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| 1 | Effects of Sini San used alone and in combination with fluoxetine on central and peripheral 5-HT levels in a rat model of depression显示文摘OBJECTIVE: To investigate the effects of Sini San and fluoxetine on the levels of central and peripheral 5-HT in a rat model of depression, and provide new insight into the treatment of depression with integrated Chinese-Western Medicine.METHODS: A rat model of depression was established by chronic mild stress(CMS). Model rats received either Sini San, fluoxetine, a combination of the two drugs, or no drug treatment. Healthy naive rats were used as controls. Open field and sucrose preference tests were used to assess depression-like behavior. ELISA and immunohistochemistry were used to determine central and peripheral levels of 5-HT.RESULTS: In the group with no drug treatment,central 5-HT expression decreased while peripheral5-HT concentrations increased as CMS continued.Four weeks after CMS, Sini San alone was less effective in reducing depression-like behavior than fluoxetine alone or in combination with Sini San,but combined use was more effective than fluoxetine alone. Eight weeks after CMS, Sini San alone or in combination with fluoxetine was more effective in reducing depression-like behavior than fluoxetine alone. Furthermore Sini San and fluoxetine used alone or in combination notably increased central 5-HT expression and decreased peripheral 5-HT levels in the rat model.CONCLUSION:The results of the present study indicate that there is a synergistic action between the two medicines in the treatment of depression. Sini San exhibited a relatively long lag before its effects were observed; however, by eight weeks the Traditional Chinese Medicine appeared at least as effective as fluoxetine. We suggest that Sini San can replace fluoxetine in the later stages of depression treatment to minimize side effects observed with long-term fluoxetine administration. | Yubo Li Yuxiu Sun Xueling Ma Xiaoxing Xue Wenting Zhang Zhiqian Wu Yulin Ouyang Jianxin Chen Weiming Wang Shuzhen Guo Wei Wang | 2013 | Journal of Traditional Chinese Medicine2013，33，5： | 6 |
| 2 | TMEM43-S358L mutation enhances NF-κBTGFp signal cascade in arrhythmogenic right ventricular dysplasia/cardiomyopathy显示文摘Arrhythmogenic right ventricular dysplasia/cardiomyopathy(ARVD/C)is a genetic cardiac muscle disease that accounts for approximately 30%sudden cardiac death in young adults.The Ser358Leu mutation of transmembrane protein 43(TMEM43)was commonly identified in the patients of highly lethal and fully penetrant ARVD subtype,ARVD5.Here,we generated TMEM43 S358L mouse to explore the underlying mechanism.This mouse strain showed the classic patholo.gies of ARVD patients,including structural abnormalities and cardiac fibrofatty.TMEM43 S358L mutation led to hyper-activated nuclear factor kB(NFkB)activation in heart tissues and primary cardiomy.ocyte cells.Importantly,this hyper activation of NF-κB directly drove the expression of pro-fibrotic gene,transforming growth factor beta(TGFβ),and enhanced downstream signal,indicating that TMEM43 S358L mutation up-regulates NF-κB-TGFβ signal cascade during ARVD cardiac fibrosis.Our study partially reveals the regulatory mechanism of ARVD development. | Guoxing Zheng Changying Jiang Yulin Li Dandan Yang Youcai Ma Bing Zhang Xuan Li Pei Zhang Xiaoyu Hu Xueqiang Zhao Jie Du Xin Lin | 2019 | Protein & Cell2019，10，2： | 5 |
| 3 | One Stone for Three Birds-Rhodium-Catalyzed Highly Diastereoselective Intramolecular [4+2] Cycloaddition of Optically Active Allene-1,3-dienes显示文摘Summary of main observation and conclusion RhCI(PPh3)3-catalyzed [4+2] intramolecular cycloaddition of optically active axially chiral allene-dienes afforded c/s-fused [3.4.0]-bicyclic products with three chiral centers in good yields with an excellent chemo-and diastereoselectivity. A pair of enantiomers of such products was gen erated highly selectively from both ena ntiomers of starting allene-die nes, indicati ng that the axial chirality dictated the absolute configurations of the three in situ generated chiral centers with a very high efficiency of chirality transfer. | Yulin Han Anni Qin Shengming Ma | 2019 | Chinese Journal of Chemistry2019，37，5： | 4 |
| 4 | Simplified full-depth precast concrete deck panel systems for accelerated bridge construction显示文摘A simplified full-depth precast concrete deck panel system for accelerating bridge construction(ABC) is introduced and a finite element analysis(FEA) is conducted to investigate the static and dynamic responses of this conceptual deck system. The FEA results are compared to those of the traditional full-depth precast concrete deck panel system. The comparison results show that the mechanical behavior of the new deck system is different from that of the traditional deck system. The concrete decks in the new system act as two-way slabs, instead of the one-way slab in the traditional system. Meanwhile, the connections in both the longitudinal and transverse directions may need to accommodate the negative moments.Compared to those in the traditional system, the longitudinal nominal stress at middle span increases a lot in the new deck system and the effective flange width varies significantly. In addition, the dynamic results show that the impact factor is influenced by the spacing of connections.Finally, some design concerns of the new deck system are proposed. | Zhongguo John Ma Yulin Zhan Lin Xiao Lungui Li Weiwei Lu | 2016 | Journal of Modern Transportation2016，24，4： | 4 |
| 5 | Copy number variations of HLA-DRB5 is associated with systemic lupus erythematosus risk in Chinese Han population显示文摘全身的豺狼座 erythematosus (SLE ) 是复合基因,全身的、自体免疫的疾病。拷贝数字变体(CNVS ) 被发现了与很多复杂混乱被联系。我们拿了当前的学习在中国汉人口探索在 genomic CNVS 和 SLE 之间的潜在的协会。在发现阶段,七个 SLE 病人在屏蔽测试与高密度的比较 genomic 杂交 microarrays 被检查因为 SLE 联系了 CNVS。在确认阶段,然后, 135 个 SLE 病人和 219 个匹配的健康题目被 AccuCopy 技术为基因 HLA-DRB5 的 CNVS 调查。量的聚合酶链反应被执行在 SLE 病人决定拷贝数字(CN ) 和 HLA-DRB5 的 mRNA 水平。尽管在在 SLE 病人的 CN 删除组和 CN 正常的组之间的 HLA-DRB5 的 mRNA 水平不是统计上积极的( P = 0.46 ),我们的结果仍然比在健康控制在 SLE 病人显示出 HLA-DRB5 的更多的 CN ( P = 3.98 業慮瑮愠摮爠'酞棙M敶洠摯汥漠?偔?挠摯湯?′敷敲瀠牥潦浲摥?敲灳'虡N敶祬?剏?ㄠ????‥??ㄠ???劳?倠吗?? | Lijun Wu Shicheng Guo Dongqin Yang Yanyun Ma Hengdong Ji Yulin Chen Jun Zhang Yi Wang Li Jin Jiucun Wang Jie Li | 2014 | Acta Biochimica et Biophysica Sinica2014，46，2： | 3 |
| 6 | Copy number variants of ABCF1, IL17REL, and FCGR3A are associated with the risk of gout显示文摘 | Dong, Zheng Li, Yuan Zhou, Jingru Jiang, Shuai Wang, Yi Chen, Yulin Zhao, Dongbao Yang, Chengde Qian, Qiaoxia Ma, Yanyun He, Hongjun Ji, Hengdong Yang, Yajun Wang, Xiaofeng Xu, Xia Pang, Yafei Zou, Hejian Jin, Li Zhang, Feng Wang, Jiucun | 2017 | Protein & Cell2017，8，6： | 3 |
| 7 | High performance liquid chromatographic separation of eight drugs collected in Chinese Pharmacopoeia 2010 on amylose ramification chiral stationary phase显示文摘The enantiomers separation of ei ght pharmaceutical racemates collected in Chinese Pharmacopoeia 2010(Ch.P2010),including nitrendipine,felodipine,omeprazole,praziquantel,sulpiride,clenbuterol hydrochloride,verapamil hydrochloride and chlorphenamine maleate,was performed on chiral stationary phase of amylose ramification by high performance liquid chromatography(HPLC)on Chiralpak AD-H column and Chiralpak AS-H column with the mobile phase consisted of isopropanol and n-hexane.The detection wavelength and the flow rate were set at 254 nm and 0.7 mL/min,respectively.The effects of proportion of organic additives,alcohol displacer and temperature on the separation were investigated.The results indicated that eight chiral drugs were separated on chiral stationary phase of amylase ramification in normal phase chroma tographic system.The chromatographic retention and resolution of enantiomers were adjusted by factors,including the changes of the concentration of alcohol displacer in mobile phase,organic alkaline modifier and column temperature.It was shown that the resolution was improved with reducing concentration of alcohol displacer.When the concentration of organic alkaline modifier was 0.2%,the resolution and the peak shape were fairly good.Most racemates mentioned above had the best resolution at column temperature of 25℃.The best temperature should be kept unchanged in the process of separation so as to obtain stable separation results. | Yan Wang Ying Zhou Chao Ma Beibei Yang Ru Feng Yiying Zhang Jie Fu Wenjing Chen Yupeng Sun Jingyi Ma Qiming Zhang Yulin Deng Yukui Zhang Wenyi He | 2012 | Acta Pharmaceutica Sinica B2012，2，5： | 3 |
| 8 | Multi-omic characterization of genome-wide abnormal DNA methylation reveals diagnostic and prognostic markers for esophageal squamous-cell carcinoma显示文摘This study investigates aberrant DNA methylations as potential diagnosis and prognosis markers for esophageal squamous-cell carcinoma(ESCC),which if diagnosed at advanced stages has<30%five-year survival rate.Comparing genome-wide methylation sites of 91 ESCC and matched adjacent normal tissues,we identified 35,577 differentially methylated CpG sites(DMCs)and characterized their distribution patterns. | Yiyi Xi Yuan Lin Wenjia Guo Xinyu Wang Hengqiang Zhao Chuanwang Miao Weiling Liu Yachen Liu Tianyuan Liu Yingying Luo Wenyi Fan Ai Lin Yamei Chen Yanxia Sun Yulin Ma Xiangjie Niu Ce Zhong Wen Tan Meng Zhou Jianzhong Su Chen Wu Dongxin Lin | 2022 | Signal Transduction and Targeted Therapy2022，7，3： | 2 |
| 9 | VIRTUAL EXPERIMENTAL ANALYSIS ON CLEANING ELEMENT OF SUGARCANE HARVESTER显示文摘The laws of influence of different factors have been analyzed in order to enhance the working efficiency and fatigue life of the cleaning element in brush shape of the sugarcane harvester.Based on the principle of orthogonal experiment design, the virtual-orthogonal-experimental analysis for the cleaning element is carried out on the finite element analysis (FEA) software-ANSYS after analyzing the nonlinear structural behavior in the working procedure. The results are analyzed with the overall balancing method, and then the optimal combination is got, which is made up of different levels of different factors. Also the optimal combination of design parameters of the cleaning element received from the virtual experimental analysis is conducted an experiment to confirm that the virtual analysis model and results are right, and the effect of factors on the function of the cleaning element is obtained by more analysis and further optimizing. | Ma Fanglan Li Shangping He Yulin Meng Yanmei Chen Weixu | 2005 | Chinese Journal of Mechanical Engineering2005，18，4： | 2 |
| 10 | Regio- and (E)-Stereoselective Triborylation of Propargylic Carbonates显示文摘 | Zheng Yang Tao Cao Yulin Han Weilong Lin Qi Liu Yang Tang Yizhan Zhai Minqiang Jia Wanli Zhang Tonghao Zhu Shengming Ma | 2017 | Chinese Journal of Chemistry2017，35，8： | 2 |
| 11 | Glial U87 cells protect neuronal SH-SY5Y cells from indirect effect of radiation by reducing oxidative stress and apoptosis显示文摘最近的研究在 neurodegeneration 表明了放射的间接效果的角色。然而,在对放射的间接效果的 neuroprotection 的 glial 房间的角色仍然不是清楚的,尽管他们被知道在中央神经系统在压力条件下面保护神经原。我们的学习证明放射的那间接效果增加了进一步提高关键 apoptotic 蛋白质的表示并且导致 neuronal 房间死亡的氧化压力。我们也在一个 transwell 合作文化系统面对 glial 房间在 neuronal 房间上调查了放射的间接效果,当我们的分析集中于 neuronal 房间时。当间接放射和 neuroprotective 效果的来源被各种各样的端点分析,照耀的调节房间的中等 ICCM 被使用。导致 ICCM 的反应氧化种类水平显著地在与 glial U87 房间 co 有教养的 SH-SY5Y 房间被减少,这被观察,它可能帮助维持 mitochondrial 膜潜力的正直。抗氧化剂酶 superoxide dismutase 和抗氧化剂谷胱甘肽的增加的层次在与 glial U87 房间 co 有教养的 SH-SY5Y 房间被观察。而且,有 glial 房间的合作文化禁止导致 ICCM 的 apoptotic 蛋白质的表示,这也被观察,即在 SH-SY5Y 房间的 Bax,细胞色素 c,和 caspase-3。因此,在合作文化系统 glial,房间可以由减少导致 ICCM 的氧化压力和 apoptotic 死亡保护 neuronal SH-SY5Y 房间,这能被推测。 | Yasmeen Saeed Bingjie Xie JinXu Abdur Rehman Ma Hong Qing Hong Yulin Deng | 2015 | Acta Biochimica et Biophysica Sinica2015，47，4： | 2 |
| 12 | Efficient CO2 to CO conversion at moderate temperatures enabled by the cobalt and copper co-doped ferrite oxygen carrier显示文摘Chemical looping technology holds great potential on efficient CO2 splitting with much higher CO production and CO2 splitting rate than photocatalytic processes.Conventional oxygen carrier requires high temperature(typically 850–1000°C)to ensure sufficient redox activity,but the stable and high CO2 conversion is favored at a lower temperature,leading to the degrading on the reaction kinetics as well as the low CO production and CO2 splitting rate.In this paper,we prepared several ternary spinels and demonstrated their performance for chemical looping CO2 splitting at moderate temperatures.Using the promotion effect of Cu to cobalt ferrite reduction and reversible phase change of the reduced metals,Cu0.4 Co0.6 Fe2 O4 exhibits high CO2 splitting rate(144.6μmol g–1 min–1)and total CO production(9100μmol g–1)at 650°C.The high performance of this earth-abundant spinel material is also consistent in repeated redox cycles,enabling their potential in industrial use. | Yu Qiu Li Ma Dewang Zeng Min Li Dongxu Cui Yulin Lv Shuai Zhang Rui Xiao | 2020 | Journal of Energy Chemistry2020，29，7： | 2 |
| 13 | Gut microbiota-derived metabolites contribute negatively to hindgut barrier function development at the early weaning goat model显示文摘Early weaning induces intestinal injury,leading to a series of long-term symptoms such as inflammation,malabsorption and diarrhea.In this study,we hypothesized that microbes and theirmetabolitesmodulate the host's inflammatory response to early weaning stress in a goatmodel.A total of 18 female Tibetan goat kids(n?9)wereweaned fromtheirmothers at 28 d(D28)and 60 d(D60)postpartum.D60 and D28 groupswere fed the same solid diet ad libitum fromweaning to 75 d of age.The colonic epithelium was subject to RNAsequencing,the caecal digesta metabolomics were assessed by liquid chromatographyetandem mass spectrometry(LC-MS/MS),and the caecal microbiota composition was analysed by 16S ribosomal RNA gene sequencing.We foundthatearlyweaningsubstantially increased the colonic pro-apoptotic gene expressionof B-cell lymphoma associated X(Bax),caspase-9,and caspase-3,and decreased the expression of zonula occludens-1(ZO-1)and claudin-1(P<0.01).In addition,a significant Bacteroides acidifaciens enrichmentwas observed in the hindgut of early-weaned goats(P<0.01),which negatively correlated with lysophosphatidylcholine products.Similarly,the chemokine signaling,IL-17 signaling,and peroxisome proliferatorsactivated receptor(PPAR)signaling pathways were upregulated in the colonic mucosa of the early-weaned goats.By applying caecal microbiota transplantation from goats to defaunated C57/6J mice,we confirmed that caecalmicrobiota of D28 goat kids increased the relative abundance of B.acidifaciens and significantly upregulated the genes of Bax,G proteinecoupled receptor(GPR)109A,GPR 43,fatty acid binding protein 6,nuclear receptor subfamily 1 group H member 3,angiotensin converting enzyme 2,and IL-6 expression(P<0.05),and decreased ZO-1,and claudin-1 protein expression in the mice jejunum and colon(P<0.001).These results proposed that the hindgut microbiota andmetabolites mediate the barrier functionweakening duringearlyweaning,and the relative abundance of B.acidifacienswas negatively correlatedwiththe hindgut barrier gene expression.This studydemonstrateshowweaningstress canaffectkeyhostemicrobe interaction regulators in the hindgut,in a lysophosphatidylcholine dependent and independent manner.Furthermore,based on our mice data,these results are transferable to other mammal species. | Ke Zhang Yangbin Xu Yuxin Yang Mengmeng Guo Ting Zhang Bo Zong Shuhong Huang Langda Suo Baohua Ma Xiaolong Wang Yujiang Wu Daniel Brugger Yulin Chen | 2022 | Animal Nutrition2022，，3： | 2 |
| 14 | Effects of surface states over core-shell Ni@SiO_2 catalysts on catalytic partial oxidation of methane to synthesis gas显示文摘In the present work, core-shell Ni@Si O2 catalysts were investigated in order to evaluate the relevance of catalytic activity and surface states of Ni core as well as Ni nanoparticles size to catalytic partial oxidation of methane(POM). The catalysts were characterized by N2 adsorption,H2-TPR, XRD, TEM and XPS techniques. The catalytic performance of the core-shell catalysts was found to be dependent on the surface states of catalyst, which influenced the formation of products. It was considered that carbon dioxide formed on the oxidized nickel sites(Ni O)and carbon monoxide produced on the reduced sites(Ni). The surface states of active metal in the dynamic were influenced both by the size of Ni core and the porosity of silica shell. However, the catalytic activity would be debased when the size of Ni core was under a certain extent,which can be ascribed to the fact the carbon deposition increased with the increasing content of Ni O. The effects of surface states of Ni@Si O2 catalyst on the catalytic performance were discussed and the reaction pathway over Ni core encapsulated inside silica shell was proposed. | Chuanmin Ding Xiaofeng Gao Yulin Han Xishun Ma Junwen Wang Shibin Liu Kan Zhang | 2015 | Journal of Energy Chemistry2015，24，1： | 2 |
| 15 | Research on intelligent vehicle platoon driving simulation experiment system under the coordination between vehicle and highway显示文摘 | Ma Yulin Yan Xinping Wu Qing | 2010 | Journal of Computers2010，5，11： | 1 |
| 16 | Effects of genistein on vertebral trabecular bone microstructure, bone mineral density, microcracks, osteocyte density, and bone strength in ovariectomized rats显示文摘 | Ruchun Dai Yulin Ma Zhifeng Sheng Yan Jin Yuhai Zhang Lingna Fang Huijie Fan Eryuan Liao | 2008 | Journal of Bone and Mineral Metabolism2008，，4： | 1 |
| 17 | Electrochemically-driven interphase conditioning of magnesium electrode for magnesium sulfur batteries显示文摘The earth-abundant magnesium metal is a kind of promising anode material due to its low reduction potential (-2.356V vs. SHE), high volumetric and gravimetric specific capacities of 3882 mAh cm-3 and 2234 mAh g_1 respectively [1]. Moreover, the magnesium anode shows high safety due to the non-dentritic electrodeposition mechanism during cycling, which is related to the strong Mg-Mg bonding and the consequent high energy barrier between the crystal boundaries of different crystal orientation [2]. | Yaqi Li Pengjian Zuo Ruinan Li Mengxue He Yulin Ma Yingxin Shi Xinqun Cheng Chunyu Du Geping Yin | 2019 | Journal of Energy Chemistry2019，28，10： | 1 |
| 18 | Surgical treatment and prognosis of cancers of hepatic flexure of colon invading the duodenum in 65 patients显示文摘学习的目的是讨论入侵十二指肠的肝的弯曲的正确结肠癌的外科的治疗的目的。方法有入侵十二指肠的肝的弯曲的正确冒号癌的 65 个病人,从 1987 ~ 2007 在我们的部门对待,在这研究被包括。他们的 clinicopathological 数据回顾地被考察并且分析。所有盒子根据十二指肠的缺点被划分成三种类型(有内部管的本地侵略,地区性的侵略,和癌症) ,包括本地侵略(< 2.0 厘米) ,宽侵略(> 2.0 厘米) 并且内部管的存在。有本地侵略的 25 个病人在十二指肠的墙的团体切除术经历了的结果。Pedicled ileal 拍动被用来盖住在 5 个病人是 2.03.0 厘米的大十二指肠的缺点。Dudenojejunostomy 被用来重建在 3 个病人是超过 5 厘米的大缺点。右边的冒号的保守切除术与宽侵略在 18 个病人被执行。四个病人经历了为包含胰腺的头的结肠癌与正确 hemicolectomy 相结合的 pancreaticoduodenectomy。十个盒子经历了十二指肠的 diverticularization。有 anastomotic 漏的一个病人在 3 个星期以内愈合了。没有手术后的复杂并发症,另外的病人被治好。在外科以后的全部的 3 年、 5 年的幸存率分别地是 53.8% 和 9.2% 。要表现的外科的过程通常是的结论根据癌症地点,程度,和十二指肠的缺点和侵略决定了,它为延长生活时间是重要的,在这些病人的生活和预后的质量改善。 | Weiliang Yang Shenglong Li Lei Zhang Fujing Wang Yulin Ma | 2011 | The Chinese-German Journal of Clinical Oncology2011，10，3： | 1 |
| 19 | Fluoroethylene carbonate as electrolyte additive to improve low temperature performance of Li Fe PO4 electrode显示文摘 | Liao Lixia Cheng Xinqun Ma Yulin | 2013 | Electrochimica Acta2013，87，： | 1 |
| 20 | Comparison of four clinical scores for the predicting lower limb deep venous thrombosis in Chinese patients显示文摘Objective:To evaluate Wells,Kahn,St.Andréand Constans scores for the prediction of deep venous thrombosis in Chinese patients. Methods:One hundred and seventy-two patients,prospectively,blinded referred for evaluation with four clinical-score systems for suspected deep venous thrombosis,were examined by ultrasonography. Sensitivity,specificity,positive predictive value,nega-tive predictive value and receiver operation curves were calculated for four clinical scores. The difference between areas of the ROC curve for each of the scores was compared with others and reference line. Results:Forty-six of 172 patients had deep venous throm-bosis proven by sonography. The sensitivity,specificity,positive predictive value and negative predictive value for Wells score was 91.3%,57.1%,43.8% and 94.7%,respectively,for Kahn score; 65.2%,71.4%,45.5% and 84.9%,respectively,for St.Andréscore; 63%,38.9%,27.4% and 74.2% respectively,for Constans score; 95.7%,34.9%,34.9% and 95.7% respectively. Area under ROV curve of Constans score was 0.814,which was similar to that of Wells score,then followed by Kahn score and that of St.Andréscore was no difference with the reference line. Conclusion:Based on the results of our study,the sensitivity,negative prediction value and area under ROC curve are larger for Constans score and Wells score in Chinese hospitalized patients than that of Kahn score or St.Andréscore. Considering the aim of the clinical assessment,Constans score and Wells score are more efficient for Chinese hospitalized patients. | Li Zhu Min Liu Xiaojuan Guo Jianguo Wang Youmin Guo Chen Wang Hongxia Ma Yulin Guo | 2008 | Journal of Nanjing Medical University2008，22，4： | 1 |
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