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| 1 | Effect of human umbilical cord-derived mesenchymal stem cells on lung damage in severe COVID-19 patients:a randomized,double-blind,placebo-controlled phase 2 trial显示文摘Treatment of severe Coronavirus Disease 2019(COVID-19)is challenging.We performed a phase 2 trial to assess the efficacy andsafety of human umbilical cord-mesenchymal stem cells(UC-MScs)to treat severe coViD-19 patients with lung damage,based onour phase 1 data.In this randomized,double-blind,and placebo-controlled trial,we recruited 101 severe coVID-19 patients withlung damage.They were randomly assigned at a 2:1 ratio to receive either UC-MSCs(4×10^(7)cells per infusion)or placebo on day 0,3,and 6.The primary endpoint was an altered proportion of whole lung lesion volumes from baseline to day 28.Other imagingoutcomes,6-minute walk test(6-MWT),maximum vital capacity,diffusing capacity,and adverse events were recorded and analyzed.In all,100 COVID-19 patients were finally received either UC-MSCs in=65)or placebo(n=35).UC-MSCs administrationexerted numerical improvement in whole lung lesion volume from baseline to day 28 compared with the placebo(the mediandifference was-13.31%,95%Cl-29.14%,2.13%,P=0.08).UC-MSCs significanty reduced the proportions of solid componentlesion volume compared with the placebo(median difference:-15.45%;95%CI-30.82%,-0.39%;P=0.043).The 6-MWT showedan increased distance in patients treated with UC-MSCs(difference:27.00 m;95%CI 0.00,57.00;P=0.057).The incidence of adverseevents was similar in the two groups.These results suggest that UC-MSCs treatment is a safe and potentially effective therapeuticapproach for COVID-19 patients with lung damage.A phase 3 trial is required to evaluate effects on reducing mortality andpreventing long-term pulmonary disability. | Lei Shi Hai Huang Xuechun Lu Xiaoyan Yan Xiaojing Jiang Ruonan Xu Siyu Wang Chao Zhang Xin Yuan Zhe Xu Lei Huang Jun-Liang Fu Yuanyuan Li Yu Zhang Wei-Qi Yao Tianyi Liu Jinwen Song Liangliang Sun Fan Yang Xin Zhang Bo Zhang Ming Shi Fanping Meng Yanning Song Yongpei Yu Jiqiu Wen Qi Li Qing Mao Markus Maeurer Alimuddin Zumla Chen Yao Wei-Fen Xie Fu-Sheng Wang | 2021 | Signal Transduction and Targeted Therapy2021，6，3： | 13 |
| 2 | Simultaneous Detection of 13 Key Bacterial Respiratory Pathogens by Combination of Multiplex PCR and Capillary Electrophoresis显示文摘Objective Lower respiratory tract infections continue to pose a significant threat to human health. It is important to accurately and rapidly detect respiratory bacteria. To compensate for the limits of current respiratory bacteria detection methods, we developed a combination of multiplex polymerase chain reaction(PCR) and capillary electrophoresis(MPCE) assay to detect thirteen bacterial pathogens responsible for lower respiratory tract infections, including Streptococcus pneumoniae, Haemophilus influenzae, Moraxella catarrhalis, Pseudomonas aeruginosa, Klebsiella pneumoniae, Escherichia coli, Staphylococcus aureus, Mycoplasma pneumoniae, Legionella spp., Bordetella pertussis, Mycobacterium tuberculosis complex, Corynebacterium diphtheriae, and Streptococcus pyogenes. Methods Three multiplex PCR reactions were built, and the products were analyzed by capillary electrophoresis using the high-throughput DNA analyzer. The specificity of the MPCE assay was examined and the detection limit was evaluated using DNA samples from each bacterial strain and the simulative samples of each strain. This assay was further evaluated using 152 clinical specimens and compared with real-time PCR reactions. For this assay, three nested-multiplex-PCRs were used to detect these clinical specimens. Results The detection limits of the MPCE assay for the 13 pathogens were very low and ranged from 10^(-7) to 10^(-2) ng/μL. Furthermore, analysis of the 152 clinical specimens yielded a specificity ranging from 96.5%-100.0%, and a sensitivity of 100.0% for the 13 pathogens. Conclusion This study revealed that the MPCE assay is a rapid, reliable, and high-throughput method with high specificity and sensitivity. This assay has great potential in the molecular epidemiological survey of respiratory pathogens. | JIANG Lu Xi REN Hong Yu ZHOU Hai Jian ZHAO Si Hong HOU Bo Yan YAN Jian Ping QIN Tian CHEN Yu | 2017 | Biomedical and Environmental Sciences2017，30，8： | 8 |
| 3 | Association of Overlapped and Un-overlapped Comorbidities with COVID-19 Severity and Treatment Outcomes: A Retrospective Cohort Study from Nine Provinces in China显示文摘Objective Several COVID-19 patients have overlapping comorbidities. The independent role of each component contributing to the risk of COVID-19 is unknown, and how some non-cardiometabolic comorbidities affect the risk of COVID-19 remains unclear.Methods A retrospective follow-up design was adopted. A total of 1,160 laboratory-confirmed patients were enrolled from nine provinces in China. Data on comorbidities were obtained from the patients’ medical records. Multivariable logistic regression models were used to estimate the odds ratio(OR) and 95% confidence interval(95% CI) of the associations between comorbidities(cardiometabolic or non-cardiometabolic diseases), clinical severity, and treatment outcomes of COVID-19.Results Overall, 158(13.6%) patients were diagnosed with severe illness and 32(2.7%) had unfavorable outcomes. Hypertension(2.87, 1.30–6.32), type 2 diabetes(T2 DM)(3.57, 2.32–5.49),cardiovascular disease(CVD)(3.78, 1.81–7.89), fatty liver disease(7.53, 1.96–28.96), hyperlipidemia(2.15, 1.26–3.67), other lung diseases(6.00, 3.01–11.96), and electrolyte imbalance(10.40, 3.00–26.10)were independently linked to increased odds of being severely ill. T2 DM(6.07, 2.89–12.75), CVD(8.47,6.03–11.89), and electrolyte imbalance(19.44, 11.47–32.96) were also strong predictors of unfavorable outcomes. Women with comorbidities were more likely to have severe disease on admission(5.46,3.25–9.19), while men with comorbidities were more likely to have unfavorable treatment outcomes(6.58, 1.46–29.64) within two weeks.Conclusion Besides hypertension, diabetes, and CVD, fatty liver disease, hyperlipidemia, other lung diseases, and electrolyte imbalance were independent risk factors for COVID-19 severity and poor treatment outcome. Women with comorbidities were more likely to have severe disease, while men with comorbidities were more likely to have unfavorable treatment outcomes. | MA Yan ZHU Dong Shan CHEN Ren Bo SHI Nan Nan LIU Si Hong FAN Yi Pin WU Gui Hui YANG Pu Ye BAI Jiang Feng CHEN Hong CHEN Li Ying FENG Qiao GUO Tuan Mao HOU Yong HU Gui Fen HU Xiao Mei HU Yun Hong HUANG Jin HUANG Qiu Hua HUANG Shao Zhen JI Liang JIN Hai Hao LEI Xiao LI Chun Yan LI Min Qing LI Qun Tang LI Xian Yong LIU Hong De LIU Jin Ping LIU Zhang MA Yu Ting MAO Ya MO Liu Fen NA Hui WANG Jing Wei SONG Fang Li SUN Sheng WANG Dong Ting WANG Ming Xuan WANG Xiao Yan WANG Yin Zhen WANG Yu Dong WU Wei WU Lan Ping XIAO Yan Hua XIE Hai Jun XU Hong Ming XU Shou Fang XUE Rui Xia YANG Chun YANG Kai Jun YUAN Sheng Li ZHANG Gong Qi ZHANG Jin Bo ZHANG Lin Song ZHAO Shu Sen ZHAO Wan Ying ZHENG Kai ZHOU Ying Chun ZHU Jun Teng ZHU Tian Qing ZHANG Hua Min WANG Yan Ping WANG Yong Yan 无 | 2020 | Biomedical and Environmental Sciences2020，33，12： | 8 |
| 4 | Synthesis and plant-growth regulatory activities of novel imine derivatives containing 1H-1,2,4-triazole and thiazole rings显示文摘Eleven new imine derivatives 6 containing 1H-1,2,4-triazole and thiazole rings were synthesized by the condensation of 5-((1H- 1,2,4-triazol-1-yl)methyl)-4-tert-butylthiazol-2-amine with various substituted benzaldehydes.The structures of the title compounds were characterized by ~1H NMR,MS and elemental analysis.The plant-growth regulatory activities of these compounds were evaluated.The primary bioassay results indicated that these target compounds exhibited promising plant-growth regulatory activities... | Qin, Xue Yu, Hai Bo Dai, Hong Qin, Zhen Fang Zhang, Xin Bing, Gui Fang Wang, Ting Ting Fang, Jian Xin | 2010 | Chinese Chemical Letters2010，21，3： | 6 |
| 5 | Effect of Soy Isoflavone Crude Extract Supplementation on High Fat Diet-induced Insulin Resistance in Ovariectomized Rats显示文摘Female Wister rats aged 8 weeks were randomly divided into sham operation group,ovariectomized(OVX)control group,and 2 OVX groups fed with soy isoflavone crude extract supplementation.The rats had free access to high fat diet and water for 9 weeks.No significant difference was found in body weight(BW),total abdominal fat,food intake and food utilization rate between OVX control group and 2 OVX groups.However,the fasting blood glucose and blood lipid levels were significantly higher in 2 OVX groups than in OVX control group(P<0.05).Intraperitoneal glucose tolerance test(IGTT)showed that the area under AUC was smaller in 2 OVX groups than in OVX control group(P<0.05).These findings showed that soy isoflavone crude extract supplementation can improve glucose tolerance and prevent high fat diet-induced insulin resistance in ovariectomized rats. | ZHANG Yun Bo LI Li Na ZHAO Xin Yu CHEN Wen Hua GUO Jing Jing FU Zheng Hai YANG Yang NA Xiao Lin | 2014 | Biomedical and Environmental Sciences2014，27，1： | 6 |
| 6 | Hierarchical Ti_(3)C_(2)T_(x)@ ZnO Hollow Spheres with Excellent Microwave Absorption Inspired by the Visual Phenomenon of Eyeless Urchins显示文摘Ingenious microstructure design and rational composition selection are effective approaches to realize high-performance microwave absorbers,and the advancement of biomimetic manufacturing provides a new strategy.In nature,urchins are the animals without eyes but can“see”,because their special structure composed of regular spines and spherical photosensitive bodies“amplifies”the light-receiving ability.Herein,inspired by the above phenomenon,the biomimetic urchin-like Ti_(3)C_(2)T_(x)@ZnO hollow microspheres are rationally designed and fabricated,in which ZnO nanoarrays(length:~2.3μm,diameter:~100 nm)as the urchin spines are evenly grafted onto the surface of the Ti_(3)C_(2)T_(x) hollow spheres(diameter:~4.2μm)as the urchin spherical photosensitive bodies.The construction of gradient impedance and hierarchical heterostructures enhance the attenuation of incident electromagnetic waves.And the EMW loss behavior is further revealed by limited integral simulation calculations,which fully highlights the advantages of the urchin-like architecture.As a result,the Ti_(3)C_(2)T_(x)@ZnO hollow spheres deliver a strong reflection loss of−57.4 dB and broad effective absorption bandwidth of 6.56 GHz,superior to similar absorbents.This work provides a new biomimetic strategy for the design and manufacturing of advanced microwave absorbers. | Yan‑Qin Wang Hai‑Bo Zhao Jin‑Bo Cheng Bo‑Wen Liu Qiang Fu Yu‑Zhong Wang | 2022 | Nano-Micro Letters2022，14，5： | 5 |
| 7 | Characterization of Avian Influenza A(H7N9) Virus Prevalence in Humans and Poultry in Huai′an,China:Molecular Epidemiology,Phylogenetic,and Dynamics Analyses显示文摘Objective To trace the source of human H7N9 cases in Huai'an and elucidate the genetic characterization of Huai'an strains associated with both humans and birds in live poultry market.Methods An enhanced surveillance was implemented when the first human H7N9 case was confirmed in Huai'an.Clinical specimens,cloacal swabs,and fecal samples were collected and screened by real-time reverse transcription-polymerase chain reaction(RT-PCR) for H7N9 virus.The positive samples were subjected to further RT-PCR and genome sequencing.The phylodynamic patterns of H7N9 virus within and separated from Huai'an and evolutionary dynamics of the virus were analyzed.Results Six patients with H7N9 infection were previously exposed to live poultry market and presented symptoms such as fever(>38.0 °C) and headaches.Results of this study support the hypothesis that live poultry markets were the source of human H7N9 exposure.Phylogenetic analysis revealed that all novel H7N9 viruses,including Huai'an strains,could be classified into two distinct clades,A and B.Additionally,the diversified H7N9 virus circulated in live poultry markets in Huai'an.Interestingly,the common ancestors of the Huai'an H7N9 virus existed in January 2012.The mean nucleotide substitution rates for each gene segment of the H7N9 virus were(3.09-7.26)×10-3 substitutions/site per year(95% HPD:1.72×10-3 to 1.16×10-2).Conclusion Overall,the source of exposure of human H7N9 cases in Huai'an was live poultry market,and our study highlights the presence of divergent genetic lineage of H7N9 virus in both humans and poultry specimens in Huai'an. | YANG Peng Fei YAN Qing Li LIU Chun Cheng XING Ya Dong ZHANG Min Hui GAO Qiang YU Hao YAO Hai Bo HE Nan Jiang | 2016 | Biomedical and Environmental Sciences2016，29，10： | 3 |
| 8 | A New Anti-Collision Algorithm for Multi-Target Real Time Recognitionin RFID System显示文摘The problem of how to distinguish and recognize more than one target when they are entering the working area of the Radio Frequency Identification( RFID ) system should be considered in design of the system. To avoid signal interference with each other among all targets, an anti collision algorithm as well as the condition of working stability is proposed. The computer simulation shows that the new algorithm will be of advantages in the process of system design. | SHEN Yu chao, WANG Hai bo, SHEN Shu qun, XU Da xiong (School of Electronic Engineering,Beijing University of Posts and Telecommunications,Beijing 100876,P.R.China) | 2000 | The Journal of China Universities of Posts and Telecommunications2000，7，3： | 3 |
| 9 | Synthesis of N-methylene phosphonic chitosan(NMPCS)and its potential as gene carder显示文摘N-Methylene phosphoulc chitosan (NMPCS),an amphiphilic macromolecule with powerful chelating ability of Ca^(2+) ions,was synthesized and characterized.The physicochemical properties of NMPCS and the interactions between NMPCS and plasmid DNA were investigated by FTIR,^(13)C NMR,X-ray,agarose gel electrophorcsis retardation assay,atomic force microscopy (AFM) and circular dichroism (CD).The results suggest that at charge ratio 2:1 or above,DNA could be completely entrapped and spherical complexes with mean size of 80-210 nm were formed.Taking HeLa as host cell,luciferase expression mediated by NMPCS improved about 100 times compared to the expression mediated by chitosan. | Dun Wan Zhu Jin Gen Bo Hai Ling Zhang Wen Guang Liu Xi Gang Leng Cun Xian Song Yu Ji Yin Li Ping Song Lan Xia Liu Lin Mei Xiu Lan Li Yang Zhang Kang De Yao | 2007 | Chinese Chemical Letters2007，18，11： | 3 |
| 10 | Synthesis and Antioxidant Properties of Novel Silybin Analogues显示文摘八新奇 silybin 类似物(7a-h ) 被综合并且他们包括清除的能力的抗氧化剂性质 DPPH 自由基上的超级氧化物阴离子自由基和禁止的效果被决定。几合成混合物显示出可比较的抗氧化的效果到橡黄素的。 | Jing Xu GONG Lin Jia WENG Feng WANG Yu Bin FENG Chang Xin ZHOU Hai Bo LI Yi Hang WU Xiao Jiang HAO Xiu Mei WU Hua BAI Joachim STOECKIGT Yu ZHAO | 2006 | Chinese Chemical Letters2006，17，4： | 2 |
| 11 | Interaction between the Circadian Clock and Chronic Stress显示文摘Life on Earth, ranging from single-celled organisms to more complex mammals, has evolved an internal circadian clock system that allows living organisms to coordinate their physiological processes and biological activities with the environmental day-night cycle^([1]). Therefore, the circadian clock system plays a critical role | KUANG Xiao Dong YU Xin Bo CAO Yuan LI Dong Shui ZHU Hai Yan | 2018 | Biomedical and Environmental Sciences2018，31，9： | 1 |
| 12 | Optimization of medi- um constituents for a novel lipopeptide production by Bacil- lus subtilis MO -01 by a response surface method 显示文摘 | Xiao - Bo Gu Zong - Ming Zheng Hai - Qing Yu Jun Wang Feng - Lai Liang Ru - Lin Liu | 2005 | Process Biochemistry2005，40，： | 1 |
| 13 | Construction of the Subtracted cDNA Library of Striatal Neurons Treated with Long-term Morphine显示文摘Objective To construct a morphine tolerance model in primarily cultured striatal neurons,and screen the differentially expressed genes in this model using suppression subtractive hybridization (SSH).Methods Sbtracted cDNA libraries were constructed using SSH from normal primarily cultured striatal neurons and long-term morphine treated striatal neurons (10-5 mol/L for 72 hours).To check reliability of the cell culture model,RT-PCR was performed to detect the cAMP-responsive element-binding protein (CREB) mRNA expression.The subtracted clones were prescreened by PCR.The clones containing inserted fragments from forward libraries were sequenced and submitted to GenBank for homology analysis.And the expression levels of genes of interest were confirmed by RT-PCR.Results CREB mRNA expression showed a significant increase in morphine treated striatal neurons (62.85±1.98) compared with normal striatal neurons (28.43±1.46,P<0.01).Thirty-six clones containing inserted fragments were randomly chosen for sequence analysis.And the 36 clones showed homology with 19 known genes and 2 novel genes.The expression of 2 novel genes,mitochondrial carrier homolog 1 (Mtch1;96.81±2.04 vs.44.20±1.31,P<0.01) and thymoma viral proto-oncogene 1 (Akt1;122.10±2.17 vs.50.11±2.01,P<0.01),showed a significant increase in morphine-treated striatal neurons compared with normal striatal neurons.Conclusions A reliable differential cDNA library of striatal neurons treated with long-term morphine is constructed.Mtch1 and Akt1 might be the candidate genes for the development of morphine tolerance. | Bo Bai Hai-qing Liu Jing Chen Ya-lin Li Hui Du Hai Lu Peng-li Yu | 2011 | Chinese Medical Sciences Journal2011，26，1： | 1 |
| 14 | The Addition of ABS-g-MAH on Properties of Nylon6/ABS Alloy显示文摘 | Zhen Jia Quan Gang Chen Yu Zhang Yi Zhou Zhang Hai Bo Zhang Lin Wu Xiang He Chao Wang | | 0，，： | 1 |
| 15 | Research on the Advanced Ceramic Die Materials and Their Properties显示文摘 | Xu Chong Hai Xiao Guang Chun Zhang Rong Bo Feng Yu Mei | 2008 | Key Engineering Materials2008，，375： | 1 |
| 16 | Two new sesquiterpenoids from Artemisia annua显示文摘 | Hai‐bo Li Yang Yu Zhen‐zhong Wang Jun Yang Wei Xiao Xin‐sheng Yao | 2015 | Magn. Reson. Chem2015，，3： | 1 |
| 17 | Computer Simulation of Aluminum Conductors Drawn in High Speed显示文摘 | Yan Yan Guo Hai Bo Wu Ming Yu Li Shuai Sun | 2014 | Advanced Materials Research . 2014 (834)2014，，834： | 1 |
| 18 | Synthesis of A Natural Cytotoxic Alkaloid Artabotrine and its Analogue显示文摘Artabotrine 1 is a novel N-methoxylated 4,5-dioxoaporphine alkaloid which has been reported to be cytotoxic against P-388 cells. The total synthesis of 1 was carried out, and one of its analogue, N-methoxycepharadione B 2, was also synthesized. Both of the alkaloids and several intermediates were cytotoxic to several selected tumor cell lines. | Hong Xia DING Wei LU Lei Xiang YANG Hai Bo LI Hua BAI Xiu Mei WU Jun Chao CAI Yu ZHAO | 2006 | Chinese Chemical Letters2006，17，1： | 1 |
| 19 | Quantitative Microbial Risk Assessment of Cryptosporidium and Giardia in Public Drinking Water in China显示文摘We aimed to assess the risks of Cryptosporidium and Giardia infections associated with drinking water for local residents,based on a quantitative microbial risk assessment,in three densely populated regions of China.In total,45 source water samples and 45 treated water samples were collected from June to December 2014. | CAO Sheng Kui JIANG Yan Yan YUAN Zhong Ying YIN Jian Hai XU Meng XUE Jing Bo TANG Lin Hua SHEN Yu Juan CAO Jian Ping | 2021 | Biomedical and Environmental Sciences2021，34，6： | 1 |
| 20 | Research on the Advanced Ceramic Die Materials and Their Properties显示文摘 | Xu Chong Hai Xiao Guang Chun Zhang Rong Bo Feng Yu Mei | 2008 | Key Engineering Materials2008，，375： | 1 |
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