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| 1 | Perfecting and extending the near-infrared imaging window显示文摘In vivo fluorescence imaging in the second near-infrared window(NIR-II)has been considered as a promising technique for visualizing mammals.However,the definition of the NIR-II region and the mechanism accounting for the excellent performance still need to be perfected.Herein,we simulate the photon propagation in the NIR region(to 2340 nm),confirm the positive contribution of moderate light absorption by water in intravital imaging and perfect the NIR-II window as 900–1880 nm,where 1400–1500 and 1700–1880 nm are defined as NIR-IIx and NIR-IIc regions,respectively.Moreover,2080–2340 nm is newly proposed as the third near-infrared(NIR-III)window,which is believed to provide the best imaging quality.The wide-field fluorescence microscopy in the brain is performed around the NIRIIx region,with excellent optical sectioning strength and the largest imaging depth of intravital NIR-II fluorescence microscopy to date.We also propose 1400 nm long-pass detection in off-peak NIR-II imaging whose performance exceeds that of NIR-IIb imaging,using bright fluorophores with short emission wavelength. | Zhe Feng Tao Tang Tianxiang Wu Xiaoming Yu Yuhuang Zhang Meng Wang Junyan Zheng Yanyun Ying Siyi Chen Jing Zhou Xiaoxiao Fan Dan Zhang Shengliang Li Mingxi Zhang Jun Qian | 2021 | Light(Science & Applications)2021，10，10： | 4 |
| 2 | A COLLABORATIVE SPECTRUM SENSING SCHEME USING FUZZY COMPREHENSIVE EVALUATION IN COGNITIVE RADIO显示文摘Cognitive Radio(CR) is a promising technology to solve the challenging spectrum scarcity problem.However, to implement CR, spectrum sensing is the groundwork and the precondition.In this paper, a collaborative spectrum sensing scheme using fuzzy comprehensive evaluation is proposed.The final sensing decision of the proposed scheme is based on the combination of distributed sensing results of different Secondary Users(SUs).To improve the reliability of the sensing decision, the combination procedure takes into account the credibility of each SU, which is evaluated using fuzzy comprehensive evaluation.The effect of the presence of malicious SUs and malfunctioning SUs on the performance of the proposed scheme is also investigated.The efficiency of the scheme is validated through analysis and simulation. | Yang Wendong Ye Yuhuang Cai Yueming Xu Youyun | 2009 | Journal of Electronics(China)2009，26，3： | 3 |
| 3 | Epidemiological Characteristics of Plague in the Meriones unguiculatus Plague Focus--Inner Mongolia Autonomous Region,China,1950−2019显示文摘From 1950 to 2019,a total of 267 plague cases in humans were reported in the Inner Mongolia Autonomous Region with 133 deaths and 10,710 Yersinia pestis isolates;21 of these cases were reported from the Meriones unguiculatus(M.unguiculatus)plague focus with 6 deaths and 6,771 isolates.According to the plague situation in the Inner Mongolia Autonomous Region and the implementation of local preventive measures,the prevalence of plague in humans in the M.unguiculatus plague focus of the Inner Mongolia Autonomous Region could be divided into four stages.The first stage was the initial stage of plague prevention and control(1950–1959),with 0.80 cases annually and a case fatality rate of 37.50%.The second stage was the plague eradication stage(1960–1979),with 0.15 cases annually and a case fatality rate of 33.33%.The third stage was the plague surveillance stage(1980-1999),with 0.25 cases annually and a case fatality rate of 20.00%.The fourth stage is the comprehensive prevention and control stage under the emergency system(2000-2019),with 0.25 cases annually and a case fatality rate of 20.00%.The surveillance of rodent density(1981-2019)and studies on plague-related factors among M.unguiculatus have shown that the higher the M.unguiculatus density,the higher the nocturnal rodent capture rate(r=0.670,p<0.05)and the higher the indirect hemagglutination assay(IHA)positive rate of M.unguiculatus(r=0.344,p<0.05);the higher the percentage of hosts infected,the lower the M.unguiculatus density(r=-0.361,p<0.05)and the lower the IHA positive rate of M.unguiculatus(r=-0.337,p<0.05);the higher the percentage of nests infected with fleas,the lower the IHA positive rate of M.unguiculatus(r=-0.348,p<0.05).Together,these results suggest that it is necessary to simultaneously monitor the pathogens,serology,and vector index of M.unguiculatus to accurately reflect the plague prevalence among local animals.Although bubonic plague is the main plague type of the M.unguiculatus plague focus,severe pneumonic plague or septic plague may be secondary when the bubonic plague is misdiagnosed or not treated in time.In addition,the plague in animals is relatively virulent in the M.unguiculatus plague focus,and the risk of spreading to humans is higher.For plague in the Inner Mongolia Autonomous Region,comprehensive control efforts should be aimed at the M.unguiculatus focus,covering host animals,vector insects,and humans. | Boxi Liu Dayu Zhang Yuhuang Chen Zhaokai He Jun Liu Dongyue Lyu Weiwei Wu Ran Duan Shuai Qin Junrong Liang Huaiqi Jing Xin Wang | 2020 | China CDC weekly2020，2，49： | 3 |
| 4 | NIR-Ⅱ Excitation and NIR-I Emission Based Two-photon Fluorescence Lifetime Microscopic Imaging Using Aggregation-induced Emission Dots显示文摘Near-infrared(NIR)lights are powerful tools to conduct deep-tissue imaging since NIR-Ⅰ wavelengths hold less photon absorption and NIR-Ⅱ wavelengths serve low photon scattering in the biological tissues compared with visible lights.Two-photon fluorescence lifetime microscopy(2PFLM)can utilize NIR-Ⅱ excitation and NIR-Ⅰ emission at the same time with the assistance of a well-designed fluorescent agent.Aggregation induced emission(AIE)dyes are famous for unique optical properties and could serve a large two-photon absorption(2PA)cross-section as aggregated dots.Herein,we report two-photon fluorescence lifetime microscopic imaging with NIR-Ⅱ excitation and NIR-Ⅰ emission using a novel deep-red AIE dye.The AIE-gens held a 2PA cross-section as large as 1.61×10^(4)GM at 1040 nm.Prepared AIE dots had a two-photon fluorescence peak at 790 nm and a stable lifetime of 2.2 ns under the excitation of 1040 nm femtosecond laser.The brain vessels of a living mouse were vividly reconstructed with the two-photon fluorescence lifetime information obtained by our home-made 2PFLM system.Abundant vessels as small as 3.17µm were still observed with a nice signal-background ratio at the depth of 750µm.Our work will inspire more insight into the improvement of the working wavelength of fluorescent agents and traditional 2PFLM. | LIU Wen ZHANG Yuhuang QI Jj QIAN Jun TANG Ben Zhong | 2021 | Chemical Research in Chinese Universities2021，37，1： | 3 |
| 5 | Designing Textile Architectures for High Energy-Efficiency Human Body Sweat-and Cooling-Management显示文摘Thermal management of textiles requires local microclimate control over heat and wet dissipation to create a comfortable thermal-wet environment at the interface of the human body and clothing.Herein,we design a fabric capable of both sweat-and cooling-management using a knitted fabric featuring a bilayer structure consisting of hydrophobic polyethylene terephthalate and hydrophilic cellulose fibers to simultaneously achieve high infrared(IR)transmittance and good thermal-wet comfort.The IR transmission of this cooling textile increased by~twofold in the dry state and~eightfold in the wet state compared to conventional cotton fabric.When the porosity changes from 10 to 47%with the comparison of conventional cotton fabric and our cooling textile,the heat flux is increased from 74.4 to 152.3 W/cm^(2).The cooling effect of the cooling fabric is 105%greater than that of commercial cotton fabric,which displays a better thermal management capacity for personal cooling.This bilayer design controls fast moisture transfer from inside out and provides thermal management,demonstrating high impact not only for garments,but also for other systems requiring heat regulation,such as buildings,which could mitigate energy demand and ultimately contribute to the relief of global energy and climate issues. | Kun Fu Zhi Yang Yong Pei Yongxin Wang Beibei Xu YuHuang Wang Bao Yang Liangbing Hu | 2019 | Advanced Fiber Materials2019，1，1： | 3 |
| 6 | Hot-band absorption of indocyanine green for advanced anti-stokes fluorescence bioimaging显示文摘Bright anti-Stokes fluorescence(ASF)in the first near-infrared spectral region(NIR-I,800 nm–900 nm)under the excitation of a 915 nm continuous wave(CW)laser,is observed in Indocyanine Green(ICG),a dye approved by the Food and Drug Administration for clinical use.The dependence of fluorescence intensity on excitation light power and temperature,together with fluorescence lifetime measurement,establish this ASF to be originated from absorption from a thermally excited vibrational level(hot-band absorption),as shown in our experiments,which is stronger than the upconversion fluorescence from widely-used rare-earth ion doped nanoparticles.To test the utility of this ASF NIR-I probe for advanced bioimaging,we successively apply it for biothermal sensing,cerebral blood vessel tomography and blood stream velocimetry.Moreover,in combination with L1057 nanoparticles,which absorb the ASF of ICG and emit beyond 1100 nm,these two probes generate multi-mode images in two fluorescent channels under the excitation of a single 915 nm CW laser.One channel is used to monitor two overlapping organs,urinary system&blood vessel of a live mouse,while the other shows urinary system only.Using in intraoperative real-time monitoring,such multi-mode imaging method can be beneficial for visual guiding in anatomy of the urinary system to avoid any accidental injury to the surrounding blood vessels during surgery. | Jing Zhou Xiaoxiao Fan Di Wu Jie Liu Yuhuang Zhang Zikang Ye Dingwei Xue Mubin He Liang Zhu Zhe Feng Andrey N.Kuzmin Wen Liu Paras N.Prasad Jun Qian | 2021 | Light(Science & Applications)2021，10，10： | 3 |
| 7 | Human scFv antibody fragments specific for hepatocellular carcinoma selected from a phage display library显示文摘AIM: To identify the scFv antibody fragments specific for hepatocellular carcinoma by biopanning from a large human naive scFv phage display library.METHODS: A large human naive scFv phage library was used to search for the specific targets by biopanning with the hepatocellular carcinoma cell line HepG2 for the positiveselecting and the normal liver cell line L02 for the counterselecting. After three rounds of biopanning, individual scFv phages binding selectively to HepG2 cells were picked out. PCR was carried out for identification of the clones containing scFv gene sequence. The specific scFv phages were selected by ELISA and flow cytometry. DNA sequences of positive clones were analyzed by using Applied Biosystem Automated DNA sequencers 3 730. The expression proteins of the specific scFv antibody fragments in E. coli HB2151were purified by the affinity chromatography and detected by SDS-PAGE, Western blot and ELISA. The biological effect of the soluble antibody fragments on the HepG2 cells was investigated by observing the cell proliferation.RESULTS: Two different positive clones were obtained and the functional variable sequences were identified.Their DNA sequences of the scFv antibody fragments were submitted to GenBank (accession nos: AY686498 and AY686499). The soluble scFv antibody fragments were successfully expressed in E. coli HB2151. The relative molecular mass of the expression products was about 36 ku,according to its predicted Mr value. The two soluble scFv antibody fragments also had specific binding activity and obvious growth inhibition properties to HepG2 cells.CONCLUSION: The phage library biopanning permits identification of specific antibody fragments for hepatocellular carcinoma and affords experiment evidence for its immunotherapy study. | BingYu MingNi Wen-HanLi PingLei WeiXing Dai-WenXiao YuHuang Zhen-JieTang Hui-FenZhu Guan-XinShen | 2005 | World Journal of Gastroenterology2005，11，26： | 2 |
| 8 | α 1 -Adrenergic receptors mediate combined signals initiated by mechanical stretch stress and norepinephrine leading to accelerated mouse vein graft atherosclerosis显示文摘 | Shuying Liu Yuhuang Li Zhengyu Zhang Fukang Xie Qingbo Xu Xi Huang Jintao Huang Chaohong Li | 2013 | Journal of Vascular Surgery2013，，6： | 2 |
| 9 | Effects of the Ratio of n-6∶n-3 Polyunsaturated Fatty Acids in the Maternal Diet on Immunoglobulins,Fatty Acid Composition,and Performance of Lactating Sows and Suckling Piglets under Conditions of Low Maternal Energy Intake显示文摘This experiment was conducted to investigate the effects of different ratios of n-6 ∶ n-3 polyunsaturated fatty acids (PUFA) in sow diets on the performance of lactating sows and their piglets at low digestible energy intakes. Twenty-one pregnant Landrace sows were assigned to one of three diets from day 108 of gestation until weaning (26 to 29 d) ,containing n-6∶n-3 PUFA ratios of 3 ∶1,8 ∶1 and 11 ∶1. The effects on sow and litter production traits and on sow body condition were examined. There were no differences among treatments in daily feed intakes or in changes in sow weight and back-fat levels during lactation. Litter size,litter weight at birth and weaning and litter average daily weight gain were also unaffected by treatment. As expected, large differences were observed in n-6 and n-3 fatty acids in the colostrum and plasma of sows and piglets (P < 0. 01) . The ratio of n6 ∶ n-3 PUFA the diet was positively correlated with those in colostrum,sow plasma and piglet plasma (R 2= 0. 55,0. 80 and 0. 80,respectively) . Sow plasma insulin and IGF-I levels at weaning were unaffected by the treatments. Plasma leptin (P < 0. 05) concentrations were increased in sows fed the diet with a n-6∶n-3 ratio of 8 ∶ 1. Immunoglobulin concentrations in colostrum were not altered by dietary treatment. Plasma IgG concentrations at d 14 were highest in piglets from sows fed the 8 ∶ 1 ratio of n-6∶n-3. Furthermore,this group had the highest IgA concentrations at day 21 of lactation compared with the other two groups (P < 0. 05) . In summary,our study demonstrated that at low digestible energy levels,altering the ratio of n-6 ∶ n-3 PUFA in the diets for lactating sows affected immune components and the fatty acid composition of lactating sows and their piglets. Further studies are needed to examine whether higher levels of fat supplementation than those used in the present study (1. 5%) can successfully enhance performance. | Wei Yao Hongliang Zhao Jie Li Zhijun Wang Yuhuang Han Shuren Dong Yuejiang Wang Fenglai Wang | 2011 | Journal of Animal Science and Biotechnology2011，2，3： | 2 |
| 10 | Wavelet shape blending 显示文摘 | Yuefeng Zhang YuHuang | 2000 | The Visual Computer2000，16，： | 1 |
| 11 | Infusion of mesenchymal stem cells overexpressing GDNF ameliorates renal function in nephrotoxic serum nephritis显示文摘 | Zheng‐YuHuang Liang‐QingHong NingNa YunLuo BinMiao JunChen | 2012 | Cell Biochem Funct2012，，2： | 1 |
| 12 | Tupisteroide A–C, three new polyhydroxylated steroidal constituents from the roots of Tupistra chinensis显示文摘 | Cheng‐XiongLiu Zhi‐yongGuo Yan‐HongXue Hong‐YanZhang Hong‐QiZhang KunZou Nian‐YuHuang | 2012 | Magn Reson Chem2012，，4： | 1 |
| 13 | A Randomized case-control study of dynamic changes in peripheral blood Th 17/Treg cell balance and interleukin-17 levels in highly active antiretro-viral-treated HIV type 1/AIDS patients显示文摘 | Yan H Jing L Yuhuang Z | | 0，，04： | 1 |
| 14 | Is money really the root of all evil? The impact of priming money on consumer choice显示文摘 | Luqiong Tong Yuhuang Zheng Ping Zhao | 2013 | Marketing Letters2013，，2： | 1 |
| 15 | Characterization and anti-tumor activities of sulfated polysaccharide SRBPS2a obtained from defatted rice bran 显示文摘 | Li Wang Hong Yuhuang Yung Yuwei | 2009 | International Journal of Biological Macromolecules2009，45，： | 1 |
| 16 | A note on the extended rosenbroek function 显示文摘 | SHANG YUNWEN QIU YUHUANG | 2006 | IEEE Transactions on Evolutionary Compu- tation2006，14，1： | 1 |
| 17 | A Note on the Ex- tended Rosenbrock Function显示文摘 | SHANG Yunwei QIU Yuhuang | 2006 | Evolutionary Com- putation2006，14，1： | 1 |
| 18 | Assessment of a web-based learning game in an information systems course显示文摘 | Zhen Yuhuang James J | 2005 | Journal of Computer Information Systems2005，，4： | 1 |
| 19 | Wavelet shape blending显示文摘 | Yuefeng Zhang YuHuang | 2000 | The Visual Computer2000，16，： | 1 |
| 20 | Vancomycin versus cefoperazone sodium and sulbactam sodium incompatibility between 显示文摘 | Chen Yuhuang Yan rouge Zheng Wenyan | 2009 | Shandong medical journal2009，49，23： | 1 |
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