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| 1 | Discovery of biclonal origin and a novel oncogene SLC12A5 in colon cancer by single-cell sequencing显示文摘单个房间的定序是为描出的一个强大的工具为个性化的癌症管理的同种细胞的关系和识别关键司机基因。这里,我们执行了结肠癌的一个盒子的单个房间的定序的分析。人口遗传分析在肿瘤房间人口识别了二独立克隆。主要肿瘤克隆作为早 oncogenic 事件怀有 APC 和 TP53 变化,而次要的克隆包含了优势的 CDC27 和 PABPC1 变化。在这二克隆的次要的克隆支持的 APC 和 TP53 变化的缺席从二细胞的起源被导出。体的变化等位基因频率系列的检查另外 21 个整个织物的定序 exome 的盒子在结肠癌揭示了同种细胞的起源的异质。下次,我们识别了在单个房间的水平显示出变化的高频率,但是在人口水平展出了低流行的变异的基因 SLC12A5。变异的 SLC12A5 的功能的描述在结肠癌揭示了它的潜在的 oncogenic 效果。我们的学习在单个房间的水平支持提供第一条 exome 宽的证据那结肠癌能具有 biclonal 起源,并且建议在一个队的低流行的变化可以也在单个水平起重要 protumorigenic 作用。 | Chang Yu Jun Yu Xlaotlan Yao Wllham KK Wu Youyong Lu Senwel Tang Xiangchun Li Li Bao Xiaoxing Li Yong Hou Renhua Wu Min Jian Ruoyan Chen Fan Zhang Lixia Xu Fan Fan Jun He Qiaoyi Liang Hongyi Wang Xueda Hu Minghui He Xiang Zhang Hancheng Zheng Qibin Li Hanjie Wu Yan Chen Xu Yang Shida Zhu Xun Xu Huanming Yang Jian Wang Xiuqing Zhang Joseph JY Sung Yingrui Li Jun Wang | 2014 | Cell Research2014，，6： | 16 |
| 2 | Human immune repertoire in hepatitis B virus infection显示文摘Hepatitis B virus(HBV)infection is a public health threat that affects 257 million people worldwide and can progress to liver cirrhosis,liver failure,and hepatocellular carcinoma.The HBV antigen-induced adaptive immune response plays an important role in HBV clearance.Immune repertoire sequencing(IRS)has been used to investigate the molecular mechanisms behind the immune system,find novel ways to treat HBV infection,and evaluate the genetic responses and immune characteristics of individuals infected by HBV or immunized by HBV vaccine.This review summarizes the human immune repertoire analysis methodology,and the application of the IRS in the prediction of HBV infection progression,treatment,and vaccination. | Qiao Zhan Jing-Hang Xu Yan-Yan Yu Emily Lo KK Felicianna Hani El-Nezami Zheng Zeng | 2021 | World Journal of Gastroenterology2021，27，25： | 4 |
| 3 | Prostate cancer: prediction of extracapsular extension with endorectal MR imaging and three-dimensional proton MR spectroscopic imaging显示文摘 | Yu KK Scheidler J Hricak H | 1999 | Radiology1999，213，2： | 1 |
| 4 | Forecasting crude oil price with an EMD-based neural network ensemble learning paradigm 显示文摘 | Yu L Wang S Lai KK | 2008 | Energy Economics2008，30，5： | 1 |
| 5 | Functional abnormalities in patients with permanent ventricular pacing: the effect of electrical stimulation显示文摘 | Tse HF Yu C Wong KK | 2002 | J Am Coll Cardiol2002，40，： | 1 |
| 6 | Treatment of profuse epistaxis in patients irradiated for nasopharyngeal casino ma显示文摘 | Wong GK Chan KK Yu SC | 2007 | ANZ J Surg2007，77，4： | 1 |
| 7 | Molecular assay to detect metastatic head and neck squamous cell carcinoma显示文摘 | Becker MT Shores CG Yu KK | 2004 | Arch Otolaryngol Head Neck Surg2004，130，1： | 1 |
| 8 | Molecular assay to detect metastatic head and neck squamous cell carcinoma显示文摘 | Becker MT Shores CG Yu KK | 2004 | Arch Otolaryngol Head Neck Surg2004，130，1： | 1 |
| 9 | Radiologic staging in patients with endometrial cancer: a meta analysis 显示文摘 | Kinkel K Kaji Y Yu KK | 1999 | Radiology1999，212，3： | 1 |
| 10 | Alkylamine capped metal nanopar- ticle 'inks' for printable SERS substrates, electronics and broadband photodetectors显示文摘 | Polavarapu L Manga KK Yu K | 2011 | Nanoscale2011，3，5： | 1 |
| 11 | Functional abnormalities in patients with permanent right ventricular pacing显示文摘 | Tse HF Yu C Wong KK | 2002 | J Am Call Cardiol2002，40，： | 1 |
| 12 | Functional abnormalitiesin patients with permanent right ventricular pacing:theeffect of sites of electrical stimulation显示文摘 | Tse HF Yu C Wong KK | 2002 | J Am Coll Car-diol2002，40，8： | 1 |
| 13 | A distance-based group decision-making methodology for multi-person multi-criteria emergency decision sup- port显示文摘 | Yu L Lai KK | 2011 | Decision Support Systems2011，51，2： | 1 |
| 14 | Smoking cessation among Hong Kong Chinese cmokers attending hospital as outpatients : impact of doctors' ad- vice, successful quitting and intention to quit 显示文摘 | Yu DKH Wul KK | 2004 | Asia Pac J Pub- lic Health2004，16，： | 1 |
| 15 | Credit risk evaluation using a weighted least squares SVM classifier with design of experiment for parameter selection 显示文摘 | YU LA YAO X WANG SY Lai KK | 2011 | Expert Systems With Applications2011，38，15： | 1 |
| 16 | Molecular assay to detect metastatic head and neck squamous cell carcinoma 显示文摘 | Becker MT Shores CG Yu KK | 2004 | Arch Otolaryngol Head Neck Surg2004，130，1： | 1 |
| 17 | Preoperative staging of cervical carcinoma:phased array coil fast spin-echo versus body coil spin-echo T2-weighted MR imaging 显示文摘 | Yu KK Hricak H Subak LL | 1998 | A JR Am J Roentgenol1998，171，3： | 1 |
| 18 | Radiologic staging in patients with endometrial cancer: a meta-analysis 显示文摘 | Kinkel K Kaji Y Yu KK | 1999 | Radiology1999，212，3： | 1 |
| 19 | Functional abnormalities in patients with permanent right ventricular pacing: The effect of sites of electrical stimulation显示文摘 | Tse HF Yu C Wong KK | 2002 | J Am Coll Cardiol2002，40，： | 1 |
| 20 | Smoking cessation among Hong Kong Chinese smokers attending hospital as outpatients: impact of doctors' advice, successful quitting and intention to quit 显示文摘 | Yu DK Wu KK Abdullah AS | 2004 | Asia Pae J Public Health2004，16，： | 1 |
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