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| 1 | p16 gene methylation in colorectal cancers associated with Duke's staging显示文摘AIM To explore the association of methylation of the CpG island in the promotor of the p16 tumor suppressor gene with the clinicopathological characteristics of the colorectal cancers.``METHODS Methylation-specific PCR (MSP) was used to detect p16 methylation of 62 sporadic colorectal cancer specimens.``RESULTS pi6 methylation was detected in 42% of the tumors. Dukes staging was associated with p16methylation status, p16 methylation occurred more frequently in Dukes C and D patients (75.9%) than in Dukes A and B patients (12.1%).``CONCLUSION p16 rnethylation plays a role in the carcinogenesis of a subset of colorectal cancer, and it might be linked to poor prognosis. | Jing Yi~1 Zhi-Wei Wang~1 Hui Cang~1 Yu-Ying Chen~1 Ren Zhao~2 Bao-Ming Yu~2 Xue-Ming Tang~1 1 Department of Cell Biology,2 Department of Surgery,Ruijin Hospital,Shanghai Second Medical University,Shanghai 200025,China | 2001 | World Journal of Gastroenterology2001，7，5： | 21 |
| 2 | Correlation analysis between the chemical contents and bioactivity for the quality control of Alismatis Rhizoma显示文摘In order to clarify regions of production and to discriminate processing methods, quantitative and qualitative analyses for saccharides and terpenes in 35 batches of Alismatis Rhizoma were performed.Methodologies included HPLC–PDA, HPLC–VWD and UHPLC–MSn, combined with principal component analysis(PCA) and partial least squares regression techniques(PLSR). The inhibitory effects of triterpenes and Alismatis Rhizoma extracts on lipase activity were evaluated in vitro. PLSR analysis revealed significant positive correlations(R2= 0.5795) between the contents of triterpenes 10, 14, 15, 18 and 22 and the inhibitory effects of Alismatis Rhizoma. The present study establishes an effective method for simultaneous determination of multiple components, and identifies key bioactive triterpenes. These results can be used for systematic and novel analytical strategies for the quality control of Alismatis Rhizoma production. | Xiaoxv Gao Chengpeng Sun Zhenglong Yu Jian Cang Xiangge Tian Xiaokui Huo Lei Feng Xinguang Liu Chao Wang Baojing Zhang Xiaochi Ma | 2018 | Acta Pharmaceutica Sinica B2018，8，2： | 4 |
| 3 | Molecular Characterization of Human Respiratory Adenovirus Infection in Children from November 2016 to October 2017 in Xining City, China显示文摘Human adenoviruses (HAdVs) belong to the genus Mastadenovirus, family Adenoviridae, and can cause respiratory tract and gastrointestinal tract infections, as well as ocular infections in humans[1]. Till date, a total of 84 unique genotypes of AdVs have been identified and classified as human Mastadenovirus species A to G, and specific types are often associated with certain clinical symptoms, epidemiological settings, and demographic risk groups[2]. Among these species, members of the species HAdV-B (HAdV-3, HAdV-7, HAdV-11, HAdV-16, HAdV-21, HAdV-34, HAdV-35, HAdV-50, etc), HAdV-C (HAdV-1, HAdV-2, HAdV-5, and HAdV-6), and HAdV-E (HAdV-4) have been generally associated with respiratory infections[3]. HAdV infections are mild and self-limited in healthy individuals, whereas they can result in high mortality rates in immunocompetent and immunocompromized patients[4]. | YU Juan LI Hong LU Nan Nan LEI You Ju JIANG Shuang Ying ZHAO Sheng Cang RAO Hua Xiang | 2019 | Biomedical and Environmental Sciences2019，32，1： | 3 |
| 4 | Effects of Fe2O3 on the properties of ceramics from steel slag显示文摘Ferric oxide is one of the key factors affecting both the microstructure and the properties of CaO-MgO-SiO_2-based ceramics. Research on this effect is significant in the utilization of iron-rich solid wastes in ceramics. Ceramic samples with various Fe_2O_3 contents(0 wt%, 5 wt%, and 10 wt%) were prepared and the corresponding physical properties and microstructure were studied. The results indicated that Fe_2O_3 not only played a fluxing role, but also promoted the formation of crystals. Ceramics with 5 wt% of Fe_2O_3 addition attained the best mechanical properties with a flexural strength of 132.9 MPa. Iron ions were dissolved into diopside, consequently causing phase transformation from diopside and protoenstatite to augite, thereby contributing to the enhancement of its properties. An excess amount of Fe_2O_3 addition(10 wt% or more) resulted in deteriorated properties due to the generation of an excess volume of liquid and the formation of high-porosity structures within ceramics. | Yu Li Li-hua Zhao Ya-kun Wang Da-qiang Cang | 2018 | International Journal of Minerals,Metallurgy and Materials2018，25，4： | 2 |
| 5 | Silver nanoparticles-decorated and mesoporous silica coated single-walled carbon nanotubes with an enhanced antibacterial activity for killing drug-resistant bacteria显示文摘The mounting threat of antibiotic-resistant bacterial infections has made it imperative to develop innovative antibacterial strategies.Here we propose a novel antibacterial nanoplatform of silver nanoparticles-decorated and mesoporous silica coated single-walled carbon nanotubes constructed via a N-[3-(trimethoxysiltyl)propyl]ethylene diamine(TSD)-mediated method(SWCNTs@mSiO2-TSD@Ag).In this system,the outer mesoporous silica shells are able to improve the dispersibility of SWCNTs,which will increase their contact area with bacteria cell walls.Meanwhile,the large number of mesopores in silica layers act as microreactors for in situ synthesis of Ag NPs with controlled small size and uniform distribution,which induces an enhanced antibacterial activity.Compared with TSD modified mesoporous silica coated single-walled carbon nanotubes(SWCNTs@mSiO2-TSD)and commercialAg NPs,this combination nanosystem of SWCNTs@mSiO2-TSD@Ag exhibits much stronger antibacterial performance against multi-drug-resistant bacteria Escherichia coli(E.coli)and Staphylococcus aureus(S.aureus)in vitro through damaging the bacterial cell membranes and a fast release of silver ions.Furthermore,the in vivo rat skin infection model verifies that SWCNTS@mSiO2-TSD@Ag have remarkably improved abilities of bacterial clearance,wound healing promoting as well as outstanding biocompatibility.Therefore,this novel nanoplatform indicates promising potentials as a safe and powerful tool for the treatment of clinical drug-resistant infections. | Yu Zhu Jia Xu Yanmao Wang Cang Chen Hongchen Gu Yimin Chai Yao Wang | 2020 | Nano Research2020，13，2： | 2 |
| 6 | Pharmacological mechanisms underlying the antinociceptive and tolerance effects of the 6,14-bridged oripavine compound 030418显示文摘瞄准: 调查位于 antinociceptive 效果和忍耐下面到 N-methyl-7α 的可能的药理学机制; -[(R)-1-hydroxy-1-methyl-3-(thien-3-yl)-propyl]-6,14-endo-ethanotetrahydronororipavine (030418 ) , thienorphine 的衍生物。 | Quan WEN Cang YU Yu-lei LI Ling-di YAN Ze-hui GONG | 2011 | Acta Pharmacologica Sinica2011，32，10： | 2 |
| 7 | Effects of sintering atmosphere on the physical and mechanical properties of modified BOF slag glass显示文摘This study proposes an efficient way to utilize all the chemical components of the basic oxygen furnace(BOF) slag to prepare high value-added glass-ceramics.A molten modified BOF slag was converted from the melting BOF slag by reducing it and separating out iron component in it,and the modified BOF slag was then quenched in water to form glasses with different basicities.The glasses were subsequently sintered in the temperature range of 600–1000°C in air or nitrogen atmosphere for 1 h.The effects of different atmospheres on the physical and mechanical properties of sintered samples were studied by using differential scanning calorimetry(DSC),X-ray diffraction(XRD) and scanning electron microscopy(SEM) and by conducting experiment on evaluating the sintering shrinkage,water absorption and bulk density.It is found that the kinetics of the sintering process is significantly affected by sintering atmosphere.In particular,compared with sintering in air atmosphere,sintering in N2 atmosphere promotes the synergistic growth of pyroxene and melilite crystalline phases,which can contribute to better mechanical properties and denser microstructure. | Wen-bin Dai Yu Li Da-qiang Cang Yuan-yuan Zhou Yong Fan | 2014 | International Journal of Minerals,Metallurgy and Materials2014，21，5： | 2 |
| 8 | Two-dimensional Electrophoresis Analysis of Proteins in Response to Cold Stress in Extremely Cold-resistant Winter Wheat Dongnongdongmai 1 Tillering Nodes显示文摘The overwintering survival ratio of the cultivar Dongnongdongmai 1 with strong cold-resistance in paramos of Heilongjiang Province in China are over 85%. The tillering nodes are the most important organs for overwintering survival of winter wheat, because there are more substances associated with cold resistance in tillering nodes than those in leaves and roots. Proteins in the tillering nodes of the cold-resistant cultivar Dongnongdongmai 1 grown under field conditions with or without any lowtemperature stress were analyzed by 2-dimensional electrophoresis and identified by mass spectrometry. In the range of pH 4-7, the expression of 37 proteins showed obvious difference (±more than two fold) in the proteomic maps of cold-stressed and non-stressed tillering nodes, including a new protein spot. All proteins exhibiting the difference in expression were identified using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry, followed by a database search for protein identification and function prediction. Five groups of proteins were confirmed, namely stress-related proteins (22%), metabolism-associated proteins (35%), and signaling molecules (24%), cell wall-binding proteins (5%), unclear proteins (14%). This indicated that tillering node cells supported the energy requirements of plant growth and stress resistance by signal transduction adapting to metabolism and structure. | Cang Jing Yu Jing Liu Li-jie Yang Yang Cui Hong Hao Zai-bin Li Zhuo-fu | 2012 | Journal of Northeast Agricultural University(English Edition)2012，19，1： | 2 |
| 9 | Compact CubeSat Gamma-ray detector for GRID mission显示文摘Gamma-Ray Integrated Detectors(GRID)mis-sion is a student project designed to use multiple gamma-ray detectors carried by nanosatellites(CubeSats),forming a full-time all-sky gamma-ray detection network that monitors the transient gamma-ray sky in the multi-mes-senger astronomy era.A compact CubeSat gamma-ray detector,including its hardware and firmware,was designed and implemented for the mission.The detector employs four Gd 2 Al 2 Ga 3 O 12:Ce(GAGG:Ce)scintillators coupled with four silicon photomultiplier(SiPM)arrays to achieve a high gamma-ray detection efficiency between 10 keV and 2 MeV with low power and small dimensions.The first detector designed by the undergraduate student team onboard a commercial CubeSat was launched into a Sun-synchronous orbit on October 29,2018.The detector was in a normal observation state and accumulated data for approximately one month after on-orbit functional and performance tests,which were conducted in 2019. | Jia-Xing Wen Xu-Tao Zheng Jian-Dong Yu Yue-Peng Che Dong-Xin Yang Huai-Zhong Gao Yi-Fei Jin Xiang-Yun Long Yi-Hui Liu Da-Cheng Xu Yu-Chong Zhang Ming Zeng Yang Tian Hua Feng Zhi Zeng Ji-Rong Cang Qiong Wu Zong-Qing Zhao Bin-Bin Zhang Peng An GRID collaboration | 2021 | Nuclear Science and Techniques2021，32，9： | 2 |
| 10 | Effect of exogenous abscisic acid on carbohydrate metabolism and the expression levels of cor- relative key enzymes in winter wheat under low temperature 显示文摘 | Liu L J Cang J Yu J | 2013 | Bioscience Biotechnology and Biochemistry2013，77，3： | 1 |
| 11 | Mechanism of phase separation in BFS (blast furnace slag) glass phase显示文摘XRD,TEM,ED,and NMR analyzed four types of blast furnace slags (BFS) with different structures in this paper. The composition requirement for phase separation in BFS glass phase was then put forward,that is the composition of slag locates in the coexisting phase region of melilite and any silicate mineral with Q0 units. The special structure of melilite units,a 5-membered ring with high degree of polymerization (DOP),plays a key role in the formation of phase separation. In BFS system,one with chemical composition of larger ratio of (CaO + MgO/(SiO2 + Al2O3) would be more promising to meet the requirement for phase separation. | LI Yu LIU XiaoMing SUN HengHu CANG DaQiang | 2011 | Science China(Technological Sciences)2011，54，1： | 1 |
| 12 | Nitrous Oxide‐Oxygen Mixture During Burn Wound Dressing: A Double‐Blind Randomized Controlled Study显示文摘 | Yu‐Xiang Li Wen‐Jun Han Hong‐Tai Tang Yin‐Sheng Wu Lu Tang Jian‐Qiang Yu Yan‐Cang Li Zhao‐Fan Xia Ji‐Jun Zhao | 2013 | CNS Neurosci Ther2013，，： | 1 |
| 13 | Cryptanalysis and improvement on a cryptosystem based on a chaotic map显示文摘 | Wang King-yuan Yu Cang hai | 2009 | Computers and Mathematics with Applications2009，，57： | 1 |
| 14 | Mutual information based input feature selection for classification problems 显示文摘 | CANG S YU H | 2012 | Decision Support Systems2012，54，1： | 1 |
| 15 | A combination selection algorithm on forecasting 显示文摘 | CANG S YU H N | 2014 | European Journal of Operational Research2014，234，1： | 1 |
| 16 | Selective removal of phenol by spherical particles of α-,β- and γ-cyclodextrin polymers: kinetics and isothermal equilibrium显示文摘球形的粒子, - 并且高效地把酚从浪费水移开的 -cyclodextrin (CD ) 聚合物被反向的暂停聚合在液体作为 crosslinker 与 epichlorohydrin 准备石蜡。由控制 crosslinker 和水的数量,有可控制的尺寸的明确的球形的聚合物粒子被获得。由于在 CD 组和酚之间的选择包括协会,这些 CD 球形的聚合物粒子被表明是酚的移动的理想的候选人。在他们之中, CD 聚合物粒子显示出最好的表演。动力学和等温的平衡模型被用来用这些 CD 聚合物粒子从水的答案适合酚移动的试验性的数据。动力学跟随了 Ho 和 Mckay 方程,这被发现,建议酚的吸附过程被在 CD 和酚之间的散开和主人客人相互作用控制。平衡等温的数据能被 Freundlich 方程很好适合。否定免费精力变化显示了酚的吸附的自发的性质由, - 并且 CD 球形的聚合物粒子当为 CD 聚合物的最低免费精力反映了它的最好的吸附能力时,与相比 - 并且 CD 聚合物粒子。 | Qingchuan CHEN Yicun WEN Yu CANG Li LI Xuhong GUO Rui ZHANG | 2013 | Frontiers of Chemical Science and Engineering2013，7，2： | 1 |
| 17 | Detection of sugar accumulation and expression levels of correlative key enzymes in winter wheat (Triticum aestivurn ) at low temperatures显示文摘 | Zeng Y Yu J Cang J | 2011 | Biosci Biotech- nol Biochem2011，75，4： | 1 |
| 18 | Combined Petri net modeling and Al-based heuristic hybrid search for flexible manufacturing systerns, part Ⅱ:heuristic hybrid search显示文摘 | Yu H Reyes A Cang S | 2003 | Computers and Industrial Engineering2003，44，： | 1 |
| 19 | Transformation of polychlorinated biphenyls by persulfate at ambient temperature显示文摘 | Guo-Dong Fang Dionysios D. Dionysiou Dong-Mei Zhou Yu Wang Xiang-Dong Zhu Jian-Xin Fan Long Cang Yu-Jun Wang | 2012 | Chemosphere2012，，： | 1 |
| 20 | Anatomical Structure Comparison Between Leaves of Two Winter Wheat Cultivars with Different Cold/Freezing Tolerance Under Low Temperature Stress显示文摘Winter wheat (Triticum aestivum) cultivars Dongnongdongmai 1 with strong cold/freezing tolerance and Jimai 22 with weak cold/freezing tolerance were used for investigating the difference of microstructure and ultrastructure between leaves of two cultivars under low temperature stress (5℃ and -15℃) using optical and electron microscope. The results showed that there was no obvious difference between leaves of Dongnongdongmai 1 and Jimai 22 in microstructure. However, the difference between those leaves was distinct in ultrastructure. The grana lamella and stroma lamella were stacked regularly and arranged parallelly along the long axis of chloroplasts in cv. Dongnongdongmai 1, while the arrangement directions of thylakoids in Jimai 22's leaves were so irregular as to form various angles with the long axis of chloroplasts. At -15℃, the mitochondrias were swelled to be round and the structure of cristaes became blurry in both cultivars' leaves, while some cristaes of Jimai 22 disappeared. These results would provide theoretical evidence for selecting cold/freezing tolerant winter wheat germplasm resources. | YU Jing CANG Jing ZHOU Zishan LIU Lijie | 2011 | Journal of Northeast Agricultural University(English Edition)2011，18，3： | 1 |
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