| 1 | Circulating miRNAs in Ageing and Ageing-Related Diseases显示文摘MicroRNAs(miRNAs) are small non-coding RNAs that negatively regulate gene expression at the post-transcriptional level.They are involved in important biological processes including development,homeostasis,and ageing.Recently,extracellular miRNAs have been discovered in the bloodstream and bodily fluids.These miRNAs are shown to be secreted and circulating in microvesicles(MVs),or in complex with other factors such as RNA-binding proteins and high-density lipoprotein(HDL) particles.These cell-free,circulating miRNAs can be taken into and function as negative regulators of target genes in recipient cells.Here we review the biogenesis and uptake of circulating miRNAs as well as their profiles in ageing and ageing-related diseases.We discuss the emerging role of circulating miRNAs as biomarkers and therapeutic targets. | Hwa Jin Jung Yousin Suh | 2014 | Journal of Genetics and Genomics2014，41，9： | 9 |
您所在的机构暂未开通此部分的功能，请联系管理员