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| 1 | Effect of human umbilical cord-derived mesenchymal stem cells on lung damage in severe COVID-19 patients:a randomized,double-blind,placebo-controlled phase 2 trial显示文摘Treatment of severe Coronavirus Disease 2019(COVID-19)is challenging.We performed a phase 2 trial to assess the efficacy andsafety of human umbilical cord-mesenchymal stem cells(UC-MScs)to treat severe coViD-19 patients with lung damage,based onour phase 1 data.In this randomized,double-blind,and placebo-controlled trial,we recruited 101 severe coVID-19 patients withlung damage.They were randomly assigned at a 2:1 ratio to receive either UC-MSCs(4×10^(7)cells per infusion)or placebo on day 0,3,and 6.The primary endpoint was an altered proportion of whole lung lesion volumes from baseline to day 28.Other imagingoutcomes,6-minute walk test(6-MWT),maximum vital capacity,diffusing capacity,and adverse events were recorded and analyzed.In all,100 COVID-19 patients were finally received either UC-MSCs in=65)or placebo(n=35).UC-MSCs administrationexerted numerical improvement in whole lung lesion volume from baseline to day 28 compared with the placebo(the mediandifference was-13.31%,95%Cl-29.14%,2.13%,P=0.08).UC-MSCs significanty reduced the proportions of solid componentlesion volume compared with the placebo(median difference:-15.45%;95%CI-30.82%,-0.39%;P=0.043).The 6-MWT showedan increased distance in patients treated with UC-MSCs(difference:27.00 m;95%CI 0.00,57.00;P=0.057).The incidence of adverseevents was similar in the two groups.These results suggest that UC-MSCs treatment is a safe and potentially effective therapeuticapproach for COVID-19 patients with lung damage.A phase 3 trial is required to evaluate effects on reducing mortality andpreventing long-term pulmonary disability. | Lei Shi Hai Huang Xuechun Lu Xiaoyan Yan Xiaojing Jiang Ruonan Xu Siyu Wang Chao Zhang Xin Yuan Zhe Xu Lei Huang Jun-Liang Fu Yuanyuan Li Yu Zhang Wei-Qi Yao Tianyi Liu Jinwen Song Liangliang Sun Fan Yang Xin Zhang Bo Zhang Ming Shi Fanping Meng Yanning Song Yongpei Yu Jiqiu Wen Qi Li Qing Mao Markus Maeurer Alimuddin Zumla Chen Yao Wei-Fen Xie Fu-Sheng Wang | 2021 | Signal Transduction and Targeted Therapy2021，6，3： | 13 |
| 2 | The Impact of Farmland Transfers on Agricultural Investment in China:A Perspective of Transaction Cost Economics显示文摘There is growing concern that farmland transfers lead to less agricultural investment, which may adversely affect agricultural productivity growth in China.Prior research has primarily focused on the differences between owned cultivated land and rented plots,but little is known about how farmland transfers between relatives,which are popular in rural China,specifically affect agricultural investment.In this paper,we present a conceptual framework of transaction cost economics to compare different contracting strategies in China's farmland rental markets.As farmland rental markets in China are immature,land transfer between relatives establishes bilateral governance,which has the advantage of addressing the opportunistic activities of both parties and can ultimately increase investment by tenants.Based on data from two waves of household surveys,we empirically examine the impact of bilateral governance on the application of organic fertilizer,an indicator for agricultural investment.Our findings show that apart from economic factors, kinship is important to the functioning of farmland rental markets in rural areas. | Liangliang Gao Dingqiang Sun Cuiping Ma | 2019 | China & World Economy2019，27，1： | 6 |
| 3 | Characteristics of gas-solid micro fluidized beds for thermochemical reaction analysis显示文摘Fuel conversion and clean energy reaction systems involve a variety of catalytic and non-catalytic gas-solid thermochemical reactions.A good understanding of the correct reaction mechanism and kinetics,as well as the profiles of reaction products,is of great significance to the development,design,and operation of such reaction systems.The micro fluidized bed reaction analysis provides an efficient and reliable method to acquire this essential information with low capital and operating costs,low energy consumption and enhanced safety.This paper provides an overview of the system and its characteristics for the micro fluidized bed reaction analyzer that has been well proven to be a reliable new approach as well as an instrument for characterizing various gas-solid thermochemical reactions. | Zhennan Han Junrong Yue Xi Zeng Jian Yu Fang Wang Shaozeng Sun Hong Yao Guangqian Luo Xuejing Liu Yining Sun Fu Ding Liangliang Fu Lei Shi Kangjun Wang Jiebin Yang Shaonan Wang Xueqing Chen Dingrong Bai Guangwen Xu | 2020 | Carbon Resources Conversion2020，3，1： | 6 |
| 4 | Multiple locus genealogies and phenotypic characters reappraise the causal agents of apple ring rot in China显示文摘Apple ring rot inflicts severe economic losses in the main apple producing areas of East Asia.The causal agent of the disease has been variously identified as Macrophoma kuwatsukai,Physalospora piricola and Botryosphaeria berengeriana f.sp.piricola,although B.dothidea is currently the most widely accepted pathogen name.The taxonomic uncertainty has delayed research that is needed to manage effectively this destructive disease.In the present study,genealogical concordance phylogenetic species recognition(GCPSR)was applied to pathogenic fungal isolates from apple and pear from several locations in China,along with several reference isolates.Phylogenetic results based on sequences of four nuclear loci(ITS,EF-1α,HIS and HSP)revealed the existence of two species within the examined isolates.One includes an ex-epitype isolate of B.dothidea and the other includes an isolate that was previously designated as B.berengeriana f.sp.piricola.Morphologically,the latter taxon presented an appressed mycelial mat on PDA whereas B.dothidea displayed columns of aerial mycelia reaching the lids,and conidia of the latter species were longer than B.dothidea.Botryosphaeria dothidea had a faster growth rate than the latter taxon under relatively high temperatures.Pathogenicity tests showed that on pear stems the latter taxon caused large-scale cankers along with blisters whereas B.dothidea was non-pathogenic,but on apple shoots the two fungi induced large and small wart-like prominences,respectively.Overall,this cryptic species demonstrated sufficient genetic variations and biological differences from B.dothidea.As a result of taxonomic study,we described here the latter taxon in a new combination,Botryosphaeria kuwatsukai and designate an epitype.Both B.kuwatsukai and B.dothidea are considered to be the main causal agents for apple ring rot in China and Japan. | Chao Xu Chunsheng Wang Liangliang Ju Rong Zhang Alan R.Biggs Eiji Tanaka Bingzhi Li Guangyu Sun | 2015 | Fungal Diversity2015，，2： | 6 |
| 5 | Research on fault detection method for heat pump air conditioning system under cold weather显示文摘Building energy consumption accounts for nearly 40% of global energy consumption, HVAC(Heating, Ventilating,and Air Conditioning) systems are the major building energy consumers, and as one type of HVAC systems, the heat pump air conditioning system, which is more energy-efficient compared to the traditional air conditioning system, is being more widely used to save energy. However, in northern China, extreme climatic conditions increase the cooling and heating load of the heat pump air conditioning system and accelerate the aging of the equipment, and the sensor may detect drifted parameters owing to climate change. This non-linear drifted parameter increases the false alarm rate of the fault detection and the need for unnecessary troubleshooting.In order to overcome the impact of the device aging and the drifted parameter, a Kalman filter and SPC(statistical process control) fault detection method are introduced in this paper. In this method, the model parameter and its standard variance can be estimated by Kalman filter based on the gray model and the real-time data of the air conditioning system. Further, by using SPC to construct the dynamic control limits, false alarm rate is reduced.And this paper mainly focuses on the cold machine failure in the component failure and its soft fault detection.This approach has been tested on a simulation model of the 'Sino-German Energy Conservation Demonstration Center' building heat pump air-conditioning system in Shenyang, China, and the results show that the Kalman filter and SPC fault detection method is simple and highly efficient with a low false alarm rate, and it can deal with the difficulties caused by the extreme environment and the non-linear influence of the parameters, and what's more, it provides a good foundation for dynamic fault diagnosis and fault prediction analysis. | Liangliang Sun Jianghua Wu Haiqi Jia Xuebin Liu | 2017 | Chinese Journal of Chemical Engineering2017，25，12： | 5 |
| 6 | Simplified mathematical model of inter-turn short circuit of field windings in hydro-generators and its application显示文摘Inter-turn short circuit of field windings is a common electrical fault of generators.Simulation is an important method of investigating the fault and providing data support for fault monitoring.However,huge numbers of pole pairs and damper loops in large hydro-generators would lead to lengthy calculation time,hindering scientific research and engineering application.To deal with this problem,we analyze a theoretical basis for a damper winding simplified model and then propose an equivalent treatment method.Through the analysis of steady-state current harmonic characteristics of generators with different stator winding configurations during the fault,the simplified models suitable for steady-state calculation are derived from two aspects,namely,additional rotor harmonic current frequency characteristics and the relationship of the amplitude as well as the phase of each branch current of the stator.The calculation and experimental results of the two simplified models are then compared to verify the models' correctness.A calculation example of the Three Gorges left bank VGS generator shows few deviations between the calculation results of the simplified model and the original model.Moreover,the calculation time using the simplified model is 1/1500 that using the original model,which provides a more effective tool for on-line fault monitoring.Finally,the sensitivity-verification application of the fault-monitoring scheme based on the stator steady-state unbalanced current RMS is depicted.The result shows that the scheme can monitor two-turn short circuits of field windings in the Three Gorges generator and provide high sensitivity. | HAO LiangLiang WU JunYong SUN YuGuang WANG XiangHeng | 2013 | Science China(Technological Sciences)2013，56，4： | 5 |
| 7 | PtrCel9A6, an Endo-l,4-β-Glucanase, Is Required for Cell Wall Formation during Xylem Differentiation in Populus显示文摘 | Liangliang Yu Jiayan Sun Laigeng Li | 2013 | Molecular Plant2013，6，6： | 3 |
| 8 | Immune checkpoint therapy for solid tumours: clinical dilemmas and future trends显示文摘Immune-checkpoint inhibitors(ICBs),in addition to targeting CTLA-4,PD-1,and PD-L1,novel targeting LAG-3 drugs have also been approved in clinical application.With the widespread use of the drug,we must deeply analyze the dilemma of the agents and seek a breakthrough in the treatment prospect.Over the past decades,these agents have demonstrated dramatic efficacy,especially in patients with melanoma and non-small cell lung cancer(NSCLC).Nonetheless,in the field of a broad concept of solid tumours,non-specific indications,inseparable immune response and side effects,unconfirmed progressive disease,and complex regulatory networks of immune resistance are four barriers that limit its widespread application.Fortunately,the successful clinical trials of novel ICB agents and combination therapies,the advent of the era of oncolytic virus gene editing,and the breakthrough of the technical barriers of mRNA vaccines and nano-delivery systems have made remarkable breakthroughs currently.In this review,we enumerate the mechanisms of each immune checkpoint targets,associations between ICB with tumour mutation burden,key immune regulatory or resistance signalling pathways,the specific clinical evidence of the efficacy of classical targets and new targets among different tumour types and put forward dialectical thoughts on drug safety.Finally,we discuss the importance of accurate triage of ICB based on recent advances in predictive biomarkers and diagnostic testing techniques. | Qian Sun Zhenya Hong Cong Zhang Liangliang Wang Zhiqiang Han Ding Ma | 2023 | Signal Transduction and Targeted Therapy2023，8，9： | 2 |
| 9 | PM_(2.5) exposure associated with microbiota gut-brain axis:Multi-omics mechanistic implications from the BAPE study显示文摘Recent studies have shown that PM_(2.5) may activate the hypothalamus-pituitary-adrenal(HPA)axis by inducing hormonal changes,potentially explaining the increase in neurological and cardiovascular risks.In addition,an association between PM_(2.5) and gut microbiota and metabolites was established.The above evidence represents crucial parts of the gut-brain axis(GBA).In view of this evidence. | Tiantian Li Jianlong Fang Song Tang Hang Du Liang Zhao Yanwen Wang Fuchang Deng Yuanyuan Liu Yanjun Du Liangliang Cui Wanying Shi Yan Wang Jiaonan Wang Yingjian Zhang Xiaoyan Dong Ying Gao Yu Shen Li Dong Huichan Zhou Qinghua Sun Haoran Dong Xiumiao Peng Yi Zhang Meng Cao Hong Zhi Jingyang Zhou Xiaoming Shi | 2022 | The Innovation2022，3，2： | 2 |
| 10 | Achieving purely organic room temperature phosphorescence in aqueous solution显示文摘Purely organic room temperature phosphorescence(RTP)materials have aroused increasing interests in recent years and have been widely applied in anticounterfeiting,biological imaging,sensing,etc.Currently,these materials can be efficiently developed in crystalline states and amorphous polymer-doped systems.However,achieving organic RTP in solution,especially in water solution,is still a formidable challenge.Recently,reports on aqueous phase RTP have been increasing and some feasible design strategies have been proposed;however,related investigations are still limited and there is a lack of systematic reviews.Therefore,we summarized the recent cases of aqueous phase organic RTP emission with primarily focusing on the RTP properties and efficient design strategies(e.g.,forming nanoparticles from phosphorescent molecules and macrocyclic supramolecular assembly).Moreover,promising applications of the aqueous phase organic RTP emission in bio-imaging and sensing were discussed.Some detailed perspectives concerning materials design and application were provided with the hope to provide inspiration for the future development of aqueous phase organic RTP. | Hao Sun Liangliang Zhu | 2023 | Aggregate2023，4，1： | 2 |
| 11 | The leaf extract of crofton weed(Eupatorium adenophorum)inhibits primary root growth by inducing cell death in maize root border cells显示文摘The extract of crofton weed(Eupatorium adenophorum) inhibits seed germination and weed growth;however,the physiological mechanisms underlying the effect of crofton weed extract on the modulation of seedling growth and root system development remain largely unclear.In this study,we investigated the effects of the leaf extract of crofton weed(LECW) on primary root(PR) growth in maize seedlings.Treatment with LECW markedly inhibited seed germination and seedling growth in a dose-dependent manner.Physiological analysis indicated that the LECW induced reactive oxygen species(ROS) accumulation in root tips,thereby leading to cell swelling and deformation both in the root cap and elongation zone of root tips,finally leading to cell death in root border cells(RBCs) and PR growth inhibition.The LECW also inhibited pectin methyl esterase(PME) activity,thereby decreasing the RBC number.Taken together,our results indicated that the LECW inhibited PR growth by inducing ROS accumulation and subsequent cell death in RBCs.The present study provides a better understanding of how the LECW modifies root system development and provides insight for evaluating the toxicity of crofton weed extracts in plants. | Jinhu Ma Xinxin Feng Xiaohuan Yang Yongheng Cao Weifeng Zhao Liangliang Sun | 2020 | Plant Diversity2020，42，3： | 2 |
| 12 | Stepwise Construction of a Ag<sup>I</sup><sub>9</sub>–Cu<sup>II</sup><sub>4</sub> Heterometallic Cluster Incorporating Two Unusual Vertex‐Shared Trigonal‐Bipyramidal Silver Polyhedra显示文摘 | Di Sun Liangliang Zhang Zhihao Yan Daofeng Sun | 2012 | Chem Asian J2012，，7： | 1 |
| 13 | Electrochemical performance of a novel CoTETA/C catalyst for the oxygen reduction reaction显示文摘 | Hui-Juan Zhang Xianxia Yuan Wen Wen Dong-Yun Zhang Liangliang Sun Qi-Zhong Jiang Zi-Feng Ma | 2008 | Electrochemistry Communications2008，，1： | 1 |
| 14 | Synthesis, structure, and magnetism of three manganese-organic framework with PtS topology显示文摘Three 3D manganese-organic frameworks, Mn2(BPTC)(DMF)2(H2O)·DMF·3H2O(1), Mn2(BPTC)(bipy)(DMF)·DMF·H2O(2), and Mn2(BPTC)(phen)(DMF)·EtOH(3), have been solvothermally synthesized using 3,3′,5,5′-biphenyltetracarboxylic acid(H4BPTC). All complexes are characterized by PXRD, EA, IR and TG. The results show that they all bear the PtS topology with(42.84)(42.84) for the vertex symbols of the planar and tetrahedral nodes, in which the BPTC ligand is considered as a square-planar 4-connected linker, and every binuclear SBU connected to the four BPTC ligands is simplified into tetrahedral 4-connected nodes. Because the three coordination sites of one metal center of SBU are occupied by the coordinated solvent molecules, complex 1 exhibits low stability. After substituting 2,2′-bipy or 1,10-phen for two coordinated solvent molecules, complexes 2 and 3 display evidently higher structure stability. The magnetism property of complex 2 is also discussed in detail. | MENG QingGuo DAI FangNa ZHANG LiangLiang WANG RongMing SUN DaoFeng | 2014 | Science China Chemistry2014，57，11： | 1 |
| 15 | Improvement of in situ LA-ICP-MS U-Pb dating method for carbonate minerals and its application in petroleum geology显示文摘In situ carbonate U-Pb dating is gaining popularity,and it has great potential for application in petroleum geology.However,the low U content(<10μg/g)and high common Pb content of carbonate minerals,along with the uneven distribution of U and Pb and the lack of matrix-matched reference material make carbonate U-Pb dating inaccurate and less successful,which limits the widespread application in geosciences.This study evaluated the limitations of in situ carbonate U-Pb dating and proposed a method to rationally determine the laser ablation parameters of samples by improving the experimental approach based on the laser ablation sector field inductively coupled plasma mass spectrometry(LA-SF-ICP-MS).By setting a different spot size and laser frequency for the reference material and unknown samples in the same session based on the U content of the sample,the ablation craters of the reference material and unknown samples were given the same depth/width ratio,avoiding systematic offset caused by differences in down-hole element fractionation and reducing the consume of reference material.Depending on the heterogeneous distribution of U and Pb contents in carbonate minerals,the method of grid screening and setting ablation spots during screening were used to quickly select domains with high U and low common Pb,which improves the efficiency of setting laser spots and the success rate of dating,as well as reduces the experimental time and economic cost.The accuracy and success rate of carbonate U-Pb dating were effectively improved by improving the experimental method,and the technique was applied to two carbonate samples with low U and high common Pb contents that were difficult to date by traditional methods.The two samples are the saddle dolomite in the central Sichuan Basin and the calcite cement in the sandstone reservoir of the Cretaceous Qingshuihe Formation in the South Junggar Basin.The robust ages have been obtained,which constrains the timing of the diagenetic and hydrocarbon accumulation process in the studied area. | Xuesong Lu Lili GUI Weiyan CHEN Shaobo LIU Shitou WU Junjia FAN Qiang LIU Jing SUN Liangliang ZHANG Yang XIAO Wenxia YANG Rizhou CAO | 2023 | Science China Earth Sciences2023，66，12： | 1 |
| 16 | LncRNA DACH1 protects against pulmonary fibrosis by binding to SRSF1 to suppress CTNNB1 accumulation显示文摘Idiopathic pulmonary fibrosis(IPF)is a progressive disease with unknown etiology and limited therapeutic options.Activation of fibroblasts is a prominent feature of pulmonary fibrosis.Here we report that lncRNA DACH1(dachshund homolog 1)is downregulated in the lungs of IPF patients and in an experimental mouse model of lung fibrosis.LncDACH1 knockout mice develop spontaneous pulmonary fibrosis,whereas overexpression of LncDACH1 attenuated TGF-β1-induced aberrant activation,collagen deposition and differentiation of mouse lung fibroblasts.Similarly,forced expression of LncDACH1 not only prevented bleomycin(BLM)-induced lung fibrosis,but also reversed established lung fibrosis in a BLM model.Mechanistically,LncDACH1 binding to the serine/arginine-rich splicing factor 1(SRSF1)protein decreases its activity and inhibits the accumulation of Ctnnb1.Enhanced expression of SRSF1 blocked the anti-fibrotic effect of LncDACH1 in lung fibroblasts.Furthermore,loss of LncDACH1 promoted proliferation,differentiation,and extracellular matrix(ECM)deposition in mouse lung fibroblasts,whereas such effects were abolished by silencing of Ctnnb1.In addition,a conserved fragment of LncDACH1 alleviated hyperproliferation,ECM deposition and differentiation of MRC-5 cells driven by TGF-β1.Collectively,LncDACH1 inhibits lung fibrosis by interacting with SRSF1 to suppress CTNNB1 accumulation,suggesting that LncDACH1 might be a potential therapeutic target for pulmonary fibrosis. | Jian Sun Tongzhu Jin Zhihui Niu Jiayu Guo Yingying Guo Ruoxuan Yang Qianqian Wang Huiying Gao Yuhan Zhang Tianyu Li Wenxin He Zhixin Li Wenchao Ma Wei Su Liangliang Li Xingxing Fan Hongli Shan Haihai Liang | 2022 | Acta Pharmaceutica Sinica B2022，12，9： | 1 |
| 17 | Coking-free direct-methanol-flame fuel cell with traditional nickel-cermet anode显示文摘 | Sun Liangliang Hao Yong Zhang Chunming | | 0，，： | 1 |
| 18 | Geometrical design of variable ratio tooth profile based on Boolean subtraction operation and a novel modification method显示文摘Variable transmission ratio racks show great potential in rice transplanters as a key component of variable transmission ratio steering to balance steering portability and sensitivity.The objective of this study was to develop a novel geometrical design method to achieve quick,high-quality modeling of the free curvilinear tooth profile of a variable transmission ratio rack.First,a discrete envelope motion 3D model was established between the pinion-sector and the variable transmission ratio rack blank based on the mapping relationship between the rotation angle of the pinion-sector and the displacement of the rack,according to the variable transmission ratio function.Based on the loop Boolean subtraction operation,which removed the pinion-sector from the rack blank during all moments of the discrete motion process,the final complex changing tooth shape of the variable transmission ratio rack was enveloped.Then,since Boolean cutting residues made the variable ratio tooth surface fluctuant and eventually affected the precision of the model,this study proposed a modification method for establishing a smooth and continuous tooth profile.First,a novel fitting algorithm used approximate variable ratio tooth profile points extracted from the Boolean cutting marks and generated a series of variable ratio tooth profiles by utilizing B-spline with different orders.Next,based on a transmission stability simulation,the variable ratio tooth profile with optimal dynamic performance was selected as the final design.Finally,tests contrasting the transmission stability of the machining samples of the initial variable ratio tooth profile and the final variable ratio tooth profile were conducted.The results indicated that the final variable ratio tooth profile is more effective than the initial variable ratio tooth profile.Therefore,the proposed variable ratio tooth profile modeling and modification method for eliminating Boolean cutting residues and improving surface accuracy is proved to be feasible. | Ziru Niu Jianlei Li Shuai Xin Liangliang Zou Yuhua Li Jialin Hou Ming Tu Ting Sun | 2020 | International Journal of Agricultural and Biological Engineering2020，13，5： | 1 |
| 19 | Steady- state calculation and online monitoring of interturn short circuit of field windings in synchronous machines 显示文摘 | HAO Liangliang SUN Yuguang QIU Arui | 2012 | IEEE Transactions on Energy Conversion2012，27，1： | 1 |
| 20 | Ground source heat pump system: A review of simulation in China显示文摘 | Yanping Yuan Xiaoling Cao Liangliang Sun | 2012 | Renewable and Sustain- able Energy Reviews2012，16，9： | 1 |
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