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| 1 | De novo mutation in ATP6V1B2 impairs lysosome acidification and causes dominant deafness-onychodystrophy syndrome显示文摘 | Yongyi Yuan Jianguo Zhang Qing Chang Jin Zeng Feng Xin Jianjun Wang Qingyan Zhu Jing Wu Jingqiao Lu Weiwei Guo Xukun Yan Hui Jiang Binfei Zhou Qi Li Xue Gao Huijun Yuan Shiming Yang Dongyi Han Zixu Mao Ping Chen Xi Lin Pu Dai | 2014 | Cell Research2014，24，11： | 13 |
| 2 | Semi-tensor product approach to controllability and stabilizability of finite automata显示文摘Using semi-tensor product of matrices, the controllability and stabilizability of finite automata are investigated. By expressing the states, inputs, and outputs in vector forms, the transition and output functions are represented in matrix forms.Based on this algebraic description, a necessary and sufficient condition is proposed for checking whether a state is controllable to another one. By this condition, an algorithm is established to find all the control sequences of an arbitrary length. Moreover, the stabilizability of finite automata is considered, and a necessary and sufficient condition is presented to examine whether some states can be stabilized. Finally, the study of illustrative examples verifies the correctness of the presented results/algorithms. | Yongyi Yan Zengqiang Chen Zhongxin Liu | 2015 | Journal of Systems Engineering and Electronics2015，26，1： | 12 |
| 3 | Solving type-2 fuzzy relation equations via semi-tensor product of matrices显示文摘The problem of solving type-2 fuzzy relation equations is investigated. In order to apply semi-tensor product of matrices,a new matrix analysis method and tool, to solve type-2 fuzzy relation equations, a type-2 fuzzy relation is decomposed into two parts as principal sub-matrices and secondary sub-matrices; an r-ary symmetrical-valued type-2 fuzzy relation model and its corresponding symmetrical-valued type-2 fuzzy relation equation model are established. Then, two algorithms are developed for solving type-2 fuzzy relation equations, one of which gives a theoretical description for general type-2 fuzzy relation equations;the other one can find all the solutions to the symmetrical-valued ones. The results can improve designing type-2 fuzzy controllers,because it provides knowledge to search the optimal solutions or to find the reason if there is no solution. Finally some numerical examples verify the correctness of the results/algorithms. | Yongyi YAN Zengqiang CHEN Zhongxin LIU | 2014 | Control Theory and Technology2014，12，2： | 10 |
| 4 | Circumjacent distribution pattern of the Lungmachian graptolitic black shale(early Silurian) on the Yichang Uplift and its peripheral region显示文摘Stratigraphic hiatuses of variable time intervals within the Rhuddanian to early Aeronian(Llandovery, Silurian) are identified in the area bordering East Chongqing, West Hubei and Northwest Hunan in central China. Their distribution suggested the existence of a local uplift, traditionally named the Yichang Uplift. The diachronous nature of the basal black shale of the Lungmachi Formation crossing different belts of this Uplift signifies the various developing stages during the uplifting process.The present paper defines the temporal and spatial distribution pattern of the Yichang Uplift, which might be one of the important controlling factors for the preservation and distribution of the shale gas in this region, as it has been demonstrated that the shale gas exploration is generally less promising in the areas where more of the basal part of the Lungmachi Formation is missing.Therefore, better understanding of the circumjacent distribution pattern developed throughout the uplifting process may provide the important guidance for the shale gas exploration. The present work is a sister study to the published paper, 'Stage-progressive distribution pattern of the Lungmachian black graplolitic shales from Guizhou to Chongqing, Central China'. These two studies thus provide a complete Ordovician-Silurian black shale distribution pattern in the Middle and Upper Yangtze, a region with the major shale gas fields in China. | Xu CHEN Qing CHEN Yongyi ZHEN Hongyan WANG Linna ZHANG Junpeng ZHANG Wenhui WANG Zhaohui XIAO | 2018 | Science China Earth Sciences2018，61，9： | 9 |
| 5 | Semi-tensor product of matrices approach to reachability of finite automata with application to language recognition显示文摘 | Yongyi YAN Zengqiang CHEN Zhongxin LIU | 2014 | Frontiers of Computer Science2014，8，6： | 9 |
| 6 | Profiling of hepatocellular carcinoma neoantigens reveals immune microenvironment and clonal evolution related patterns显示文摘Objective: Neoantigens derived from tumor-specific genomic alterations have demonstrated great potential for immunotherapeutic interventions in cancers. However, the comprehensive profile of hepatocellular carcinoma(HCC) neoantigens and their complex interplay with immune microenvironment and tumor evolution have not been fully addressed.Methods: Here we integrated whole exome sequencing data, transcriptome sequencing data and clinical information of 72 primary HCC patients to characterize the HCC neoantigen profile, and systematically explored its interactions with tumor clonal evolution, driver mutations and immune microenvironments.Results: We observed that higher somatic mutation/neoantigen load was associated with better clinical outcomes and HCC patients could be further divided into two subgroups with distinct prognosis based on their neoantigen expression patterns. HCC subgroup with neoantigen expression probability high(NEP-H) showed more aggressive pathologic features including increased incidence of tumor thrombus(P=0.038), higher recurrence rate(P=0.029),more inclined to lack tumor capsule(P=0.026) and with more microsatellite instability sites(P=0.006). In addition,NEP-H subgroup was also characterized by higher chance to be involved in tumor clonal evolution [odds ratio(OR)=46.7, P<0.001]. Gene set enrichment analysis revealed that upregulation of MYC and its targets could suppress immune responses, leading to elevated neoantigen expression proportion in tumor cells. Furthermore, we discovered an immune escape mechanism that tumors could become more inconspicuous by evolving subclones with less immunogenicity. We observed that smaller clonal mutation clusters with higher immunogenicity in tumor were more likely to involve in clonal evolution. Based on identified neoantigen profiles, we also discovered series of neoantigenic hotspot genes, which could serve as potential actionable targets in future.Conclusions: Our results revealed the landscape of HCC neoantigens and discovered two clinically relevant subgroups with distinct neoantigen expression patterns, suggesting the neoantigen expression should be fully considered in future immunotherapeutic interventions. | Zhenli Li Geng Chen Zhixiong Cai Xiuqing Dong Lei He Liman Qiu Yongyi Zeng Xiaolong Liu Jingfeng Liu | 2021 | Chinese Journal of Cancer Research2021，33，3： | 3 |
| 7 | Hollow Gradient-Structured Iron-Anchored Carbon Nanospheres for Enhanced Electromagnetic Wave Absorption显示文摘In the present paper,a microwave absorber with nanoscale gradient structure was proposed for enhancing the electromagnetic absorption performance.The inorganic-organic competitive coating strategy was employed,which can effectively adjust the thermodynamic and kinetic reactions of iron ions during the solvothermal process.As a result,Fe nanoparticles can be gradually decreased from the inner side to the surface across the hollow carbon shell.The results reveal that it offers an outstanding reflection loss value in combination with broadband wave absorption and flexible adjustment ability,which is superior to other relative graded distribution structures and satisfied with the requirements of lightweight equipment.In addition,this work elucidates the intrinsic microwave regulation mechanism of the multiscale hybrid electromagnetic wave absorber.The excellent impedance matching and moderate dielectric parameters are exhibited to be the dominative factors for the promotion of microwave absorption performance of the optimized materials.This strategy to prepare gradient-distributed microwave absorbing materials initiates a new way for designing and fabricating wave absorber with excellent impedance matching property in practical applications. | Cao Wu Jing Wang Xiaohang Zhang Lixing Kang Xun Cao Yongyi Zhang Yutao Niu Yingying Yu Huili Fu Zongjie Shen Kunjie Wu Zhenzhong Yong Jingyun Zou Bin Wang Zhou Chen Zhengpeng Yang Qingwen Li | 2023 | Nano-Micro Letters2023，15，1： | 2 |
| 8 | Prognostic factors and recurrence of hepatitis B-related hepatocellular carcinoma after argon-helium cryoablation: a prospective study显示文摘 | Chunping Wang Yinying Lu Yan Chen Yongyi Feng Linjing An Xinzhen Wang Shuhui Su Wenlin Bai Lin Zhou Yongping Yang Dongping Xu | 2009 | Clinical & Experimental Metastasis2009，，7： | 1 |
| 9 | Prediction of solar cycle based on the invariant显示文摘A new method of predicting solar activities has been introduced in this paper. The method can predict both the occurrence time and the maximum number of sunspot at the same time. By studying the variation of sunspot, we find that the combination of the several variables was nearly in-variable during the entire solar cycles, as called invariant. And just only by determining the start time of a cycle, we can predict the occurrence time of cycles peak value accurately. Furthermore, according to observational data of the sunspot cycles, it showed that the sunspot maximum number has correlation not only with the prophase variety of the number in the cycle but also with the anaphase of the previous period. So we can introduce an equivalent regression coefficient, which can dynamically self-adapt to different cycle lengths, and effectively solve the inconsistency between the accuracy and the lead-time of the forecast. It can guarantee the satis-fied accuracy and effectively increases the lead-time of the forecast. This method can predict the maximum sunspot number for solar cycle at the approximate half rise of the period. This method predicts that the occurrence time of the maximum sunspot number for cycle 24 will be in January 2011. | LIU Shijun, YU Xiaoding & CHEN Yongyi Chinese Meteorological Administration Training Centre, Beijing 100081, China Correspondence should be addressed to Liu Shijun (e-mail: liushj@ cma.gov.cn) | 2003 | Chinese Science Bulletin2003，48，23： | 1 |
| 10 | 20世纪汉语“史诗问题”探论显示文摘本文探讨了二十世纪一直为学界争论的汉语'史诗问题'。一个世纪以来,为解决这个在西方文学起源的视野下而产生的问题,前辈学人提出了许多看法。可是在仔细检视之下即可发现,各种假设和解释均不具有切合事实本身的充分真实性。这件学术公案是学者们在西风东渐的大背景下,将西方文学的起源模式移至中土,解释中国文学的起源而产生的。本文认为,将西方文学史的起源模式当作具有普世性的文学史起源的解释框架,以史诗作为解说中国文学源头方案的合理性是可以质疑的。因为其学术意识并非源自对事实和材料本身的深切了解,而它背后存在的对西方话语不加反省的盲从,也应引以为鉴。 | 林岗 Chen Yongyi Zhang Zhiping | 2007 | Social Sciences in China2007，28，2： | 1 |
| 11 | Phase structure and microstructure of a nanoscale TiO2-RuO2-IrO2-Ta205 anode coating on titanium显示文摘 | Chen Yongyi Zhang Teng Wang Xin | 2008 | Journal of the American Ceramic Society2008，91，12： | 1 |
| 12 | Prognostic factors and recurrence of hepatitis B-related hepatocellular carcinoma after argon-helium cryoablation: a prospective study显示文摘 | Chunping Wang Yinying Lu Yan Chen Yongyi Feng Linjing An Xinzhen Wang Shuhui Su Wenlin Bai Lin Zhou Yongping Yang Dongping Xu | 2009 | Clinical & Experimental Metastasis2009，，7： | 1 |
| 13 | Hybrid C8-BTBT/In GaAs nanowire heterojunction for artificial photosynaptic transistors显示文摘The emergence of light-tunable synaptic transistors provides opportunities to break through the von Neumann bottleneck and enable neuromorphic computing.Herein,a multifunctional synaptic transistor is constructed by using 2,7-dioctyl[1]benzothieno[3,2-b][1]benzothiophene(C8-BTBT)and indium gallium arsenide(InGaAs)nanowires(NWs)hybrid heterojunction thin film as the active layer.Under illumination,the Type-I C8-BTBT/InGaAs NWs heterojunction would make the dissociated photogenerated excitons more difficult to recombine.The persistent photoconductivity caused by charge trapping can then be used to mimic photosynaptic behaviors,including excitatory postsynaptic current,long/short-term memory and Pavlovian learning.Furthermore,a high classification accuracy of 89.72%can be achieved through the single-layer-perceptron hardware-based neural network built from C8-BTBT/InGaAs NWs synaptic transistors.Thus,this work could provide new insights into the fabrication of high-performance optoelectronic synaptic devices. | Yiling Nie Pengshan Xie Xu Chen Chenxing Jin Wanrong Liu Xiaofang Shi Yunchao Xu Yongyi Peng Johnny C.Ho Jia Sun Junliang Yang | 2022 | Journal of Semiconductors2022，43，11： | 1 |
| 14 | Osteopontin protects against cardiac ischemia-reperfusion injury through late preconditioning显示文摘 | Yongyi Wang Baofu Chen Dafu Shen Song Xue | 2009 | Heart and Vessels2009，，2： | 1 |
| 15 | Advances in wide-tuning and narrow-linewidth external-cavity diode lasers显示文摘The external-cavity diode laser is advantageous in terms of low noise,high side-mode suppression ratio,high temperature stability,simple structure,and low cost,which has been the preferred scheme to realize wide-tuning and narrow-linewidth characteristics.Thus,it has been widely used in optical communication,lidar,environmental monitoring,spectral analysis,optical coherence tomography,and other frontier fields.Herein,we introduce the technical scheme and review the development status of wide-tuning and narrow-linewidth external-cavity diode lasers in detail.Primarily,the structure,working principles,and performance characteristics of external-cavity diode lasers are deeply analyzed according to different structures.The structural characteristics,key technologies,optical performance and application fields of state-of-theart studies in recent years are discussed.Finally,the challenges and potential development prospects of wide-tuning and narrow-linewidth external-cavity diode lasers are analyzed and discussed. | Qiang CUI Yuxin LEI Yongyi CHEN Cheng QIU Ye WANG Dexiao ZHANG Lutai FAN Yue SONG Peng JIA Lei LIANG Yubing WANG Li QIN Yongqiang NING Lijun WANG | 2022 | Science China(Information Sciences)2022，65，8： | 1 |
| 16 | A graph-aided method for planning two-level experiments when certain interactions are important显示文摘 | Wu C F J Chen Yongyi | 1992 | Technometrics1992，34，： | 1 |
| 17 | Advances in narrow linewidth diode lasers显示文摘The smart travel era has come and requirement for high precision lidar detection technology is higher and higher. The new solid-state lidars can meet the requirements of intelligent cars in the future, with the advantages of high resolution, strong anti-active jamming ability, small volume, light weight, low cost and so on. The narrow linewidth diode laser is the perfect light source of solid-state lidars. The progress and development of narrow linewidth diode laser technique can greatly improve the application of solidstate lidar. The technology and development status of narrow linewidth diode lasers has been described detailly in the paper. And the design ideas, key fabrication technologies and optical characteristics of various narrow linewidth diode lasers have been analyzed and discussed as well. Finally, the developments of narrow linewidth diode lasers are prospected. | Xingkai LANG Peng JIA Yongyi CHEN Li QIN Lei LIANG Chao CHEN Yubing WANG Xiaonan SHAN Yongqiang NING Lijun WANG | 2019 | Science China(Information Sciences)2019，62，6： | 1 |
| 18 | Public Power and Public Responsibility: Limiting Power and Demanding Responsibility显示文摘Recent reports on the 'basic failure of reform in the health care system' have trig- gered a widespread debate on the 'crisis in the supply of public goods,' | Qin Hui Chen Yongyi(译) Zhang Zhiping(译) | 2007 | Social Sciences in China2007，28，3： | 1 |
| 19 | Low microRNA-199a expression in human amniotic epithelial cell feeder layers maintains human-induced pluripotent stem cell pluripotency via increased leukemia inhibitory factor expression显示文摘导致人的 pluripotent 茎(iPS ) 房间分享象胚胎的干细胞的一样的关键性质,并且可以从病人特定或疾病特定的来源被产生,它为个性化的药,药屏幕,或细胞的治疗使他们漂亮。处于一个无差别的自我更新的状态的正常 iPS 房间的长期的耕作和维护是主要挑战。我们的以前的研究证明了人的羊膜的上皮的房间(HuAECs ) 能为老鼠和人提供 feeder 房间的好来源胚胎的干细胞,或 spermatogonial 干细胞,他们表示内长的白血病禁止的因素(LIF ) 在高级。这里,我们在 HuAECs 在内长的 LIF 表示上检验了外长的 microRNA-199a 规定的效果,并且接着在人的 iPS 房间 pluripotency 上。我们发现有 microRNA-199a 异种的 HuAECs feeder 房间 transfected 在高水平表示了 LIF,允许 iPS 维持在长期的文化的碱的磷酸酶活动和在严重联合 immunodeficient 老鼠的形式 teratomas 的高水平。干细胞标记的表达式与 microRNA-199a 异种在在 HuAECs feeder 房间 transfected 上有教养的 iPS 被增加,与在有 microRNA-199a 或鼠标胚胎成纤维细胞的 HuAECs transfected 上有教养的 iPS 相比。一起拿,这些结果建议那 LIF 表情可能被 microRNA-199a,和 LIF 调整是在 feeder 房间的一个关键部件,并且也为人的 iPS 房间的维护被要求在一无差别,能够自强的 proliferative 状态。 | Te Liu Qing Chen Yongyi Huang Qin Huang Lizhen Jiang Lihe Guo | 2012 | Acta Biochimica et Biophysica Sinica2012，44，3： | 1 |
| 20 | Preparation and characterization of poly (L-lactide) membranes prepared by 3'- radiation-induced grafting of N-vinyl pyrrolidone 显示文摘 | Chen Hao Peng Chaorong Yao Yongyi | 2009 | Journal of Applied Polymer Science2009，114，5： | 1 |
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