<0.001)and secondary prevention treatments(from 0.46 to 0.70,Ptrend<0.001)were improved.A temporal decrease was found in discharge against medical advice(DAMA)(from 15.2%(95%CI 13.7%to 16.7%)to 8.6%(8.1%to 9.0%);adjusted Ptrend=0.046),and decreases in in-hospital mortality(0.7%in 2015 vs 1.8%in 2005;adjusted OR(aOR)0.52;95%CI 0.32 to 0.85)and the composite outcome of in-hospital mortality or DAMA(8.4%in 2015 vs 13.9%in 2005;aOR 0.65;95%CI 0.47 to 0.89)were observed.Disparities between rural and urban hospitals narrowed;however,disparities persisted in in-hospital management(brain MRI:rural-urban difference from−14.4%to−11.2%;cerebrovascular assessment:from−20.3%to−16.7%;clopidogrel:from−2.1%to−10.3%;anticoagulant for atrial fibrillation:from−10.9%to−8.2%)and in-hospital outcomes(DAMA:from 2.7%to 5.0%;composite outcome of in-hospital mortality or DAMA:from 2.4%to 4.6%).Conclusions From 2005 to 2015,improvements in hospital admission and in-hospital management for ischaemic stroke in China were found.A temporal improvement in DAMA and improvements in in-hospital mortality and the composite outcome of in-hospital mortality or DAMA were observed.Disparities between rural and urban hospitals generally narrowed but persisted. | Chun-Juan Wang Hong-Qiu Gu Xin-Miao Zhang Yong Jiang Hao Li Janet Prvu Bettger Xia Meng Ke-Hui Dong Run-Qi Wangqin Xin Yang Meng Wang Chelsea Liu Li-Ping Liu Bei-Sha Tang Guo-Zhong Li Yu-Ming Xu Zhi-Yi He Yi Yang Winnie Yip Gregg C Fonarow Lee H Schwamm Ying Xian Xing-Quan Zhao Yi-Long Wang Yongjun Wang Zixiao Li | 2023 | Stroke & Vascular Neurology2023，8，1： | 0 |
| 17 | 伴颈动脉狭窄的急性缺血性卒中患者应用透皮吸收的硝酸甘油降压是安全的显示文摘背景对伴有颈动脉狭窄的急性卒中患者给予降压治疗可能会损害大脑灌注和患者转归,临床上一直对此存在顾虑。我们应用一氧化氮对卒中疗效研究(Efficacy of Nitric Oxide inStroke,ENOS)的数据,评价了硝酸甘油(GTN)对伴颈动脉狭窄的患者的效应。 | Jason P Appleton Lisa J Woodhouse Andrew Belcher Daniel Bereczki Eivind Berge Valeria Caso Hui Meng Chang Hanne K Christensen Ronan Collins John Gommans Ann C Laska George Ntaios Serefnur Ozturk Gillian M Sare Szabolcs Szatmari Yongjun Wang Joanna M Wardlaw Nikola Sprigg Philip M Bath 霍永丰(译) | 2019 | 英国医学杂志中文版2019，22，5： | 0 |
| 18 | Simulation of bacterial flagellar phase transition by non-convex and non-local continuum modeling显示文摘Bacterial flagellar filament can undergo a stress-induced polymorphic phase transition in both vitro and vivo environments.The filament has 12 different helical forms(phases) characterized by different pitch lengths and helix radii.When subjected to the frictional force of flowing fluid,the filament changes between a left-handed normal phase and a right-handed semi-coiled phase via phase nucleation and growth.This paper develops non-local finite element method(FEM) to simulate the phase transition under a displacement-controlled loading condition(controlled helix-twist).The FEM formulation is based on the Ginzburg-Landau theory using a one-dimensional non-convex and non-local continuum model.To describe the processes of the phase nucleation and growth,viscosity-type kinetics is also used.The non-local FEM simulation captures the main features of the phase transition:two-phase coexistence with an interface of finite thickness,phase nucleation and phase growth with interface propagation.The non-local FEM model provides a tool to study the effects of the interfacial energy/thickness and loading conditions on the phase transition. | Xiaoling Wang,1,a) Yongjun He,2,b) and Qingping Sun 3,c) 1) School of Mechanical Engineering,University of Science and Technology Beijing,Beijing 100083,China 2) UME-MS,ENSTA-ParisTech,Chemin de la Huni`ere,91761 Palaiseau Cedex,France 3) Department of Mechanical Engineering,The Hong Kong University of Science and Technology,Clear Water Bay,Kowloon,Hong Kong,China | 2011 | Theoretical & Applied Mechanics Letters2011，1，4： | 0 |
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