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| 1 | Pretreatment of emulational manual acupuncture versus electroacupuncture against visceral traction pain in rats显示文摘BACKGROUND:Acupuncture and moxibustion against visceral noxious stimulation present different mechanisms in the peripheral and central nervous systems,involving release of neurotransmitter substance P,acetylcholine esterase,leucine-enkephalin,and c-Fos protein expression.However,there are few reports addressing changes in neurotransmitter expression following manual acupuncture and electroacupuncture against visceral traction pain.OBJECTIVE:To explore changes in neurotransmitter expression in the ileum and protein expression in the medullary visceral zone of visceral traction pain rats undergoing pretreatment of emulational manual acupuncture,and to investigate the differences between emulational manual acupuncture and electroacupuncture.DESIGN,TIME AND SETTING:The randomized,controlled study was performed at the Biomedical Engineering Laboratory,Shanghai University of Traditional Chinese Medicine,Shanghai,China from August 2008 to July 2009.MATERIALS:G6805 electroacupuncture apparatus(Shanghai Medical Electronic Machine Factory,China) and ZSF-I acupuncture manipulation simulation therapeutic system(Chinese Medical Engineering Room,Shanghai University of Traditional Chinese Medicine,Shanghai China) were used in the present study.METHODS:A total of 40 male Sprague Dawley rats were equally and randomly assigned to sham surgery,model,emulational manual acupuncture and electroacupuncture groups.In the emulational manual acupuncture and electroacupuncture groups,emulational manual acupuncture and electroacupuncture were applied at bilateral Zusanli(ST 36) acupoints for 30 minutes,and models of visceral traction pain were established immediately.MAIN OUTCOME MEASURES:Substance P expression,c-Fos and glial fibrillary acidic protein expression were measured using immunohistochemistry.Acetylcholine esterase activity was examined utilizing a colorimetric method.Leucine-enkephalin content was detected using a radioimmune assay.Degree of pain in rats was assessed by pain score.RESULTS:Pain score,substance P expression in the ileum,acetylcholine esterase activity,expression of c-Fos protein and glial fibrillary acidic protein in the medullary visceral zone were significantly decreased following pretreatment of emulational manual acupuncture and electroacupuncture in rats with visceral traction pain(P < 0.05).Compared with the electroacupuncture group,the leucine-enkephalin content was significantly increased,and pain score was significantly diminished in the emulational manual acupuncture group(P < 0.05).CONCLUSION:Emulational manual acupuncture pretreatment decreases acetylcholine esterase activity,increases leucine-enkephalin release,downregulates expression of c-Fos protein and glial fibrillary acidic protein and ultimately inhibits visceral traction pain by reducing substance P release.The effectiveness in inhibiting visceral traction pain is greater when using emulational manual acupuncture compared with electroacupuncture.This is because emulational manual acupuncture effectively increases leucine-enkephalin release. | Huayuan Yang Tingting Guo Youjiang Min Tangyi Liu Ming Gao | 2010 | Neural Regeneration Research2010，5，10： | 2 |
| 2 | Acupoint electrogymnastics therapy in stroke hemiplegia显示文摘BACKGROUND: Electrogymnastics can offer a range of proprioceptive, motor, and cutaneous sensation impulses to the central nerve system. The center receives perception of the paralyzed muscle through the aid of these impulses. During this process, functional reorganization of connecting network between segment and intersegment takes place. OBJECTIVE: To observe the therapeutic efficacy of acupoint electrogymnastics and traditional electroacupuncture on stroke hemiplegia. DESIGN, TIME AND SETTING: A multicenter, randomized, controlled, blinded, clinical study was performed at the College of Acu-moxibustion and Massage in Shanghai University of Traditional Chinese Medicine from May 2004 to September 2006. PARTICIPANTS: A total of 153 patients suffering from stroke hemiplegia, comprising 83 males and 70 females, aged 63-70 years, were admitted to outpatient and inpatient at LongHua Hospital Affiliated Shanghai University of Traditional Chinese medicine, Putuo District Traditional Chinese Medicine Hospital and Changqiao Street Community Health Service Center of Shanghai. METHODS: The patients were randomly divided into treatment (n = 77) and control (n = 76) groups. They were treated with acupoint electrogymnastics and traditional electroacupuncture, respectively. In the treatment group, two pairs of positive and negative JD-2008 type electrodes from a hemiplegia treatment apparatus were directly pasted on the Shousanli (LI 10) and Waiguan (SJ 5) acupoints of the upper limb, as well as the Zusanli (S 36) and Yanglingquan (GB 34) acupoints of the lower limb, respectively. In the control group, needles were consecutively inserted into the above acupoints. Using the method of lifting-inserting and twisting-rotating, the needle was manipulated with small amplitude of 5-7 mm and a fast frequency of 80-120 times/min when the needle was inserted to a suitable depth. When the sensation of needling was attained, the two pairs of positive and negative electrodes of type G6805-II electro-acupuncture apparatus were connected to the Shousanli (LI 10) and Waiguan (SJ 5) acupoints of the upper limb, as well as the Zusanli (S 36) and Yanglingquan(GB 34) acupoints of the lower limb, respectively. MAIN OUTCOME MEASURES: The Fugl-Meyer evaluation method was used to assess upper limb movement, lower limb movement, sensory stimulation of all limbs, balance, and joint range of motion. RESULTS: Upper-lower limb motor function, limb sensory function, balance, and joint range of motion were significantly ameliorated following treatment, compared with pre-treatment (P < 0.01). There was no significant difference in various indexes between the two groups after treatment (P > 0.05). CONCLUSION: Acupoint electrogymnastics and traditional electroacupuncture exhibited similar curative effects in the treatment of stroke hemiplegia, | Huayuan Yang Tangyi Liu Yanhong Wang Shengguo Ying Chaoying Zheng Le Kuai MingGao Youjiang Min | 2008 | Neural Regeneration Research2008，3，10： | 1 |
| 3 | Efficacy of suspended moxibustion stimulating Shenshu(BL23)and Guanyuan(CV4)on the amygdala-HPA axis in rats with kidney-Yang deficiency symptom pattern induced by hydrocortisone显示文摘OBJECTIVE:To investigated the effects of suspended moxibustion stimulating Shenshu(BL23)and Guanyuan(CV4)acupoints on the amygdala and HPA axis in our rat model and elucidated the possible molecular mechanisms of moxibustion on kidney-Yang deficiency symptom pattern(KYDS).METHODS:Sixty male Sprague Dawley rats were randomly divided into a control group(n=12)and an experimental group(n=48).Rats in the experimental group were given intramuscular injections of hydrocortisone to establish a KYDS model.The 48 rats successfully modeled were then randomly divided into a model group(model,n=12),a carbenoxolone intraperitoneal injection group(CBX,n=12),a moxibustion group(moxi,n=12),and a moxi+CBX group(n=12).In the moxi,the Shenshu(BL23)and Guanyuan(CV 4)acupoints were treated with moxibustion for 14 d.After treatment,measures were taken of serum levels of corticosterone(CORT),adrenocorticotropic hormone(ACTH),and corticotropinreleasing hormone(CRH).The expression of mineralocorticoid receptors(MRs),glucocorticoid receptors(GRs),11beta-hydroxysteroid dehydrogenase type 1(11β-HSD1),CRH,and ACTH in the rats’amygdala,hypothalamus,or pituitary(as appropriate)was detected.Data were analyzed using one-way analysis of variance.RESULTS:Compared with those of the control group,the serum levels of CRH,ACTH,and CORT;the mRNA and protein expressions of MR,GR,and 11β-HSD1 in the amygdala;the mRNA and protein expressions of 11β-HSD1 in the hypothalamus;the CRH mRNA expression in the amygdala and hypothalamus;and the ACTH mRNA expression in the pituitary of the rats in the model group were all significantly decreased(P<0.05 or 0.01).After treatment with moxibustion,all the aforementioned observation indices except for 11β-HSD1 m RNA expression were ameliorated compared with those in the model group(P<0.05 or 0.01).CONCLUSIONS:Suspended moxibustion can effectively improve the serum levels of ACTH,CRH,and CORT and can up-regulate the mRNA and protein expressions of MR,GR,11β-HSD1,CRH,and ACTH in the amygdala and hypothalamus of KYDS rats.This may be one of the molecular mechanisms with which moxibustion alleviates KYDS. | MIN Youjiang YAO Haihua WANG Zhiqin LUO Kaitao SUN Jie YUAN Zheng WU Huiqi CHENG Lihong | 2023 | Journal of Traditional Chinese Medicine2023，43，1： | 0 |
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