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您的检索式：作者名="Yuqiao Qin"
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| 1 | Natural long-chain saturated fatty acids doped LNPs enabling spleen selective mRNA translation and potent cancer immunotherapy显示文摘Rationally tailored lipid nanoparticles(LNPs)with efficient and tunable delivery of mRNA in vivo are crucial for mRNA vaccines.Selective expression of antigenic protein in lymphoid tissues/organs could improve the immunostimulatory efficacy and safety of LNPs-based mRNA vaccines.Inspired by the metabolic behavior that long-chain saturated fatty acids tending to enter lymphoid tissue rather than the liver,we developed fatty acid-doped LNPs capable of mediating differential protein expressions in the liver and spleen when administered intravenously.When the molar ratio of saturated fatty acid located 60%–70%,the doped LNPs achieved the spleen selective mRNA translation.The mechanism could be attributed to the different cellular uptake behaviors of saturated fatty acids in hepatocytes.Immunization with a model antigen(ovalbumin)mRNA-loaded spleen selective LNPs,we observed enhanced antigen-specific T cell immune responses,and potent immunotherapeutic and immunoprophylactic efficacy in the mouse lymphoma model.Our natural long-chain saturated fatty acids metabolic characteristics-inspired design of LNPs for spleen-selective mRNA vaccines delivery will provide references for designing mRNA vaccines with high efficacy and safety for tumor immunotherapy. | Fazhan Wang Meng Zhang Meiling Tian Jia Lou Longze Pan Xiaoke Gao Lijing Zhang Xiaohan Lou Linyu Zhu Yuqiao Sheng Ming Wang Rui Xue Wenjing Deng Shuai Shao Zhihai Qin | 2024 | Nano Research2024，17，3： | 0 |
| 2 | Tie2-expressing monocytes/macrophages promote cerebral revascularization in peri-infarct lesions upon ischemic insult显示文摘Dear Editor,Strokes cause 5.8 million deaths each year.Among these victims,~30% are from China1.Acute ischemic stroke(AIS)is the most prevalent subtype of strokes.Although drugs can alleviate the symptoms,the recoveries of functional vessels within ischemic areas are the critical factor determining the prognosis of patients suffering from AIS2.Nevertheless,the mechanisms involved in cerebral revascularization remain largely unknown. | Yuqiao Sheng Xixi Duan Yanru Liu Feng Li Shengli Ma Xiaoping Shang Xiao Wang Yangyang Liu Rui Xue Zhihai Qin | 2021 | Signal Transduction and Targeted Therapy2021，6，9： | 0 |
| 3 | A Cluster of Rhabdomyolysis Syndrome Resulting from Carp Consumption in Gongcheng Yao Autonomous County,Guangxi,2016显示文摘What is already known about this topic?A common food that has been associated globally with rhabdomyolysis syndrome is freshwater fish including freshwater cod,barracuda,buffalo fish,and pomfret.However,cases caused by freshwater fish have been relatively rare in China.What is added by this report?In this investigation,a cluster of five cases of rhabdomyolysis syndrome were found that were linked to consumption of carp testes and eggs,one of the first carp-related rhabdomyolysis syndrome cases reported in China.What are the implications for public health practice?To avoid similar incidents,food safety education for local residents needs to be prioritized and implemented.In addition,case monitoring of rhabdomyolysis syndrome should be strengthened through more thorough collection of epidemiological data and monitoring of pathogenic foods. | Jinshui Zeng Yinpin Liu Huilai Ma Huihui Liu Yonghong Li Shunli Mo Yuqiao Qin Lijie Zhang | 2020 | China CDC weekly2020，2，2： | 0 |
| 4 | Construction of Angularly Fused Tricyclic Compounds via Photo-induced Radical Cascade Cyclization显示文摘Photo-induced electron transfer (PET) of silyl enol ethers has been employed to synthesize several fused ring systems. However, the method has limited applicability due to its narrow substrate scope, low product yields, unsatisfactory stereo- and regioselectivity. Herein, we report a PET-triggered cascade reaction of silyl enolates that leads to the formation of angularly fused tricyclic scaffolds. The reaction exhibits broad substrate scope and excellent stereoselectivity. The regio- and stereoselectivity of this cascade reaction is elucidated via DFT calculation and conformational analysis. | Mengqin Hu Wei Cao Zhen Wang Yan Hao Ganxing Huang Yuqiao Zhou Song Qin Shaomin Fu Bo Liu | 2023 | Chinese Journal of Chemistry2023，41，19： | 0 |
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