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| 1 | Higher PD-1 expression concurrent with exhausted CD8+ T cells in patients with de novo acute myeloid leukemia显示文摘Objective: To investigate the association between the T cell inhibitory receptor programmed death 1(PD-1)and T cell exhaustion status in T cells from patients with de novo acute myeloid leukemia(AML) and AML in complete remission(CR).Methods:Surface expression of PD-1 and the exhaustion and immunosenescence markers CD244 and CD57 on CD3+,CD4+ and CD8+ T cells from peripheral blood samples from 20 newly diagnosed,untreated AML patients and 10 cases with AML in CR was analyzed by flow cytometry.Twenty-three healthy individuals served as control.Results:A significantly higher percentage of PD-1+ cells were found for CD3+ T cells in the de novo AML group compared with healthy controls.In addition,an increased level of PD-1+ CD8+ T cells,but not PD-1+ CD4+,was found for CD3+ T cells in the de novo AML and AML-CR samples.A higher percentage of CD244+ CD4+,CD244+ CD8+,CD57+ CD4+ and CD57+ CD8+ T cells was found in CD3+ T cells in samples from those with de novo AML compared with those from healthy controls.Strong increased PD-1+ CD244+ and PD-1+ CD57+ coexpression was found for CD4+ and CD8+ T cells in the de novo AML group compared with healthy controls.Conclusions:We characterized the major T cell defects,including co-expression of PD-1 and CD244,CD57-exhausted T cells in patients with de novo AML,and found a particular influence on CD8+ T cells,suggesting a poor anti-leukemia immune response in these patients. | Jiaxiong Tan Shaohua Chen Yuhong Lu Danlin Yao Ling Xu Yikai Zhang Lijian Yang Jie Chen Jing Lai Zhi Yu Kanger Zhu Yangqiu Li | 2017 | Chinese Journal of Cancer Research2017，29，5： | 10 |
| 2 | Compact, submilliwatt, 2 × 2 silicon thermo-optic switch based on photonic crystal nanobeam cavities显示文摘We propose and experimentally demonstrate a 2×2 thermo-optic(TO) crossbar switch implemented by dual photonic crystal nanobeam(PCN)cavities within a silicon-on-insulator(SOI)platform.By thermally tuning the refractive index of silicon,the resonance wavelength of the PCN cavities can be red-shifted.With the help of the ultrasmall mode volumes of the PCN cavities,only~0.16 mW power is needed to change the switching state.With a spectral passband of 0.09 nm at the 1583.75 nm operation wavelength,the insertion loss(IL)and crosstalk(CT)performances were measured as IL(bar)=-0.2 dB,CT(bar)=-15 dB,IL(cross)=-1.5 dB,and CT(cross)=-15 dB.Furthermore,the thermal tuning efficiency of the fabricated device is as high as1.23 nm/mW. | HUANYING ZHOU CIYUAN QIU XINHONG JIANG QINGMING ZHU YU HE YONG ZHANG YIKAI SU RICHARD SOREF | 2017 | Photonics Research2017，5，2： | 8 |
| 3 | On-chip silicon photonic 2 × 2 mode-and polarization-selective switch with low inter-modal crosstalk显示文摘Mode-and polarization-division multiplexing offer new dimensions to increase the transmission capacity of optical communications. Selective switches are key components in reconfigurable optical network nodes. An on-chip silicon 2 × 2 mode-and polarization-selective switch that can route four data channels on two modes and two polarizations simultaneously is proposed and experimentally demonstrated for the first time, to the best of our knowledge. The overall insertion losses are lower than 8.6 d B. To reduce the inter-modal crosstalk, polarization beam splitters are added to filter the undesired polarizations or modes. The measured inter-modal andintra-modal crosstalk values are below-23.2 and-22.8 d B for all the channels, respectively. | YONG ZHANG YU HE QINGMING ZHU CIYUAN QIU YIKAI SU | 2017 | Photonics Research2017，5，5： | 7 |
| 4 | A trilogy antimicrobial strategy for multiple infections of orthopedic implants throughout their life cycle显示文摘Bacteria-associated infection represents one of the major threats for orthopedic implants failure during their life cycles.However,ordinary antimicrobial treatments usually failed to combat multiple waves of infections during arthroplasty and prosthesis revisions etc.As these incidents could easily introduce new microbial pathogens in/onto the implants.Herein,we demonstrate that an antimicrobial trilogy strategy incorporating a sophisticated multilayered coating system leveraging multiple ion exchange mechanisms and fine nanotopography tuning,could effectively eradicate bacterial infection at various stages of implantation.Early stage bacteriostatic effect was realized via nano-topological structure of top mineral coating.Antibacterial effect at intermediate stage was mediated by sustained release of zinc ions from doped CaP coating.Strong antibacterial potency was validated at 4 weeks post implantation via an implanted model in vivo.Finally,the underlying zinc titanate fiber network enabled a long-term contact and release effect of residual zinc,which maintained a strong antibacterial ability against both Staphylococcus aureus and Escherichia coli even after the removal of top layer coating.Moreover,sustained release of Sr2+and Zn2+during CaP coating degradation substantially promoted implant osseointegration even under an infectious environment by showing more peri-implant new bone formation and substantially improved bone-implant bonding strength. | Yikai Wang Wangsiyuan Teng Zengjie Zhang Xingzhi Zhou Yuxiao Ye Peng Lin An Liu Yan Wu Binghao Li Chongda Zhang Xianyan Yang Weixu Li Xiaohua Yu Zhongru Gou Zhaoming Ye | 2021 | Bioactive Materials2021，6，7： | 3 |
| 5 | Multi-channel 28-GHz millimeter-wave signal generation on a silicon photonic chip with automated polarization control显示文摘We propose and experimentally demonstrate an integrated silicon photonic scheme to generate multi-channel millimeter-wave(MMW) signals for 5 G multi-user applications. The fabricated silicon photonic chip has a footprint of 1.1 × 2.1 mm^2 and integrates 7 independent channels each having on-chip polarization control and heterodyne mixing functions. 7 channels of4-Gb/s QPSK baseband signals are delivered via a 2-km multi-core fiber(MCF) and coupled into the chip with a local oscillator(LO) light. The polarization state of each signal light is automatically adjusted and aligned with that of the LO light, and then 7 channels of 28-GHz MMW carrying 4-Gb/s QPSK signals are generated by optical heterodyne beating. Automated polarizationcontrol function of each channel is also demonstrated with ~7-ms tuning time and ~27-dB extinction ratio. | Ruiyuan Cao Yu He Qingming Zhu Jingchi Li Shaohua An Yong Zhang Yikai Su | 2019 | Journal of Semiconductors2019，40，5： | 2 |
| 6 | Metamaterial-enabled arbitrary on-chip spatial mode manipulation显示文摘On-chip spatial mode operation,represented as mode-division multiplexing(MDM),can support high-capacity data communications and promise superior performance in various systems and numerous applications from optical sensing to nonlinear and quantum optics.However,the scalability of state-of-the-art mode manipulation techniques is significantly hindered not only by the particular mode-order-oriented design strategy but also by the inherent limitations of possibly achievable mode orders.Recently,metamaterials capable of providing subwavelength-scale control of optical wavefronts have emerged as an attractive alternative to manipulate guided modes with compact footprints and broadband functionalities.Herein,we propose a universal yet efficient design framework based on the topological metamaterial building block(BB),enabling the excitation of arbitrary high-order spatial modes in silicon waveguides.By simply programming the layout of multiple fully etched dielectric metamaterial perturbations with predefined mathematical formulas,arbitrary high-order mode conversion and mode exchange can be simultaneously realized with uniform and competitive performance.The extraordinary scalability of the metamaterial BB frame is experimentally benchmarked by a record high-order mode operator up to the twentieth.As a proof of conceptual application,an 8-mode MDM data transmission of 28-GBaud 16-QAM optical signals is also verified with an aggregate data rate of 813 Gb/s(7%FEC).This user-friendly metamaterial BB concept marks a quintessential breakthrough for comprehensive manipulation of spatial light on-chip by breaking the long-standing shackles on the scalability,which may open up fascinating opportunities for complex photonic functionalities previously inaccessible. | Jinlong Xiang Zhiyuan Tao Xingfeng Li Yaotian Zhao Yu He Xuhan Guo Yikai Su | 2022 | Light(Science & Applications)2022，11，7： | 2 |
| 7 | Differential gene network analysis from single cell RNA-seq显示文摘Study of gene expression has been arguably the most activeresearch field in functional genomics. Over the last two decades,various high-throughput technologies, from gene expressionmicroarray to RNA-seq, have been widely applied to the whole-genome profiling of gene expression. The commonality of these ex-periments is that they measure the gene expression levels of"bulk"sample, which pools a large number (often in the scale of millions)of cells, and thus the measurements reflect the average expressionof a population of cells. | Yikai Wang Hao Wu Tianwei Yu | 2017 | Journal of Genetics and Genomics2017，44，6： | 2 |
| 8 | High-efficiency and broadband four-wave mixing in a silicon-graphene strip waveguide with a windowed silica top layer显示文摘We experimentally demonstrate high-efficiency and broadband four-wave mixing in a silicon-graphene strip waveguide. A four-wave mixing conversion efficiency of -38.7 d B and a 3-dB conversion bandwidth of 35 nm are achieved in the silicon-graphene strip waveguide with an optimized light-graphene interaction length of 60 μm. The interaction length is controlled by a windowed area of silica layer on the silicon waveguide.Numerical simulations and experimental studies are carried out and show a nonlinear parameter γGOSas large as 10~4 W^(-1)· m^(-1). | YUXING YANG ZHENZHEN XU XINHONG JIANG YU HE XUHAN GUO YONG ZHANG CIYUAN QIU YIKAI SU | 2018 | Photonics Research2018，6，10： | 2 |
| 9 | On-chip silicon polarization and mode handling devices显示文摘 | Yong ZHANG Yu HE Qingming ZHU Xinhong JIANG Xuhan Guo Ciyuan QIU Yikai SU | 2018 | Frontiers of Optoelectronics2018，11，1： | 1 |
| 10 | Synthesis and properties of poly(aryl ether ketone ketone) poly(aryl ether ether ketone ketone) copolymers with pendant cyano groups 显示文摘 | Yu Yikai Xiao Feng Cai Mingzhong | 2007 | Appl Polym Sci2007，104，： | 1 |
| 11 | Ultracompact topological photonic switch based on valley-vortex-enhanced high-efficiency phases shift显示文摘Topologically protected edge states based on valley photonic crystals(VPCs)have been widely studied,from theoretical verifcation to technical applications.However,research on integrated tuneable topological devices is still lacking.Here,we study the phase-shifting theory of topological edge modes based on a VPC structure.Benefiting from the phase vortex formed by the VPC structure,the optical path of the topological edge mode in the propagation direction is approximately two-fold that of the conventional optical mode in a strip waveguide.In experiments,we show a 1.57-fold improvement inπ-phase tuning efficiency.By leveraging the highefficiency phase-shifting properties and the sharp-turn features of the topological waveguide,we demonstrate an ultracompact 1×2 thermo-optic topological switch(TOTS)operating at telecommunication wavelengths.A switching power of 18.2 mW is needed with an ultracompact device footprint of 25.66×28.3μm in the wavelength range of 1530-1582 nm.To the best of our knowledge,this topological photonic switch is the smallest switch of any dielectric or semiconductor 1×2/2×2 broadband optical switches,including thermo-optic and electro-optic switches.In addition,a high-speed transmission experiment employing the proposed TOTS is carried out to demonstrate the robust transmission of high-speed data.Our work reveals the phase shifting mechanism of valley edge modes,which may enable diverse topological functional devices in many fields,such as optical communications,nanophotonics,and quantum information processing. | Hongwei Wang Gujing Tang Yu He Zhen Wang Xingfeng Li Lu Sun Yong Zhang Luqi Yuan Jianwen Dong Yikai Su | 2022 | Light(Science & Applications)2022，11，11： | 1 |
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