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| 1 | Recombinant expression of different mutant K-ras gene in pancreatic cancer Bxpc-3 cells and its effects on chemotherapy sensitivity显示文摘K-ras is a member of ras gene family which is involved in cell survival,proliferation and differentiation.When a mutation occurs in ras gene,the activation of Ras proteins may be prolonged to induce oncogenesis.However,the relationship between K-ras mutation and clinical outcomes in pancreatic cancer patients treated with chemotherapy agents is still under debate.In this study,we constructed five pAcGFP1-C3 plasmids for different types of K-ras gene(WT,G12V,G12R,G12D,and G13D)and stably transfected human pancreatic cancer Bxpc-3 cells with these genes.The wild type and mutant clones showed a comparable growth and expression of K-Ras-GFP fusion protein.The expression of some K-ras mutations resulted in a reduced sensitivity to gefitinib,5-FU,docetaxel and gemcitabine,while showed no effects on erlotinib or cisplatin.Moreover,compared with the wild type clone,K-Ras downstream signals(phospho-Akt and/or phospho-Erk)were increased in K-ras mutant clones.Interestingly,different types of K-ras mutation had non-identical K-Ras downstream signal activities and drug responses.Our results are the first to reveal the relationship between different K-ras mutation and drug sensitivities of these anti-cancer drugs in pancreatic cancer cells in vitro. | SHAO TengFei ZHENG YuanTing ZHAO Bei LI Tao CHENG KeGuang CAI WeiMin | 2014 | Science China(Life Sciences)2014，57，10： | 2 |
| 2 | Pd catalysts supported on MnCeO x mixed oxides and their catalytic application in solvent-free aerobic oxidation of benzyl alcohol: Support composition and structure sensitivity显示文摘 | Yuanting Chen Huijian Zheng Zhen Guo Chunmei Zhou Chuan Wang Armando Borgna Yanhui Yang | 2011 | Journal of Catalysis2011，，1： | 1 |
| 3 | Oxalic Acid Promoted Hydrolysis of Sodium Borohydride for Transition Metal Free Hydrogen Generation显示文摘We reported an inexpensive and high-efficiency hydrogen generation method from NaBH4 hydrolysis promoted by oxalic acid.NaBH4 and H2C2O4 were premixed and hydrogen generation was initiated by adding water into the solid mixture.H2C2O4 was selected as the acid promotor due to its solid state and low mass per proton.The effect of reactant ratio on the hydrogen yield and hydrogen storage density was investigated.With optimized reactant ratio,high gravimetric hydrogen storage up to 4.4wt%based on all the reactants can be achieved with excellent hydrogen generation kinetics. | PENG Yuanting ZENG Hui SHI Yu XU Jinrong 谢镭 陈均 ZHENG Jie LI Xingguo | 2020 | Journal of Wuhan University of Technology(Materials Science)2020，35，6： | 0 |
| 4 | Correction:Both IDO1 and TDO contribute to the malignancy of gliomas via the Kyn-AhR-AQP4 signaling pathway显示文摘In the process of collating the raw data,the authors noticed the inadvertent mistakes in Fig.4h&6g that need to be corrected.The correct data are provided as follows.The key findings of the article are not affected by the corrections.We apologize for the inadvertent mistakes.The authors mistakenly placed the wrong representative image showing the invasion ability of U87MG cells in the IFN-γ+1-MT group.The correct version of Fig.4h is shown above. | Lisha Du Zikang Xing Bangbao Tao Tianqi Li Dan Yang Weirui Li Yuanting Zheng Chunxiang Kuang Qing Yang | 2021 | Signal Transduction and Targeted Therapy2021，6，12： | 0 |
| 5 | 三阴性乳腺癌基因组与转录组全景图:亚型及治疗策略显示文摘文章简介三阴性乳腺癌(triple-negative breast cancer,TNBC)是雌激素受体、孕激素受体和HER-2均为阴性的一群乳腺癌,缺乏有效靶向治疗,预后差,是乳腺癌学界的世界性难题。近年的研究表明TNBC是一个异质性很强的群体,为更全面而深入地认识这类疾病,寻找精准治疗的突破口,研究团队全面分析了465例原发性三阴性乳腺癌(TNBC)队列的临床、基因组学和转录组学数据。 | Yi-Zhou Jiang Ding Ma Chen Suo Jinxiu Shi Mengzhu Xue Xin Hu Yi Xiao Ke-Da Yu Yi-Rong Liu Ying Yu Yuanting Zheng Xiangnan Li Chenhui Zhang Pengchen Hu Jing Zhang Qi Hua Jiyang Zhang Wanwan Hou Luyao Ren Ding Bao Bingying Li Jingcheng Yang Ling Yao Wen-Jia Zuo Shen Zhao Yue Gong Yi-Xing Ren Ya-Xin Zhao Yun-Song Yang Zhenmin Niu Zhi-Gang Cao Daniel G.Stover Claire Verschraegen Virginia Kaklamani Anneleen Daemen John R.Benson Kazuaki Takabe Fan Bai Da-Qiang Li 王鹏 石乐明 黄薇 邵志敏 | 2020 | 科学新闻2020，，2： | 0 |
| 6 | Both IDO1 and TDO contribute to the malignancy of gliomas via the Kyn–AhR–AQP4 signaling pathway显示文摘Indoleamine 2,3-dioxygenase 1(IDO1),indoleamine 2,3-dioxygenase 2(IDO2),and tryptophan 2,3-dioxygenase(TDO)initiate the first step of the kynurenine pathway(KP),leading to the transformation of L-tryptophan(Trp)into L-kynurenine(Kyn)and other downstream metabolites.Kyn is known as an endogenous ligand of the aryl hydrocarbon receptor(AhR).Activation of AhR through TDO-derived Kyn is a novel mechanism to support tumor growth in gliomas.However,the role of IDO1 and IDO2 in this mechanism is still unknown.Herein,by using clinical samples,we found that the expression and activity of IDO1 and/or TDO(IDO1/TDO)rather than IDO2 were positively correlated with the pathologic grades of gliomas.The expression of IDO1/TDO rather than IDO2 was positively correlated with the Ki67 index and overall survival.The expression of IDO1/TDO was positively correlated with the expression of aquaporin 4(AQP4),implying the potential involvement of IDO1/TDO in glioma cell motility.Mechanistically,we found that IDO1/TDO accounted for the release of Kyn,which activated AhR to promote cell motility via the Kyn–AhR–AQP4 signaling pathway in U87MG glioma cells.RY103,an IDO1/TDO dual inhibitor,could block the IDO1/TDO–Kyn–AhR–AQP4 signaling pathway and exert anti-glioma effects in GL261 orthotopic glioma mice.Together,our results showed that the IDO1/TDO–Kyn–AhR–AQP4 signaling pathway is a new mechanism underlying the malignancy of gliomas,and suggest that both IDO1 and TDO might be valuable therapeutic targets for gliomas. | Lisha Du Zikang Xing Bangbao Tao Tianqi Li Dan Yang Weirui Li Yuanting Zheng Chunxiang Kuang Qing Yang | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 0 |
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