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| 1 | Triazole-forming waterborne polyurethane composites fabricated with silane coupling agent functionalized nano-silica显示文摘 | Daoxing Sun Xiao Miao Kejie Zhang Hern Kim Yongan Yuan | 2011 | Journal of Colloid And Interface Science2011，，2： | 1 |
| 2 | TRPV4 Regulates Soman-Induced Status Epilepticus and Secondary Brain Injury via NMDA Receptor and NLRP3 Inflammasome显示文摘Nerve agents are used in civil wars and terrorist attacks,posing a threat to public safety.Acute exposure to nerve agents such as soman(GD)causes serious brain damage,leading to death due to intense seizures induced by acetylcholinesterase inhibition and neuronal injury resulting from increased excitatory amino-acid levels and neuroinflammation.However,data on the anticonvulsant and neuroprotective efficacies of currently-used countermeasures are limited.Here,we evaluated the potential effects of transient receptor vanilloid 4(TRPV4)in the treatment of soman-induced status epilepticus(SE)and secondary brain injury.We demonstrated that TRPV4 expression was markedly up-regulated in rat hippocampus after soman-induced seizures.Administration of the TRPV4 antagonist GSK2193874 prior to soman exposure significantly decreased the mortality rate in rats and reduced SE intensity.TRPV4-knockout mice also showed lower incidence of seizures and higher survival rates than wild-type mice following soman exposure.Further in vivo and in vitro experiments demonstrated that blocking TRPV4 prevented NMDA receptor-mediated glutamate excitotoxicity.The protein levels of the NLRP3 inflammasome complex and its downstream cytokines IL-1βand IL-18 increased in soman-exposed rat hippocampus.However,TRPV4 inhibition or deletion markedly reversed the activation of the NLRP3 inflammasome pathway.In conclusion,our study suggests that the blockade of TRPV4 protects against soman exposure and reduces brain injury following SE by decreasing NMDA receptor-mediated excitotoxicity and NLRP3-mediated neuroinflammation.To our knowledge,this is the first study regarding the“dual-switch”function of TRPV4 in the treatment of soman intoxication. | Shuai Wang Huanhuan He Jianhai Long Xin Sui Jun Yang Guodong Lin Qian Wang Yongan Wang Yuan Luo | 2021 | Neuroscience Bulletin2021，37，7： | 1 |
| 3 | Triazole-forming waterborne polyurethane composites fabricated with silane coupling agent functionalized nano-silica 显示文摘 | Sun Daoxing Miao Xiao Zhang Kejie Kim Hern Yuan Yongan | 2011 | Journal of Colloid and Interface Science2011，361，： | 1 |
| 4 | Effects of different protein and lipid levels on the growth performance and intestinal microflora of loach(Paramisgurnus dabryanus)显示文摘The aim of this study was to examine the effects of dietary protein and lipid levels on the growth per-formance and homeostasis of the intestinal flora in Paramisgurnus dabryanus.An 8-week 3×3 two-factorial experiment was conducted to investigate the interaction between dietary crude protein(CP:30%,35%,40%)and ether extract(EE:6%,10%,14%)on the growth rate and the intestinal microflora of P.dabryanus.A total of 2,160 fish(5.19±0.01 g)were randomly allotted to 36 aquariums each with 60 fish.Fish were fed the experimental diet twice daily.Results revealed that weight gain rate(WGR),specific growth rate(SGR),protein efficiency ratio and net protein utilization significantly increased when increasing protein levels from 30%to 40%(P<0.05).Both WGR and SGR enhanced first but reduced thereafter with maximum value at 10%lipid level as dietary lipid increased from 6%to 14%(P<0.05).Significant interactions between protein and lipid were found with feed conversion rate,lipid efficiency ratio and net lipid utilization(P<0.05).At the phylum level,Proteobacteria and Actinobacteria were the dominant bacteria;at the genus level,Burkholderia-Caballeronia-Paraburkholderia was the dominant bacteria.Fish fed the diet containing 10%lipid had a higher abundance of Proteobacteria and unclassi-fied_f_Eenterobacteriaceae than those fed the 14%lipid diet,and a higher abundance of Rhodobacter than those fed the 6%lipid diet(P<0.05).Analysis of the predicted functions showed that metabolism in the intestine of fish in the CP40EE10 group was more active than that in CP30EE14 group.Polynomial regression analysis found that a diet containing 40.87%protein and 9.88%lipid can be considered optimal for P.dabryanus. | Zirui Wang Shuyao Li Qiubai Zhou Jinhua Zhang Yongan Li Youjie Li Zhiwen Yuan Guanghua Huang | 2023 | Animal Nutrition2023，，2： | 0 |
| 5 | Engineered microneedles arrays for wound healing显示文摘Wound healing is the regenerative process of original skin structure after destructing by different damage sources.Due to their transdermal delivery capability and high specific surface area,microneedles arrays(MAs)have been recognized as encouraging biomaterials for wound healing.In this review,we have outlined the engineered MAs used for tissue regeneration and wound healing.Engineered MAs were first classified by design methodologies such as bionic design,intelligent-responsive design,actively-triggered design,matrix materials innovation,and composite smart design.Then,the MAs were divided into two categories based on the different loading substances:drug-loaded MAs and living component-loaded MAs.Finally,we have summed up the important elements of the preceding discussions and forecasted their future evolution. | Shun Yao Yuan Luo Yongan Wang | 2022 | Engineered Regeneration2022，3，3： | 0 |
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