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| 1 | A Genomic Variation Map Provides Insights into the Genetic Basis of Spring Chinese Cabbage (Brassica rapa ssp.pekinensis)Selection显示文摘Chinese cabbage is the most consumed leafy crop in East Asian countries.However,premature bolting induced by continuous low temperatures severely decreases the yield and quality of the Chinese cabbage, and therefore restricts its planting season and geographic distribution.In the past 40years,spring Chinese cabbage with strong winterness has been selected to meet the market demand.Here,we report a genome variation map of Chinese cabbage generated from the resequencing data of 194 geographically diverse accessions of three ecotypes.In-depth analyses of the selection sweeps and genome-wide patterns revealed that spring Chinese cabbage was selected from a specific population of autumn Chinese cabbage around the area of Shandong peninsula in northern China.We identified 23 genomic loci that underwent intensive selection,and further demonstrated by gene expression and haplotype analyses that the incorporation of elite alleles of VERNALISATION INSENTIVE 3.1(BrVIN3.1)and FLOWER LOCUS C 1(BrFLC1)is a determinant genetic source of variation during selection.Moreover,we showed that the quantitative response of BrVIN3.1 to cold due to the sequence variations in the cis elements of the BrVlN3.1 promoter significantly contributes to bolting-time variation in Chinese cabbage.Collectively, our study provides valuable insights into the genetic basis of spring Chinese cabbage selection and will facilitate the breeding of bolting-resistant Varieties by molecular-marker-assisted selection,transgenic or gene editingapproaches. | Tongbing Su Weihong Wang Peirong Li Bin Zhang Pan Li Xiaoyun Xin Honghe Sun Yangjun Yu Deshuang Zhang Xiuyun Zhao Changlong Wen Gang Zhou Yuntong Wang Hongkun Zheng Shuancang Yu Fenglan Zhang | 2018 | Molecular Plant2018，11，11： | 6 |
| 2 | Numerical study of coarse coal particle breakage in pneumatic conveying显示文摘 | Jiawei Zhou Yu Liu Changlong Du Songyong Liu Jianping Li | 2018 | Particuology2018，16，3： | 6 |
| 3 | Pain threshold, anxiety and other factors affect intensity of postoperative pain in gastric cancer patients: A prospective cohort study显示文摘Objective: This prospective cohort study explored factors related to postoperative pain in gastric cancer patients.Methods: A total of 236 patients who underwent gastrectomy were enrolled. All patients enrolled in the study completed the Hospital Anxiety and Depression Scale(HADS) questionnaire and Life Orientation Test-Revised(LOT-R) questionnaire on the day before surgery. Heat pain threshold(HPT), cold pain threshold(CPT) and pressure pain threshold(PPT) were measured for all patients one day prior to surgery and demographic details were collected. All patients were connected to a patient-controlled intravenous analgesia(PCIA) pump at the end of the surgery. The occurrence of postoperative pain was used as a dependent variable, and multivariate logistic regression analyses were conducted to screen for factors affecting postoperative pain.Results: In total, 83 patients(35.2%) had postoperative pain. Body mass index(BMI) ≥28 kg/m^(2) [odds ratio(OR): 2.67;95% confidence interval(95% CI): 1.07-6.67], total gastrectomy(OR: 2.64;95% CI: 1.42-4.91),preoperative anxiety score ≥8(OR: 2.37;95% CI: 1.12-5.02), heat pain threshold ≤4.9 s(OR: 2.14;95% CI:1.06-4.32), pressure pain threshold ≤4 g(OR: 2.05;95% CI: 1.05-4.03), and female gender(OR: 1.99;95% CI:1.04-3.83) were risk factors for postoperative pain.Conclusions: Obesity, wide range of gastrectomy, high preoperative anxiety, low HPT and PPT, and female gender are associated with increased risk for postoperative pain. | Hongyu Tan Jin Wei Shuo Li Ling Yu Hongwei Sun Ke Ji Yinkui Wang Changlong Li | 2021 | Chinese Journal of Cancer Research2021，33，3： | 5 |
| 4 | Repair of Full-Thickness Cartilage Defects With Cells of Different Origin in a Rabbit Model显示文摘 | Hui Yan Changlong Yu | 2007 | Arthroscopy: The Journal of Arthroscopic and Related Surgery2007，，： | 1 |
| 5 | Adenovirus-mediated transfer of siRNA against Runx2/Cbfa1 inhibits the formation of heterotopic ossification in animal model显示文摘 | Lin Lin Lianxu Chen Haijun Wang Xuelei Wei Xin Fu Jiying Zhang Kangtao Ma Chunyan Zhou Changlong Yu | 2006 | Biochemical and Biophysical Research Communications2006，，2： | 1 |
| 6 | Positive solutions for a class of singular boundary value problems with fractional q-difference equations显示文摘 | Wang Jufang Yu Changlong Gao Yanping | 2015 | Journal of Function Spaces2015，2015，： | 1 |
| 7 | Experimental pathology of passive pulling of bone muscle in rabbits显示文摘 | | 1985 | Chinese Sports Medicine1985，4，： | 1 |
| 8 | General solution-based route to V–VI semiconductors nanorods from hydrolysate显示文摘 | Qiang Wang Changlong Jiang Caofang Yu Qianwang Chen | 2007 | Journal of Nanoparticle Research2007，，2： | 1 |
| 9 | Existence of three positive solutions form-point boundary value problems on infinite intervals显示文摘 | GUO Yanping YU Changlong WANG Jufang | 2009 | Nonliner Analysis2009，71，： | 1 |
| 10 | Magnetic mesoporous clay adsorbent: Preparation, characterization and adsorption capacity for atrazine显示文摘 | Haicheng Liu Wei Chen Cheng Liu Yu Liu Changlong Dong | 2014 | Microporous and Mesoporous Materials2014，，： | 1 |
| 11 | Synthesis of magnetic chitosan nanoparticle and its adsorption property for humic acid from aqueous solution显示文摘 | Changlong Dong Wei Chen Cheng Liu Yu Liu Haicheng Liu | 2014 | Colloids and Surfaces A: Physicochemical and Engineering Aspects2014，，： | 1 |
| 12 | A pangenomic study of Bacillus thuringiensis显示文摘杆菌 thuringiensis (B。thuringiensis ) 是一个土壤住所克积极的细菌和它的编码 plasmid 的毒素(叫喊) 通常被用作杀虫剂的生物选择。在 pangenomic 研究,我们定序七 B。thuringiensis 在高范围并且基础质量的使用孤立下一代的定序站台。B。当一个新染色体被增加时, thuringiensis pangenome 被外推有 4196 核心基因和 558 唯一的基因的 asymptotic 价值。比作它一样的类的密切相关的种的 pangenomes, B。thuringiensis pangenome 显示出一个开的特征,类似于 B。仙影拳然而并非到 B。anthracis;后者有关上的 pangenome。我们也在七 B 之中发现了广泛的分叉。thuringiensis 染色体集会,它怀有宽大的重复和单个核苷酸多型性(SNP ) 。在 orthologous 基因之中的身份比 84.5% 大,为染色体变化的热点在 2.32.8 Mb 和 5.05.6 Mb 的 genomic 区域被发现。我们断定在所有差距被关上以前,从多重种类的高范围的顺序集会为 pangenomic 研究是很有用的。 | Yongjun Fang Zhaolong Li Jiucheng Liu Changlong Shu Xumin Wang Xiaowei Zhang Xiaoguang Yu Duojun Zhao Guiming Liu Songnian Hu Jie Zhang Ibrahim Al-Mssallem Jun Yu | 2011 | Journal of Genetics and Genomics2011，38，12： | 1 |
| 13 | Existence of three positive solutions for m-point boundary value problems on infinite intervals显示文摘 | GUO Yanping YU Changlong WANG Jufang | | 0，，： | 1 |
| 14 | Existence of solutions for m-point boundary value problems on a half-line显示文摘 | YU Changlong GUO Yanping JI Yude | | 0，，： | 1 |
| 15 | Characterization of two novel cry8 genes from Bacillus thuringiensis strain BT185显示文摘 | Shu Changlong Yu Hong Wang Rongyan | 2009 | Current Microbiology2009，58，4： | 1 |
| 16 | Existence of three positive solutions for m-point boundary value problems on infinite intervals显示文摘 | GUO Yanping YU Changlong WANG Jufang | 2009 | Nonliner Analysis2009，71，： | 1 |
| 17 | Simple bone cyst the effeets methylprednisolone on synovial cells in culture显示文摘 | Changlong YU Astous JD Finnegan M | 1991 | Clin Orthop1991，262，： | 1 |
| 18 | Synthesis of a ternary amide LixKy(NH2)x+y and a novel Li3K(NH2)4–xMgH2 combination system for hydrogen storage显示文摘The ternary amides LiK2(NH2)3, LiK(NH2)2, and Li3 K(NH2)4 are successfully synthesized by ball milling mixtures of LiNH2 and KNH2, and the hydrogen storage properties of Li3K(NH2)4–xMgH2(x = 1, 2, 3,4) are systematically investigated. The Li3K(NH2)4–2 Mg H2 sample displays optimized hydrogen storage properties, releasing 6.37 wt% of hydrogen in a two-stage reaction with an onset temperature of 60 °C.The first dehydrogenation stage exhibits good reaction kinetics and thermodynamic properties because of a lower activation energy and appropriate enthalpy change. After full dehydrogenation at 130 °C, the Li3K(NH2)4–2 MgH2 sample absorbs 3.80 wt% of H2 below 160 °C in a variable temperature hydrogenation mode. Mechanistic investigations indicate that Li3 K(NH2)4 reacts with Mg H2 to produce Mg(NH2)2, LiH,and KH during ball milling. In the heating process, Mg(NH2)2 first reacts with Li H to form Li2 Mg2 N3 H3 and Li NH2, while KH works as a catalyst, and then, KH reacts with Li2Mg2N3H3 and Li NH2 to generate a new K-containing compound. | Chao Li Changlong Li Meiqiang Fan Haichao Chen Kangying Shu Yu Zhang Mingxia Gao Yongfeng Liu Hongge Pan | 2019 | Journal of Energy Chemistry2019，28，8： | 0 |
| 19 | Intelligent Knee Prostheses: A Systematic Review of Control Strategies显示文摘The intelligent knee prosthesis is capable of human-like bionic lower limb control through advanced control systems and artificial intelligence algorithms that will potentially minimize gait limitations for above-knee amputees and facilitate their reintegration into society.In this paper,we sum up the control strategies corresponding to the prevailing control objectives(position and impedance)of the current intelligent knee prosthesis.Although these control strategies have been successfully implemented and validated in relevant experiments,the existing deficiencies still fail to achieve optimal performance of the controllers,which complicates the definition of a standard control method.Before a mature control system can be developed,it is more important to realize the full potential for the control strategy,which requires upgrading and refining the relevant key technologies based on the existing control methods.For this reason,we discuss potential areas for improvement of the prosthetic control system based on the summarized control strategies,including intent recognition,sensor system,prosthetic evaluation,and parameter optimization algorithms,providing future directions toward optimizing control strategies for the next generation of intelligent knee prostheses. | Linrong Li Xiaoming Wang Qiaoling Meng Changlong Chen Jie Sun Hongliu Yu | 2022 | Journal of Bionic Engineering2022，19，5： | 0 |
| 20 | The Novel PRRSV Strain HBap4-2018 with a Unique Recombinant Pattern Is Highly Pathogenic to Piglets显示文摘Currently, various porcine reproductive and respiratory syndrome virus(PRRSV) variants emerged worldwide with different genetic characteristics and pathogenicity, increasing the difficulty of PRRS control. In this study, a PRRSV strain named HBap4-2018 was isolated from swine herds suffering severe respiratory disease with high morbidity in Hebei Province of China in 2018. The genome of HBap4-2018 is 15,003 nucleotides in length, and compared with NADC30-like PRRSV, nsp2 of HBap4-2018 has an additional continuous deletion of five amino acids. Phylogenetic analysis based on complete genome and ORF5 showed that HBap4-2018 belonged to lineage 8 of PRRSV-2, which was characterized by highly variable genome. However, HBap4-2018 was classified into lineage 1 based on phylogenetic analysis of nsp2,sharing higher amino acid homology(85.3%–85.5%) with NADC30-like PRRSV. Further analysis suggested that HBap4-2018 was a novel natural recombinant PRRSV with three recombinant fragments in the genome, of which highly pathogenic PRRSV(HP-PRRSV) served as the major parental strains, while NADC30-like PRRSV served as the minor parental strains. Five recombination break points were identified in nsp2, nsp3, nsp5, nsp9 and ORF6, respectively,presenting a novel recombinant pattern in the genome. Piglets inoculated with HBap4-2018 presented typical clinical signs with a mortality rate of 60%. High levels of viremia and obvious macroscopic and histopathological lesions in the lungs were observed, revealing the high pathogenicity of HBap4-2018 in piglets. | Pengfei Chen Xiangmei Tan Mengqin Lao Xia Wu Xiongwei Zhao Shuting Zhou Jiarong Yu Junrui Zhu Lingxue Yu Wu Tong Fei Gao Hai Yu Changlong Liu Yifeng Jiang Guangzhi Tong Yanjun Zhou | 2021 | Virologica Sinica2021，36，6： | 0 |
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