|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | The Prevalence of Nonalcoholic Fatty Liver Disease and its Association with Lifestyle/dietary Habits among University Faculty and Staff in Chengdu显示文摘Objective To investigate the prevalence of nonalcoholic fatty liver disease(NAFLD) in different university categories and its association with lifestyle/dietary habits.Methods A cross-sectional study was carried out on 9 378 faculty members and staff who participated in an annual health checkup at three universities selected by random cluster sampling.Demographic,anthropometric,biochemical indices and abdominal ultrasound measurements were collected.A nested case-control study was conducted with 200 NAFLD cases and 200 controls matched by gender,age(±3 years),and university.Results The overall prevalence of NAFLD was 10.3%(13.7% in males and 6.8% in females).The prevalence was significantly higher in the science and engineering university(22.1%) than in the comprehensive universities with(6.4%) and without(10.9%) medical colleges.Obesity/overweight,hyperlipidemia,diabetes mellitus,and family history of NAFLD were independently associated with higher risk of NAFLD,as were frequent consumption of desserts and salty/spicy foods.Using nutritional supplements was a protective factor against NAFLD.Intake of coarse cereals,potatoes,vegetables,fruits,and milk was significantly lower,and intake of red meat,viscera,candies and pastries,cooking oil,and total energy was significantly higher in participants with NAFLD than in controls.Conclusion Science and engineering university faculty and staff are key targets for NAFLD prevention.NAFLD is closely associated with age,gender,university type,metabolic diseases,and lifestyle/dietary habits. | SHI Lei LIU Zhong Wu LI Yun GONG Cai ZHANG Huan SONG Li Juan HUANG Cheng Yu LI Ming | 2012 | Biomedical and Environmental Sciences2012，25，4： | 16 |
| 2 | Propofol Attenuates a-Synuclein Aggregation and Neuronal Damage in a Mouse Model of Ischemic Stroke显示文摘a-Synuclein is a soluble monomer abundant in the central nervous system. Aggregates of a-synuclein,consisting of higher-level oligomers and insoluble fibrils,have been observed in many chronic neurological diseases and are implicated in neurotoxicity and neurodegeneration.a-Synuclein has recently been shown to aggregate following acute ischemic stroke, exacerbating neuronal damage.Propofol is an intravenous anesthetic that is commonly used during intravascular embolectomy following acute ischemic stroke. While propofol has demonstrated neuroprotective properties following brain injury, the mechanism of protection in the setting of ischemic stroke is unclear. In this study, propofol administration significantly reduced the neurotoxic aggregation of a-synuclein, decreased the infarct area, and attenuated the neurological deficits after ischemic stroke in a mouse model. We then demonstrated that the propofol-induced reduction of a-synuclein aggregation was associated with increased mammalian target of rapamycin/ribosomal protein S6 kinase beta-1 signaling pathway activity and reduction of the excessive autophagy occurring after acute ischemic stroke. | Yuzhu Wang Dan Tian Changwei Wei Victoria Cui Huan Wang Yanbing Zhu Anshi Wu Yun Yue | 2020 | Neuroscience Bulletin2020，36，3： | 14 |
| 3 | CO_2 gas emplacement age in the Songliao Basin: Insight from volcanic quartz ^(40)Ar-^(39)Ar stepwise crushing显示文摘Due to a lack of suitable minerals, the gas/oil emplacement ages have never been accurately obtained before. CH4-CO2-saline- bearing secondary inclusions are found in quartz from the volcanic rocks of the Yingcheng Formation, the container rocks of the deep CO2 gas reservoir in the Songliao Basin. The inclusion fluid was trapped into microcracks in quartz during the gas em- placement and accumulation, providing an optimal target for the 40Ar-39Ar stepwise crushing technique to determine the CO2 gas emplacement age. 40Ar-39Ar dating results of a quartz sample by stepwise crushing yield a highly linear-regression isochron with an age of 78.4±1.3 Ma, indicating that the accumulation of the deep CO2 gas reservoir in the Songliao Basin occurred in the late Cretaceous. This is the first time to report an exact isotopic age for a CO2 gas reservoir, which indicates that the 40Ar-39Ar dating can serve as a new technique to date the oil/gas emplacement ages. | YUN JianBing WU HeYong FENG ZiHui MEI LianFu QIU HuaNing | 2010 | Chinese Science Bulletin2010，55，17： | 11 |
| 4 | Influence of aquatic plants on the hydrogen isotope composition of sedimentary long-chain n-alkanes in the Lake Qinghai region, Qinghai-Tibet Plateau显示文摘The hydrogen isotopic composition(δD) of leaf wax long-chain n-alkanes(C27, C29, and C31) from lacustrine sediments has been widely applied to reconstruct terrestrial paleoclimatic and paleohydrological changes. However, few studies have addressed whether the aquatic-derived n-alkanes can affect the δD values of lake sedimentary long-chain n-alkanes, which are usually regarded as a recorder of the terrestrial hydrological signals. Here we systematically investigated δD values of long-chain n-alkanes from modern aquatic plants, both near-shore and off-shore surface sediments, surrounding terrestrial plant litters, as well as river water and lake water in Lake Qinghai and its satellite lakes on the northeastern Qinghai-Tibet Plateau. Our data showed that(i) δD values of long-chain n-alkanes from aquatic plants varied from-184‰ to-132‰ for n-C27, from-183‰ to-138‰ for n-C29, and from-189‰ to-130‰ for n-C31, respectively, with no significant differences among the three n-alkanes homologues;(ii) δD values of long-chain n-alkanes from aquatic plants were generally more positive than those from surrounding terrestrial plants, possibly because that they recorded the D-enrichment of lake water in this semi-arid region;(iii) δD values of long-chain n-alkanes from surface sediments showed significant differences among the three n-alkanes homologues, due to the larger aquatic input of n-C27 to the sedimentary lipid pool than that of n-C31, and(iv) n-C27 δD values of near-shore aquatic plants and near-shore sediments are more negative than those from off-shore as a result of lower δD values of near-shore lake water. Our findings indicate that in this region(i) the offset between sedimentary n-C27 and n-C31 δD values(ΔδDC27-C31) could potentially be used to evaluate if sedimentary long-chain n-alkanes are derived from a single source;(ii) while δD values of n-C27 may be influenced by lake water hydrological changes, sedimentary n-C31 is derived predominantly from terrestrial plants and thus its δD can serve as a relatively reliable indicator for terrestrial paleoclimatic and paleohydrological reconstructions. | LIU Wei Guo YANG Hong WANG Huan Ye YAO Yuan WANG Zheng CAO Yun Ning | 2016 | Science China Earth Sciences2016，59，7： | 10 |
| 5 | Detrital K-feldspar^(40)Ar/^(39)Ar Ages:Source Constraints of the Lower Miocene Sandstones in the Pearl River Mouth Basin,South China Sea显示文摘The South China Sea began to outspread in the Oligocene.A great quantity of terraneous detritus was deposited in the northern continental shelf of the sea,mostly in Pearl River Mouth Basin,which constituted the main paleo-Pearl River Delta.The delta developed for a long geological time and formed a superimposed area.Almost all the oil and gas fields of detrital rock reservoir distribute in this delta.Thirty-three oil sandstone core samples in the Zhujiang Formation,lower Miocene(23-16 Ma),were collected from nine wells.The illite samples with detrital K feldspar(Kfs) separated from these sandstone cores in four sub-structural belts were analysed by the high-precision 40Ar/39Ar laser stepwise heating technique.All 33 illite 40Ar/39Ar data consistently yielded gradually rising age spectra at the low-temperature steps until reaching age plateaus at mid-high temperature steps.The youngest ages corresponding to the beginning steps were interpreted as the hydrocarbon accumulation ages and the plateau ages in mid-high temperature steps as the contributions of the detrital feldspar representing the ages of the granitic parent rocks in the provenances.The ages of the detrital feldspar from the Zhujiang Formation in the four sub-structural belts were different:(1) the late Cretaceous ages in the Lufeng 13 fault structural belt;(2) the late Cretaceous and early Cretaceous-Jurassic ages in the Huizhou 21 buried hill-fault belt;(3) the Jurassic and Triassic ages in the Xijiang 24 buried hill-fault belt;and(4) the early Cretaceous-late Jurassic ages in the Panyu 4 oil area.These detrital feldspar 40Ar/39Ar ages become younger and younger from west to east,corresponding to the age distribution of the granites in the adjacent Guangdong Province,Southern China. | LIU Zaisheng SHI Hesheng ZHU Junzhang QIU Huaning ZHANG Zhilin YUN Jianbing | 2012 | Acta Geologica Sinica(English Edition)2012，86，2： | 9 |
| 6 | ^(40)Ar/^(39)Ar geochronology constraints on hydrocarbon accumulation and destruction periods in the Bankeng paleo-reservoir in the southern margin of the middle Yangtze block显示文摘The exact determination of isotopic ages of hydrocarbon accumulation,reconstruction and destruction periods using traditional isotopic dating methods is complex because of the small numbers of minerals that correlate with hydrocarbons.The quantitative and direct study of hydrocarbon geochronology is therefore an important scientific problem for isotope geochronology and petroleum geology.This study obtains two isotopic ages from a quartz vein sample associated with bitumen in a reverse fault located in the Bankeng paleo-reservoir on the southern margin of the middle Yangtze block (the northern margin of the JiangnanXuefeng uplift) by inclusion 40Ar/39Ar stepwise crushing in a vacuum.Two different and good linear inverse isochrons that correspond to two age plateaus were determined.The two ages correspond to primary inclusions of about 228 Ma and secondary inclusions of about 149 Ma.These inclusion groups represent two distinct kinds of fluids.Quartz veins associated with bitumen in faulted paleo-reservoirs,which have a strict response relationship with tectonization and hydrocarbon accumulation,are the unified products of tectonic processes,hydrocarbon accumulation and reconstruction.Therefore,they can be used to constrain the hydrocarbon accumulation,reconstruction and destruction periods that are controlled by multiphase and complicated tectonic actions.The evolutionary processes of hydrocarbon accumulation can be divided into two periods consisting of a primary oil and gas reservoir formation period in the late Indosinian epoch (about 228 Ma) and a period of oil and gas reservoir reconstruction in the early Yanshan epoch (about 149 Ma).This study quantitatively reconstructs the hydrocarbon accumulation and destruction chronological framework of a giant hydrocarbon accumulation belt along the southern margin of the middle Yangtze block (the northern margin of the Jiangnan-Xuefeng uplift) controlled by multiphase and complicated tectonism.The two ages associated with hydrocarbons here correspond to the special controlling actions of continental tectonics in the Jiangnan-Xuefeng uplift that affected the timeline of reconstruction and destruction in this giant marine hydrocarbon accumulation.This study shows the feasibility and usefulness of dating inclusions with the 40Ar/39Ar technique for hydrocarbon geochronology,especially in the marine hydrocarbon accumulation region of southern China within a geological setting of old strata,high thermal evolution hydrocarbons,and complex,multiphase and multicycle tectonization. | LIU ZhaoQian MEI LianFu QIU HuaNing SHEN ChuanBo TANG JiGuang YUN JianBing | 2011 | Chinese Science Bulletin2011，56，26： | 7 |
| 7 | Fe/MCM-41 as a promising heterogeneous catalyst for ozonation of p-chlorobenzoic acid in aqueous solution显示文摘Mesoporous MCM-41 和 Fe 装载了 MCM-41 (Fe/MCM-41 ) ,它被一个热水的方法和一个蘸的方法成功地分别地准备,在水的答案为 p-chlorobenzoic 酸(p-CBA ) 的 ozonation 作为异构的催化剂被使用。MCM-41 和 Fe/MCM-41 被 XRD,英尺红外和弥漫的反射 UVvis (DR-UVvis ) 技术描绘。MCM-41 或 Fe/MCM-41 的存在改进 p-CBA 和全部的器官的碳(TOC ) 与 ozonation 相比的移动效率独自一个。在试验性的条件下面, Fe/MCM-41/O3 过程的 TOC 移动率在 60 min 氧化时间是超过 63.5% , 44.5% 使用 MCM-41 作为催化剂,仅仅 37.7% 与 ozonation 独自一个。在 Fe/MCM-41/O3 过程的 turt-butanol (TBA ) 的存在显示 p-CBA 的氧化机制发生经由哦在液体体积。并且 Fe/MCM-41 是有希望的催化剂。 | Rui Huan Huang Jie Liu Lai Sheng Li Qiu Yun Zhang Li Xuan Zeng Ping Lu | 2011 | Chinese Chemical Letters2011，22，6： | 6 |
| 8 | Antiangiogenic therapy with bevacizumab in recurrent malignant gliomas: analysis of the response and core pathway aberrations显示文摘背景 Bevacizumab,对脉管的 endothelial 生长因素的人性化的 monoclonal 抗体,在周期性的恶意的 gliomas 显示出有希望的活动。我们与周期性的恶意的 glioma 在一系列六个病人为 bevacizumab 和化疗的联合报导了治疗反应并且从这些 patients.Methods 标准治疗用外科的活体检视在癌症小径调查了分子的改变,主要切除术由辅助 chemoradiotherapy 列在后面在所有 patients.Bevacizumab 失败了在剂量被管理 10 mg/kg 每 2 个星期。附随地,四个病人收到了 temozolomide (50 mg-m-2-d-1 ) ,一耐心的 irinotecan (125 mg/m2 每 2 个星期) 并且一耐心的 topotecan (1.2 mg.m-2.d-1 ) 。对治疗的反应被磁性的回声成像主要决定。地岬的表示, phosphorylated mitogen 激活蛋白质 kinase ( p-MAPK ), phosphorylated AKT ( p-AKT ), phosphorylated rapamycin ( p-mTOR )和 phosphorylated 信号变换器和抄写 3 的使活跃之物( p-STAT3 )的哺乳动物的目标被 immunohistochemistry semiquantitatively 在六个病人中的五个有的起始的 treatment.Results 前用外科的活体检视估计X光线照相术的回答。三是完全的反应,并且二是部分反应。仅仅一耐心的有的进步疾病。6 月的 progession 免费的幸存(PFS ) 是 33% ,中部的 PFS 是 15 个星期,与到超过 60 个星期的 6 的一个范围。在这分析的三条核心小径中,学习, Ras/MAPK 和 phosphatidylinositol-3-kinase (PI3K )/AKT/mTOR 小径是更可能的与对 bevacizumab 的治疗反应被联系。在二个更年轻的病人(年龄 < 50 ) 可能与完全的反应, p-MAPK 的同时的 overexpression, p.AKT 和 p-mTOR 是在有化学疗法的代理人的联合的关键 feature.Conclusions Bevacizumab 可以是为有周期性的恶意的 glioma 的病人的有效策略。激活的 MAPK 和 AKT 可能是为为这指向的治疗选择合适的病人的可能的 biomarkers。 | ZHANG Wei QIU Xiao-guang CHEN Bao-shi LI Shou-wei CUI Yun REN Huan JIANG Tao | 2009 | Chinese Medical Journal2009，，11： | 6 |
| 9 | Poly(ADP-ribosyl)ation of Apoptosis Antagonizing Transcription Factor Involved in Hydroquinone-Induced DNA Damage Response显示文摘The molecular mechanism of DNA damage induced by hydroquinone(HQ)remains unclear.Poly(ADP-ribose)polymerase-1(PARP-1)usually works as a DNA damage sensor,and hence,it is possible that PARP-1 is involved in the DNA damage response induced by HQ.In TK6 cells treated with HQ,PARP activity as well as the expression of apoptosis antagonizing | ling xiao xuan liu jia xian yun lin du yu jun chen shao qian chen jia long tang huan wen liu lin hua | 2016 | Biomedical and Environmental Sciences2016，29，1： | 6 |
| 10 | Evolutionary analysis of allotetraploid hybrids of red crucian carp×common carp,based on ISSR,AFLP molecular markers and cloning of cyclins genes显示文摘The allotetraploid hybrids of red crucian carp × common carp are the first reported artificially cultured polyploid fish with bisexual fertility and stable inheritance in vertebrate. Using ISSR and AFLP markers and the cyclins genes, the genomes and cyclin gene sequence changes were analyzed between the allotetraploid hybrids and their parents. The results indicated that the allotetraploids inherited many genetic characteristics from their parents and the genetic characteristics were stable after 15 generations. However, the allotetraploids had a closer genetic relationship with their original female parents and represented a bias toward the maternal progenitor. DNA fingerprinting analysis showed that the allotetraploids had undergone sequences deletion from their original parents and that the deleted sequences were mostly from the male parent's genome. Some non-parental bands were found in the allotetraploid hybrids. Sequences analysis of the cyclin A1 and B1 genes showed nonsynonymous substitutions of single nucleotides in codons that were different from their original parents, leading to non-parental amino acid loci. We speculate that the non-additivity in the allotetraploids, compared with their progenitors, could be an adjustment to the genomic shock from heterozygosity and polyploidy, allowing maintenance of genetic stability. | LIU LiangGuo YAN JinPeng LIU ShaoJun LIU Dong YOU CuiPing ZHONG Huan TAO Min LIU Yun | 2009 | Chinese Science Bulletin2009，54，16： | 6 |
| 11 | Association between Metabolic Syndrome and Carotid Atherosclerosis: A Cross-sectional Study in Northern China显示文摘Objective Increased carotid artery intima-media thickness(CIMT)and carotid plaque as manifestations of carotid atherosclerosis have been used as markers of cardiovascular disease(CVD).The components of metabolic syndrome(Met S)are linked to CVD,but the association between Met S and CVD is controversial.Methods A total of 8,933 Chinese adults aged 40 years or older from 2010 to 2014 were selected from the Jidong and Kailuan communities.Met S was defined by the International Diabetes Federation criteria.CIMT and carotid plaque were measured using color Doppler ultrasound.Logistic regression models were used to assess the association of Met S with carotid plaque and CIMT.Results Met S was found among 3,461(3,461/8,933)participants.The odds ratio and 95%confidence internal(CI)for carotid plaques in participants with Met S was 1.16(1.03-1.30).The risk of carotid plaques increased with the number of Met S components.The average CIMT was higher in participants with Met S(β=0.020,95%CI,0.014-0.027)and in participants with more Met S components.Conclusion Individuals with Met S are at an increased risk for carotid atherosclerosis compared to those without MetS. | ZHOU Ping An ZHANG Chen Huan CHEN Yan Ru LI Dong SONG Dai Yu LIU Hua Min ZHOU Ming Yue SONG Guo Shun CHEN Sheng Yun | 2019 | Biomedical and Environmental Sciences2019，32，12： | 6 |
| 12 | Cells in G_2/M phase increased in human nasopharyngeal carcinoma cell line by EBV-LMP1 through activation of NF-кB and AP-1显示文摘Although previous studies showed that the principal oncoprotein encoded by Epstein-Barr virus, latent membrane protein 1 (LMP1), could induce the nasopharyngeal carcinoma cells in G2/M phase increased, littleis known about the target molecules and mechanisms. The present study demonstrated that LMP1 couldinduce the accumulation of p53 protein and upregulate its transactivity in a dose dependent manner, whichresulted in the decrease of the kinase activity of cdc2/cyclin B complex and inducing arrest at G2/M phasethrough the activation of NF-kB and AP-1 signaling pathways, and the effect of NF-kB was more obviousthan that of AP-1. This study provided some significant evidence for further elucidating the molecular mechanisms that LMP1 had effects on the surveillance mechanism of cell cycle and promoting the survivalof transformed cells and tumorigenesis. | LIN DENG,JING YANG,XIAO RONG ZHAO,XI YUN DENG,LIANG ZENG,HUAN HUA GU,MIN TANG,YA CAOCancer Research Institute,Xiangya School of Medicine,Central South University,Xiangya Road 88,Chang-sha,Hunan 410078,China | 2003 | Cell Research2003，13，3： | 5 |
| 13 | Downregulation of mi R ‐101 in gastric cancer correlates with cyclooxygenase‐2 overexpression and tumor growth显示文摘 | Xiao‐Pu He Yun Shao Xiao‐Lin Li Wei Xu Guo‐Sheng Chen Huan‐Huan Sun Hai‐Chen Xu Xian Xu Dan Tang Xi‐Feng Zheng Yi‐Ping Xue Guo‐Chang Huang Wei‐Hao Sun | 2012 | FEBS J2012，，22： | 4 |
| 14 | A Reverse-transcription Recombinase-aided Amplification Assay for the Rapid Detection of the Far-Eastern Subtype of Tick-borne Encephalitis Virus显示文摘Objective Tick-borne encephalitis virus(TBEV) is an emerging pathogen in Europe and North Asia that causes tick-borne encephalitis(TBE). A simple, rapid method for detecting TBEV RNA is needed to control this disease. Methods A reverse-transcription recombinase-aided amplification(RT-RAA) assay was developed. This assay can be completed in one closed tube at 39℃ within 30 minutes. The sensitivity and specificity of RT-RAA were validated using non-infectious synthetic RNA representing a fragment of the NS5 region of the wild-type(WT) TBEV genome and the Senzhang strain. Additionally, 10 batches of tick samples were used to evaluate the performance of the RT-RAA assay. Results The analytical limit of detection of the assay was 20 copies per reaction of the TBEV synthetic transcript and 3 plaque-forming units(pfu) per reaction of TBEV titers. With the specific assay, no signal due to other arboviruses was observed. Of the 10 batches of tick samples obtained from the Changbai Mountains of China, three were TBEV-positive, which was consistent with the results of the quantitative real-time PCR assay. Conclusion A rapid, highly sensitive, specific, and easy-to-use method was developed for the detection of the TBEV Far-Eastern subtype. | WANG Qian Ying LI Fan SHEN Xin Xin FU Shi Hong HE Ying LEI Wen Wen LIANG Guo Dong WANG Huan Yun MA Xue Jun | 2019 | Biomedical and Environmental Sciences2019，32，5： | 4 |
| 15 | A Centralized Report on Pediatric Japanese Encephalitis Cases from Beijing Children's Hospital,2013显示文摘Fifteen pediatric cases of suspected Japanese encephalitis(JE)were reported in Beijing Children’s Hospital during the late summer of 2013.The clinical manifestations in most cases included high fever,seizures,and abnormal magnetic resonance imaging findings.Twelve of 15 cases were laboratory-confirmed as JE cases by pathogen identification.Epidemiological investigations showed that five of the 12 | LI Jiu Wei GAO Xiao Yan WU Yun FU Shi Hong TAN Xiao Juan CAO Yu Xi ZHANG Wei Hua YIN Zun Dongs HE Ying LI Yi Xing LIANG Guo Dong XU Wen Bo FANG Fang WANG Huan Yu | 2016 | Biomedical and Environmental Sciences2016，29，12： | 4 |
| 16 | Molecular characterization and genetic analysis of Gnrh2 and Gthβin different ploidy level fishes显示文摘释放 gonadotropin 荷尔蒙(GnRH ) 和 gonadotropin 荷尔蒙(GTH ) 在调整脊椎动物的 gonadal 发展起关键作用。在这研究, Gnrh2, Fshβ并且 LhβcDNAs 在红被克隆并且描绘鲫鱼鲤鱼, triploids 和 tetraploids,和他们的种系发生的关系比较地被分析。在不同 ploidy 鱼的所有 Gnrh2 cDNAs 编码了 86 氨基酸的蛋白质,它由信号肽, GnRH2 十肽和一个解朊的劈开地点(Gly-Lys-Arg ) 连接的联系 GnRH 的肽(差距) 组成了。GnRH2 十肽和解朊的劈开地点在在 diploids 之间的信号肽和差距在三条 ploidy 鱼,而是差别之中绝对是一致的, tetraploids 比在 diploids 和 triploids 之间的那些是少数。红鲫鱼鲤鱼是 tetraploids 的原来的母亲的父母,这被假定,因此他们有更靠近的关系。另外, Fshβ并且 Lhβ这三条鱼的 cDNAs 分别地编码了 130 和 140 氨基酸的蛋白质。与另外的 teleosts,半胱氨酸残余和 Lhβ 的潜在的 glycosylation 地点的分子相比;在这三,鱼充分被保存。然而, Fshβ 的大多数 teleosts;当这三条鱼的那些是 13,和哪个力量,形式六保存二硫化物由利用劈开地点在之间衔接中的 12 个时,有 12 半胱氨酸残余第一并且第二半胱氨酸残余。而且,在 Fshβ 的第二个 glycosylation 地点的缺乏;这三,鱼可能影响特殊结构和生物活动。在另一方面,系统发生的树分析揭示了那 Gnrh2, Fshβ并且 Lhβ在鲤科之鱼之中的有的类似的发展史关系,它显示他们在进化期间在分子的结构和功能被保存。 | Yu Long Huan Zhong Shaojun Liu Min Tao Lin Chen Jun Xiao Yun Liu | 2009 | Progress in Natural Science:Materials International2009，19，11： | 3 |
| 17 | Cell wallβ-1,4-galactan regulated by the BPC1/BPC2-GALS1 module aggravates salt sensitivity in Arabidopsis thaliana显示文摘Salinity severely reduces plant growth and limits agricultural productivity.Dynamic changes and rearrangement of the plant cell wall is an important response to salt stress,but relatively little is known about the biological importance of specific cell wall components in the response.Here,we demonstrate a specific function ofβ-1,4-galactan in salt hypersensitivity.We found that salt stress induces the accumulation ofβ-1,4-galactan in root cell walls by up regulating the expression of GALACTAN SYNTHASE 1(GALS1),which encodes aβ-1,4-galactan synthase.The accumulation ofβ-1,4-galactan negatively affects salt tolerance.Exogenous application of D-galactose(D-Gal)causes an increase inβ-1,4-galactan levels in the wild type and GALS1 mutants,especially in GALS1 overexpressors,which correlated with the aggravated salt hypersensitivity.Furthermore,we discovered that the BARLEY B RECOMBINANT/BASIC PENTACYSTEINE transcription factors BPC1/BPC2 positively regulate plant salt tolerance by repressing GALS1 expression andβ-1,4-galactan accumulation.Genetic analysis suggested that GALS1 is genetically epistatic to BPC1/BPC2 with respect to the control of salt sensitivity as well as accumulation ofβ-1,4-galactan.Taken together,our results reveal a new regulatory mechanism by whichβ-1,4-galactan regulated by the BPC1/BPC2-GALS1 module aggravates salt sensitivity in Arabidopsis thaliana. | Jingwei Yan Ya Liu Lan Yang Huan He Yun Huang Lin Fang Henrik Vibe Scheller Mingyi Jiang Aying Zhang | 2021 | Molecular Plant2021，14，3： | 3 |
| 18 | Bloodstream Infection with Carbapenem-resistant Klebsiella Pneumoniae and Multidrug-resistant Acinetobacter Baumannii:a Case Report显示文摘IN the presence of septic shock,every hour in delaying the administration of effective antibiotics is associated with a measurable increase in mortality.This is especially true for neutropenic patients with septic shock.1 As there is a higher incidence of involving multi-drug resistant pathogens for neutropenic patients,the decision on antibiotics regime remains a challenge for physicians.2 Immunosuppression and previous | Hong-min Zhang Da-wei Liu Xiao-ting Wang Yun Long Huan Chen | 2014 | Chinese Medical Sciences Journal2014，29，1： | 2 |
| 19 | A general communication performance evaluation model based on routing path decomposition显示文摘The network-on-chip (NoC) architecture is a main factor affecting the system performance of complicated multi-processor systems-on-chips (MPSoCs).To evaluate the effects of the NoC architectures on communication efficiency,several kinds of techniques have been developed,including various simulators and analytical models.The simulators are accurate but time consuming,especially in large space explorations of diverse network configurations;in contrast,the analytical models are fast and flexible,providing alternative methods for performance evaluation.In this paper,we propose a general analytical model to esti-mate the communication performance for arbitrary NoCs with wormhole routing and virtual channel flow control.To resolve the inherent dependency of successive links occupied by one packet in wormhole routing,we propose the routing path decomposition approach to generating a series of ordered link categories.Then we use the traditional queuing system to derive the fine-grained transmission latency for each network component.According to our experiments,the proposed analytical model provides a good approximation of the average packet latency to the simulation results,and estimates the network throughput precisely under various NoC configurations and workloads.Also,the analytical model runs about 10 5 times faster than the cycle-accurate NoC simulator.Practical applications of the model including bottleneck detection and virtual channel allocation are also presented. | Ai-lian CHENG 1,Yun PAN 1,2,Xiao-lang YAN 2,Ruo-hong HUAN 3 (1 Department of Information Science and Electronic Engineering,Zhejiang University,Hangzhou 310027,China) (2 Institute of VLSI Design,Zhejiang University,Hangzhou 310027,China) (3 College of Computer Science and Technology,Zhejiang University of Technology,Hangzhou 310023,China) | 2011 | Journal of Zhejiang University-Science C(Computers and Electronics)2011，12，7： | 2 |
| 20 | Current and Passive Smokers Have Poorer Quantity and Quality of Diet in Shanghai, China: A Crosssectional Survey显示文摘Smoking is a major risk factor for chronic diseases,it has been estimated that 300 million adults currently smoke in China,and the smoking prevalence in males is as high as 52.9%,with 1million smoking-related deaths yearly.Therefore,smoking is also a huge health burden in China[1].Researchers have suggested an association between diet and smoking status with respect to both food and nutrient intakes.According to such studies,smokers tended to have a poor diet. | WANG Zheng Yuan LI Li ZANG Jia Jie SHI Ze Huan JIN Wei QI De Yun TANG Chuan Xi GAO Hong Mei WANG Jin Xiang ZHU Zhen Ni JIA Xiao Dong GUO Chang Yi | 2019 | Biomedical and Environmental Sciences2019，32，10： | 2 |
您所在的机构暂未开通此部分的功能，请联系管理员