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| 1 | A life support-based comprehensive treatment regimen dramatically lowers the in-hospital mortality of patients with fulminant myocarditis: a multiple center study显示文摘Fulminant myocarditis(FM) has unacceptable high mortality. This study aimed to evaluate the therapeutic efficacy of a life support-based comprehensive treatment regimen(LSBCTR), a completely novel treatment regimen, for FM. A total of 169 FM patients recruited from January 2008 to December 2018 were divided into two groups: patients receiving LSBCTR(81 cases),which includes(i) mechanical life support(positive pressure respiration, intra-aortic balloon pump with or without extracorporeal membrane oxygenation),(ii) immunomodulation therapy using sufficient doses of glucocorticoids and immunoglobulins, and(iii) application of neuraminidase inhibitors, and those receiving conventional treatment(88 cases). The endpoints were in-hospital death and heart-transplantation. Of all the population, 44 patients(26.0%) died in hospitals. Inhospital mortality was 3.7%(3/81) for LSBCTR group and 46.6%(41/88) for traditional treatment(P<0.001). Early application of LSBCTR, mechanical life support, neuraminidase inhibitors, and immunomodulation therapy significantly contributed to reduction in in-hospital mortality. This study describes a novel treatment regimen for FM patients that dramatically reduces inhospital mortality. Its generalization and clinical application will efficiently save lives although further optimization is needed.This study offers an insight that virus infection induced inflammatory waterfall results in cardiac injury and cardiogenic shock and is the therapeutic target. | Sheng Li Shengyong Xu Chenze Li Xiao Ran Guanglin Cui Mengying He Kun Miao Chunxia Zhao Jiangtao Yan Rutai Hui Ning Zhou Yan Wang Jiangang Jiang Jing Zhang Daowen Wang | 2019 | Science China(Life Sciences)2019，62，3： | 43 |
| 2 | The Relationship between Glucose Excursion and Cognitive Function in Aged Type 2 Diabetes Patients显示文摘Objective Evidence suggests that type 2 diabetes (T2DM) is associated with an increased risk of dementia and that glucose variability is an independent risk factor for diabetic complications.This study investigated the relationship between glucose excursion and cognitive function in aged T2DM patients.Methods A total of 248 aged T2DM patients wore a continuous glucose monitoring system (CGMS) for 3 days in order to evaluate glucose excursion,including mean amplitude of glycemic excursions (MAGE) and mean of daily difference (MODD).All subjects were evaluated with a number of accepted cognitive function tests,including themini‐mental status examination (MMSE).The relationship between MAGE and MODD and performance on these cognitive tests was assessed.Results The MAGE and MMSE score were negatively correlated,likewise with the correlation between MODD and MMSE.Liner multivariate regression analysis showed that MAGE and MODD were also negatively related to MMSE independent of age,sex,glycemic control,hypertension,smoking,or coronary heart disease history.Conclusion Glucose excursion is related to cognitive function in aged T2DM patients.Elevated glucose excursion decreased the MMSE score,which reflects general cognitive function.Thus,therapy aimed at controlling glucose excursion may be beneficial for maintaining cognitive function in aged T2DM patients. | ZHONG Yuan ZHANG Xiao Yan MIAO Ya ZHU Jie Hua YAN Hong WANG Bei Yun JIN Jun HU Ting Jun JIA Wei Ping | 2012 | Biomedical and Environmental Sciences2012，25，1： | 34 |
| 3 | Suppression of P-gp induced multiple drug resistance in a drug resistant gastric cancer cell line by overexpression of Fas显示文摘AIM To observe the drug sensitizing effect andrelated mechanisms of fas gene transduction onhuman drug-resistant gastric cancer cellSGC7901/VCR(resistant to Vincristine).METHODS The cell cycle alteration wasobserved by FACS.The sensitivity of gastriccancer cells to apoptosis was determined by invitro apoptosis assay.The drug sensitization ofcells to several anti-tumor drugs was observedby MTT assay.Immunochemical method wasused to show expression of P-gp and Topo Ⅱ ingastric cancer cells.RESULTS Comparing to SGC7901 and pBK-SGC7901/VCR,fas-SGC7901/VCR showeddecreasing G2 cells and increasing S cells,theG2 phase fraction of pBK-SGC7901/VCR wasabout 3.0 times that of fas-SGC7901/VCR,but Sphase fraction of fas-SGC7901/VCR was about1.9 times that of pBK-SGC7901/VCR,indicatingS phase arrest of fas-SGC7901/VCR.FACS alsosuggested apoptosis of fas-SGC7901/VCR,fas-SGC7901/VCR was more sensitive to apoptosisinducing agent VM-26 than pBK-SGC7901/VCR.MTT assay showed increased sensitization offas-SGC7901/VCR to DDP,MMC and 5-FU,butsame sensitization to VCR according to pBK-SGC7901/VCR.SGC7901,pBK-SGC7901/ VCRand fas-SGC7901/VCR had positively stainedTopo Ⅱ equally.P-gp staining in pBK- SGC7901/VCR was stronger than in SG07901,but there was little staining of P-gp in fas.SGC7901/VCR.CONCLUSION fas gene transduction couldreverse the MDR of human drug-resistant gastriccancer cell SGC7901/VCR to a degree,possiblybecause of higher sensitization to apoptosis anddecreased expression of P-gp. | Yin F Shi YQ Zhao WP Xiao B Miao JY Fan DM | 2000 | World Journal of Gastroenterology2000，6，5： | 24 |
| 4 | MiR-135a promotes growth and invasion of colorectal cancer via metastasis suppressor 1 in vitro显示文摘MicroRNAs (miRNAs ) 是参予送信人 RNA 和蛋白质合成的空间与时间的规定的小非编码的 RNA。异常 miRNA 表示导致发展畸形和疾病。miR-135a 被认为是 oncogenic;然而,在 colorectal 癌症(CRC ) 的 miR-135a 的功能和机制大部分是未知的。因此,我们调查了 miR-135a 的功能和机制,特别与转移 suppressor 的它的关系 1 (MTSS1 ) 在 CRC 的基因。当它房间增长,移植,和侵略上的效果被 MTT 决定时, miR-135a 的表达式被即时聚合酶链反应分别地决定,没有并且与 matrigel。MTSS1 的表示被西方的污点分析检测。miR-135a 表示比在非肿瘤控制织物在人的 CRC 样品是更高的,这被发现。用 SW480 和 SW620 CRC 房间行,增加了增长响应 miR-135a 被观察。我们也证明分别地, miR-135a CRC 房间有或没有 Matrigel 经由 transwell 试金支持了活动性和侵略。相反, miR-135a 的抑制减少了他们的 proliferative 和侵略能力。MTSS1 被酶报告试金作为 miR-135a 的候选人目标基因识别。西方的污点分析证明 MTSS1 的表示被 miR-135a overexpression 调整并且击倒。同样,在 MTSS1 被小介入 RNA 击倒以后, miR-135a-mediated 房间活动性和侵略被减少。这些数据显示 miR-135a 支持 CRC 细胞的生长和侵略,至少部分,通过指向 MTSS1。 | Weiwei Zhou Xiayu Li Fen Liu Zhiming Xiao Miao He Shourong Shen Shaojun Liu | 2012 | Acta Biochimica et Biophysica Sinica2012，44，10： | 19 |
| 5 | Gene therapy for human colorectal carcinoma using human CEA promoter controlled bacterial ADP-ribosylating toxin genes:PEA and DTA gene transfer显示文摘INTRODUCTIONAmajorrequirementforinvivogenetherapyforcanceristotargetthetherapeuticgeneexpresiontomalignanttissuesbyselectingp... | CAO Guang Wen 1, QI Zhong Tian 1, PAN Xin 1, ZHANG Xiao Qin 1, MIAO Xiao Hui 1, FENG Yan 1, LU Xin Hua 1, Shigeki Kuriyama 2 and DU Ping 1 | 1998 | World Journal of Gastroenterology1998，4，5： | 18 |
| 6 | Analysis of air quality characteristics of Beijing–Tianjin–Hebei and its surrounding air pollution transport channel cities in China显示文摘Beijing–Tianjin–Hebei(BTH)and its surrounding areas are very important to air pollution control in China.To analyze the characteristics of BTH and its surrounding areas of China,we collected 5,641,440 air quality data from 161 air monitoring stations and 37,123,000 continuous monitoring data from air polluting enterprises in BTH and surrounding cities to establish an indicator system for urban air quality portraits.The results showed that particulate matter with aerodynamic diameters of<2.5μm(PM2.5),particulate matter with aerodynamic diameters of<10μm(PM10)and SO2 improved significantly in 31 cities from2015 to 2018,but ozone deteriorated.Air quality in BTH and the surrounding areas showed obvious seasonal characteristics,among which PM2.5,PM10,SO2,and NO2 showed a'U'type distribution from January to December,while O3 had an'inverted U'distribution.The hourly changes in air quality revealed that peaks of PM2.5,PM10 and NO2 appeared from 8:00 to 10:00,while those for O3 appeared at 15:00–16:00.The exposure characteristics of the 31 cities showed that six districts in Beijing had the highest air quality population exposure,and that exposure levels in Zhengzhou,Puyang,Anyang,Jincheng were higher than the average of the 31 investigated cities.Additionally,multiple linear regression revealed a negative correlation between meteorological factors(especially wind and precipitation)and air quality,while a positive correlation existed between industrial pollution emissions and air quality in most of BTH and its surrounding cities. | Cuicui Xiao Miao Chang Peikun Guo Meifeng Gu Yang Li | 2020 | Journal of Environmental Sciences2020，32，1： | 15 |
| 7 | Performance of transient elastography in assessing liver fibrosis in patients with autoimmune hepatitis-primary biliary cholangitis overlap syndrome显示文摘AIM To investigate the performance of transient elastography(TE) for diagnosis of fibrosis in patients with autoimmune hepatitis-primary biliary cholangitis(AIHPBC) overlap syndrome.METHODS A total of 70 patients with biopsy-proven AIH-PBC overlap syndrome were included. Spearman correlation test was used to analyze the correlation of liver stiffness measurement(LSM) and fibrosis stage. Independent samples Student's t-test or one-way analysis of variance was used to compare quantitative variables. Receiver operating characteristics(ROC) curve was used to calculate the optimal cut-off values of LSM for predicting individual fibrosis stages. A comparison on the diagnostic accuracy for severe fibrosis was made between LSM and other serological scores.RESULTS Patients with AIH-PBC overlap syndrome had higher median LSM than healthy controls(11.3 ± 6.4 k Pa vs 4.3 ± 1.4 k Pa, P < 0.01). LSM was significantly correlated with fibrosis stage(r = 0.756, P < 0.01). LSM values increased gradually with an increased fibrosis stage. The areas under the ROC curves of LSM for stages F ≥ 2, F ≥ 3, and F4 were 0.837(95%CI: 0.729-0.914), 0.910(0.817-0.965), and 0.966(0.893-0.995), respectively. The optimal cut-off values of LSM for fibrosis stages F ≥ 2, F ≥ 3, and F4 were 6.55, 10.50, and 14.45 k Pa, respectively. LSM was significantly superior to fibrosis-4, glutaglumyl-transferase/platelet ratio, and aspartate aminotransferase-to-platelet ratio index scores in detecting severe fibrosis(F ≥ 3)(0.910 vs 0.715, P < 0.01; 0.910 vs 0.649, P < 0.01; 0.910 vs 0.616, P < 0.01, respectively).CONCLUSION TE can accurately detect hepatic fibrosis as a noninvasive method in patients with AIH-PBC overlap syndrome. | Hui-Min Wu Li Sheng Qi Wang Han Bao Qi Miao Xiao Xiao Can-Jie Guo Hai Li Xiong Ma De-Kai Qiu Jing Hua | 2018 | World Journal of Gastroenterology2018，24，6： | 13 |
| 8 | Surgical operation and re-operation for hepatocellular carcinoma with bile duct thrombosis显示文摘很少报告评估了的背景为在为有这研究的 .The 目的是调查起始的外科的功效的胆汁管血栓( BDT )的 hepatocellular 癌( HCC )的起始的外科以后的恶化的重新操作和为有 BDT 的 HCC 的随后的重新操作的功效,并且他们 prognosis.Methods 上的效果包括在我们的医院里经历了在 1998 和 2008 之间的激进的 hepatectomy 的有 BDT 的 28 个病人,有 HCC 的 880 个病人的临床的数据是 BDT 的 reviewed.The | WANG Ya-dong XUE Huan-zhou JIANG Qing-feng SHEN Quan WANG Lian-cai ZHANG Xiao LU Bing YU Miao LI Ke | 2010 | Chinese Medical Journal2010，，16： | 11 |
| 9 | Expression of chemokine receptors CCR3, CCR5 and CXCR3 on CD4^+ T cells in CBA/J×DBA/2 mouse model, selectively induced by IL-4 and IL-10, regulates the embryo resorption rate显示文摘背景 Chemokines 和他们的受体是在移植 immunology.Chemokines 的一个研究焦点,他们的受体在淋巴细胞招募和试图观察 IL-4 和 IL-10 是否可以调整 chemokine 受体 CCR3 的表示的区别 process.This 学习起一个作用,在 CBA/JxDBA/2 老鼠模型并且到的CD4+ T 房间上的 CCR5 和 CXCR3 探索 CCR3 的角色, CCR5 ,在在 pregnancy.Methods 的有免疫力的忍耐的 CXCR3 自发的流产( CBA/JxDBA/2 ) | JIANG Pei-juan ZHAO Ai-min BAO Shi-min XIAO Shi-jin XIONG Miao | 2009 | Chinese Medical Journal2009，，16： | 10 |
| 10 | Essential roles of exosome and circRNA_101093 on ferroptosis desensitization in lung adenocarcinoma显示文摘Background:Resistance to ferroptosis,a regulated cell death caused by irondependent excessive accumulation of lipid peroxides,has recently been linked to lung adenocarcinoma(LUAD).Intracellular antioxidant systems are required for protection against ferroptosis.The purpose of the present studywas to investigate whether and how extracellular system desensitizes LUAD cells to ferroptosis.Methods:Established human lung fibroblasts MRC-5,WI38,and human LUAD H1650,PC9,H1975,H358,A549,and H1299 cell lines,tumor and matched normal adjacent tissues of LUAD,and plasma from healthy individuals and LUAD patients were used in this study.Immunohistochemistry and immunoblotting were used to analyze protein expression,and quantitative reverse transcription-PCR was used to analyze mRNA expression.Cell viability,cell death,and the lipid reactive oxygen species generationwere measured to evaluate the responses to ferroptosis.Exosomes were observed using transmission electron microscope.The localization of arachidonic acid(AA)was detected using click chemistry labeling followed by confocal microscopy.Interactions between RNAs and proteins were detected using RNA pull-down,RNA immunoprecipitation and photoactivatable ribonucleoside-enhanced crosslinking and immunoprecipitation methods.Proteomic analysis was used to investigate RNA-regulated proteins,and metabolomic analysis was performed to analyze metabolites.Cellderived xenograft,patient-derived xenograft,cell-implanted intrapulmonary LUAD mouse models and plasma/tissue specimens from LUAD patients were used to validate the molecular mechanism.Results:Plasma exosome from LUAD patients specifically reduced lipid peroxidation and desensitized LUAD cells to ferroptosis.A potential explanation is that exosomal circRNA_101093(cir93)maintained an elevation in intracellular cir93 in LUAD to modulate AA,a poly-unsaturated fatty acid critical for ferroptosisassociated increased peroxidation in the plasma membrane.Mechanistically,cir93 interacted with and increased fatty acid-binding protein 3(FABP3),which transported AA and facilitated its reaction with taurine.Thus,global AA was reduced,whereas N-arachidonoyl taurine(NAT,the product of AA and taurine)was induced.Notably,the role of NAT in suppressing AA incorporation into the plasma membrane was also revealed.In pre-clinical in vivo models,reducing exosome improved ferroptosis-based treatment.Conclusion:Exosome and cir93 are essential for desensitizing LUAD cells to ferroptosis,and blocking exosome may be helpful for future LUAD treatment. | Xiao Zhang Yunhua Xu Lifang Ma Keke Yu Yongjie Niu Xin Xu Yi Shi Susu Guo Xiangfei Xue Yikun Wang Shiyu Qiu Jiangtao Cui Hong Wang Xiaoting Tian Yayou Miao Fanyu Meng Yongxia Qiao Yongchun Yu Jiayi Wang | 2022 | Cancer Communications2022，42，4： | 10 |
| 11 | Imbalance of Fecal Microbiota at Newly Diagnosed Type Diabetes in Chinese Children显示文摘 | Cui-Juan Qi Qian Zhang Miao Yu Jian-Ping Xu Jia Zheng Tong Wang Xin-Hua Xiao | 2016 | Chinese Medical Journal2016，，11： | 10 |
| 12 | Enhanced aromatic selectivity by the sheet-like ZSM-5 in syngas conversion显示文摘Aromatics are important basic chemicals. However, direct conversion of syngas via the conventional Fischer-Tropsch synthesis produces little aromatics. We presented herein that a bifunctional composite of ZSM-5 in combination with Zn Cr Oxcatalyzes syngas conversion to aromatics. Particularly, ZSM-5 crystals with a sheet-like morphology can enhance significantly the aromatization activity. The lower length ratio of the b/a axes of the crystals, the more aromatics form but without influencing the selectivity of small molecules such as CH4 and C2–C4. Since the acid properties and the Al chemical environment were not altered while the morphology changed, the enhanced aromatic selectivity is likely attributed to the favored diffusion of aromatics in these sheet-like crystals. | Junhao Yang Ke Gong Dengyun Miao Feng Jiao Xiulian Pan Xiangju Meng Fengshou Xiao Xinhe Bao | 2019 | Journal of Energy Chemistry2019，28，8： | 10 |
| 13 | Simulated Microgravity Conditions and Carbon Ion Irradiation Induce Spermatogenic Cell Apoptosis and Sperm DNA Damage显示文摘Objective To investigate the effect of simulated microgravity and carbon ion irradiation(CIR) on spermatogenic cell apoptosis and sperm DNA damage to the testis of male Swiss Webster mice,and assess the risk associated with space environment.Methods Sperm DNA damage indicated by DNA fragmentation index(DFI) and high DNA stainability(HDS) was measured by sperm chromatin structure assay(SCSA).Apoptosis of spermatogenic cells was detected by annexin V-propidium iodide assay.Bax(the expression levels of p53) and proliferating cell nuclear antigen(PCNA) were measured by immunoblotting;p53 and PCNA were located by immunohistology.Results HDS,DFI,apoptosis index,and the expression levels of p53 and Bax were detected to be significantly higher in the experimental groups(P<0.05) compared with those in the control group;however,the PCNA expression varied to a certain degree.p53-and PCNA-positive expression were detected in each group,mainly in relation to the spermatogonic cells and spermatocytes.Conclusion The findings of the present study demonstrated that simulated microgravity and CIR can induce spermatogenic cell apoptosis and sperm DNA damage.Sperm DNA damage may be one of the underlying mechanisms behind male fertility decline under space environment.These findings may provide a scientific basis for protecting astronauts and space traveler's health and safety. | LI Hong Yan ZHANG Hong MIAO Guo Ying XIE Yi SUN Chao DI Cui Xia LIU Yang LIU Yuan Yuan ZHANG Xin MA Xiao Fei XU Shuai GAN Lu ZHOU Xin | 2013 | Biomedical and Environmental Sciences2013，26，9： | 10 |
| 14 | Ginsenoside Rb1 Attenuates Isoflurane/surgery-induced Cognitive Dysfunction via Inhibiting Neuroinflammation and Oxidative Stress显示文摘Objective Anesthetic isoflurane plus surgery has been reported to induce cognitive impairment. The underlying mechanism and targeted intervention remain largely to be determined. Ginsenoside Rb1 was reported to be neuroprotective. We therefore set out to determine whether ginsenoside Rb1 can attenuate isoflurane/surgery-induced cognitive dysfunction via inhibiting neuroinflammation and oxidative stress. Methods Five-months-old C57BL/6J female mice were treated with 1.4% isoflurane plus abdominal surgery for two hours. Sixty mg/kg ginsenoside Rb1 were given intraperitoneally from 7 days before surgery. Cognition of the mice were assessed by Barnes Maze. Levels of postsynaptic density-95 and synaptophysin in mice hippocampus were measured by Western blot. Levels of reactive oxygen species, tumor necrosis factor-α and interleukin-6 in mice hippocampus were measured by ELISA. Results Here we show for the first time that the ginsenoside Rb1 treatment attenuated the isoflurane/surgery-induced cognitive impairment. Moreover, ginsenoside Rb1 attenuated the isoflurane/surgery-induced synapse dysfunction. Finally, ginsenoside Rb1 mitigated the isoflurane/surgery-induced elevation levels of reactive oxygen species, tumor necrosis factor-α and interleukin-6 in the mice hippocampus. Conclusion These results suggest that ginsenoside Rb1 may attenuate the isoflurane/surgery-induced cognitive impairment by inhibiting neuroinflammation and oxidative stress pending future studies. | MIAO Hui Hui ZHANG Ye DING Guan Nan HONG Fang Xiao DONG Peng TIAN Ming | 2017 | Biomedical and Environmental Sciences2017，30，5： | 9 |
| 15 | Clinical and Radiological Profile of Acute Fibrinous and Organizing Pneumonia: A Retrospective Study显示文摘 | Jing-Hong Dai Hui Li Wei Shen Li-Yun Miao Yong-Long Xiao Mei Huang Meng-Shu Cao Yang Wang Bin Zhu Fan-Qing Meng Hou-Rong Cai | 2015 | Chinese Medical Journal2015，，20： | 9 |
| 16 | Ginsenoside Rg1 Attenuates Isoflurane-induced Caspase-3 Activation via Inhibiting Mitochondrial Dysfunction显示文摘Objective The inhalation anesthetic isoflurane has been shown to induce mitochondrial dysfunction and caspase activation, which may lead to learning and memory impairment. Ginsenoside Rg1 is reported to be neuroprotective. We therefore set out to determine whether ginsenoside Rg1 can attenuate isoflurane-induced caspase activation via inhibiting mitochondrial dysfunction. Methods We investigated the effects of ginsenoside Rg1 at concentrations of 12.5, 25, and 50 μmol/L and pretreatment times of 12 h and 24 h on isoflurane-induced caspase-3 activation in H4 na?ve and stably transfected H4 human neuroglioma cells that express full-length human amyloid precursor protein(APP)(H4-APP cells). For mitochondrial dysfunction, we assessed mitochondrial permeability transition pore(m PTP) and adenosine-5'-triphosphate(ATP) levels. We employed Western blot analysis, chemiluminescence, and flowcytometry. Results Here we show that pretreatment with 50 μmol/L ginsenoside Rg1 for 12 h attenuated isoflurane-induced caspase-3 activation and mitochondrial dysfunction in H4-APP cells, while pretreatment with 25 and 50 μmol/L ginsenoside Rg1 for 24 h attenuated isoflurane-induced caspase-3 activation and mitochondrial dysfunction in both H4 na?ve and H4-APP cells. Conclusion These data suggest that ginsenoside Rg1 may ameliorate isoflurane-induced caspase-3 activation by inhibiting mitochondrial dysfunction. Pending further studies, these findings might recommend the use of ginsenoside Rg1 in preventing and treating isoflurane-induced neurotoxicity. | MIAO Hui Hui ZHEN Yu DING Guan Nan HONG Fang Xiao XIE Zhong Cong TIAN Ming | 2015 | Biomedical and Environmental Sciences2015，28，2： | 9 |
| 17 | Prevalence and molecular characteristics of Listeria monocytogenes in cooked products and its comparison with isolates from listeriosis cases显示文摘这研究试图在 Zigong 城市里在煮的产品调查流行和 Listeria monocytogenes 的分子的特征,中国。L 的全面出现。在商店和羊肉餐馆调查了的 ready-to-eat (RTE ) 的 monocytogenes 是 16.2%(141/873 ) 。13.5% 的出现在 RTE 猪肉被观察, 6.5% 在 RTE 蔬菜,并且非常, 24.0% 在也煮了羊肉或煮了将羊杂切碎加麦片纳入羊胃中煮成的食物。Serotype 1/2b (45.4%) , 1/2a (33.3%) ,和 1/2c (14.2%) 是占优势的类型。由基于 L 的打字的 multilocus 顺序(MLST ) 比较同种细胞的建筑群(CC ) 。从从中国, CC87, CC9, CC8,和 CC3 的不同区域的 Zigong 城市和 33 个 listeriosis 案例里的煮的食物的 monocytogenes 被显示在煮的产品和 CC87 流行, CC3 是在 33 诊所来源紧张的开始的二种经常的类型。所有 CC87 污点怀有最新报导的 Listeria 致病力岛 4 (LIPI-4 ) 基因碎片 ptsA,和所有 CC3 紧张拥有了 Listeria 致病力岛 3 (LIPI-3 ) 基因碎片 llsX。这些可以增加在中国在 listeriosis 情况中属于 CC87 和 CC3 的紧张的出现并且也从 Zigong 由于煮的产品的消费加重感染的风险。ST619 (serotype 1/2b ) 怀有 llsX 和 ptsA,显示在 Zigong 的一种潜在的 hypervirulent 顺序类型。 | Hong Wang Lijuan Luo Zhengdong Zhang Jianping Deng Yan Wang Yimao Miao Ling Zhang Xi Chen Xiang Liu Songsong Sun Bo Xiao Qun Li Changyun Ye | 2018 | Frontiers of Medicine2018，12，1： | 9 |
| 18 | Association between VDR and ESR1 gene polymorphisms with bone and obesity phenotypes in Chinese male nuclear families显示文摘 | Jie-mei GU Wen-jin XIAO Jin-wei HE Hao ZHANG Wei-wei HU Yun-qiu HU Miao LI Yu-juan LIU Wen-zhen FU Jin-bo YU Gao GAO Hua YUE Yao-hua KE Zhen-lin ZHANG | 2009 | Acta Pharmacologica Sinica2009，30，12： | 8 |
| 19 | Ultra-sensitive graphene strain sensor for sound signal acquisition and recognition显示文摘为健全信号获得和识别的一个便携、高精确的传感器从编织的特殊设计的 graphene 的薄电影被制作织物(GWF ) 。在被拉长之上,随机的裂缝的高密度出现在网络,它减少当前的小径,从而增加电阻。因此,这部电影能对人的喉咙作为一个紧张传感器起作用以便测量通过肌肉运动,一个声音是否被生产的讲话。超离频敏感允许由提取声波的签名特征的快速、低频率的讲话采样的实现。在这研究, 26 封英语信,典型汉字和音调的代表性的信号,甚至短语和句子被测试,揭示在电阻的明显、典型的变化。而且, graphene 传感器的电阻变化与预告录下的声音完美地反应了。由把人工智能与数字信号处理相结合,我们期望以后,这个 graphene 传感器将能成功地达成复杂声学的系统和听觉的数据的大数量。 | Yan Wang Tingting Yang Junchao Lao Rujing Zhang Yangyang Zhang Miao Zhu Xiao Li Xiaobei Zang Kunlin Wang Wenjian YU Hu Jin Li Wang Hongwei Zhu | 2015 | Nano Research2015，8，5： | 8 |
| 20 | Chromium-containing traditional Chinese medicine, Tianmai Xiaoke Tablet improves blood glucose through activating insulin-signaling pathway and inhibiting PTP1B and PCK2 in diabetic rats显示文摘OBJECTIVE: Chromium is an essential mineral that is thought to be necessary for normal glucose homeostasis.Numerous studies give evidence that chromium picolinate can modulate blood glucose and insulin resistance.The main ingredient of Tianmai Xiaoke(TMXK) Tablet is chromium picolinate.In China, TMXK Tablet is used to treat type 2 diabetes.This study investigated the effect of TMXK on glucose metabolism in diabetic rats to explore possible underlying molecular mechanisms for its action.METHODS: Diabetes was induced in rats by feeding a high-fat diet and subcutaneously injection with a single dose of streptozotocin(50 mg/kg, tail vein).One week after streptozotocin-injection, model rats were divided into diabetic group, low dose of TMXK group and high dose of TMXK group.Eight normal rats were used as normal control.After 8 weeks of treatment, skeletal muscle was obtained and was analyzed using Roche NimbleGen mRNA array and quantitative polymerase chain reaction(qPCR).Fasting blood glucose, oral glucose tolerance test and homeostasis model assessment of insulin resistance(HOMA-IR) index were also measured.RESULTS: The authors found that the administration of TMXK Tablet can reduce the fasting blood glucose and fasting insulin level and HOMA-IR index.The authors also found that 2 223 genes from skeletal muscle of the high-dose TMXK group had significant changes in expression(1 752 increased, 471 decreased).Based on Kyoto encyclopedia of genes and genomes pathway analysis, the most three significant pathways were 'insulin signaling pathway', 'glycolysis/gluconeogenesis' and 'citrate cycle(TCA)'.qPCR showed that relative levels of forkhead box O3(FoxO3), phosphoenolpyruvate carboxykinase 2(Pck2), and protein tyrosine phosphatase 1B(Ptp1b) were signifi cantly decreased in the high-dose TMXK group, while v-akt murine thymoma viral oncogene homolog 1(Akt1) and insulin receptor substrate 2(Irs2) were increased.CONCLUSION: Our data show that TMXK Tablet reduces fasting glucose level and improves insulin resistance in diabetic rats.The mechanism may be linked to the inactivation of PTP1B and PCK enzymes, or through intracellular pathways, such as the insulin signaling pathway. | Qian Zhang Xin-hua Xiao Ming Li Wen-hui Li Miao Yu Hua-bing Zhang Fan Ping Zhi-xin Wang Jia Zheng | 2014 | Journal of Integrative Medicine2014，12，3： | 8 |
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