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| 1 | EXPERIMENTAL STUDY ON HIGH-SPEED CENTRIFUGAL PUMPS WITH DIFFERENT IMPELLERS显示文摘The experimental study is carded out on high-speed centrifugal pumps with three different impellers. The ex-perimental results and analysis show that high-speed centrifugal pumps with a closed complex impeller can achieve thehighest efficiency and the lowest head coefficient followed by those with half-open impeller and open-impeller, and canobtain much easily stable head-capacity characrastic curve, while those with a half-open complex impeller can't. Thecharacteristic curve with a open impeller is almost constant horizontal line before dropping sharply. The results also showthat the axial clearance between pump casing and impeller can influence greatly on the performance of centrifugal pumps. | Zhu Zuchao Chen YingState Key Laboratory of Fluid Power Transmission and Control, Zhejiang University,Hangzhou 310027, ChinaHuang Dunhui Jin Qingming Cangnan Special Pumps Co.Ltd of Zhejiang Province | 2002 | Chinese Journal of Mechanical Engineering2002，15，4： | 10 |
| 2 | Compact, submilliwatt, 2 × 2 silicon thermo-optic switch based on photonic crystal nanobeam cavities显示文摘We propose and experimentally demonstrate a 2×2 thermo-optic(TO) crossbar switch implemented by dual photonic crystal nanobeam(PCN)cavities within a silicon-on-insulator(SOI)platform.By thermally tuning the refractive index of silicon,the resonance wavelength of the PCN cavities can be red-shifted.With the help of the ultrasmall mode volumes of the PCN cavities,only~0.16 mW power is needed to change the switching state.With a spectral passband of 0.09 nm at the 1583.75 nm operation wavelength,the insertion loss(IL)and crosstalk(CT)performances were measured as IL(bar)=-0.2 dB,CT(bar)=-15 dB,IL(cross)=-1.5 dB,and CT(cross)=-15 dB.Furthermore,the thermal tuning efficiency of the fabricated device is as high as1.23 nm/mW. | HUANYING ZHOU CIYUAN QIU XINHONG JIANG QINGMING ZHU YU HE YONG ZHANG YIKAI SU RICHARD SOREF | 2017 | Photonics Research2017，5，2： | 8 |
| 3 | On-chip silicon photonic 2 × 2 mode-and polarization-selective switch with low inter-modal crosstalk显示文摘Mode-and polarization-division multiplexing offer new dimensions to increase the transmission capacity of optical communications. Selective switches are key components in reconfigurable optical network nodes. An on-chip silicon 2 × 2 mode-and polarization-selective switch that can route four data channels on two modes and two polarizations simultaneously is proposed and experimentally demonstrated for the first time, to the best of our knowledge. The overall insertion losses are lower than 8.6 d B. To reduce the inter-modal crosstalk, polarization beam splitters are added to filter the undesired polarizations or modes. The measured inter-modal andintra-modal crosstalk values are below-23.2 and-22.8 d B for all the channels, respectively. | YONG ZHANG YU HE QINGMING ZHU CIYUAN QIU YIKAI SU | 2017 | Photonics Research2017，5，5： | 7 |
| 4 | Attribution analysis based on Budyko hypothesis for land evapotranspiration change in the Loess Plateau, China显示文摘Land evapotranspiration(ET) is an important process connecting soil, vegetation and the atmosphere, especially in regions that experience shortage in precipitation.Since 1999, the implementation of a large-scale vegetation restoration project has significantly improved the ecological environment of the Loess Plateau in China.However, the quantitative assessment of the contribution of vegetation restoration projects to long-term ET is still in its infancy.In this study, we investigated changes in land ET and associated driving factors from 1982 to 2014 in the Loess Plateau using Budyko-based partial differential methods.Overall, annual ET slightly increased by 0.28 mm/a and there were no large fluctuations after project implementation.An attribution analysis showed that precipitation was the driving factor of inter-annual variability of land ET throughout the study period;the average impacts of precipitation, potential evapotranspiration, and vegetation restoration on ET change were 61.5%, 11.5% and 26.9%, respectively.These results provide an improved understanding of the relationship between vegetation condition change and climate variation on terrestrial ET in the study area and can support future decision-making regarding water resource availability. | HE Guohua ZHAO Yong WANG Jianhua GAO Xuerui HE Fan LI Haihong ZHAI Jiaqi WANG Qingming ZHU Yongnan | 2019 | Journal of Arid Land2019，11，6： | 5 |
| 5 | 2022 Chinese expert consensus and guidelines on clinical management of toxicity in anti-CD19 chimeric antigen receptor T-cell therapy for B-cell non-Hodgkin lymphoma显示文摘Adoptive cellular immunotherapy with chimeric antigen receptor(CAR)T cells has emerged as a novel modality for treating relapsed and/or refractory B-cell non-Hodgkin lymphoma(B-NHL).With increasing approval of CAR T-cell products and advances in CAR T cell therapy,CAR T cells are expected to be used in a growing number of cases.However,CAR T-cell-associated toxicities can be severe or even fatal,thus compromising the survival benefit from this therapy.Standardizing and studying the clinical management of these toxicities are imperative.In contrast to other hematological malignancies,such as acute lymphoblastic leukemia and multiple myeloma,anti-CD19 CAR T-cell-associated toxicities in B-NHL have several distinctive features,most notably local cytokine-release syndrome(CRS).However,previously published guidelines have provided few specific recommendations for the grading and management of toxicities associated with CAR T-cell treatment for B-NHL.Consequently,we developed this consensus for the prevention,recognition,and management of these toxicities,on the basis of published literature regarding the management of anti-CD19 CAR T-cell-associated toxicities and the clinical experience of multiple Chinese institutions.This consensus refines a grading system and classification of CRS in B-NHL and corresponding measures for CRS management,and delineates comprehensive principles and exploratory recommendations for managing anti-CD19 CAR T-cell-associated toxicities in addition to CRS. | Ping Li Yang Liu Yun Liang Jian Bo Sujun Gao Yongxian Hu Yu Hu He Huang Xiaojun Huang Hongmei Jing Xiaoyan Ke Jianyong Li Yuhua Li Qifa Liu Peihua Lu Heng Mei Ting Niu Yongping Song Yuqin Song Liping Su Sanfang Tu Jianxiang Wang Depei Wu Zhao Wang Kailin Xu Zhitao Ying Qingming Yang Yajing Zhang Fengxia Shi Bin Zhang Huilai Zhang Xi Zhang Mingfeng Zhao Weili Zhao Xiangyu Zhao Liang Huang Jun Zhu Wenbin Qian Weidong Han Aibin Liang | 2023 | Cancer Biology & Medicine2023，20，2： | 3 |
| 6 | Biomimetic polyetheretherketone microcarriers with specific surface topography and self-secreted extracellular matrix for large-scale cell expansion显示文摘Reusable microcarriers with appropriate surface topography,mechanical properties,as well as biological modification through decellularization facilitating repeated cell culture are crucial for tissue engineering applications.Herein,we report the preparation of topological polyetheretherketone(PEEK)microcarriers via gas-driven and solvent exchange method followed by hydrothermal treatment at high temperature and pressure.After hydrothermal treated for 8 h,the resulting topological PEEK microcarriers exhibit walnut-like surface topography and good sphericity as well as uniform size distribution of 350.24619.44 mm.And the average width between ravine-patterned surface of PEEK microcarriers is 7806290 nm.After repeated steam sterilization by autoclaving for three times,topological PEEK microcarriers show nearly identical results compared with previous ones indicating strong tolerance to high temperature and pressure.This is a unique advantage for large-scale cell expansion and clinical applications.Moreover,PEEK microcarriers with special topography possess higher protein adsorption efficiency.In addition,the reutilization and biofunctionalization with repeated decellularization of topological PEEK microcarriers show highly beneficial for cell adhesion and proliferation.Therefore,our study is of great importance for new generation microcarriers with micro-and nano-scale surface feature for a broad application prospect in tissue engineering. | Qingming Ji ZongliangWang Zixue Jiao Yu Wang Zhenxu Wu Peng Wang Yuhang Zhu Shuo Sun Yi Liu Peibiao Zhang | 2020 | Regenerative Biomaterials2020，7，1： | 3 |
| 7 | Study on the mechanical behavior of adhesive interface by digital image correlation显示文摘The shear modulus of the adhesive layer and the failure mode of adhesive structure on single lap joint specimens under tensile tests are investigated in this paper.The aluminum-aluminum adherends are bonded by two different adhesives:polydimethylsiloxane (PDMS) and epoxy.The full deformation fields are measured using the digital image correlation (DIC) method with the images on the middle part of the adhesive layer recorded by a high resolution microscope.Then,the shear modulus values of the two adhesives are calculated with a simple pure shear strain model.A numerical model is proposed to simulate the single lap joint structure under tensile load in comparison with the experimental results.The results show that this method can successfully estimate the shear modulus of the adhesive layer.The failure behavior of epoxy adhesive/adherend interface is also analyzed and discussed. | GUO BaoQiao XIE HuiMin ZHU JianGuo WANG HuaiXi CHEN PengWan ZHANG QingMing | 2011 | Science China(Physics,Mechanics & Astronomy)2011，54，4： | 3 |
| 8 | Multi-channel 28-GHz millimeter-wave signal generation on a silicon photonic chip with automated polarization control显示文摘We propose and experimentally demonstrate an integrated silicon photonic scheme to generate multi-channel millimeter-wave(MMW) signals for 5 G multi-user applications. The fabricated silicon photonic chip has a footprint of 1.1 × 2.1 mm^2 and integrates 7 independent channels each having on-chip polarization control and heterodyne mixing functions. 7 channels of4-Gb/s QPSK baseband signals are delivered via a 2-km multi-core fiber(MCF) and coupled into the chip with a local oscillator(LO) light. The polarization state of each signal light is automatically adjusted and aligned with that of the LO light, and then 7 channels of 28-GHz MMW carrying 4-Gb/s QPSK signals are generated by optical heterodyne beating. Automated polarizationcontrol function of each channel is also demonstrated with ~7-ms tuning time and ~27-dB extinction ratio. | Ruiyuan Cao Yu He Qingming Zhu Jingchi Li Shaohua An Yong Zhang Yikai Su | 2019 | Journal of Semiconductors2019，40，5： | 2 |
| 9 | IMPROVE OPTICAL CLEARING OF SKIN IN VITRO WITH PROPYLENE GLYCOL AS A PENETRATION ENHANCER显示文摘In order to enhance the optical clearing effect of topically applied optical clearing agents(OCAs),we evaluated the effect of propylene glycol(PG)as a chemical penetration enhancer(PE)on optical clearing of skin in vitro by observation and measurement of optical-transmittance and diffuse-reflectance spectra.Three OCAs,i.e.,glycerol,D-sorbitol and PEG400,and two other penetration enhancers,Azone and Thiazone,were used in this study.The results indicated that the decrease of reduced scattering coefficient caused by OCA/PG was larger than that by pure OCA,and the change by OCA/water was the least after the same treatment time.There were significant differences for the reduced scattering coefficient at 630 nm after 120 min application of agents between OCA and OCA/PG.The efficacy of optical clearing caused by OCA/PG depended on the OCA itself.When PEG400 was mixed with three different PEs,we found the optical clearing were different.The penetration enhancing ability of PG was much better compared to Azone,and suboptimal to Thiazone.Also,this study provides evidence for the use of PG as a PE in order to improve skin optical clearing. | ZHONGWEI ZHI ZHENZHEN HAN QINGMING LUO DAN ZHU | 2009 | Journal of Innovative Optical Health Sciences2009，2，3： | 2 |
| 10 | Impact of large-scale vegetation restoration project on summer land surface temperature on the Loess Plateau, China显示文摘A large-scale afforestation project has been carried out since 1999 in the Loess Plateau of China. However, vegetation-induced changes in land surface temperature (LST) through the changing land surface energy balance have not been well documented. Using satellite measurements, this study quantified the contribution of vegetation restoration to the changes in summer LST and analyzed the effects of different vegetation restoration patterns on LST during both daytime and nighttime. The results show that the average daytime LST decreased by 4.3°C in the vegetation restoration area while the average nighttime LST increased by 1.4°C. The contributions of the vegetation restoration project to the changes in daytime LST and nighttime LST are 58% and 60%, respectively, which are far greater than the impact of climate change. The vegetation restoration pattern of cropland (CR) converting into artificial forest (AF) has a cooling effect during daytime and a warming effect at nighttime, while the conversion of CR to grassland has an opposite effect compared with the conversion of CR to AF. Our results indicate that increasing evapotranspiration caused by the vegetation restoration on the Loess Plateau is the controlling factor of daytime LST change, while the nighttime LST change is affected by soil humidity and air humidity. | HE Guohua ZHAO Yong WANG Jianhua WANG Qingming ZHU Yongnan | 2018 | Journal of Arid Land2018，10，6： | 2 |
| 11 | On-chip silicon polarization and mode handling devices显示文摘 | Yong ZHANG Yu HE Qingming ZHU Xinhong JIANG Xuhan Guo Ciyuan QIU Yikai SU | 2018 | Frontiers of Optoelectronics2018，11，1： | 1 |
| 12 | Puerarin blocks the signaling transmission mediated by P2X 3 in SG and DRG to relieve myocardial ischemic damage显示文摘 | Shuangmei Liu Chunping Zhang Qingming Shi Guilin Li Miaomiao Song Yun Gao Changshui Xu Hong Xu Bo Fan Shicheng Yu Chaoran Zheng Qicheng Zhu Bing Wu Lichao Peng Huangui Xiong Qin Wu Shangdong Liang | 2014 | Brain Research Bulletin2014，，： | 1 |
| 13 | Kinetic thermal response and damage in laser coagulation of tissue显示文摘 | Dan Zhu Qingming Luo Guangming Zhu | 2002 | Lasers in Surgery and Medicine2002，31，： | 1 |
| 14 | Glycerol-3-phosphate acyltransferase 4 gene is involved in mouse spermatogenesis显示文摘Glycerol-3-phosphate acyltransferase (GPAT ) 由把 glycerol-3-phosphate 变换成 lysophosphatidic 酸(LPA ) 催化 de novo triacylglycerol 合成的首先承诺的步。LPA 是调停的 mitogen 多重细胞的过程包括房间增长。四 GPAT isoforms 迄今为止被克隆。GPAT4 强烈在老鼠睾丸被表示。反向的 transcriptionpolymerase 链反应(PCR ) ,即时 PCR,并且在 situ,杂交(ISH ) 被用来分析 GPAT4 表达式并且在出生后的开发期间在鼠标睾丸本地化表示房间类型。GPAT4 cDNA 被插入到 pcDNA4/His 构造 recombinant 向量,它是进一根老鼠 spermatogonial 房间线(GC-1spg ) 的 transfected。GPAT4 首先出生后地在 2 个星期在老鼠被表示。表示从第三个星期是丰富的,在星期 56 点的 plateaued 然后在成年人在高水平维持了。ISH 表明那 GPAT4 基因在以后的精子形式期间在成熟分裂期间然而并非在伸长的 spermatids 在 spermatocytes 并且在 spermatids 附近富有地被表示。GC-1spg 房间与 GPAT4 在 transfection 以后在增长显示出显著增加;房间周期分析在在 S 阶段的 G0/G1 阶段和增加在房间的百分比显示出减少。因此, GPAT4 可能在精子发生起一个重要作用,在特别中间成熟分裂。 | Qingming Qiu Gang Liu Weina Li Qiuwen Shi Fuxi Zhu Guangxiu Lu | 2009 | Acta Biochimica et Biophysica Sinica2009，41，8： | 1 |
| 15 | Environmental Security in the Viewof Macro-Security显示文摘 | Hao Zhang Qingming Zhu | 2011 | Communications in Information Scienceand Management Engineering2011，，10： | 1 |
| 16 | Environmental Security in the View of Macro-Security显示文摘 | Hao Zhang Qingming Zhu | 2011 | Communications in Information Science and Management Engineering2011，1，10： | 1 |
| 17 | Kinetic Thermal Response and Damage in Laser Coagulation of Tissue显示文摘 | Dan Zhu Qingming Luo Guangming Zhu | 2002 | Lasers in Surgery and Medicine2002，31，： | 1 |
| 18 | INTRODUCTION:SPECIAL ISSUE ON ADVANCES IN BIOPHOTONICS AND BIOMEDICAL OPTICS-PART I显示文摘The 5th Russian-Chinese Workshop on Biophotonics and Biomedical Optics was hosted in Saratov,Russia on 26-28,September,2012.The bilateral Workshop brought together both Russian and Chinese scientists,engineers and clinical researchers from a variety of disciplines engaged in applying optical science,photonics and imaging technologies to problems in biology and medicine.During the W orkshop,2 plenary lectures,11 invited presentations,4 oral presentations and 13 poster reports were presented.A special Internet session with 5 presentations-1 plenary,2 invited,and 2 posters was also organized.This special issue selects some papers from the attendees,and is made up of 12 original research articles and one review.Seven articles will be presented in Vol.6 No.1 of JIOHS,while the remaining five articles will be presented in Vol.6 No.2. | Dan Zhu Valery V.Tuchin Qingming Luo | 2013 | Journal of Innovative Optical Health Sciences2013，6，1： | 0 |
| 19 | INTRODUCTION:SPECIAL ISSUE ON ADV ANCES IN BIOPHOTONICS AND BIOMEDICAL OPTICS-PART II显示文摘The 5th Russian-Chinese W orkshop on Biophotonics and Biomedical Optics was hosted in Saratov,Russia on 26-28,September,2012.The bilateral Workshop brought together both Russian and Chinese scientists,engineers and clinical researchers from a variety of disciplines engaged in applying optical science,photonics and imaging technologies to problems in biology and medicine.During the Workshop,2 plenary lectures,11 invited presentations,4 oral presentations and 13 poster reports were presented.A special Internet session with 5 presentations-1 plenary,2 invited,and 2 posters,was also organized.This special issue selects some papers from the attendees,and is made up of 12 original research articles and one review.Seven articles have been presented in Vol.6,No.1 of JIOHS;this issue presents the remaining six articles. | Dan Zhu Valery V.Tuchin Qingming Luo | 2013 | Journal of Innovative Optical Health Sciences2013，6，2： | 0 |
| 20 | Restoration of FMRP expression in adult V1 neurons rescues visual deficits in a mouse model of fragile X syndrome显示文摘Many people affected by fragile X syndrome(FXS)and autism spectrum disorders have sensory processing deficits,such as hypersensitivity to auditory,tactile,and visual stimuli.Like FXS in humans,loss of Fmr1 in rodents also cause sensory,behavioral,and cognitive deficits.However,the neural mechanisms underlying sensory impairment,especially vision impairment,remain unclear.It remains elusive whether the visual processing deficits originate from corrupted inputs,impaired perception in the primary sensory cortex,or altered integration in the higher cortex,and there is no effective treatment.In this study,we used a genetic knockout mouse model(Fmr1^(KO)),in vivo imaging,and behavioral measurements to show that the loss of Fmr1 impaired signal processing in the primary visual cortex(V1).Specifically,Fmr1^(KO) mice showed enhanced responses to low-intensity stimuli but normal responses to high-intensity stimuli.This abnormality was accompanied by enhancements in local network connectivity in V1 microcircuits and increased dendritic complexity of V1 neurons.These effects were ameliorated by the acute application of GABAA receptor activators,which enhanced the activity of inhibitory neurons,or by reintroducing Fmr1 gene expression in knockout V1 neurons in both juvenile and young-adult mice.Overall,V1 plays an important role in the visual abnormalities of Fmr1^(KO) mice and it could be possible to rescue the sensory disturbances in developed FXS and autism patients. | Chaojuan Yang Yonglu Tian Feng Su Yangzhen Wang Mengna Liu Hongyi Wang Yaxuan Cui Peijiang Yuan Xiangning Li Anan Li Hui Gong Qingming Luo Desheng Zhu Peng Cao Yunbo Liu Xunli Wang Min-hua Luo Fuqiang Xu Wei Xiong Liecheng Wang Xiang-yao Li Chen Zhang | 2022 | Protein & Cell2022，13，3： | 0 |
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