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| 1 | Pachytene piRNAs instruct massive mRNA elimination during late spermiogenesis显示文摘在哺乳动物的精子发生被 piRNA 表示的二个波浪描绘:一个人对应于负责的经典 piRNAs 因为 silencing retrotransponsons 和第二个波浪主要在 pachytene spermatocytes 从 nontransposon intergenic 区域被导出,但是这些 pachytene piRNAs 的功能大部分是未知的。这里,我们在在老鼠伸长指示巨大的 mRNA 消除报导 pachytene piRNAs 的参与 spermatids (ES ) 。我们证明包含鼠科的 PIWI (MIWI ) 和 deadenylase CAF1 的导致 piRNA 的 silencing 建筑群(pi-RISC ) 有选择地在 ES 被装配,它负责经由在体的房间类似于 miRNAs 的行动的机制导致 mRNA deadenylation 和腐烂。如此的一个高度安排的节目看起来充分利用 pachytene piRNAs 的能力从 nontransposon intergenic 区域导出的多样化的指向的庞大的全部剧目。这些调查结果建议 pachytene piRNAs 负责为精子生产作准备,从 ES 使广阔细胞的节目失去活性。 | Lan-Tao Gou Peng Dai Jian-Hua Yang Yuanchao Xue Yun-Ping Hu Yu Zhou Jun-Yan Kang Xin Wang Hairi Li Min-Min Hua Shuang Zhao Si-Da Hu Li-Gang Wu Hui-Juan Shi Yong Li Xiang-Dong Fu Liang-Hu Qu En-Duo Wang Mo-Fang Liu | 2014 | Cell Research2014，24，6： | 39 |
| 2 | Phytophthora sojae Effector PsAvh240 Inhibits Host Aspartic Protease Secretion to Promote Infection显示文摘Plants secrete defense molecules into the extracellular space (the apoplast) to combat attacking microbes. However, the mechanisms by which successful pathogens subvert plant apoplastic immunity remain poorly understood. In this study, we show that PsAvh240, a membrane-localized effector of the soybean pathogen Phytophthora sojae, promotes P. sojae infection in soybean hairy roots. We found that PsAvh240 interacts with the soybean-resistant aspartic protease GmAP1 in planta and suppresses the secretion of GmAP1 into the apoplast. By solving its crystal structure we revealed that PsAvh240 contain six a helices and two WY motifs. The first two a helices of PsAvh240 are responsible for its plasma membrane-localization and are required for PsAvh240's interaction with GmAP1. The second WY motifs of two PsAvh240 molecules form a handshake arrangement resulting in a handshake-like dimer. This dimerization is required for the effector's repression of GmAP1 secretion. Taken together, these data reveal that PsAvh240 localizes at the plasma membrane to interfere with GmAP1 secretion, which represents an effective mechanism by which effector proteins suppress plant apoplastic immunity. | Baodian Guo Haonan Wang Bo Yang Wenjing Jiang Maofeng Jing Haiyang Li Yeqiang Xia Yuanpeng Xu Qinli Hu Fangfang Wang Feng Yu Yan Wang Wenwu Ye Suomeng Dong Weiman Xing Yuanchao Wang | 2019 | Molecular Plant2019，12，4： | 12 |
| 3 | PTB/nPTB: master regulators of neuronal fate in mammals显示文摘 | Jing Hu Hao Qian Yuanchao Xue Xiang-Dong Fu | 2018 | Biophysics Reports2018，4，4： | 4 |
| 4 | The RNA-binding protein ROD1/PTBP3 cotranscriptionally defines AID-loading sites to mediate antibody class switch in mammalian genomes显示文摘 | Juan Chen Zhaokui Cai Meizhu Bai Xiaohua Yu Chao Zhang Changchang Cao Xihao Hu Lei Wang Ruibao Su Di Wang Yingpeng Yao Rong Ye Baidong Hou Yang Yu Shuyang Yu Jinsong Li Yuanchao xue | 2018 | Cell Research2018，28，10： | 4 |
| 5 | Significant Inhibition of Porcine Epidemic Diarrhea Virus In Vitro by Remdesivir,Its Parent Nucleoside and β-D-N^(4)-hydroxycytidine显示文摘Porcine epidemic diarrhea(PED)caused by porcine epidemic diarrhea virus(PEDV)is widespread in the world.In recent years,the increased virulence of the virus due to viral variations,has caused great economic losses to the pig industry in many countries.It is always worthy to find effective therapeutic methods for PED.As an important class of antivirals,nucleoside drugs which target viral polymerases have been applied in treating human viral infections for half a century.Herein,we evaluated the anti-PEDV potential of three broad-spectrum antiviral nucleoside analogs,remdesivir(RDV),its parent nucleoside(RDV-N)andβ-D-N^(4)-hydroxycytidine(NHC).Among them,RDV-N was the most active agent in Vero E6 cells with EC_(50) of 0.31μmol/L,and more potent than RDV(EC_(50)=0.74μmol/L)and NHC(EC_(50)=1.17μmol/L).The activity of RDV-N was further confirmed using an indirect immuno-fluorescence assay.Moreover,RDV-N exhibited a good safety profile in cells and in mice.The high sequence similarity of the polymerase functional domains of PEDV with other five porcine coronaviruses indicated a broader antiviral spectrum for the three compounds.Generally,RDV-N is a promising broad-spectrum antiviral nucleoside,and it would be worthy to make some structural modifications to increse its oral bioavailability. | Yuanchao Xie Xiaozhen Guo Tianwen Hu Daibao Wei Xiuli Ma Jiaqiang Wu Bing Huang Jingshan Shen | 2021 | Virologica Sinica2021，36，5： | 3 |
| 6 | Carbon footprints of food production in China显示文摘 | Lin Jianyi Hu Yuanchao Cui Shenghui Kang Jiefeng Xu Lilai | 2015 | Joumal of Cleaner Produc- tion2015，90，： | 1 |
| 7 | Puri- fication and immunocytolocalization of a novel Phytoph- thora boehmeriae protein inducing the hypersensitive re-sponse and systemic acquired resistance in tobacco and Chinese cabbage 显示文摘 | WANG Yuanchao HU D W ZHANG Z G | 2003 | Physiological and Molecular Plant Pathology2003，63，： | 1 |
| 8 | Constructing a'pea-pod'-like nanostructure to provide valid conductive matrix and volume change accommodation for silicon anode in lithium ion batteries显示文摘A'pea-pod'-like composite of graphene-wrapped silicon nanoparticles(P–Si@GS)was successfully prepared via a new and facial technique utilizing freeze-drying and subsequent solvothermal process.The cross-linked'pods'formed by curled few-layer graphene sheets constituted a conductive network,in which silicon nanoparticles were tightly wrapped.The unique graphene-wrapped structure with mesopores on the surface can effectively enhance the conductivity of silicon,alleviate its volume effect and provide rapid transport channels for electrons and ions,thus resulting in excellent electrochemical performance.The strategy of combining freeze-drying and solvothermal methods is facile,low-cost and effective,which provides new ideas for the preparation of highperformance graphene-wrapped nanoparticles composites. | Jingjing Ma Huan Zhang Yuanchao Li Linfeng Hu Qing Wang WanQing Zhang Li Yang Guang-Ri Xu Yu-Shi He Tianjun Lou Zi-Feng Ma | 2021 | Green Chemical Engineering2021，2，3： | 0 |
| 9 | Dealloying of an amorphous TiCuRu alloy results in a nanostructured electrocatalyst for hydrogen evolution reaction显示文摘Development of an electrocatalyst that is cheap and has good properties to replace conventional noble metals is important for H_(2) applications.In this study,dealloying of an amorphous Ti_(37)Cu_(60)Ru_(3) alloy was performed to prepare a freestanding nanostructured hydrogen evolution reaction(HER)catalyst.The effect of dealloying and addition of Ru to TiCu alloys on the microstructure and HER properties under alkaline conditions was investigated.3 at.%Ru addition in Ti_(40)Cu_(60) decreases the overpotential to reach a current density of 10mA cm^(-2) and Tafel slope of the dealloyed samples to 35 and 34mV dec−1.The improvement of electrocatalytic properties was attributed to the formation of a nanostructure and the modification of the electronic structure of the catalyst.First-principles calculations based on density function theory indicate that Ru decreases the Gibbs free energy of water dissociation.This work presents a method to prepare an efficient electrocatalyst via dealloying of amorphous alloys. | Jinsen Tian Yuanchao Hu Wenfei Lu Jiahua Zhu Xiaodi Liu Jun Shen Gang Wang Jan Schroers | 2023 | Carbon Energy2023，5，8： | 0 |
| 10 | STRATEGIES FOR A LOW-CARBON FOOD SYSTEM IN CHINA显示文摘In China,there has been insufficient study of whole food system greenhouse gas(GHG)accounting,which limits the development of mitigation strategies and may preclude the achievement of carbon peak and carbon neutrality goals.The paper presents the development of a carbon extension of NUFER(NUtrient flows in Food chain,Environment and Resources use model),a food system GHG emission accounting model that covers land use and land-use change,agricultural production,and post-production subsectors.The spatiotemporal characteristics of GHG emissions were investigated for the Chinese food system(CFS)from 1992 to 2017,with a focus on GHG emissions from the entire system.The potential to achieve a low-carbon food system in China was explored.The net GHG emissions from the CFS increased from 785Tg CO_(2)equivalent(CO_(2)-eq)in 1992 to 1080 Tg CO_(2)-eq in 2017.Agricultural activities accounted for more than half of the total emissions during the study period,while agricultural energy was the largest contributor to the GHG increase.In 2017,highest emitting regions were located in central and southern China(Guangdong and Hunan),the North China Plain(Shandong,Henan and Jiangsu)and Northeast China(Heilongjiang and Inner Mongolia)and contributed to over half of the total GHG emissions.Meanwhile,Xinjiang,Qinghai and Tibet are shown as carbon sink areas.It was found that foodsystem GHG emissions could be reduced to 355 Tg CO_(2)-eq,where enhancing endpoint mitigation technologies,transforming social-economic and diet conditions,and increasing agricultural productivities can contribute to 60%,25%and 15%,respectively.Synergistic mitigation effects were found to exist in agricultural activities. | Xinpeng JIN Xiangwen FAN Yuanchao HU Zhaohai BAI Lin MA | 2023 | Frontiers of Agricultural Science and Engineering2023，10，2： | 0 |
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