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| 1 | Metal-Organic Framework Nanocarriers for Drug Delivery in Biomedical Applications显示文摘Investigation of metal–organic frameworks(MOFs)for biomedical applications has attracted much attention in recent years.MOFs are regarded as a promising class of nanocarriers for drug delivery owing to well-defined structure,ultrahigh surface area and porosity,tunable pore size,and easy chemical functionalization.In this review,the unique properties of MOFs and their advantages as nanocarriers for drug delivery in biomedical applications were discussed in the first section.Then,state-ofthe-art strategies to functionalize MOFs with therapeutic agents were summarized,including surface adsorption,pore encapsulation,covalent binding,and functional molecules as building blocks.In the third section,the most recent biological applications of MOFs for intracellular delivery of drugs,proteins,and nucleic acids,especially aptamers,were presented.Finally,challenges and prospects were comprehensively discussed to provide context for future development of MOFs as efficient drug delivery systems. | Yujia Sun Liwei Zheng Yu Yang Xu Qian Ting Fu Xiaowei Li Zunyi Yang He Yan Cheng Cui Weihong Tan | 2020 | Nano-Micro Letters2020，12，8： | 10 |
| 2 | Fura-2/AM法测定突触体内游离Ca^(2+)浓度的方法显示文摘采用新型Ca2+荧光指示剂Fura-2,测定冷冻伤性脑水肿时突触体内游离钙的离子浓度。 | Chen Liuhua Yan Yujia He Zhengwen, et al(Neurological and Neurosurgical Institute of Ncurosurgery, Xiangya Hospital, Hunan Medical University, Changsha 410008) | 1998 | 湖南医科大学学报1998，23，4： | 9 |
| 3 | Significance and expression of Bax, Survivin and p53 in gastric carcinoma and precancerous lesions using tissue microarray显示文摘Objective: To explore the relationship between expressions of apoptosis-related protein Bax, Survivin and p53 and the molecular mechanisms of carcinogenesis and progression of gastric carcinoma. Methods: Tissue microarray and immunohistochemistry were used in this study. Results: The positive rate of Bax protein in gastric cancer (17.7%,17/96) was significantly lower than those in adjacent normal mucosa (51%), intestinal metaplasia (69.2%) and dysplasia (75%), P < 0.01. The positive rate of Survivin expression in gastric cancer (80.6%, 89/98) was significantly higher than that in adjacent normal mucosa (3.9%), P < 0.01. The positive rates of Survivin expression in tumors with different organ metastases (in lymph node metastasis 86.2%, liver 100% and ovarian 100%) were statistically higher than in tumors without metastasis (64.3%), P < 0.05. Bax expression was correlated with Survivin but not with mp53 that was closely related to Survivin expression (P < 0.05) in gastric cancer. Conclusion: The abnormal expressions of Bax, Survivin and mp53 were correlated with the tumorigenesis and progression of gastric carcinoma. P53 and Survivin genes may share the similar mechanism in regulating cell apoptosis, and because of the mutation, p53 gene may lower its down-regulation to Survivin expression. | Yuping Xiao Zhi Lin Lili Mao Dongying Wu Yujia Gao Hongwei Sun Yan Xin | 2007 | The Chinese-German Journal of Clinical Oncology2007，6，4： | 5 |
| 4 | Peniazaphilones A—I,Produced by Co-culturing of Mangrove Endophytic Fungi,Penicillium sclerotiorum THSH-4 and Penicillium sclerotiorum ZJHJJ-18显示文摘Co-culturing the mangrove endophytic fungus Penicillium sclerotiorum THSH-4 with Penicillium sclerotiorum ZJHJJ-18 in PDB medium resulted in the production of nine new azaphilones derivatives,peniazaphilones A—I(1-9),and six known azaphilones derivatives(10-15).Their structures were elucidated by analysis of detailed spectroscopic data,single-crystal X-ray diffraction,ECD spectra,^(13)C NMR calculation and DP4+analysis.It is noteworthy that compound 1 with an isoquinoline quinone moiety,was isolated from natural source for the first time.Besides,compound 2 is the third reported phenylhydrazone derivative from fungi.In the bioactivity assays,compounds 1,12,14 and 15(IC_(50)=4.71-17.64μmol/L)exhibited potent inhibition of LPS-induced NO release from RAW264.7 without obvious cytotoxicity within 50μmol/L compared to the positive control indomethacin(IC_(50)=35.27μmol/L).Moreover,compounds 1 and 13 displayed moderate to strong cytotoxicity to A549 and MDA-MB-435,with IC_(50) values in the range of 6.84-14.63μmol/L.Together compound 1 showed moderate broad-spectrum antibacterial activity. | Wencong Yang Jie Yuan Qi Tan Yan Chen Yujia Zhu Hongming Jiang Ge Zou Zhenming Zang Bo Wang Zhigang She | 2021 | Chinese Journal of Chemistry2021，39，12： | 3 |
| 5 | Identification and characterization of soybean dreg soluble dietary fibre by combination of extrusion pre-treatment and enzymatic modification显示文摘OBJECTIVES:Soybean dreg is a by-product of soy milk processing,which contains high levels of soluble dietary fibre(SDF).In this study,we aimed to provide comprehensive processes of pre-treated extrusion for the improving structure and properties of soybean dreg soluble dietary fibre(SDSDF),which would be a valuable approach to enhance physiological activity.METHODS:Here,we characteristic the functional role of SDSDF employing to extrusion pretreatment.Soybean dregs were pre-treated using the twin screw extrusion method followed by enzymatic modification using neutral protease,α-amylase,glucoamylase,and cellulose to produce SDSDF.The physical properties and antioxidant activity of SDSDF were investigated.RESULTS:The morphology and crystal structure of SDSDF were observed that,through extrusion processing and enzymatic modification,the SDSDF yield increased by 106.28%.Moreover,the surface structure showed block-shaped or reticular formations in the extruded SDSDF,and the size of block-shaped cells was about 10μm.Infrared spectroscopic analysis showed that a characteristic absorption peak of polysaccharide appeared at 1631 cm−1 during extrusion processing.However,after extrusion processing,decreased absorption peaks were observed for the extruded SDSDF.Furthermore,XRD analysis showed that the 2θdiffraction peak changed at 24.16°for the extruded SDSDF.CONCLUSIONS:The overall findings suggest that the water holding capacity(WHC),oil holding capacity(OHC),expansibility,and the water solubility were significantly decreased in extruded SDSDF.In addition,the scavenging ability of 1,1-diphenyl-2-picrylhydrazyl(DPPH),-OH,O_(2)^(-),and the total reducing power were significantly improved,indicating that beneficial changes had taken place in the crystal structure of cellulose or hemicellulose to improve the physiological activity in extruded SDSDF. | Min Qu Yujia Liu Guang Zhang Sophia Jun Xue Hongchen Fan Yan Wang Shiyou Yu | 2017 | Food Quality and Safety2017，1，2： | 3 |
| 6 | Visualization of Film Wavelike Characteristics and Measurement of Film Thickness in Spray Cooling显示文摘An experimental investigation was performed to study the heat transfer in an eight-nozzle spray cooling system with de-ionized water as the working fluid. Visualization of the liquid-solid contact area and the flow near the heated surface was made using a microscopic lens system in conjunction with an advanced high-speed camera. The film thickness and film wavelike characteristics under liquid volume flow rates ranged from 2.78×10 -6 m 3 /s to 1.39×10 -5 m 3 /s and surface temperatures between 22℃ and 78.2℃ were examined respectively. The development process of the liquid film on the heated surface was observed. The local mean film thickness, the film wavelike characteristics and the behavior of the bubbles appeared in the liquid film were captured using an image processing technique. It is discovered that there exists a climax of local mean film thickness during the starting process of spray cooling. When the liquid film reaches the dynamic stable state, the dimensionless mean film thickness decreases with the increase of the liquid volume flow rate, and increases with the increase of surface temperature generally. Besides, the volume flow rate has a more significant impact on the wavelength and amplitude of the liquid film compared to the surface temperature. | Yan Hou Yujia Tao Xiulan Huai | 2013 | Journal of Thermal Science2013，22，2： | 3 |
| 7 | Time-slot multiplexing based bandwidth enhancement for fiber distributed acoustic sensing显示文摘Dear editor,The phase-sensitive optical time-domain reflectometry(φ-OTDR)has been demonstrated as the most common technique in fiber distributed acoustic sensing(DAS).However,traditional φ-OTDR based DAS suffered from the inherent trade-off between the maximum frequency response and the distance which can be characterized by distance bandwidth product(DBP),since the time interval of the probe pulses should be larger than the pulse round-trip flight time. | Hao LI Cunzheng FAN Tao LIU Yujia LIU Zhijun YAN Perry SHUM Qizhen SUN | 2022 | Science China(Information Sciences)2022，65，1： | 2 |
| 8 | A novel series of histone deacetylase inhibitors incorporating hetero aromatic ring systems as connection units显示文摘 | Yujia D Yan G Michael L | 2003 | Bioorg Med Chem Lett2003，13，21： | 1 |
| 9 | Constructions of ROS-responsive titanium-hydroxyapatite implant for mesenchymal stem cell recruitment in peri-implant space and bone formation in osteoporosis microenvironment显示文摘To solve the issue of unsatisfactory recruitment of mesenchymal stem cells(MSCs)around implant in osteoporotic fractures,we fabricated a ROS-responsive system on titanium surface through hydroxyapatite coating and biomolecule grafting.The porous hydroxyapatite and phosphorylated osteogenic growth peptides(p-OGP)were introduced onto titanium surface to synergistically improve osteogenic differentiation of MSCs.After the p-OGPpromoted expression of osteogenic related proteins,the calcium and phosphate ions were released through the degradation of hydroxyapatite and integrated into bone tissues to boost the mineralization of bone matrix.The ROS-triggered release of DNA aptamer(Apt)19S in the osteoporotic microenvironment guides MSC migration to implant site due to its high affinity with alkaline phosphatase on the membrane of MSCs.Once MSCs reached the implant interface,their osteogenic differentiation potential was enhanced by p-OGP and hydroxyapatite to promote bone regeneration.The study here provided a simple and novel strategy to prepare functional titanium implants for osteoporotic bone fracture repair. | Maohua Chen Yuting Sun Yanhua Hou Zhong Luo Menghuan Li Yujia Wei Maowen Chen Lu Tan Kaiyong Cai Yan Hu | 2022 | Bioactive Materials2022，7，12： | 1 |
| 10 | Genetic modification of miR-34a enhances efficacy of transplanted human dental pulp stem cells after ischemic stroke显示文摘Human dental pulp stem cells(hDPSCs) promote recovery after ischemic stro ke;however,the therapeutic efficacy is limited by the poor survival of transplanted cells.For in vitro expe riments in the present study,we used oxygen-glucose deprivation/reoxygenation in hDPSCs to mimic cell damage induced by ischemia/reperfusion.We found that miRNA-34a-5p(miR-34a) was elevated under oxygen-glucose deprivation/reoxygenation conditions in hDPSCs.Inhibition of miR-34a facilitated the prolife ration and antioxidant capacity and reduced the apoptosis of hDPSCs.Moreove r,dual-luciferase reporter gene assay showed WNT1and SIRT1 as the targets of miR-34a.In miR-34a knockdown cell lines,WNT1 suppression reduced cell prolife ration,and SIRT1 suppression decreased the antioxidant capacity.Togethe r,these results indicated that miR-34a regulates cell prolife ration and antioxidant stress via targeting WNT1 and SIRT1,respectively.For in vivo expe riments,we injected genetically modified hDPSCs(anti34a-hDPSCs) into the brains of mice.We found that anti34a-hDPSCs significantly inhibited apoptosis,reduced cerebral edema and cerebral infarct volume,and improved motor function in mice.This study provides new insights into the molecular mechanism of the cell prolife ration and antioxidant capacity of hDPSCs,and suggests a potential gene that can be targeted to improve the survival rate and efficacy of transplanted hDPSCs in brain after ischemic stroke. | Jianfeng Wang Peibang He Qi Tian Yu Luo Yan He Chengli Liu Pian Gong Yujia Guo Qingsong Ye Mingchang Li | 2023 | Neural Regeneration Research2023，18，9： | 1 |
| 11 | Upregulation of SATB 1 promotes tumor growth and metastasis in liver cancer显示文摘 | Wei Tu Min Luo Zhijun Wang Wei Yan Yujia Xia Huan Deng Jiayi He Ping Han Dean Tian | 2012 | Liver Int2012，，7： | 1 |
| 12 | Comparative study of different electrochemical methods for petroleum refinery wastewater treatment显示文摘 | Long Yan Yufei Wang Jian Li Hongzhu Ma Huijin Liu Te Li Yujia Zhang | 2014 | Desalination2014，，： | 1 |
| 13 | Assessing the product quality and biological activities of barley(Hordeum vulgare L.)grasses at different harvest times显示文摘Barley(Hordeum vulgare L.)grasses(BG)have attracted considerable interest due to their multiple physiological activities and health benefits.In this paper,eight BG at four different growth stages were collected:seedling,tillering,stem elongation,and heading,and their product qualities and biological activities were examined and studied.Results demonstrated that harvest time obviously influenced proximate composition,surface color,and amino acid profile.Z21 and Z23 harvested at the seedling and early tillering stages,respectively,had higher total phenolic content(TPC)and total flavonoid content(TFC)than the other BG.Moreover,Z21 and Z23 possessed better DPPH radical-scavenging ability,antioxidant capacity,andα-glucosidase inhibitory activity,which were positively correlated with TPC,TFC,and protein and total amino acid contents.Our findings suggested that the early tillering stages were the preferable harvest times for BG with good product quality and biological properties. | Jing-Kun Yan Ting-Ting Chen Xu Chen Yujia Liu Chenghong Liu Lin Li | 2022 | Food Bioscience2022，46，2： | 0 |
| 14 | Superelastic Radiative Cooling Metafabric for Comfortable Epidermal Electrophysiological Monitoring显示文摘Epidermal electronics with superb passive-cooling capabilities are of great value for both daytime outdoor dressing comfort and low-carbon economy. Herein, a multifunctional and skinattachable electronic is rationally developed on a porous all-elastomer metafabric for efficient passive daytime radiative cooling(PDRC) and human electrophysiological monitoring. The cooling characteristics are realized through the homogeneous impregnation of polytetrafluoroethylene microparticles in the styrene–ethylene–butylene–styrene fibers, and the rational regulation of microporosity in SEBS/PTFE metafabrics, thus synergistically backscatter ultraviolet–visible–near-infrared light(maximum reflectance over 98.0%) to minimize heat absorption while efficiently emit human-body midinfrared radiation to the sky. As a result, the developed PDRC metafabric achieves approximately 17℃ cooling effects in an outdoor daytime environment and completely retains its passive cooling performance even under 50% stretching. Further, high-fidelity electrophysiological monitoring capability is also implemented in the breathable and skin-conformal metafabric through liquid metal printing, enabling the accurate acquisition of human electrocardiograph, surface electromyogram, and electroencephalograph signals for comfortable and lengthy health regulation. Hence, the fabricated superelastic PDRC metafabric opens a new avenue for the development of body-comfortable electronics and low-carbon wearing technologies. | Jiancheng Dong Yidong Peng Yiting Zhang Yujia Chai Jiayan Long Yuxi Zhang Yan Zhao Yunpeng Huang Tianxi Liu | 2023 | Nano-Micro Letters2023，15，10： | 0 |
| 15 | China's Economic Growth:The“Two-Dimensional Driving Effect”of Data Factors显示文摘Data factors have become one of the five essential production factors,but their role in economic growth has always been ambiguous.Starting from AI technologies,this paper establishes an endogenous growth model of data factors affecting economic growth,constructs the generation path and value path of data factors,and estimates the value of new data factors at the provincial level in China from 1999 to 2018 accordingly.Based on theoretical analyses and empirical tests,it clarifes that data factors have a“two-dimensional driving effect”on China's economic growth,that is,data factors can drive growth both directly through its own economic growth effect and indirectly by promoting technological progress.Furthermore,this paper makes three extended discussions,aiming to make a trial study on the impacts of local government big data transaction platforms on data factors and their growth effects,discuss whether it is possible to reduce the uncertainties of local economic policy based on the nature of data factors,and make a preliminary survey of the output elasticity of data factors between 1999 and 2018. | Yan Yang Li Wang Yujia Li Zujun Liao | 2023 | China Finance and Economic Review2023，12，4： | 0 |
| 16 | High-resolution,multi-frequency and full-polarization radar database of small and group targets in clutter environment显示文摘Detection of small low-altitude targets such as drone swarms,migrating insects and birds is crucial for both military and civilian applications[1].There exist two main challenges which significantly affect the radar detection and tracking performance.Firstly,weak echo signals of small targets will be buried in strong ground clutter and rain clutter[2]. | Cheng HU Yujia YAN Rui WANG Qi JIANG Jiong CAI Weidong LI | 2023 | Science China(Information Sciences)2023，66，12： | 0 |
| 17 | QpefBD:A Benchmark Dataset Applied to Machine Learning for Minute-Scale Quantitative Precipitation Estimation and Forecasting显示文摘Nowcasts of strong convective precipitation and radar-based quantitative precipitation estimations have always been hot yet challenging issues in meteorological sciences.Data-driven machine learning,especially deep learning,provides a new technical approach for the quantitative estimation and forecasting of precipitation.A high-quality,large-sample,and labeled training dataset is critical for the successful application of machine-learning technology to a specific field.The present study develops a benchmark dataset that can be applied to machine learning for minutescale quantitative precipitation estimation and forecasting(QpefBD),containing 231,978 samples of 3185 heavy precipitation events that occurred in 6 provinces of central and eastern China from April to October 2016-2018.Each individual sample consists of 8 products of weather radars at 6-min intervals within the time window of the corresponding event and products of 27 physical quantities at hourly intervals that describe the atmospheric dynamic and thermodynamic conditions.Two data labels,i.e.,ground precipitation intensity and areal coverage of heavy precipitation at 6-min intervals,are also included.The present study describes the basic components of the dataset and data processing and provides metrics for the evaluation of model performance on precipitation estimation and forecasting.Based on these evaluation metrics,some simple and commonly used methods are applied to evaluate precipitation estimates and forecasts.The results can serve as the benchmark reference for the performance evaluation of machine learning models using this dataset.This paper also gives some suggestions and scenarios of the QpefBD application.We believe that the application of this benchmark dataset will promote interdisciplinary collaboration between meteorological sciences and artificial intelligence sciences,providing a new way for the identification and forecast of heavy precipitation. | Anyuan XIONG Na LIU Yujia LIU Shulin ZHI Linlin WU Yongjian XIN Yan SHI Yunjian ZHAN | 2022 | Journal of Meteorological Research2022，36，1： | 0 |
| 18 | Deletion of Gab2 in mice protects against hepatic steatosis and steatohepatitis:a novel therapeutic target for fatty liver disease显示文摘Fatty liver disease is a serious health problem worldwide and is the most common cause for chronic liver disease and metabolic disorders.The major challenge in the prevention and intervention of this disease is the incomplete understanding of the underlying mechanism and thus lack of potent therapeutic targets due to multifaceted and interdependent disease factors.In this study,we investigated the role of a signaling adaptor protein,GRB2-associated-binding protein 2(Gab2),in fatty liver using an animal disease model.Gab2 expression in hepatocytes responded to various disease factor stimulations,and Gab2 knockout mice exhibited resistance to fat-induced obesity,fat-or alcohol-stimulated hepatic steatosis,as well as methionine and choline deficiency-induced steatohepatitis.Concordantly,the forced expression or knockdown of Gab2 enhanced or diminished oleic acid(OA)-or ethanol-induced lipid production in hepatocytes in vitro,respectively.During lipid accumulation in hepatocytes,both fat and alcohol induced the recruitment of PI3K or Socs3 by Gab2 and the activation of their downstream signaling proteins AKT,ERK,and Stat3.Therefore,Gab2 may be a disease-associated protein that is induced by pathogenic factors to amplify and coordinate multifactor-induced signals to govern disease development in the liver.Our research provides a novel potential target for the prevention and intervention of fatty liver disease. | Shuai Chen Yujia Kang Yan Sun Yanhong Zhong Yanli Li Lijuan Deng Jin Tao Yang Li Yingpu Tian Yinan Zhao Jianghong Cheng Wenjie Liu Gen-Sheng Feng Zhongxian Lu | 2016 | Journal of Molecular Cell Biology2016，8，6： | 0 |
| 19 | Low-Dose CT Image Denoising Based on Improved WGAN-gp显示文摘In order to improve the quality of low-dose computational tomography (CT)images, the paper proposes an improved image denoising approach based on WGAN-gpwith Wasserstein distance. For improving the training and the convergence efficiency, thegiven method introduces the gradient penalty term to WGAN network. The novelperceptual loss is introduced to make the texture information of the low-dose imagessensitive to the diagnostician eye. The experimental results show that compared with thestate-of-art methods, the time complexity is reduced, and the visual quality of low-doseCT images is significantly improved. | Xiaoli Li Chao Ye Yujia Yan Zhenlong Du | 2019 | Journal of New Media2019，1，2： | 0 |
| 20 | Complexation between NBR and Zinc Chloride显示文摘1 Results Complexation between polymer and metal cation is one of the most active and important areas of polymer science,and almost all complexed polymers were obtained in solutions[1-3].However,this method is rather limited to employ in material processing and applications.In our previous work,complexation between nitrile rubber (NBR) and CuSO4 in polymer bulk have been achieved for the first time.In this paper,complexation between NBR and ZnCl2 both in bulk and in solution were studied and the differe... | Yan Li, Hui Li, Yujia Jing, Haiyong Cao, Zhewen Han(School of Material Science and Engineering, East China University of Science and Technology, Shanghai 200237,China) | 2007 | 复旦学报(自然科学版)2007，46，5： | 0 |
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