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| 1 | Data mining-aided materials discovery and optimization显示文摘Recent developments in data mining-aided materials discovery and optimization are reviewed in this paper,and an introduction to the materials data mining(MDM)process is provided using case studies.Both qualitative and quantitative methods in machine learning can be adopted in the MDM process to accomplish different tasks in materials discovery,design,and optimization.State-of-the-art techniques in data mining-aided materials discovery and optimization are demonstrated by reviewing the controllable synthesis of dendritic Co_(3)O_(4) superstructures,materials design of layered double hydroxide,battery materials discovery,and thermoelectric materials design.The results of the case studies indicate that MDM is a powerful approach for use in materials discovery and innovation,and will play an important role in the development of the Materials Genome Initiative and Materials Informatics. | Wencong Lu Ruijuan Xiao Jiong Yang Hong Li Wenqing Zhang | 2017 | Journal of Materiomics2017，3，3： | 11 |
| 2 | Peniazaphilones A—I,Produced by Co-culturing of Mangrove Endophytic Fungi,Penicillium sclerotiorum THSH-4 and Penicillium sclerotiorum ZJHJJ-18显示文摘Co-culturing the mangrove endophytic fungus Penicillium sclerotiorum THSH-4 with Penicillium sclerotiorum ZJHJJ-18 in PDB medium resulted in the production of nine new azaphilones derivatives,peniazaphilones A—I(1-9),and six known azaphilones derivatives(10-15).Their structures were elucidated by analysis of detailed spectroscopic data,single-crystal X-ray diffraction,ECD spectra,^(13)C NMR calculation and DP4+analysis.It is noteworthy that compound 1 with an isoquinoline quinone moiety,was isolated from natural source for the first time.Besides,compound 2 is the third reported phenylhydrazone derivative from fungi.In the bioactivity assays,compounds 1,12,14 and 15(IC_(50)=4.71-17.64μmol/L)exhibited potent inhibition of LPS-induced NO release from RAW264.7 without obvious cytotoxicity within 50μmol/L compared to the positive control indomethacin(IC_(50)=35.27μmol/L).Moreover,compounds 1 and 13 displayed moderate to strong cytotoxicity to A549 and MDA-MB-435,with IC_(50) values in the range of 6.84-14.63μmol/L.Together compound 1 showed moderate broad-spectrum antibacterial activity. | Wencong Yang Jie Yuan Qi Tan Yan Chen Yujia Zhu Hongming Jiang Ge Zou Zhenming Zang Bo Wang Zhigang She | 2021 | Chinese Journal of Chemistry2021，39，12： | 3 |
| 3 | Acetylcholinesterase inhibitors and antioxidants mining from marine fungi:bioassays,bioactivity coupled LC-MS/MS analyses and molecular networking显示文摘Marine fungi are potentially important resources for bioactive lead compounds for discovering new drugs for diseases such as Alzheimer's disease.In this paper,the combined bioassay model of acetylcholinesterase(AChE)inhibition,1,1-diphenyl-2-picrylhydrazyl(DPPH)free radical scavenging,and Artemi ci larval lethality was used to evaluate the activity and toxicity of 35 n narine fun gal strains from seas around China.Their bioactive constitue nfs were revealed by thin layer chromatography(TLC)autography,bioactivity coupled LC-MS/MS and Global Natural Products Social Molecular Networking(GNPS).The results show that the extracts of five strains exhibited higher AChE inhibition ratios than the positive control compound,'tacrine;for which the ratio was 89.8%at 200 pig/ml.Six strains displayed both AChE inhibition(inhibition ratios>20%at 200 pg/ml)and DPPH scavenging activity(scavenging ratios>30%at 200 pg/ml)together with low Artemia larval toxicity(lethal rates<12%).TLC autography showed that the fractioned extracts of four strains contained highly diverse and different bioactive constituents,includi ng strains Talaromyces sp.C2\-\,Aspergillus ter re us C23-3,Trichoderma harzianum DLEN2008005,and Penicillium corylophilum TBG1-17.From the most potent sample F-l 1-1-b(derived from Aspergillus tern us C23-3),five AChE inhibitors and seven antioxida nts were recognized as bioactive molecules by AChE coupled ultrafiltration followed by LC-MS/MS,and LC-MS/MS coupled with DPPH incubation.Furthermore,with the aid of GNPS,the AChE inhibitors were plausibly annotated as territrem analogues including territrems A-C/D,arisugacin A and an unknown compound 4,and the seven antioxidants were assigned as butyrolactone I.aspernolide E,a phenolic derivative and possibly unknown compounds 8-10 and 12. | Yingying Nie Wencong Yang Yayue Liu Jingming Yang Xiaoling Lei William HGerwick Yi Zhang | 2020 | Marine Life Science & Technology2020，2，4： | 2 |
| 4 | S14G-humanin restored cellular homeostasis disturbed by amyloid-beta protein显示文摘Humanin is a potential therapeutic agent for Alzheimer's disease,and its derivative,S14G-humanin,is 1 000-fold stronger in its neuroprotective effect against Alzheimer's disease-relevant insults.Although effective,the detailed molecular mechanism through which S14G-humanin exerts its effects remains unclear.Data from this study showed that fibrillar amyloid-beta 40 disturbed cellular homeostasis through the cell membrane,increasing intracellular calcium,generating reactive oxygen species,and decreasing the mitochondrial membrane potential.S14G-humanin restored these responses.The results suggested that S14G-humanin blocked the effects of amyloid-beta 40 on the neuronal cell membrane,and restored the disturbed cellular homeostasis,thereby exerting a neuroprotective effect on hippocampal neurons. | Xue Li Wencong Zhao Hongqi Yang Junhong Zhang Jianjun Ma | 2013 | Neural Regeneration Research2013，8，27： | 1 |
| 5 | Active learning for the power factor prediction in diamond-like thermoelectric materials显示文摘The Materials Genome Initiative requires the crossing of material calculations,machine learning,and experiments to accelerate the material development process.In recent years,data-based methods have been applied to the thermoelectric field,mostly on the transport properties.In this work,we combined data-driven machine learning and first-principles automated calculations into an active learning loop,in order to predict the p-type power factors(PFs)of diamond-like pnictides and chalcogenides.Our active learning loop contains two procedures(1)based on a high-throughput theoretical database,machine learning methods are employed to select potential candidates and(2)computational verification is applied to these candidates about their transport properties.The verification data will be added into the database to improve the extrapolation abilities of the machine learning models.Different strategies of selecting candidates have been tested,finally the Gradient Boosting Regression model of Query by Committee strategy has the highest extrapolation accuracy(the Pearson R=0.95 on untrained systems).Based on the prediction from the machine learning models,binary pnictides,vacancy,and small atom-containing chalcogenides are predicted to have large PFs.The bonding analysis reveals that the alterations of anionic bonding networks due to small atoms are beneficial to the PFs in these compounds. | Sheng Yasong Wu Jiong Yang Wencong Lu Pierre Villars Wenqing Zhang | 2020 | npj Computational Materials2020，，1： | 1 |
| 6 | Support vector regression based QSPR for the prediction of some physicochemical properties of alkyl benzenes显示文摘 | Yang Shansheng Lu Wencong Chen Nianyi | 2005 | Journal of Molecular Structure:Theochem2005，719，： | 1 |
| 7 | Microstructure and Properties of 3.5 vol.%TiBw/Ti6A14V Composite Tubes Fabricated by Hot-hydrostatic Extrusion显示文摘Tubes of 3.5 vol.%TiB whiskers reinforced Ti6AI4 V matrix composites(TiBw/Ti6AI4V) were successfully fabricated by a two-step hot-hydrostatic extrusion process:β extrusion at 1100 ℃ and subsequent near-βextrusion at 950 ℃.The dimensions of tubes were about 7 mm in diameter and 2 mm in thickness.A refined basket-weave structure in Ti6AI4 V matrix was achieved at ambient temperature after the extrusion process.Besides,the original network structure formed by TiB whiskers synthesized was broken,while the TiB whiskers were preferentially aligned in the extruding direction.Meanwhile,a fibrous texture was evolved finally,resulting from partial dynamic recrystallization during the β extrusion and the involvement of a phase during the near-β extrusion.The tensile and compressive tests results showed that both the strength and ductility of the tubes were significantly improved.In particular,the tubes exhibited good mechanical properties at elevated temperatures. | Wencong Zhang Xueyan Jiao Yang Yu Jianlei Yang Yangju Feng | 2014 | Journal of Materials Science & Technology2014，30，7： | 1 |
| 8 | Effect of slow-release iron fertilizer on iron-deficiency chlorosis, yield and quality of Lilium davidii var.unicolor in a two-year field experiment显示文摘Iron deficiency chlorosis of Lilium davidii var. unicolor is often the case in practice in alkaline soils of northwest region of China. It is difficult to control iron chlorosis because of high cost and short effective work time of conventional iron fertilizers. In this study, a 2-year field experiment was conducted to evaluate the effects of two slow-release fertilizers on the suppression of iron deficiency chlorosis, soil chemical properties, and the yield and quality of L. davidii var. unicolor. Results show that both coated slow-release iron fertilizers and embedded slow-release iron fertilizer effectively controlled iron-deficiency chlorosis. The application of slow-release iron fertilizers significantly increased plant height and chlorophyll content of L. davidii var. unicolor at different growth stages. Furthermore, coated iron fertilizer application significantly increased starch, protein, soluble sugar and vitamin C content of L. davidii var. unicolor, and it also significantly improved total amino acid content, with increases in essential amino acids(Trp, Leu, Lys, Phe, Val, and Thr contents) and in nonessential amino acids(Asp, Glu, Cit, Ihs, Acc, Ala, Pro, and Cys contents). It was concluded that application of coated slow-release iron fertilizer could be a promising option for suppression of iron deficiency chlorosis and deserves further study. | Yang Qiu ZhongKui Xie XinPing Wang YaJun Wang YuBao Zhang YuHui He WenMei Li WenCong Lv | 2018 | Research in Cold and Arid Regions2018，10，5： | 1 |
| 9 | Griseofulvin enantiomers and bromine-containing griseofulvin derivatives with antifungal activity produced by the mangrove endophytic fungus Nigrospora sp.QQYB1显示文摘Marine microorganisms have long been recognized as potential sources for drug discovery.Griseofulvin was one of the first antifungal natural products and has been used as an antifungal agent for decades.In this study,12 new griseofulvin derivatives[(±)-1-2,(+)-3,(±)-4,10-12,and 14-15]and two new griseofulvin natural products(9 and 16)together with six known analogues[(-)-3,5-8,and 13]were isolated from the mangrove-derived fungus Nigrospora sp.QQYB1 treated with 0.3%NaCl or 2%NaBr in rice solid medium.Their 2D structures and absolute configurations were established by extensive spectroscopic analysis(1D and 2D NMR,HRESIMS),ECD spectra,computational calculation,DP4+analysis,and X-ray single-crystal diffraction.Compounds 1-4 represent the first griseofulvin enantiomers with four absolute configurations(2S,6'S;2R,6'R;2S,6'R;2R,6'S),and compounds 9-12 represent the first successful production of brominated griseofulvin derivatives from fungi via the addition of NaBr to the culture medium.In the antifungal assays,compounds 6 and 9 demonstrated significant inhibitory activities against the fungi Colletotrichum truncatum,Microsporum gypseum,and Trichophyton mentagrophyte with inhibition zones varying between 28 and 41 mm(10μg/disc).The structure-activity relationship(SAR)was analyzed,which showed that substituents at C-6,C-7,C-6'and the positions of the carbonyl and double bond of griseofulvin derivatives significantly affected the antifungal activity. | Ge Zou Wencong Yang Tao Chen Zhaoming Liu Yan Chen Taobo Li Gulab Said Bing Sun Bo Wang Zhigang She | 2024 | Marine Life Science & Technology2024，6，1： | 0 |
| 10 | A Rat Model of Autologous Oral Mucosal Epithelial Transplantation for Corneal Limbal Stem Cell Failure显示文摘Purpose: To establish an animal model of autologous oral mucosa grafting for limbal stem cell deficiency.Methods: The study was carried from August to October2012. Fourteen SD rats were randomly and evenly allocated to study group A and control group B. Limbal stem cell deficiency was established by alkali burn in the right eye of each rat in both groups. Rats in group A received autologous oral mucosa strip transplantation following the chemical burn. Rats in group B did not receive surgery after the chemical burn.Topical antibiotics and dexamethasone were used in all rats.Corneal clarity, corneal fluorescein staining, oral mucosal graft survival, and complications at postoperative days 1,3,7,14 were observed.Results: The oral mucosa strip graft was detached in one rat in group A. Reepithelialization was observed starting from the graft position and was completed within 14 days in the remaining 6 eyes in group A. However, persistent corneal epithelium defect was observed in all eyes in group B, among which corneal melting and perforation was observed in 2 eyes and corneal opacification with neovascularization was observed in the remaining 5 eyes.Conclusion: Autologous oral mucosa strip grafting for limbal stem cell deficiency can be achieved by a rat model following chemical burn. The fate of the transplanted oral mucosal epithelial cells warrants further study. | Weihua Li Qiaoli Li Wencong Wang Kaijing Li Shiqi Ling Yuanzhe Yang Lingyi Liang | 2014 | Eye Science2014，29，1： | 0 |
| 11 | Topology change and emergent scale symmetry in compact star matter via gravitational wave detection显示文摘Topological structure has been extensively studied and confirmed in highly correlated condensed matter physics. We explore the gravitational waves emitted from binary neutron star mergers using the pseudoconformal model for dense nuclear matter for compact stars. This model considers the topology change and the possible emergent scale symmetry and satisfies all the constraints from astrophysics. We find that the location of the topology change affects gravitational waves dramatically owing to its effect on the equation of state. In addition, the effect of this location on the waveforms of the gravitational waves is within the ability of the on-going and up-coming facilities for detecting gravitational waves, thus suggesting a possible way to measure the topology structure in nuclear physics. | WenCong Yang YongLiang Ma YueLiang Wu | 2021 | Science China(Physics,Mechanics & Astronomy)2021，64，5： | 0 |
| 12 | Construction of the panoptosis-related gene model and characterization of tumor microenvironment infiltration in hepatocellular carcinoma显示文摘Hepatocellular carcinoma(HCC)is the most common fatal cancer worldwide,patients with HCC have a high mortality rate and poor prognosis.PANoptosis is a novel discovery of programmed cell death associated with cancer development.However,the role of PANoptosis in HCC remains obscure.In this study,we enrolled 274 PANoptosisrelated genes(PANRGs)and screened 8 genes to set up a prognostic model.A previous scoring system calculated PANscore was utilized to quantify the individual risk level of each HCC patient,and the reliability of the prognostic model has been validated in an external cohort.Nomogram constructed with PANscore and clinical characteristics were used to optimize individualized treatment for each patient.Single-cell analysis revealed a PANoptosis model associated with tumor immune cell infiltration,particularly natural killer(NK)cells.Further exploration of hub genes and assessment of the prognostic role of these 4 hub genes in HCC by quantitative real-time PCR(qRT-PCR)and immunohistochemistry(IHC).In conclusion,we evaluated a PANoptosis-based prognostic model as a potential prognostic biomarker for HCC patients. | XINRUI SHI XIA GAO WENCONG LIU XUEJIAO TANG JIAYI LIU DONGCHEN PAN XUEQING DUAN YUQING JIN WEIYAN REN LEI YANG WENXUAN LIU | 2023 | Oncology Research2023，31，4： | 0 |
| 13 | Evaluating the short-term effect of ambient temperature on non-fatal outdoor falls and road traffic injuries among children and adolescents in China: a time-stratified case-crossover study显示文摘studies have suggested that non-optimal temperatures may increase the risk of injury,epidemiological studies focusing on the association between temperature and non-fatal injury among children and adolescents are limited.Therefore,we investigated the short-term effect of ambient temperature on non-fatal falls and road traffic injuries(RTIs)among students across Jiangsu Province,China.Meteorological data and records of non-fatal outdoor injuries due to falls and RTIs among students aged 6–17 were collected during 2018–2020.We performed a time-stratified case-crossover analysis with a distributed lag nonlinear model to examine the effect of ambient temperature on the risk of injury.Individual meteorological exposure was estimated based on the address of the selected school.We also performed stratified analyses by sex,age,and area.A total of 57322 and 5455 cases of falls and RTIs were collected,respectively.We observed inverted U-shaped curves for temperatureinjury associations,with maximum risk temperatures at 18℃(48th of daily mean temperature distribution)for falls and 22℃(67th of daily mean temperature distribution)for RTIs.The corresponding odds ratios(95%confidence intervals)were 2.193(2.011,2.391)and 3.038(1.988,4.644)for falls and RTIs,respectively.Notably,there was a significant age-dependent trend in which the temperature effect on falls was greater in older students(P-trend<0.05).This study suggests a ignificant association between ambient temperature and students’outdoor falls and RTIs.Our findings may help advance tailored strategies to reduce the incidence of outdoor falls and RTIs in children and adolescents. | Hao Zheng Jian Cheng Hung Chak Ho Baoli Zhu Zhen Ding Wencong Du Xin Wang Yang Yu Juan Fei Zhiwei Xu Jinyi Zhou Jie Yang | 2023 | Frontiers of Environmental Science & Engineering2023，17，9： | 0 |
| 14 | PREVENTIVE EFFECTS ON SENILE ANEMIA IN RATS BY MOXIBUSTION显示文摘The aim of the present study is to observe the preventive effects of moxibustion onseniIe anemia in rats and certify the anti-aging effects of moxibustion. The results show that thehemoglobin in 20 months old rats is lower than that in young rats, and the osmotic fragility and thehematocrit are higher than those in young rats. The hernoglobin in moxibustion group rats is signifi-cantly higher than that in old group, and the osmotic fragility and the hematocrit are markedly lowerthan those in old group, suggesting that moxibustion can delay the age-related changes of erythrocytein the rat and decrease the incidence rate of senile anemia of rat. | Huang Cheng,Chen Hanping, Zhao Cuiying, Gu Wencong,Yang HuijunShanghai Research Institute of Acupuncture and Meridian, Shanghai 200030, China | 1995 | World Journal of Acupuncture-Moxibustion1995，5，2： | 0 |
| 15 | A Case of Colon Cancer Surgery Complicated with Acute Myocardial Infarction显示文摘Objective:To investigate the treatment and prevention of acute myocardial infarction after colon cancer surgery.Methods:A patient with acute anterior myocardial infarction who underwent stent implantation in the Seventh Affiliated Hospital,Sun Yat-sen University in 2017 was selected as the subject.The patient was admitted to the emergency department for stent implantation and took antiplatelet and lipid regulating drugs orally on time after the operation.The patient also had a history of colon cancer.The lesion was resected,and the complication after operation was acute myocardial infarction.After active and effective treatment and intervention,the treatment effect of the patient was analyzed.Results:Urgent PTCA was performed,and 0.5 mg Tirofiban was injected into the coronary artery.The results of angiography showed that the blood flow of anterior descending branch recovered to grade 2.Conclusion:The condition of patients with myocardial infarction after colon cancer surgery changes rapidly.Surgery combined with drug treatment can achieve a good prognosis,reduce mortality,and improve patients’cardiac function. | Fang Huang Sicong Yang Yang Wu Kaiyu Tang Wencong Yang | 2022 | Journal of Clinical and Nursing Research2022，6，6： | 0 |
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