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| 1 | Oxidative stress and antioxidants in hepatic pathogenesis显示文摘Long term hepatitis B virus (HBV) infection is a major risk factor in pathogenesis of chronic liver diseases,including hepatocellular carcinoma (HCC). The HBV encod-ed proteins,hepatitis B virus X protein and preS,appear to contribute importantly to the pathogenesis of HCC. Both are associated with oxidative stress,which can damage cellular molecules like lipids,proteins,and DNA during chronic infection. Chronic alcohol use is another important factor that contributes to oxidative stress in the liver. Previous studies reported that treatment with antioxidants,such as curcumin,silymarin,green tea,and vitamins C and E,can protect DNA from damage and regulate liver pathogenesis-related cascades by reducing reactive oxygen species. This review summarizes some of the relationships between oxidative stress and liver pathogenesis,focusing upon HBV and alcohol,and suggests antioxidant therapeutic approaches. | Hye-Lin Ha Hye-Jun Shin Mark A Feitelson Dae-Yeul Yu | 2010 | World Journal of Gastroenterology2010，16，48： | 18 |
| 2 | Characterization of CD8+CD57+ T cells in patients wit acute myocardial infarction显示文摘 | Hee Tae Yu Jong-Chan Youn Jino Lee Seunghyun Park Ho-Seok Chi Jungsul Lee Chulhee Choi Sungha Park Donghoon Choi Jong-Won Ha Eui-Cheol Shin | 2015 | Cellular & Molecular Immunology2015，12，4： | 3 |
| 3 | Adjuvant capecitabine plus oxaliplatin for gastric cancer after D2 gastrectomy (CLASSIC): 5-year follow-up of an open-label, randomised phase 3 trial显示文摘 | Sung Hoon Noh Sook Ryun Park Han-Kwang Yang Hyun Cheol Chung Ik-Joo Chung Sang-Woon Kim Hyung-Ho Kim Jin-Hyuk Choi Hoon-Kyo Kim Wansik Yu Jong Inn Lee Dong Bok Shin Jiafu Ji Jen-Shi Chen Yunni Lim Stella Ha Yung-Jue Bang | 2014 | Lancet Oncology2014，，12： | 3 |
| 4 | Development of seeder for mixed planting of corn and soybeans显示文摘Corn and soybeans should be sown between 5 cm and 10 cm apart in mixed cultivation to increase protein content and improve productivity of the forage.However,existing sowers cannot plant at intervals of less than 20 cm.Consequently,mixed cultivation of corn and soybeans is currently performed by first sowing corn seeds with a tractor and then manually planting soybean seeds.This method results in irregular intervals between the seeds,it is laborious and time consuming.This study aimed at developing a seeder that can simultaneously,precisely and efficiently plant corn and soybean.The geometrical and rheological properties of corn and soybeans were initially measured.The seed conveying equipment were designed using the EDEM software.The sowing interval between seeds,depth of soil over planted seed,and sowing performance were analyzed.The EDEM simulation results indicated that a 6-mm-wide and 3-mm-deep grooved seed-delivering roller had the highest particle mobility of the designs considered,with a 2.5%misplanting rate.A performance test showed that no misplanting occurred in the sections sowed with soybean seeds at a seeding interval that averaged 32 mm(321 seeds sown in 10 m)and that misplanting occurred in one section sowed with corn at a seeding interval that averaged 247 mm(40 seeds sown over 10 m).The sowing efficiency for both corn and soybeans was found to be 0.42 h/hm2.The average depth of soil over seed was 32.7 mm for soybean and 39.7 mm for corn.These average depths are within the stipulated range for the depth of soil over seed,which is 5 to 10 times the seed size.This study developed an efficient seeding machine that can simultaneously plant soybean and corn precisely,consequently improving forage yield and saving man-hours. | Seung Min Woo Daniel Dooyum Uyeh Moon Sang Sagong Yu Shin Ha | 2017 | International Journal of Agricultural and Biological Engineering2017，10，3： | 3 |
| 5 | Easy calibration method of vision system for in-situ measurement of strain of thin films显示文摘An easy calibration method was presented for in-situ measurement of displacement in the order of nanometer during micro-tensile test for thin films by using CCD camera as a sensing device. The calibration of the sensing camera in the system is a central element part to measure displacement in the order of nanometer using images taken with the camera. This was accomplished by modeling the optical projection through the camera lens and relative locations between the object and camera in 3D space. A set of known 3D points on a plane where the film is located on is projected to an image plane as input data. These points, known as a calibration points, are then used to estimate the projection parameters of the camera. In the measurement system of the micro-scale by CCD camera, the calibration data acquisition and one-to-one matching steps between the image and 3D planes need precise data extraction procedures and repetitive user's operation to calibrate the measuring devices. The lack of the robust image feature extraction and easy matching prevent the practical use of these methods. A data selection method was proposed to overcome these limitations and offer an easy and convenient calibration of a vision system that has the CCD camera and the 3D reference plane with calibration marks of circular type on the surface of the plane. The method minimizes the user's intervention such as the fine tuning of illumination system and provides an efficient calibration method of the vision system for in-situ axial displacement measurement of the micro-tensile materials. | Jun-Hyub PARK Dong-Joong KANG Myung-Soo SHIN Sung-Jo LIM Son-Cheol YU Kwang-Soo LEE Jong-Eun HA Sung-Hoon CHOA | 2009 | 中国有色金属学会会刊:英文版2009，19，B09： | 3 |
| 6 | Methylsulfonylmethane suppresses hepatic tumor development through activation of apoptosis显示文摘AIM:To investigate the effect of methylsulfonylmethane(MSM), recently reported to have anti-cancer effects, in liver cancer cells and transgenic mice. METHODS: Three liver cancer cell lines, HepG2, Huh7-Mock and Huh7-H-rasG12V, were used. Cell growth was measured by Cell Counting Kit-8 and soft agar assay. Western blot analysis was used to detect caspases, poly(ADP-ribose) polymerase(PARP), and B-cell lymphoma2(Bcl-2) expressions. For in vivo study, we administered MSM to H-ras12V transgenic mice for 3 mo. RESULTS: MSM decreased the growth of HepG2, Huh7-Mock and Huh7-H-rasG12V cells in a dose-dependent manner. That was correlated with significantly increased apoptosis and reduced cell numbers in MSM treated cells. Cleaved caspase-8, cleaved caspase-3 and cleaved PARP were remarkably increased in the liver cancer cells treated with 500 mmol/L of MSM; however, Bcl-2 was slightly decreased in 500 mmol/L. Liver tumor development was greatly inhibited in the H-ras12V transgenic mice treated with MSM, compared to control, by showing reduced tumor size and number. Cleaved PARP was significantly increased in non-tumor treated with MSM compared to control. CONCLUSION: Liver injury was also significantly attenuated in the mice treated with MSM. Taken together, all the results suggest that MSM has anti-cancer effects through inducing apoptosis in liver cancer. | Joo-Hyun Kim Hye-Jun Shin Hye-Lin Ha Young-Ho Park Tae-Ho Kwon Mi-Ra Jung Hyung-Bae Moon Eun-Sang Cho Hwa-Young Son Dae-Yeul Yu | 2014 | World Journal of Hepatology2014，6，2： | 1 |
| 7 | Plaque Characteristics in Culprit Lesions and Inflammatory Status in Diabetic Acute Coronary Syndrome Patients显示文摘 | Young Joon Hong Myung Ho Jeong Yun Ha Choi Jum Suk Ko Min Goo Lee Won Yu Kang Shin Eun Lee Soo Hyun Kim Keun Ho Park Doo Sun Sim Nam Sik Yoon Hyun Ju Yoon Kye Hun Kim Hyung Wook Park Ju Han Kim Youngkeun Ahn Jeong Gwan Cho Jong Chun Park Jung Chaee Kang | 2009 | JACC: Cardiovascular Imaging2009，，3： | 1 |
| 8 | Prognostic Value of Serial Global Longitudinal Strain Measured by Two-Dimensional Speckle Tracking Echocardiography in Patients With ST-Segment Elevation Myocardial Infarction显示文摘 | Jong Shin Woo Woo-Shik Kim Tae-Kyung Yu Sang Jin Ha Seok Yeon Kim Jong-Hoa Bae Kwon Sam Kim | 2011 | The American Journal of Cardiology2011，，： | 1 |
| 9 | Symptomatic Hemorrhagic Transformation and Its Predictors in Acute Ischemic Stroke with Atrial Fibrillation显示文摘 | Lee Ju-hun Park Kwang-yeol Shin Joon-hyun Cha Jae-kwan Kim Hahn-young Kwon Jee-hyun Oh Hyung Geun Lee Kyung Bok Kim Dong-eog Ha Sang-won Cho Kyung-hee Sohn Sung-il Oh Mi-sun Yu Kyung-ho Lee Byung-chul Kwon Sun U | 2010 | European Neurology2010，，4： | 1 |
| 10 | Propofol limits rat myocardial ischemia and reperfusion injury with an associated reduction in apoptotic cell death in vivo显示文摘 | Yong Chun Jin WooYeol Kim Yu Mi Ha Il Woo Shin Ju Tae Sohn Hye Jung Kim Han Geuk Seo Jea Heun Lee Ki Churl Chang | 2008 | Vascular Pharmacology2008，，1： | 1 |
| 11 | DA-1229, a novel and potent DPP4 inhibitor, improves insulin resistance and delays the onset of diabetes显示文摘 | Mi-Kyung Kim Yu Na Chae Ha Dong Kim Eun Kyoung Yang Eun Jung Cho Song-hyen Choi Ye-Hwang Cheong Hae-Sun Kim Heung Jae Kim Yeong Woo Jo Moon-Ho Son Soon-Hoe Kim Chang Yell Shin | 2011 | Life Sciences2011，，1： | 1 |
| 12 | Liver transplantation for hepatocellular carcinoma: Korean experience显示文摘 | SungGyu Lee ChulSoo Ahn TaeYong Ha DeokBog Moon KunMoo Choi GiWon Song DongHwan Chung GilChun Park YoungDong Yu NamKyu Choi KwanWoo Kim KiHun Kim Shin Hwang | 2010 | Journal of Hepato - Biliary - Pancreatic Sciences2010，，5： | 1 |
| 13 | Predictors of no-reflow after percutaneous coronary intervention for culprit lesion with plaque rupture in infarct-related artery in patients with acute myocardial infarction显示文摘 | Young Joon Hong Myung Ho Jeong Yun Ha Choi Jum Suk Ko Min Goo Lee Won Yu Kang Shin Eun Lee Soo Hyun Kim Keun Ho Park Doo Sun Sim Nam Sik Yoon Hyun Ju Youn Kye Hun Kim Hyung Wook Park Ju Han Kim Youngkeun Ahn Jeong Gwan Cho Jong Chun Park Jung Chaee Kang | 2009 | Journal of Cardiology2009，，1： | 1 |
| 14 | Cytomegalovirus infection-associated fulminant hepatitis in an immunocompetent adult requiring emergency living-donor liver transplantation: report of a case显示文摘 | Young-Dong Yu Gil-Chun Park Pyoung-Jae Park Young-Il Choi Shin Hwang Gi-Won Song Dong-Hwan Jung Chul-Soo Ahn Ki-Hun Kim Deog-Bok Moon Tae-Yong Ha Sung-Gyu Lee | 2013 | Surgery Today2013，，4： | 1 |
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