|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Effect of human umbilical cord-derived mesenchymal stem cells on lung damage in severe COVID-19 patients:a randomized,double-blind,placebo-controlled phase 2 trial显示文摘Treatment of severe Coronavirus Disease 2019(COVID-19)is challenging.We performed a phase 2 trial to assess the efficacy andsafety of human umbilical cord-mesenchymal stem cells(UC-MScs)to treat severe coViD-19 patients with lung damage,based onour phase 1 data.In this randomized,double-blind,and placebo-controlled trial,we recruited 101 severe coVID-19 patients withlung damage.They were randomly assigned at a 2:1 ratio to receive either UC-MSCs(4×10^(7)cells per infusion)or placebo on day 0,3,and 6.The primary endpoint was an altered proportion of whole lung lesion volumes from baseline to day 28.Other imagingoutcomes,6-minute walk test(6-MWT),maximum vital capacity,diffusing capacity,and adverse events were recorded and analyzed.In all,100 COVID-19 patients were finally received either UC-MSCs in=65)or placebo(n=35).UC-MSCs administrationexerted numerical improvement in whole lung lesion volume from baseline to day 28 compared with the placebo(the mediandifference was-13.31%,95%Cl-29.14%,2.13%,P=0.08).UC-MSCs significanty reduced the proportions of solid componentlesion volume compared with the placebo(median difference:-15.45%;95%CI-30.82%,-0.39%;P=0.043).The 6-MWT showedan increased distance in patients treated with UC-MSCs(difference:27.00 m;95%CI 0.00,57.00;P=0.057).The incidence of adverseevents was similar in the two groups.These results suggest that UC-MSCs treatment is a safe and potentially effective therapeuticapproach for COVID-19 patients with lung damage.A phase 3 trial is required to evaluate effects on reducing mortality andpreventing long-term pulmonary disability. | Lei Shi Hai Huang Xuechun Lu Xiaoyan Yan Xiaojing Jiang Ruonan Xu Siyu Wang Chao Zhang Xin Yuan Zhe Xu Lei Huang Jun-Liang Fu Yuanyuan Li Yu Zhang Wei-Qi Yao Tianyi Liu Jinwen Song Liangliang Sun Fan Yang Xin Zhang Bo Zhang Ming Shi Fanping Meng Yanning Song Yongpei Yu Jiqiu Wen Qi Li Qing Mao Markus Maeurer Alimuddin Zumla Chen Yao Wei-Fen Xie Fu-Sheng Wang | 2021 | Signal Transduction and Targeted Therapy2021，6，3： | 13 |
| 2 | Status and development of high-power laser facilities at the NLHPLP显示文摘In this paper, we review the status of the multifunctional experimental platform at the National Laboratory of High Power Laser and Physics(NLHPLP). The platform, including the SG-II laser facility, SG-II 9th beam, SG-II upgrade(SG-II UP) facility, and SG-II 5 PW facility, is operational and available for interested scientists studying inertial confinement fusion(ICF) and a broad range of high-energy-density physics. These facilities can provide important experimental capabilities by combining different pulse widths of nanosecond, picosecond, and femtosecond scales. In addition, the SG-II UP facility, consisting of a single petawatt system and an eight-beam nanosecond system, is introduced including several laser technologies that have been developed to ensure the performance of the facility. Recent developments of the SG-II 5 PW facility are also presented. | Jianqiang Zhu Jian Zhu Xuechun Li Baoqiang Zhu Weixin Ma Xingqiang Lu Wei Fan Zhigang Liu Shenlei Zhou Guang Xu Guowen Zhang Xinglong Xie Lin Yang Jiangfeng Wang Xiaoping Ouyang Li Wang Dawei Li Pengqian Yang Quantang Fan Mingying Sun Chong Liu Dean Liu Yanli Zhang Hua Tao Meizhi Sun Ping Zhu Bingyan Wang Zhaoyang Jiao Lei Ren Daizhong Liu Xiang Jiao Hongbiao Huang Zunqi Lin | 2018 | High Power Laser Science and Engineering2018，6，4： | 8 |
| 3 | Progress of the injection laser system of SG-Ⅱ显示文摘A high power laser system was used to drive the ignition of inertial confinement fusion(ICF), of which the high energy,the uniform focal spot, the accurate laser waveform, and the synchronization between the laser beams are key parameters.To accomplish this, global laser characteristics control should be assured, which was the main purpose of the injection laser system. In this paper, the key technological progress involved in the improvement of the performance of the injection laser of SG-II is reported, including frequency domain control, time domain control, near-field spatial shaping, preamplifier technology, and the optical parametric chirped pulse amplification pump source. | Wei Fan Youen Jiang Jiangfeng Wang Xiaochao Wang Dajie Huang Xinghua Lu Hui Wei Guoyang Li Xue Pan Zhi Qiao Chao Wang He Cheng Peng Zhang Wenfa Huang Zhuli Xiao Shengjia Zhang Xuechun Li Jianqiang Zhu Zunqi Lin | 2018 | High Power Laser Science and Engineering2018，6，2： | 3 |
| 4 | Effect of Ningmitai capsule plus sertraline on patients with premature ejaculation and enlarged seminal vesicles:A randomized clinical trial显示文摘OBJECTIVE: To investigate the effects of Ningmitai capsule combined with sertraline on patients with premature ejaculation(PE) and an increased anterior-posterior diameter(APD) of the seminal vesicles(SVs).METHODS: Sixty men with acquired PE were enrolled and randomly divided into two groups. The combined group was treated with Ningmitai capsule and sertraline, while the control group was treated with sertraline alone. Main outcomes were measured using the premature ejaculation diagnostic tool(PEDT), APD of SVs, and Clinical Global Impression of Change questionnaire and compared before and after 3 months of treatment.RESULTS: Comparing after treatment with before treatment outcomes within each group, the PEDT score was significantly reduced in the combined group(12.1 ± 2.5 vs 8.6 ± 3.2, P < 0.001, respectively) and control group(12.9 ± 2.6 vs 10.3 ± 1.6, P <0.001, respectively). Furthermore, the PEDT score after treatment was significantly lower in the combined compared with control group(8.6 ± 3.2 vs10.3 ± 1.6, P = 0.011, respectively). The APD of SVs in the combined group was significantly decreased after treatment [(10.8 ± 2.4) vs(12.9 ± 2.2) mm, P =0.001], while the APD of SVs in the control group was equivalent before and after treatment. The treatment response rate was not significantly higher in the combined compared with control group.CONCLUSION: These results indicated that the effect of Ningmitai capsule combined with sertraline was better than that of sertraline alone for the treatment of PE patients exhibiting an increased APD of SVs. The therapeutic effect found for the combined treatment may be due to antibacterial and anti-inflammatory activity reported for Ningmitai capsule,and may suggest that seminal vesiculitis is a potential pathophysiological factor in acquired PE. | Peng Longping Hong Zhiwei Shen Jiaming Hu Xuechun Shao Yong Jing Jun Lu Jinchun Yao Bing | 2018 | Journal of Traditional Chinese Medicine2018，38，2： | 3 |
| 5 | Analysis of adverse events following the treatment of autologous cytokine-induced killer cells for adoptive immunotherapy in malignant tumour sufferers显示文摘 | Yajing Zhang Lei Xia Yan Zhang Yao Wang Xuechun Lu Fengxia Shi Yang Liu Meixia Chen Kaixhao Feng Wenying Zhang Xiaobing Fu Weidong Han | 2015 | Expert Opinion on Biological Therapy2015，，： | 1 |
| 6 | Pathogenesis of premature coronary artery disease:Focus on risk factors and genetic variants显示文摘The development of premature coronary artery disease(PCAD)is dependent on both genetic predisposition and traditional risk factors.Strategies for unraveling the genetic basis of PCAD have evolved with the advent of modern technologies.Genome-wide association studies(GWASs)have identified a considerable number of common genetic variants that are associated with PCAD.Most of these genetic variants are attributable to lipid and blood pressure-related single-nucleotide polymorphisms(SNPs).The genetic variants that predispose individuals to developing PCAD may depend on race and ethnicity.Some characteristic genetic variants have been identified in Chinese populations.Although translating this genetic knowledge into clinical applications is still challenging,these genetic variants can be used for CAD phenotype identification,genetic prediction and therapy.In this article we will provide a comprehensive review of genetic variants detected by GWASs that are predicted to contribute to the development of PCAD.We will highlight recent findings regarding CAD-related genetic variants in Chinese populations and discuss the potential clinical utility of genetic variants for preventing and managing PCAD. | Haiming Wang Zifan Liu Junjie Shao Min Jiang Xuechun Lu Lejian Lin Lin Wang Qiang Xu Haomin Zhang Xin Li Jingjing Zhou Yundai Chen Ran Zhang | 2022 | Genes & Diseases2022，9，2： | 1 |
| 7 | Cost-Effective Membrane and Advanced Electrode for Stable Polysulfide-Ferricyanide Flow Battery显示文摘Based on inexpensive,safe,and environmentally friendly active redox species,neutral polysulfide-ferrocyanide redox flow batteries(PFRFBs)have attracted much attention for large-scale energy storage.However,the development of PFRFBs is undermined by the expensive commercial membrane materials as well as the sluggish polysulfide redox reactions.This work attempts to solve these critical problems by combining the economical membrane with the highly catalytic electrode.In specific,K^(+)-exchanged sulfonated polyether ether ketone(SPEEK-K)membranes have been investigated in PFRFBs to replace the costly Nafion membrane.SPEEK-K with optimized degree of sulfonation enables the PFRFB high average coulombic efficiency of 99.80%and superior energy efficiency of 90.42%at a current density of 20mAcm^(-2).Meanwhile,to overcome the kinetic limitations of polysulfide redox reactions,a CuS-modified carbon felt electrode is demonstrated with excellent catalytic performance,enabling the PFRFB higher and more stable energy efficiency over cycling.The combination of the cost-effective membrane with the catalytic electrode in one cell leads to a capacity retention of 99.54%after 1180 cycles and an outstanding power density(up to 223mWcm^(-2)).The significant enhancements of electrochemical performance at reduced capital cost will make the PFRFB more promising for large-scale energy storage systems. | Xuechun Lou Hu Fu Jian Xu Yong Long Su Yan Haitao Zou Bo Lu Murong He Mei Ding Xiaobo Zhu Chuankun Jia | 2022 | Energy Material Advances2022，，1： | 1 |
| 8 | Conductive PS inverse opals for regulating proliferation and differentiation of neural stem cells显示文摘The development of neural tissue engineering has brought new hope to the treatment of spinal cord injury(SCI).Up to date,various scaffolds have been developed to induce the oriented growth and arrangement of nerves to facilitate the repair after injury.In this work,a conductive and anisotropic inverse opal substrate was presented by modifying polystyrene(PS)inverse opal films with carbon nanotubes and then stretching them to varying degrees.The film had good biocompatibility,and neural stem cells(NSCs)grown on the film displayed good orientation along the stretching direction.In addition,benefiting from the conductivity and anisotropy of the film,NSCs differentiated into neurons significantly.These results suggest that the conductive and anisotropic PS inverse opal substrates possess value in nerve tissue engineering regeneration. | Yangnan Hu Han Zhang Hao Wei Menghui Liao Xiaoyan Chen Jiayue Xing Lian Duan Cuntu Cheng Weicheng Lu Xuechun Yang Peina Wu Huan Wang Jingdun Xie Renjie Chai | 2023 | Engineered Regeneration2023，4，2： | 0 |
| 9 | Impact of immunosenescence and inflammaging on the effects of immune checkpoint inhibitors显示文摘Immune checkpoint inhibitors(ICIs)are employed in immunotherapeutic applications for patients with weakened immune systems and can improve the ability of T cells to kill cancer cells.Although ICIs can potentially treat different types of cancers in various groups of patients,their effectiveness may differ among older individuals.The reason ICIs are less effective in older adults is not yet clearly understood,but age-related changes in the immune system,such as immunosenescence and inflammation,may play a role.Therefore,this review focuses on recent advances in understanding the effects of immunosenescence and inflammation on the efficacy of ICIs. | Chuandong Hou Zining Wang Xuechun Lu | 2024 | Cancer Pathogenesis and Therapy2024，2，1： | 0 |
| 10 | Rapid and mass manufacturing of soft hydrogel microstructures for cell patterns assisted by 3D printing显示文摘Micro-/nano-patterns on hydrogels are widely used in cell patterning.However,manufacturing molds with traditional lithography is time-consuming and expensive.In addition,the excessive demolding force can easily damage patterns since biocompatible hydrogels are ultra-soft or brittle.Here,we presented a novel method for rapid and mass fabrication of cell patterns.High-precision three-dimensional(3D)printing was used to manufacture a mold with a resolution of 2µm,and the gelatin-based hydrogel was cured by thermal–photo-crosslinking so that the low-concentration and low-substitutionrate hydrogel could be demolded successfully.We found that pre-cooling before illumination made gelatin-based hydrogels resilient due to the partial regain of triple-helix structures.With this method,arbitrarily customized hydrogel patterns with a feature size of 6–80µm can be fabricated stably and at low cost.When cardiomyocytes were seeded on ultra-soft hydrogels with parallel groove structures,a consistent and spontaneous beating with 216 beats per minute(BPM)could be observed,approaching the natural beating rate of rat hearts(300 BPM).Overall,this work provides a general scheme for manufacturing cell patterns which has great potential for cell ethology and tissue repair. | Chaofan He Xuechun Chen Yuan Sun Mingjun Xie Kang Yu Jing He Jinwei Lu Qing Gao Jing Nie Yi Wang Yong He | 2022 | Bio-Design and Manufacturing2022，5，4： | 0 |
| 11 | Two cases on primary bone marrow lymphoma显示文摘Managing Editor:Peng Lyu Primary bone marrow lymphoma(PBML)is a rare lymphoma accounting for 1.23%of non-Hodgkin lymphoma(NHL)cases.It is characterized by tumor cells invading only the bone marrow without systemic lymphadenopathy or extranodal organ involvement.Owing to the lack of standardized treatment regimens,most patients are treated using rituximab with cyclophosphamide,doxorubicin,vincristine,and prednisone(R-CHOP)regimens;however,their efficacy needs to be further investigated. | Zining Wang Lu Sun Yue Wang Haoran Chen Hongbin Pu Bo Yang Xuechun Lu | 2024 | Cancer Pathogenesis and Therapy2024，2，1： | 0 |
| 12 | Bioinformatics analysis of SARS-CoV-2 infectionassociated immune injury and therapeutic prediction for COVID-19显示文摘Background:Severe acute respiratory syndrome coronavirus 2 is a highly contagious viral infection,without any available targeted therapies.The high mortality rate of COVID-19 is speculated to be related to immune damage.Methods:In this study,clinical bioinformatics analysis was conducted on transcriptome data of coronavirus infection.Results:Bioinformatics analysis revealed that the complex immune injury induced by coronavirus infection provoked dysfunction of numerous immune-related molecules and signaling pathways,including immune cells and toll-like receptor cascades.Production of numerous cytokines through the Th17 signaling pathway led to elevation in plasma levels of cytokines(including IL6,NF-kB,and TNF-a)followed by concurrent inflammatory storm,which mediates the autoimmune response.Several novel medications seemed to display therapeutic effects on immune damage associated with coronavirus infection.Conclusions:This study provided insights for further large-scale studies on the target therapy on reconciliation of immunological damage associated with COVID-19. | Haomin Zhang Haoran Chen Jundong Zhang Ximeng Chen Bin Guo Peng Zhi Zhuoyang Li Geliang Liu Bo Yang Xiaohua Chi Yixing Wang Feng Cao Jun Ren Xuechun Lu | 2021 | Emergency and Critical Care Medicine2021，1，1： | 0 |
| 13 | LD-pumped gas-cooled multislab Nd:glass laser amplification to joule level显示文摘We demonstrate a laser diode end-pumped helium gas-cooled multislab Nd:glass laser amplifier. The design and thermal management of the proposed laser amplifier are discussed. The thermally induced wavefront aberration of the slabs was also measured and compared with simulation results. A small-signal single-pass longitudinal gain of 1.8 was measured with a pump energy of 7.3 J. With an injected seed energy of 0.6 m J, the output energy from the amplifier reached 0.5 J at 0.2 Hz and 0.43 J at 0.5 Hz in a multipass extraction geometry, thus demonstrating the feasibility of diode-pumped,high-energy lasers with direct gas cooling. | Wenfa Huang Jiangfcng Wang Xinghua Lu Tingrui Huang Jiangtao Guo Wei Fan Xuechun Li | 2018 | High Power Laser Science and Engineering2018，6，2： | 0 |
| 14 | Effect of methylprednisolone therapy on hospital stay and viral clearance in patients with moderate COVID-19显示文摘Background:The benefits and harms of methylprednisolone treatment in patients with moderate coronavirus disease 2019(COVID-19)remain controversial.In this study,we investigated the effect of methylprednisolone on mortality rate,viral clearance,and hospitalization stay in patients with moderate COVID-19.Methods:This retrospective study included 4827 patients admitted to Wuhan Huoshenshan and Wuhan Guanggu hospitals from February to March 2020 diagnosed with COVID-19 pneumonia.The participants’epidemiological and demographic data,comorbidities,laboratory test results,treatments,outcomes,and vital clinical time points were extracted from electronic medical records.The primary outcome was in-hospital death;secondary outcomes were time from admission to viral clearance and hospital stay.Univariate and multivariate logistic or linear regression analysis were used to assess the roles of methylprednisolone in different outcomes.The propensity score matching(PSM)method was used to control for confounding factors.Results:A total of 1320 patients were included in this study,of whom 100 received methylprednisolone.Overall,in-hospital mortality was 0.91%(12/1320);the 12 patients who died were all in the methylprednisolone group,though multivariate logistic regression analysis showed methylprednisolone treatment was not a risk factor for in-hospital death in moderate patients before or after adjustment for confounders by PSM.Methylprednisolone treatment was correlated with longer length from admission to viral clearance time and hospital stay before and after adjustment for confounders.Conclusions:Methylprednisolone therapy was not associated with increased in-hospital mortality but with delayed viral clearance and extended hospital stay in moderate COVID-19 patients. | Xiaoyan Li Xin Yuan Zhe Xu Lei Huang Lei Shi Xuechun Lu Fu-Sheng Wang Junliang Fu | 2022 | Infectious Medicine2022，1，4： | 0 |
| 15 | A case of diffuse large B-cell lymphoma with interstitial pneumonia显示文摘This report involves a 54-year-old female patient diagnosed with diffuse large B-cell lymphoma who developed interstitial pneumonia(IP)during treatment.The patient presented to the ward with enlarged lymph nodes in the neck and was treated with the standard regimen,which included rituximab,cyclophosphamide,doxorubicin liposomes,vincristine,and prednisone(R-CDOP regimen).After 3 cycles,the treatment was assessed as effective.However,following the 4th cycle,the patient experience shortness of breath after physical activity.A repeat lung computer tomography indicated IP,which completely recovered after receiving“full coverage”treatment.Subsequently,the patient underwent 2 cycles of cyclophosphamide,doxorubicin liposomes,vincristine,and prednisone(CDOP),followed by local radiotherapy.Currently,the patient is now being followed up with regular reviews. | Ge Song Changxi Zhou Shuxia Wang Tianqi Tao Weiping Guan Xuan Wu Ping Zhu Bo Yang Xuechun Lu | 2023 | Cancer Pathogenesis and Therapy2023，1，3： | 0 |
| 16 | Association of DNA methylation/demethylation with the functional outcome of stroke in a hyperinflammatory state显示文摘Inflammation is closely related to stroke prognosis, and high inflammation status leads to poor functional outcome in stroke. DNA methylation is involved in the pathogenesis and prognosis of stroke. However, the effect of DNA methylation on stroke at high levels of inflammation is unclear. In this study, we constructed a hyperinflammatory cerebral ischemia mouse model and investigated the effect of hypomethylation and hypermethylation on the functional outcome. We constructed a mouse model of transient middle cerebral artery occlusion and treated the mice with lipopolysaccharide to induce a hyperinflammatory state. To investigate the effect of DNA methylation on stroke, we used small molecule inhibitors to restrain the function of key DNA methylation and demethylation enzymes. 2,3,5-Triphenyltetrazolium chloride staining, neurological function scores, neurobehavioral tests, enzyme-linked immunosorbent assay, quantitative reverse transcription PCR and western blot assay were used to evaluate the effects after stroke in mice. We assessed changes in the global methylation status by measuring DNA 5-mc and DNA 5-hmc levels in peripheral blood after the use of the inhibitor. In the group treated with the DNA methylation inhibitor, brain tissue 2,3,5-triphenyltetrazolium chloride staining showed an increase in infarct volume, which was accompanied by a decrease in neurological scores and worsening of neurobehavioral performance. The levels of inflammatory factors interleukin 6 and interleukin-1 beta in ischemic brain tissue and plasma were elevated, indicating increased inflammation. Related inflammatory pathway exploration showed significant overactivation of nuclear factor kappa B. These results suggested that inhibiting DNA methylation led to poor functional outcome in mice with high inflammation following stroke. Further, the effects were reversed by inhibition of DNA demethylation. Our findings suggest that DNA methylation regulates the inflammatory response in stroke and has an important role in the functional outcome of hyperinflammatory stroke. | Yubo Wang Ling Zhang Tianjie Lyu Lu Cui Shunying Zhao Xuechun Wang Meng Wang Yongjun Wang Zixiao Li | 2024 | Neural Regeneration Research2024，19，10： | 0 |
| 17 | Effect of Methylprednisolone on Mortality and Clinical Courses in Patients with Severe CoVID-19: A Propensity Score Matching Analysis显示文摘Background Whether methylprednisolone therapy can reduce the mortality rate of patients with severe coronavirus disease 2019(COVID-19)remains controversial,and its effects on the length of hospital stay and virus shedding time are also unknown.This retrospective study investigates the previous issues to provide more evidence for methylprednisolone treatment in severe COVID-19.Methods This retrospective study included 563 of 4827 patients with confirmed COVID-19 admitted to Wuhan Huoshenshan Hospital or Wuhan Guanggu Hospital between February 3,2020 and March 30,2020 who met the screening criteria.The participants’epidemiological and demographic data,comorbidities,laboratory test results,treatments,outcomes,and vital clinical time points were extracted from electronic medical records.The primary outcome was in-hospital death,and the secondary outcomes were 2 clinical courses:length from admission to viral clearance and discharge.Univariate and multivariate logistic or linear regression analyses were used to assess the role of methylprednisolone in different outcomes.Propensity score matching was performed to control for confounding factors.Results Of the 563 patients who met the screening criteria and were included in the subsequent analysis,138 were included in the methylprednisolone group and 425 in the nonmethylprednisolone group.The in-hospital death rate between the methylprednisolone and nonmethylprednisolone groups showed a significant difference(23.91%vs.1.65%,P<0.001),which was maintained after propensity score matching(13.98%vs.5.38%,P=0.048).However,univariate logistic analysis in the matched groups showed that methylprednisolone treatment(odds ratio[OR],5.242;95%confidence interval[CI],0.802 to 34.246;P=0.084)was not a risk factor for in-hospital death in severe patients.Further multivariate logistic regression analysis found comorbidities(OR,3.327;95%CI,1.702 to 6.501;P<0.001),lower lymphocyte count(OR,0.076;95%CI,0.012 to 0.461;P=0.005),higher lactate dehydrogenase(LDH)levels(OR,1.008;95%CI,1.003 to 1.013;P=0.002),and anticoagulation therapy(OR,11.187;95%CI,2.459 to 50.900;P=0.002)were associated with in-hospital mortality.Multivariate linear regression analysis in the matched groups showed that methylprednisolone treatment was not a risk factor for a prolonged duration from admission to viral clearance(βValue 0.081;95%CI,−1.012 to 3.657;P=0.265)or discharge(βValue 0.114;95%CI,−0.723 to 6.408;P=0.117).d-dimer(βValue,0.144;95%CI,0.012 to 0.817;P=0.044),LDH(βValue 0.260;95%CI,0.010 to 0.034;P<0.001),and antiviral therapy(βValue 0.220;95%CI,1.373 to 6.263;P=0.002)were associated with a longer length from admission to viral clearance.The lymphocyte count(βValue−0.206;95%CI,−6.248 to−1.197;P=0.004),LDH(βValue 0.231;95%CI,0.012 to 0.048;P=0.001),antiviral therapy(βValue 0.143;95%CI,0.058 to 7.497;P=0.047),and antibacterial therapy(βValue 0.152;95%CI,0.133 to 8.154;P=0.043)were associated with a longer hospitalization duration from admission to discharge.Further stratified analysis revealed that the low daily dose group(≤60 mg/d)and the low total dose group(≤200 mg)had shorter duration from admission to viral clearance(Z=−2.362,P=0.018;Z=−2.010,P=0.044)and a shorter hospital stay(Z=−2.735,P=0.006;Z=−3.858,P<0.001).Conclusions In patients with severe COVID-19,methylprednisolone is safe and does not prolong the duration from admission to viral clearance or discharge.Low-dose,short-term methylprednisolone treatment may be more beneficial in shortening the disease course. | Xiaoyan Li Xin Yuan Zhe Xu Lei Shi Lei Huang Xuechun Lu Junliang Fu | 2023 | Infectious Diseases & Immunity2023，3，1： | 0 |
| 18 | Coherence phase spectrum analyzer for a randomly fluctuated fractional vortex beam显示文摘Fractional vortex beams exhibit a higher degree of modulation dimensions than conventional vortices,thus inheriting superior anti-turbulent transmission properties through the incorporation of additional coherence modulation.However,aliasing the mixed modes induced by coherence degradation makes the quantitative measurement of the topological charge in fractional vortex beams challenging.In this study,a coherence phase spectrum was introduced,and experimental demonstrations to quantitatively determine the fractional topological charge of partially coherent fractional vortex beams were performed.By leveraging the four-dimensional measurement of a partially coherent light field,the source coherence function was inversely reconstructed,and fractional topological charges were determined with high precision by extracting the phase spectrum of the coherence function.Laguerre–Gaussian,elliptical Gaussian,and plane-wave-fraction vortex beams with various degrees of coherence were used to demonstrate measurement precision.The proposed method is applicable to X-rays and electron vortices.It has potential applications in optical encryption,high-capacity optical communication,and quantum entanglement. | ZHUOYI WANG XINGYUAN LU JIANBO GAO XUECHUN ZHAO QIWEN ZHAN YANGJIAN CAI CHENGLIANG ZHAO | 2024 | Photonics Research2024，12，1： | 0 |
| 19 | Combination of two target agonists of the thrombopoietin and thrombopoietin receptor in the treatment of elderly patients with refractory immune thrombocytopenia显示文摘Immune thrombocytopenia(ITP)is common in the elderly.Because of the coexistence of multiple diseases,there are many reservations regarding corticosteroid use in the elderly.Thrombopoietin(TPO)and its analogs can promote platelet production,but it is often difficult to correct TP in a short period.Recombinant human TPO(rh-TPO)acting on the cell membrane and the small-molecule TPO-receptor(MPL)agonist acting on the transmembrane receptor may have synergistic effects and accelerate platelet production because of different sites of action in the signaling pathway.In this study,two elderly patients with refractory ITP were successfully treated with two TPO-MPL signaling pathway agonists:recombinant human thrombopoietin(rh-TPO)and eltrombopag.This combination is safe with rapid and lasting effects.However,in elderly patients with refractory,recurrent,and glucocorticoid contraindications,the combination of different TPO agonists'clinical efficacy and adverse reactions needs to be further evaluated. | Jundong Zhang Zining Wang Haoran Chen Xuechun Lu | 2023 | Cancer Pathogenesis and Therapy2023，1，2： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员