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| 1 | Mutation of kri1l causes definitive hematopoiesis failure via PERK-dependent excessive autophagy induction显示文摘 | Xiao-E Jia Ke Ma Tao Xu Lei Gao Shuang Wu Cong Fu Wenjuan Zhang Zhizhang Wang Kaiyu Liu Mei Dong Changbin Jing Chunguang Ren Zhiwei Dong Yi Chen Yi Jin Qiuhua Huang Xing Chang Min Deng Li Li Lingfei Luo Jun Zhu Yongjun Dang Hung-Chun Chang Leonard I Zon Yi Zhou Saijuan Chen Weijun Pan | 2015 | Cell Research2015，25，8： | 8 |
| 2 | Polygenetic Mineralization of the Early ProterozoicTongkuangyu Metaporphyry Copper Deposit inthe Zhongtiao Mountains,Shanxi Province显示文摘The Tongkuangyu metaporphyry copper deposit formed in the Early Proterozoic is tectonically located in the northern part of the Zhongtiao X -type palaeorift depression, on the southern margin of the North China platform. The genesis of the deposit has long been a hot subject of research of geologists working on mineral deposits. By means of the protolith reconstruction and fluid inclusion and isotope studies of host rocks of the deposits, the authors hold that this deposit is the product of combined exogenic, endogenic and metamorphic processes. Its formation mainly involved the following four stages: (1) the stage of formation of Mg- and Fe-rich tuffaceous variegated cupriferous sand-shale and K-rich biomodal volcanic rocks; (2) the early stage of formation of the metaporphyry copper deposit; (3) the stage of formation of the metaporphyry copper deposit; and (4) the stage of reworking of the metaporphyry copper deposit. | CHEN Wenming ZHANG Chengxin LU Jiren DANG Zefa LI Shuping CUI Wenbin NING Yuan | 1998 | Acta Geologica Sinica(English Edition)1998，72，2： | 7 |
| 3 | Ethacrynic acid targets GSTM1 to ameliorate obesity by promoting browning of white adipocytes显示文摘Dear Editor,Obesity is caused by an imbalance between energy intake and expenditure,and has become a global epidemic with over 650 million adults affected.Adipose tissues in mammals are composed of white adipose tissue(WAT)and classical brown adipose tissue(BAT),and their balance is highly related to the occurrence of obesity.The browning of white adipocytes results in“beige”or“brite”adipocytes,which appear functionally similar to classical brown adipocytes,and can be detected in WAT deposits of animals that have been exposed to cold or other inducers(Fu et al.,2015). | Zhaomeng Cui Yang Liu Wei Wan Yuyan Xu Yehui Hu Meng Ding Xin Dou Ruina Wang Hailing Li Yongmei Meng Wei Li Wei Jiang Zengxia Li Yiming Li Minjia Tan Dengke KMa Yu Ding Jun OLiu Cheng Luo Biao Yu Qiqun Tang Yongjun Dang | 2021 | Protein & Cell2021，12，6： | 1 |
| 4 | Continuous culture of urine-derived bladder cancer cells for precision medicine显示文摘Dear Editor,Bladder cancer is the most common type of genitourinary cancer in China,with an estimated 80,500 new cases and 32,900 related deaths in 2015 alone(Chen et al.,2016).Unlike many other cancers,there has been no significant improvement in survival rates for bladder cancer over the last three decades.Specific treatment regimens for bladder cancer and their efficacy vary depending not only on clinical stages,but also on associated risk factors and other personal clinical characteristics.Patients with non-muscle invasive bladder cancer(NMIBC)have a high 5-year recurrence rate of 60%-70%(Berdik,2017)and those with muscle invasive bladder cancer(MIBC)has a relatively poor prognosis with approximately 65%risk of death within 5-year follow-up(Kamat et al.,2016).Therefore,there is an urgent need to develop models for bladder cancer to screen for rational treatment strategies by personalized medicine to improve the clinical assessment and treatment of bladder cancer. | Shuai Jiang Jiaqi Wang Chen Yang Renke Tan Jun Hou Yuan Shi Huihui Zhang Shiyu Ma Jianan Wang Mengmeng Zhang George Philips Zengxia Li Jian Ma Wanjun Yu Guohua Wang Yuanming Wu Richard Schlegel Huina Wang Shanbo Cao Jianming Guo Xuefeng Liu Yongjun Dang | 2019 | Protein & Cell2019，10，12： | 1 |
| 5 | A novel in vitro prognostic model of bladder cancer based on urine-derived living tumor cells显示文摘Bladder cancer(BLCA)remains a difficult malignancy to manage because of its high recurrence,intense follow-up,and invasive diagnostic and treatment techniques.Immune checkpoint inhibitors(ICIs)have forged a new direction for the treatment of BLCA,but it is currently challenging to predict whether an individual patient will be sensitive to ICIs.We collected 43 urine/tumor samples from BLCA patients for primary bladder cancer cells(BCCs)culturing using our previously reported BCC culture platform.We used flow cytometry(FCM)to measure the expression levels of Programmed Death-Ligand 1(PD-L1)on BCCs before and after interferon-gamma(IFN-γ)treatment and found that PD-L1 expression and the sensitivities to IFN-γvaried among patients.RNA-sequencing,western blotting,and programmed death-1(PD-1)binding assays confirmed that the BCC FCM-based PD-L1 detection platform(BC-PD-L1)was reliable and was not hindered by the glycosylation of PD-L1.In the subsequent retrospective study,we found that IFN-γ-stimulated PD-L1(sPD-L1)expression on BCCs detected by BC-PD-L1 could predict the prognosis of BLCA patients.Importantly,the prognostic value was similar or even better in urine-derived BC-PD-L1(UBC-PD-L1).Transcriptome analysis showed that BCCs with high sPD-L1 tended to enrich genes associated with the collagen-containing extracellular matrix,cell–cell adhesion,and positive regulation of the immune system.In addition,the UBC-PD-L1 also exhibited predictive value for ICI response in BLCA patients.In conclusion,as a novel personalized urine-detection method,UBC-PD-L1 may provide a rapid,accurate,and non-invasive tool for monitoring tumor progression,predicting therapeutic responses,and helping improve BLCA clinical treatment in future. | Jiaqi Wang Jiying Zhu Junchi Hu Ziruoyu Wang Xiaobo Wang Jianbo Pan Yiwei Chu Zengxia Li Wei Jiang Chunmin Liang Jun Hou Jianming Guo Yongjun Dang Shuai Jiang | 2023 | Genes & Diseases2023，10，6： | 0 |
| 6 | Nucleolus localization of SpyCas9 affects its stability and interferes with host protein translation in mammalian cells显示文摘The CRISPR/Cas9 system,originally derived from the prokaryotic adaptive immune system,has been developed as efficient genome editing tools.It enables precise gene manipulation on chromosomal DNA through the specific binding of programmable sgRNA to target DNA,and the Cas9 protein,which has endonuclease activity,will cut a double strand break at specific locus.However,Cas9 is a foreign protein in mammalian cells,and the potential risks associated with its introduction into mammalian cells are not fully understood.In this study,we performed pull-down and mass spectrometry(MS)analysis of Streptococcus pyogenes Cas9(SpyCas9)interacting proteins in HEK293T cells and showed that the majority of Cas9-associated proteins identified by MS were localized in the nucleolus.Interestingly,we further discovered that the Cas9 protein contains a sequence encoding a nucleolus detention signal(NoDS).Compared with wild-type(WT)Cas9,NoDS-mutated variants of Cas9(mCas9)are less stable,although their gene editing activity is minimally affected.Overexpression of WT Cas9,but not mCas9,causes general effects on transcription and protein translation in the host cell.Overall,identification of NoDS in Cas9 will improve the understanding of Cas9's biological function in vivo,and the removal of NoDS in Cas9 may enhance its safety for future clinical use. | Renke Tan Wenhao Du Yiyang Liu Xiaoji Cong Meirong Bai Chenxiao Jiang Zengxia Li Minjia Tan Dengke K.Ma Qiang Huang Wei Jiang Yongjun Dang | 2022 | Genes & Diseases2022，9，3： | 0 |
| 7 | Integrative multi-omics and drug-response characterization of patient-derived prostate cancer primary cells显示文摘Prostate cancer(PCa)is the second most prevalent malignancy in males across the world.A greater knowledge of the relationship between protein abundance and drug responses would benefit precision treatment for PCa.Herein,we establish 35 Chinese PCa primary cell models to capture specific characteristics among PCa patients,including gene mutations,mRNA/protein/surface protein distributions,and pharmaceutical responses.The multi-omics analyses identify Anterior Gradient 2(AGR2)as a pre-operative prognostic biomarker in PCa.Through the drug library screening,we describe crizotinib as a selective compound for malignant PCa primary cells.We further perform the pharmacoproteome analysis and identify 14,372 significant protein-drug correlations.Surprisingly,the diminished AGR2 enhances the inhibition activity of crizotinib via ALK/c-MET-AKT axis activation which is validated by PC3 and xenograft model.Our integrated multi-omics approach yields a comprehensive understanding of PCa biomarkers and pharmacological responses,allowing for more precise diagnosis and therapies. | Ziruoyu Wang Yanan Li Wensi Zhao Shuai Jiang Yuqi Huang Jun Hou Xuelu Zhang Zhaoyu Zhai Chen Yang Jiaqi Wang Jiying Zhu Jianbo Pan Wei Jiang Zengxia Li Mingliang Ye Minjia Tan Haowen Jiang Yongjun Dang | 2023 | Signal Transduction and Targeted Therapy2023，8，6： | 0 |
| 8 | The nuclear bodies formed by histone demethylase KDM7A显示文摘Dear Editor,In the nucleus of higher eukaryotes,chromatin occupies only a small proportion of the nuclear space,while many proteins and RNAs segregate into membrane-less nuclear bodies(NBs).These NBs follow a stochastic or ordered assembly model and constantly exchange components with the surrounding nucleoplasm(Jain et al.,2016). | Hui Ming Qianfeng Wang Yuwen Zhang Luzhang Ji Lu Cheng Xiangru Huo Zixiang Yan Zhexiao Liu Yongjun Dang Bo Wen | 2021 | Protein & Cell2021，12，4： | 0 |
| 9 | Synthesis and Antiproliferative Activities of OSW-1 Analogues Bearing 2'-0-p-Acylaminobenzoyl Residues显示文摘Summary of main observation and conclusion OSW-1 is a well-known natural saponin with potent antitumor activities.We have designed and pre-pared a small library of 22 OSW-1 analogues with a variety of p-acylamino-benzoyl groups installed at C2'of the xylose residue,wherein a regioselective(1>3)-glycosylation of arabinoside 3,4-diol has been achieved by manipulatian of the protecting groups on the imidate donors.Bioassays lead to new structure-activity relationships as well as two aplicable fluorescent probes,which are found to localize to lysosomes in HeLa cells and could be used in further antitumor mechanism studies of OSW-1 in living cells. | Lijun Sun Di Zhu Laura Olde Groote Beverborg Ruina Wang Yongjun Dang Mingming Ma Wei Li Biao Yu | 2020 | Chinese Journal of Chemistry2020，38，10： | 0 |
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