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| 1 | Combined assessment of myocardial damage and electrical disturbance in chronic heart failure显示文摘AIM To investigate feasibility of combined assessment of biochemical and electrophysiological myocardial impairment markers risk-stratifying patients with chronic heart failure(CHF). METHODS Serum levels of heart-type fatty acid binding protein(H-FABP) as a marker of ongoing myocardial damage and QRS duration on electrocardiogram were measured at admission in 322 consecutive patients with CHF. A prolonged QRS duration was defined as 120 ms or longer. The cut-off value for H-FABP level(4.5 ng/mL) was determined from a previous study. Patients were prospectively followed during a median follow up period of 534 d. The primary endpoint was cardiac deaths and rehospitalization for worsening CHF.RESULTS There were 117 primary events, including 27 cardiac deaths and 90 rehospitalizations. Patients were stratified into four groups according to H-FABP level and QRS duration(≥ 120 ms). Multivariate analysis demonstrated that high H-FABP levels [hazard ratio(HR) = 1.745, P = 0.021] and QRS prolongation(HR1.612, P = 0.0258) were independent predictors of cardiac events. Kaplan-Meier analysis demonstrated that the combination of high H-FABP levels and QRS prolongation could be used to reliably stratify patients at high risk for cardiac events(log rank test P < 0.0001).CONCLUSION Combined assessment of myocardial damage and electrical disturbance can be used to risk-stratify patients with CHF. | Shinpei Kadowaki Tetsu Watanabe Yoichiro Otaki Taro Narumi Yuki Honda Hiroki Takahashi Takanori Arimoto Tetsuro Shishido Takuya Miyamoto Isao Kubota | 2017 | World Journal of Cardiology2017，9，5： | 14 |
| 2 | Pancreatic stents for the prevention of post-endoscopic retrograde cholangiopancreatography pancreatitis should be inserted up to the pancreatic body or tail显示文摘AIM To investigate the location to which a pancreatic stent should be inserted to prevent post-endoscopic retrograde cholangiopancreatography(ERCP) pancreatitis(PEP).METHODS Over a ten-year period at our hospital, 296 patients underwent their first ERCP procedure and had a pancreatic stent inserted; this study included 147 patients who had ERCP performed primarily for biliary investigation and had a pancreatic stent inserted to prevent PEP. We dividedthese patients into two groups: 131 patients with a stent inserted into the pancreatic head(head group) and 16 patients with a stent inserted up to the pancreatic body or tail(body/tail group). Patient characteristics and ERCP factors were compared between the groups.RESULTS Pancreatic amylase isoenzyme(p-AMY) levels in the head group were significantly higher than those in the body/tail group [138.5(7.0-2086) vs 78.5(5.0-1266.5), P = 0.03] [median(range)]. No cases of PEP were detected in the body/tail group [head group, 12(9.2%)]. Of the risk factors for post-ERCP hyperamylasemia(≥ p-AMY median, 131 IU/L), procedure time ≥ 60 min [odds ratio(OR) 2.65, 95%CI: 1.17-6.02, P = 0.02) and stent insertion into the pancreatic head(OR 3.80, 95%CI: 1.12-12.9, P = 0.03) were identified as independent risk factors by multivariate analysis.CONCLUSION Stent insertion up to the pancreatic body or tail reduces the risk of post-ERCP hyperamylasemia and may reduce the risk of PEP. | Mitsuru Sugimoto Tadayuki Takagi Rei Suzuki Naoki Konno Hiroyuki Asama Yuki Sato Hiroki Irie Ko Watanabe Jun Nakamura Hitomi Kikuchi Yuichi Waragai Mika Takasumi Takuto Hikichi Hiromasa Ohira | 2018 | World Journal of Gastroenterology2018，24，22： | 13 |
| 3 | Randomized phase II study of gemcitabine and S-1 combination versus gemcitabine alone in the treatment of unresectable advanced pancreatic cancer (Japan Clinical Cancer Research Organization PC-01 study)显示文摘 | Masato Ozaka Yuji Matsumura Hiroshi Ishii Yasushi Omuro Takao Itoi Hisatsugu Mouri Keiji Hanada Yasutoshi Kimura Iruru Maetani Yoshinobu Okabe Masaji Tani Takaaki Ikeda Susumu Hijioka Ryouhei Watanabe Shinya Ohoka Yuki Hirose Masafumi Suyama Naoto Egawa A | 2012 | Cancer Chemotherapy and Pharmacology2012，，5： | 3 |
| 4 | Delayed neuronal death prevented by inhibition of increased hydroxyl radical formation in a transient cerebral ischemia显示文摘 | Toshihiro Yamamoto Satoshi Yuki Toshiaki Watanabe Masayuki Mitsuka Ken-Ichi Saito Kyuya Kogure | 1997 | Brain Research1997，，1： | 3 |
| 5 | Predictive factors for the failure of endoscopic stent-instent self-expandable metallic stent placement to treat malignant hilar biliary obstruction显示文摘AIM To investigate the factors predictive of failure when placing a second biliary self-expandable metallic stents(SEMSs). METHODS This study evaluated 65 patients with an unresectable malignant hilar biliary obstruction who were examined in our hospital. Sixty-two of these patients were recruited to the study and divided into two groups: the success group, which consisted of patients in whom a stent-in-stent SEMS had been placed successfully, and the failure group, which consisted of patients in whom the stent-in-stent SEMS had not been placed successfully. We compared the characteristics of the patients, the stricture state of their biliary ducts, and the implemented endoscopic retrograde cholangiopancreatography(ERCP) procedures between the two groups.RESULTS The angle between the target biliary duct stricture and the first implanted SEMS was significantly larger in the failure group than in the success group. There were significantly fewer wire or dilation devices(ERCP catheter, dilator, or balloon catheter) passing the first SEMS cell in the failure group than in the success group. The cut-off value of the angle predicting stent-in-stent SEMS placement failure was 49.7 degrees according to the ROC curve(sensitivity 91.7%, specificity 61.2%). Furthermore, the angle was significantly smaller in patients with wire or dilation devices passing the first SEMS cell than in patients without wire or dilation devices passing the first SEMS cell. CONCLUSION A large angle was identified as a predictive factor for failure of stent-in-stent SEMS placement. | Mitsuru Sugimoto Tadayuki Takagi Rei Suzuki Naoki Konno Hiroyuki Asama Ko Watanabe Jun Nakamura Hitomi Kikuchi Yuichi Waragai Mika Takasumi Yuki Sato Takuto Hikichi Hiromasa Ohira | 2017 | World Journal of Gastroenterology2017，23，34： | 3 |
| 6 | Bacterial community structures in MBRs treating municipal wastewater: Relationship between community stability and reactor performance显示文摘 | Yuki Miura Mirian Noriko Hiraiwa Tsukasa Ito Takanori Itonaga Yoshimasa Watanabe Satoshi Okabe | 2006 | Water Research2006，，3： | 2 |
| 7 | Antiviral effects of the interferon‐induced protein guanylate binding protein 1 and its interaction with the hepatitis C virus NS5B protein显示文摘 | Yasuhiro Itsui Naoya Sakamoto Sei Kakinuma Mina Nakagawa Yuko Sekine‐Osajima Megumi Tasaka‐Fujita Yuki Nishimura‐Sakurai Gouki Suda Yuko Karakama Kako Mishima Machi Yamamoto Takako Watanabe Mayumi Ueyama Yusuke Funaoka Seishin Azuma Mamoru Watanabe | 2009 | Hepatology2009，，6： | 1 |
| 8 | 1%显示文摘 | Yasuo CHIBA Asharaful ISLAM Yuki Watanabe Dye-Sensitized Solar Cells with Conversion Efficiency of 11 | 2006 | The Japan Society of Applied Physics2006，45，25： | 1 |
| 9 | Delayed neuronal death prevented by inhibition of increased hydroxylradical formation in transient cerebral ischemia显示文摘 | Yamamoto T Yuki S Watanabe T | 1997 | Brain Res1997，762，12： | 1 |
| 10 | Delayed neuronal death prevented by inhibition of increased hydroxyl radical formation in transient cerebral ischemia显示文摘 | Yamamoto T Yuki S Watanabe T | 1997 | J Brain Res1997，762，： | 1 |
| 11 | Studies on the concentration of 3-meTh1-1-lphenyl-2-pyrazoln-5-one (MCL-186) in MCA occlusion and reperfuslon model of rats 显示文摘 | Takamatsu Y Yuki S Watanabe T | 1997 | J PN Pharmacol Ther1997，，： | 1 |
| 12 | IVIG blocks complement deposition mediated by anti-GM1 antibodies in multifocal motor neuropathy显示文摘 | Yuki N Watanabe H Nakajima T | 2011 | J Neurol Neurosurg Psychiatry2011，82，1： | 1 |
| 13 | Delayed neuronal death prevented by inhibition of increased hydroxyl radical formation in a transientcerebral ischemia显示文摘 | Yamamoto T Yuki S Watanabe T | 1997 | Brain Res1997，762，3： | 1 |
| 14 | Protective effects of MCI2186 on cerebral ischemia:possible involvement of free radical scavenging and antioxidant actions显示文摘 | Yuki S Egawa M | 1994 | J Pharmacol Exp Ther1994，268，3： | 1 |
| 15 | Protective effects of MCI-186 on cerebral ischemia:possible involvement of free radical scavenging and antioxidant actions显示文摘 | Watanabe T Yuki S Egawa M | 1994 | J Pharmacol Exp Ther1994，268，3： | 1 |
| 16 | The Rho kinase inhibitor fasudil is involved in p53-mediated apoptosis in human hepatocellular carcinoma cells显示文摘 | Yuko Takeba Naoki Matsumoto Minoru Watanabe Sachiko Takenoshita-Nakaya Yuki Ohta Toshio Kumai Masayuki Takagi Satoshi Koizumi Takeshi Asakura Takehito Otsubo | 2012 | Cancer Chemotherapy and Pharmacology2012，，6： | 1 |
| 17 | Delayed neuromal death prevented by inhibition of increased hydroxyl radical formation in a transient cerebral ischemia显示文摘 | Yamamoto T Yuki S Watanabe T | 1997 | Brain Res1997，762，12： | 1 |
| 18 | Protective effects of MCI-186 on cerebral ischemia:possible involvement of free radical scavenging and antioxidant actions显示文摘 | Watanabe T Yuki S Egawa M | 1994 | J Pharmacol Exp Ther1994，268，3： | 1 |
| 19 | Delayed neuronal death prevented by inhibition of increased hydroxyl radical formation in a transient cerebral ischemia显示文摘 | Yamamoto T Yuki S Watanabe T | 1997 | Brain Res1997，762，3： | 1 |
| 20 | Studies on the concentration of 3-methyl-1-1phenyl-2-pyrazolin-5-one (MCI 2186) in MCA occlusion and reperfusion model of rats显示文摘 | Takamatsu Y Yuki S Watanabe T | 1997 | Jpn Pharmacol Ther1997，，： | 1 |
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