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| 1 | Microvascular decompression in patients with hemifacial spasm: report of 1200 cases显示文摘Background Microvascular Decompression (MVD) operation is the most reliable treatment for hemifacial spasm (HFS), but it causes many complications. The aim of this retrospective study was to investigate the factors relavent to the effects and postoperative complications of microvascular decompression on hemifacial spasm. Methods A total of 1200 HFS patients treated with MVD were studied retrospectively. The root exit zone (REZ) of the facial nerve was exposed through the infraflocculus approach, the offending vessels were identified and separated from the REZ, and a Teflon graft was interposed between the offending vessels and the brain stem. Brain stem auditory evoked potential (AEP) was monitored intraoperatively. Results The offending vessels can be identified in all patients. The anteroinferior cerebellar artery was the main offending vessel (42.6%). Patients with vertebral artery compression had a multiple vascular compression fashion. Follow-up for 2-10 years (mean 4.2 years) showed that 88.7% patients were cured and 5.6% relieved, with an effective rate of 94.3%. Recurrence rate was 3.2%, and the ineffective rate was 2.6%. The most frequent complication was hearing dysfunction (2.8%). Conclusions MVD is the most definitive treatment method of HFS. The key procedures of this operation include adequate exposure of the REZ, identification of the offending vessels, and proper positioning of Teflon grafts. Complications can be reduced effectively by utilizing a real-time AEP monitoring during the operation. | YUANYue WANGYan ZHANGSi-xun ZHANGLi LIRui GUOJing | 2005 | Chinese Medical Journal2005，，10： | 36 |
| 2 | Climate change, water resources and sustainable development in the arid and semi-arid lands of Central Asia in the past 30 years显示文摘The countries of Central Asia are collectively known as the five '-stans': Uzbekistan, Kyrgyzstan, Turkmenistan, Tajikistan and Kazakhstan. In recent times, the Central Asian region has been affected by the shrinkage of the Aral Sea, widespread desertification, soil salinization, biodiversity loss, frequent sand storms, and many other ecological disasters. This paper is a review article based upon the collection, identification and collation of previous studies of environmental changes and regional developments in Central Asia in the past 30 years. Most recent studies have reached a consensus that the temperature rise in Central Asia is occurring faster than the global average. This warming trend will not only result in a higher evaporation in the basin oases, but also to a significant retreat of glaciers in the mountainous areas. Water is the key to sustainable development in the arid and semi-arid regions in Central Asia. The uneven distribution, over consumption, and pollution of water resources in Central Asia have caused severe water supply problems, which have been affecting regional harmony and development for the past 30 years. The widespread and significant land use changes in the 1990 s could be used to improve our understanding of natural variability and human interaction in the region. There has been a positive trend of trans-border cooperation among the Central Asian countries in recent years. International attention has grown and research projects have been initiated to provide water and ecosystem protection in Central Asia. However, the agreements that have been reached might not be able to deliver practical action in time to prevent severe ecological disasters. Water management should be based on hydrographic borders and ministries should be able to make timely decisions without political intervention. Fully integrated management of water resources, land use and industrial development is essential in Central Asia. The ecological crisis should provide sufficient motivation to reach a consensus on unified water management throughout the region. | YU Yang PI Yuanyue YU Xiang TA Zhijie SUN Lingxiao Markus DISSE ZENG Fanjiang LI Yaoming CHEN Xi YU Ruide | 2019 | Journal of Arid Land2019，11，1： | 20 |
| 3 | Bio-replicated forming of the biomimetic drag-reducing surfaces in large area based on shark skin显示文摘On the investigation of biomimetic drag-reducing surface, direct replication of the firm scarfskins on low-resistance creatures to form biomimetic drag-reducing surfaces with relatively vivid morphology relative to the living prototype is a new attempt of the bio-replicated forming technology.Taking shark skin as the bio-replication template, the hot embossing method was applied to the microreplication of its outward morphology. Furthermore, the skins were jointed together to form the drag-reducing surface in large area. The results of the resistance measurements in a water tunnel according to the flat-plate sample pieces have shown that the biomimetic shark-skin coating fabricated by the bio-replicated forming method has significant drag reduction effect, and that the drag reduction efficiency reached 8.25% in the test conditions. | HAN Xin ZHANG DeYuan LI Xiang LI YuanYue | 2008 | Chinese Science Bulletin2008，53，10： | 16 |
| 4 | High-precision bio-replication of synthetic drag reduction shark skin显示文摘Nano-long chains were grafted over the replicated micro-grooves of shark skin in a novel attempt to replicate bio-synthetic drag reduction structure with high precision through synthetic bio-replication. Pre-treated shark skin was used as casting template to prepare a flexible female die of silicone rubber by soft die formation. A waterborne epoxy resin was then used to graft long-chains of drag reduction agent and prepare a synthetic drag reduction shark skin with nano-long chain drag reduction interface and lifelike micro-grooves. Replication precision analysis shows that this technology could replicate the complicated three-dimensional morphology of a biological drag reduction surface with high precision. Drag reduction experiments show that the material had an excellent synthetic drag reduction effect, with a maximal drag reduction rate of up to 24.6% over the velocities tested. | ZHANG DeYuan LI YuanYue HAN Xin LI Xiang CHEN HuaWei | 2011 | Chinese Science Bulletin2011，56，9： | 13 |
| 5 | Effect of Amino Acid Residue and Oligosaccharide Chain Chemical Modifications on Spectral and Hemagglutinating Activity of Millettia dielsiana Harms.ex Diels.Lectin显示文摘The effects of modifying the carbohydrate chain and amino acids on the conformation and activity of Millettia dielsiana Harms. ex Diels. lectin (MDL) were studied by hemagglutination, fluorescence and circular dichroism analysis. The modification of tryptophan residues led to a compete loss of hemagglutinating activity; however, the addition of mannose was able to prevent this loss of activity. The results indicate that two tryptophan residues are involved in the carbohydrate-binding site. Modifications of the carboxyl group residues produced an 80% loss of activity, but the presence of mannose protected against the modification. The results suggest that the carboxyl groups of aspartic and glutamic acids are involved in the carbohydrate-binding site of the lectin. However, oxidation of the carbohydrate chain and modification of the histidine and arginine residues did not affect the hemagglutinating activity of MDL. Fluorescence studies of MDL indicate that tryptophan residues are present in a relatively hydrophobic region, and the binding of mannose to MDL could quench tryptophan fluorescence without any change in λmax. The circular dichroism spectrum showed that all of these modifications affected the conformation of the MDL molecule to different extents, except the modification of arginine residues. Fluorescence quenching showed that acrylamide and iodoacetic acids are able to quench 77% and 98% of the fluorescence of tryptophan in MDL, respectively. However, KI produced a barely perceptible effect on the fluorescence of MDL, even when the concentration of I^- was 0.15M. This demonstrates that most of tryptophan residues are located in relatively hydrophobic or negatively charged areas near the surface of the MDL molecule. | ShunGAO JieAN Chuan-FangWU YingGU FangCHEN YuanYU Qia-QingWU Jin-KuBAO | 2005 | Acta Biochimica et Biophysica Sinica2005，37，1： | 11 |
| 6 | Reactive dividing wall column for hydrolysis of methyl acetate:Design and control显示文摘Reactive distillation and dividing wall column distillation are two kinds of effective separation technologies,and their integrated configuration,reactive dividing wall column(RDWC),presents attractive advantages.In this study,the rigorous simulation of RDWC for methyl acetate hydrolysis is performed,and sensitivity analysis is conducted to obtain the minimum reboiler duty.Then a comparison is made between the conventional process and RDWC process,and it shows that 20.1% energy savings can be achieved by RDWC process.In addition,the dynamic characteristic of RDWC is studied and an effective control strategy is proposed.The simple PI control scheme with three temperature loops can obtain reasonable control performance and maintain products at desired purities.It is proved that this RDWC process is an energy efficiency alternative with good controllability. | Lumin Li Lanyi Sun Delian Yang Wang Zhong Yi Zhu Yuanyu Tian | 2016 | Chinese Journal of Chemical Engineering2016，24，10： | 11 |
| 7 | Thickness-dependent patterning of MoS2 sheets with well-oriented triangular pits by heating in air显示文摘自从 MoS2 表的性质对边结构敏感,有常规边或可控制的形状的 Patterning ultrathin MoS2 层正在呼吁。在这个工作,我们介绍了一种简单、有效、控制得好的技术由简单地在空中加热样品与面向井的等边的三角形的坑蚀刻分层的 MoS2 表。各向异性的氧化蚀刻被包围温度和 MoS2 层的数字极大地影响,坑由此随包围温度和 MoS2 层的数字的增加缩放增加。第一原则的计算被执行了解释三角形的坑的形成机制。这种技术把一条其他的大街提供给设计 MoS2 表的结构。 | Haiqing Zhou Fang Yu Yuanyue Liu Xiaolong Zou Chunxiao Cong Caiyu Qiu Ting Yu Zheng Yan Xiaonan Shen Lianfeng Sun Boris I. Yakobson James M. Tour | 2013 | Nano Research2013，6，10： | 9 |
| 8 | Efficient hepatic delivery and protein expression enabled by optimized mRNA and ionizable lipid nanoparticle显示文摘mRNA is a novel class of therapeutic modality that holds great promise in vaccination,protein replacement therapy,cancer immunotherapy,immune cell engineering etc.However,optimization of mRNA molecules and efficient in vivo delivery are quite important but challenging for its broad application.Here we present an ionizable lipid nanoparticle(iLNP)based on iBL0713 lipid for in vitro and in vivo expression of desired proteins using codon-optimized mRNAs.mRNAs encoding luciferase or erythropoietin(EPO)were prepared by in vitro transcription and formulated with proposed iLNP,to form iLP171/mRNA formulations.It was revealed that both luciferase and EPO proteins were successfully expressed by human hepatocellular carcinoma cells and hepatocytes.The maximum amount of protein expression was found at 6 h post-administration.The expression efficiency of EPO with codon-optimized mRNA was significantly higher than that of unoptimized mRNA.Moreover,no toxicity or immunogenicity was observed for these mRNA formulations.Therefore,our study provides a useful and promising platform for mRNA therapeutic development. | Tongren Yang Chunhui Li Xiaoxia Wang Deyao Zhao Mengjie Zhang Huiqing Cao Zicai Liang Haihua Xiao Xing-Jie Liang Yuhua Weng Yuanyu Huang | 2020 | Bioactive Materials2020，5，4： | 7 |
| 9 | Imputation from SNP chip to sequence: a case study in a Chinese indigenous chicken population显示文摘Background: Genome-wide association studies and genomic predictions are thought to be optimized by using whole-genome sequence(WGS) data. However, sequencing thousands of individuals of interest is expensive.Imputation from SNP panels to WGS data is an attractive and less expensive approach to obtain WGS data. The aims of this study were to investigate the accuracy of imputation and to provide insight into the design and execution of genotype imputation.Results: We genotyped 450 chickens with a 600 K SNP array, and sequenced 24 key individuals by whole genome re-sequencing. Accuracy of imputation from putative 60 K and 600 K array data to WGS data was 0.620 and 0.812 for Beagle, and 0.810 and 0.914 for FImpute, respectively. By increasing the sequencing cost from 24 X to 144 X, the imputation accuracy increased from 0.525 to 0.698 for Beagle and from 0.654 to 0.823 for FImpute. With fixed sequence depth(12 X), increasing the number of sequenced animals from 1 to 24, improved accuracy from 0.421 to0.897 for FImpute and from 0.396 to 0.777 for Beagle. Using optimally selected key individuals resulted in a higher imputation accuracy compared with using randomly selected individuals as a reference population for resequencing. With fixed reference population size(24), imputation accuracy increased from 0.654 to 0.875 for FImpute and from 0.512 to 0.762 for Beagle as the sequencing depth increased from 1 X to 12 X. With a given total cost of genotyping, accuracy increased with the size of the reference population for FImpute, but the pattern was not valid for Beagle, which showed the highest accuracy at six fold coverage for the scenarios used in this study.Conclusions: In conclusion, we comprehensively investigated the impacts of several key factors on genotype imputation. Generally, increasing sequencing cost gave a higher imputation accuracy. But with a fixed sequencing cost, the optimal imputation enhance the performance of WGP and GWAS. An optimal imputation strategy should take size of reference population, imputation algorithms, marker density, and population structure of the target population and methods to select key individuals into consideration comprehensively. This work sheds additional light on how to design and execute genotype imputation for livestock populations. | Shaopan Ye Xiaolong Yuan Xiran Lin Ning Gao Yuanyu Luo Zanmou Chen Jiaqi Li Xiquan Zhang Zhe Zhang | 2018 | Journal of Animal Science and Biotechnology2018，9，2： | 6 |
| 10 | Fig fruit ripening is regulated by the interaction between ethylene and abscisic acid显示文摘Fleshy fruit ripening is typically regulated by ethylene in climacteric fruits and abscisic acid(ABA)in non-climacteric fruits.Common fig(Ficus carica)shows a dual-ripening mechanism,which is not fully understood.Here,we detected separate peaks of ethylene and ABA in fig fruits at the onset-and onripening stages,in conjunction with a sharp rise in glucose and fructose contents.In a newly-designed split-fruit system,exogenous ethylene failed to rescue fluridone-inhibited fruit ripening,whereas exogenous ABA rescued 2-amino-ethoxy-vinyl glycine(AVG)-inhibited fruit ripening.Transcriptome analysis revealed changes in the expression of genes key to both ABA and ethylene biosynthesis and perception during fig fruit ripening.At the degreening stage,downregulation of FcACO2 or FcPYL8 retarded ripening,but downregulation of FcETR1/2 did not;unexpectedly,downregulation of FcAAO3 promoted ripening,but it inhibited ripening only before the de-greening stage.Furthermore,we detected an increase in ethylene emissions in the FcAAO3-RNAi ripening fruit and a decrease in ABA levels in the FcACO2-RNAi unripening fruit.Importantly,FcPYL8 can bind to ABA,suggesting that it functions as an ABA receptor.Our findings support the hypothesis that ethylene regulates the fig fruit ripening in an ABA-dependent manner.We propose a model for the role of the ABA-ethylene interaction in climacteric/non-climacteric processes. | Han Qiao Han Zhang Zhun Wang Yuanyue Shen | 2021 | Journal of Integrative Plant Biology2021，63，3： | 5 |
| 11 | Therapeutic siRNA:state of the art显示文摘RNA interference(RNAi)is an ancient biological mechanism used to defend against external invasion.It theoretically can silence any disease-related genes in a sequence-specific manner,making small interfering RNA(siRNA)a promising therapeutic modality.After a two-decade journey from its discovery,two approvals of siRNA therapeutics,ONPATTRO®(patisiran)and GIVLAARI™(givosiran),have been achieved by Alnylam Pharmaceuticals.Reviewing the long-term pharmaceutical history of human beings,siRNA therapy currently has set up an extraordinary milestone,as it has already changed and will continue to change the treatment and management of human diseases.It can be administered quarterly,even twice-yearly,to achieve therapeutic effects,which is not the case for small molecules and antibodies.The drug development process was extremely hard,aiming to surmount complex obstacles,such as how to efficiently and safely deliver siRNAs to desired tissues and cells and how to enhance the performance of siRNAs with respect to their activity,stability,specificity and potential off-target effects.In this review,the evolution of siRNA chemical modifications and their biomedical performance are comprehensively reviewed.All clinically explored and commercialized siRNA delivery platforms,including the GalNAc(N-acetylgalactosamine)–siRNA conjugate,and their fundamental design principles are thoroughly discussed.The latest progress in siRNA therapeutic development is also summarized.This review provides a comprehensive view and roadmap for general readers working in the field. | Bo Hu Liping Zhong Yuhua Weng Ling Peng Yuanyu Huang Yongxiang Zhao Xing-Jie Liang | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 4 |
| 12 | Advances of mRNA vaccines for COVID-19:A new prophylactic revolution begins显示文摘The world is in the midst of 2019 coronavirus infection disease(COVID-19)pandemic.As of 30 January 2021,more than 100 million cases and 2.1 million deaths were confirmed according to the data from the World Health Organization(WHO),resulting in a widespread social and economic turmoil.Therefore,researches worldwide are racing to deploy safe and effective COVID-19 vaccines. | Yuhua Weng Yuanyu Huang | 2021 | Asian Journal of Pharmaceutical Sciences2021，16，3： | 3 |
| 13 | High Energy X-ray Telescope Data Analysis Method显示文摘The science analysis of the data from the High Energy X-ray Telescope(HE) on the Hard X-ray Modulation Telescope(HXMT) satellite is organized in three stages:calibration,screening and extraction of high-level scientific products.At the first stage,the raw PHA value of each event is converted to PI value accounting for temporal changes in gain and energy offset.At the second stage,the calibrated events are screened by applying cleaning criteria.At the third stage,scientific products,i.e.spectra,light curves and redistribution matrix files,are extracted.This work will introduce the three stages as well as the screening criteria and the data combining method. | ZHAO Haisheng LI Chengkui LI Xiaobo NIE Jianyin GE Mingyu PAN Yuanyue SONG Liming | 2016 | 空间科学学报2016，36，6： | 3 |
| 14 | ^(131)I-Evans blue: evaluation of necrosis targeting property and preliminary assessment of the mechanism in animal models显示文摘Necrosis is a form of cell death, which is related to various serious diseases such as cardiovascular disease, cancer, and neurodegeneration. Necrosis-avid agents(NAAs) selectively accumulated in the necrotic tissues can be used for imaging and/or therapy of related diseases. The aim of this study was to preliminarily investigate necrosis avidity of ^(131)I-evans blue( ^(131)I-EB) and its mechanism. The biodistribution of ^(131)I-EB at 24 h after intravenous administration showed that the radioactivity ratio of necrotic to viable tissue was 3.41 in the liver and 11.82 in the muscle as determined by γ counting in model rats. Autoradiography and histological staining displayed preferential uptake of ^(131)I-EB in necrotic tissues. In vitro nuclear extracts from necrotic cells exhibited 82.3% of the uptake in nuclei at 15 min, as well as 79.2% of the uptake at 2 h after ^(131)I-EB incubation. The DNA binding study demonstrated that evans blue(EB) has strong binding affinity with calf-thymus DNA(CT-DNA)(K_(sv)= 5.08×10~5 L/(mol/L)). Furthermore,the accumulation of ^(131)I-EB in necrotic muscle was efficiently blocked by an excess amount of unlabeled EB.In conclusion, ^(131)I-EB can not only detect necrosis by binding the DNA released from necrotic cells, but also image necrotic tissues generated from the disease clinically. | Qiaomei Jin Xin Shan Qi Luo Dongjian Zhang Yuanyu Zhao Nan Yao Fei Peng Dejian Huang Zhiqi Yin Wei Liu Jian Zhang | 2018 | Acta Pharmaceutica Sinica B2018，8，3： | 3 |
| 15 | Optimization and Control of Extractive Distillation with Heat Integration for Separating Benzene/Cyclohexane Mixtures显示文摘In this work, the extractive distillation with heat integration process is extended to separate the pressure-insensitive benzene-cyclohexane azeotrope by using furfural as the entrainer. The optimal design of extractive distillation process is established to achieve minimum energy requirement using the multi-objective genetic algorithm, and the results show that energy saving for this heat integration process is 15.7%. Finally, the control design is performed to investigate the system's dynamic performance, and three control structures are studied. The pressure-compensated temperature control scheme is proposed based on the first two control structures, and the dynamic responses reveal that the feed disturbances in both flow rate and benzene composition can be mitigated well. | Li Lumin Tu Yangqin Guo Lianjie Sun Lanyi Tian Yuanyu | 2016 | China Petroleum Processing & Petrochemical Technology2016，18，4： | 3 |
| 16 | Recent progress of green sorbents-based technologies for low concentration CO_(2) capture显示文摘The increased concentration of CO_(2) due to continuous breathing and no discharge of human beings in the manned closed space,like spacecraft and submarines,can be a threat to health and safety.Effective removal of low concentration CO_(2) from the manned closed space is essential to meet the requirements of long-term space or deep-sea exploration,which is an international frontier and trend.Ionic liquids(ILs),as a widespread and green solvent,already showed its excellent performance on CO_(2) capture and absorption,indicating its potential application in low concentration CO_(2) capture.In this review,we first summarized the current methods and strategies for direct capture from low concentration CO_(2) in both the atmosphere and manned closed spaces.Then,the multi-scale simulation methods of CO_(2) capture by ionic liquids are described in detail,including screening ionic liquids by COSMO-RS methods,capture mechanism by density functional theory and molecular dynamics simulation,and absorption process by computational fluid dynamics simulation.Lastly,some typical IL-based green technologies for low concentration CO_(2) capture,such as functionalized ILs,co-solvent systems with ILs,and supported materials based on ILs,are introduced,and analyzed the subtle possibility in manned closed spaces.Finally,we look forward to the technology and development of low concentration CO_(2) capture,which can meet the needs of human survival in closed space and proposed that supported materials with ionic liquids have great advantages and infinite possibilities in the vital area. | Yuanyue Zhao Yihui Dong Yandong Guo Feng Huo Fang Yan Hongyan He | 2021 | Chinese Journal of Chemical Engineering2021，34，3： | 3 |
| 17 | Design and Control of Self-Heat Recuperative Distillation Process for Separation of Close-Boiling Mixtures: n-Butanol and iso-Butanol显示文摘In order to explore the advantages of self-heat recuperative distillation(SHRD) process, the design and control of the SHRD process was studied for the separation of n-butanol and iso-butanol mixtures. The economic superiority of SHRD process is presented when a comparison on the total annual cost(TAC) of the conventional distillation process, the vapor recompression distillation process and the SHRD process was made. For the SHRD process, 37.74% and 11.35% savings of TAC can be achieved as compared to the conventional distillation process and vapor recompression distillation process, respectively. The dynamic characteristics of this promising SHRD sequence had been studied, and the dynamic responses demonstrated that 10% changes in both feed flow rate and feed composition can be well handled by the control strategy with dual-temperature control. It is proven that the SHRD system not only can provide economical savings but also can operate normally with good controllability. | Li Lumin Liu Yuliang Zhai Jian Sun Lanyi Tian Yuanyu | 2015 | China Petroleum Processing & Petrochemical Technology2015，17，4： | 3 |
| 18 | Overexpression of the CmJAZ1-like gene delays flowering in Chrysanthemum morifolium显示文摘Chrysanthemum(Chrysanthemum morifolium)is one of the four major cut-flower plants worldwide and possesses both high ornamental value and cultural connotation.As most chrysanthemum varieties flower in autumn,it is costly to achieve annual production.JAZ genes in the TIFY family are core components of the jasmonic acid(JA)signaling pathway;in addition to playing a pivotal role in plant responses to defense,they are also widely implicated in regulating plant development processes.Here,we characterized the TIFY family gene CmJAZ1-like from the chrysanthemum cultivar‘Jinba’.CmJAZ1-like localizes in the nucleus and has no transcriptional activity in yeast.Tissue expression pattern analysis indicated that CmJAZ1-like was most active in the root and shoot apex.Overexpressing CmJAZ1-like with Jas domain deletion in chrysanthemum resulted in late flowering.RNA-Seq analysis of the overexpression lines revealed some differentially expressed genes(DEGs)involved in flowering,such as the homologs of the flowering integrators FT and SOC1,an FUL homolog involved in flower meristem identity,AP2 domain-containing transcription factors,MADS box genes,and autonomous pathway-related genes.Based on KEGG pathway enrichment analysis,the differentially transcribed genes were enriched in carbohydrate metabolic and fatty acid-related pathways,which are notable for their role in flowering in plants.This study preliminarily verified the function of CmJAZ1-like in chrysanthemum flowering,and the results can be used in molecular breeding programs aimed at flowering time regulation of chrysanthemum. | Yunxiao Guan Lian Ding Jiafu Jiang Yuanyue Shentu Wenqian Zhao Kunkun Zhao Xue Zhang Aiping Song Sumei Chen Fadi Chen | 2021 | Horticulture Research2021，8，1： | 3 |
| 19 | Design and Control of Thermally Coupled Reactive Distillation Sequence for Biodiesel Production显示文摘Decreasing petroleum reserves and growing alternative fuels requirements have promoted the study of biodiesel production. In this work, two thermally coupled reactive distillation designs for biodiesel production were investigated, and the sensitivity analysis was conducted to obtain the appropriate design values. The thermodynamic analysis and economics evaluation were performed to estimate the superiority of the thermally coupled designs over the base case. The proposed biodiesel production processes were simulated using the simulator Aspen Plus, and calculation results show that the exergy loss and economic cost in the two thermally coupled designs can be greatly reduced. It is found that the thermally coupled side-stripper reactive distillation design provides more economic benefits than the side-rectifier one. The dynamic performance of the thermally coupled side-stripper design was investigated and the results showed that the proposed control structure could effectively handle large feed disturbances. | Li Lumin Sun Lanyi Xie Xu Tian Yanan Shang Jianlong Tian Yuanyu | 2016 | China Petroleum Processing & Petrochemical Technology2016，18，2： | 2 |
| 20 | Shear-responsive peptide/siRNA complexes as lung-targeting gene vectors显示文摘Particles administrated intravenously will pass through the pulmonary capillary network before being distributed to the body.Therefore,fabrication of vectors sensitive to blood shear and active with blood components should be a practical approach to develop lung-targe ting gene carriers self-regulated by circulatory system.In this work,we designed a series of cationic peptides with the same charge density but varying hydrophobicity and capacity to form hydrogen bonds,and investigated their ability to form co mplexes with siRNA,the behaviours of peptide/siRNA complexes in the presence of serum under shear,and the lung-targeting efficacy of the complexes regulated by blood.The hydrophobic interaction co ntrols the complexation between peptide and siRNA,while the hydrogen bonds are responsible for the binding of peptides to the serum components in blood.In vivo tests show that all the peptide/siRNA complexes can accumulate in lung.However,only the complexes that exhibit weak interaction with serum components and can be broken down by shear avoid the inflammation and death caused by pulmonary embolism.Moreover,the peptide with strong hydrophobicity can retain siRNA in lung without early release of the cargo.Our study provides a step toward the development of adaptive gene carriers under the regulation of circulatory system. | Dongxiao Yin Mengjie Zhang Jiaxin Chen Yuanyu Huang Dehai Liang | 2021 | Chinese Chemical Letters2021，32，5： | 2 |
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