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| 1 | Fault detection of flywheel system based on clustering and principal component analysis显示文摘Considering the nonlinear, multifunctional properties of double-flywheel with closedloop control, a two-step method including clustering and principal component analysis is proposed to detect the two faults in the multifunctional flywheels. At the first step of the proposed algorithm,clustering is taken as feature recognition to check the instructions of ‘‘integrated power and attitude control' system, such as attitude control, energy storage or energy discharge. These commands will ask the flywheel system to work in different operation modes. Therefore, the relationship of parameters in different operations can define the cluster structure of training data. Ordering points to identify the clustering structure(OPTICS) can automatically identify these clusters by the reachability-plot. K-means algorithm can divide the training data into the corresponding operations according to the reachability-plot. Finally, the last step of proposed model is used to define the relationship of parameters in each operation through the principal component analysis(PCA) method.Compared with the PCA model, the proposed approach is capable of identifying the new clusters and learning the new behavior of incoming data. The simulation results show that it can effectively detect the faults in the multifunctional flywheels system. | Wang Rixin Gong Xuebing Xu Minqiang Li Yuqing | 2015 | Chinese Journal of Aeronautics2015，28，6： | 5 |
| 2 | Characteristics of oral methicillin-resistant Staphylococcus epidermidis isolated from dental plaque显示文摘The oral microbial community is widely regarded as a latent reservoir of antibiotic resistance genes. This study assessed the molecular epidemiology, susceptibility profile, and resistance mechanisms of 35 methicillin-resistant Staphylococcus epidermidis(MRSE) strains isolated from the dental plaque of a healthy human population. Broth microdilution minimum inhibitory concentrations(MICs) revealed that all the isolates were nonsusceptible to oxacillin and penicillin G. Most of them were also resistant to trimethoprim(65.7%) and erythromycin(54.3%). The resistance to multiple antibiotics was found to be largely due to the acquisition of plasmid-borne genes. The mec A and dfr A genes were found in all the isolates, mostly dfr G(80%), aac A-aph D(20%), aad D(28.6%), aph A3(22.9%), msr A(5.7%), and the erm C gene(14.3%). Classical mutational mechanisms found in these isolates were mainly efflux pumps such as qac A(31.4%), qac C(25.7%), tet K(17.1%), and nor A(8.6%). Multilocus sequence type analysis revealed that sequence type 59(ST59) strains comprised 71.43% of the typed isolates, and the e BURST algorithm clustered STs into the clonal complex 2-II(CC2-II). The staphyloccoccal cassette chromosome mec(SCCmec) type results showed that 25(71.43%) were assigned to type IV. Moreover, 88.66% of the isolates were found to harbor six or more biofilm-associated genes. The aap, atl E, embp, sdr F, and IS256 genes were detected in all 35 isolates. This research demonstrates that biofilm-positive multipleantibiotic-resistant ST59-SCCmec IV S. epidermidis strains exist in the dental plaque of healthy people and may be a potential risk for the transmission of antibiotic resistance. | Boyu Tang Tao Gong Yujia Cui Lingyun Wang Chao He Miao Lu Jiamin Chen Meiling Jing Anqi Zhang Yuqing Li | 2020 | International Journal of Oral Science2020，12，2： | 2 |
| 3 | Photoreceptive reaction spectrum effect and phototactic activity intensity of locusts’ visual display characteristics stimulated by spectral light显示文摘To reveal the nature of locusts’visual reaction when stimulated by light,and to clarify the regulation characteristics of locusts’phototactic visual physiology and obtain good spectral light features for locusts’phototactic action,this study investigated locusts’visual spectrum response by characterizing their photoreceptive reaction to LED light using an AvaSpec fiber-optic spectrometer system.Locusts’phototactic response to spectral light was compared using this system.The results showed that locusts’visual reaction characterization presents a photo-induced vision spectrum effect and that by offsetting the main wavelength of light and the spectral peak intensity,a time-varying bio-regulation effect emerges.In addition,locusts’visual regulation ability to UV light is higher than that to violet light,whereas their reaction intensity is lower than to violet light,and the visual bio-regulatory force of locusts’visual system absorbing orange light to react sensitively becomes gradually higher than when absorbing green light as time goes on.Moreover,corresponding to nominal illumination with the same radiant energy and a visual spectrum response stimulated by UV,violet,orange,and green light,it appears that the visual spectrum window is symmetrical around 382 nm,400 nm,602 nm,and 530 nm,respectively,with no significant difference between spectral amplitudes and having a time-varying incremental characteristic with amplitude peak width.This indicates that the stimulus intensity of UV,violet,orange,and green light exceeds locusts’visual tolerance,causing them to generate regulation inactivation as a visual physiological reaction,whereas the visual window response effect stimulated by UV light presents an illumination timeliness effect.Simultaneously,time-varying characteristics of locusts’bio-behavior intensity show that light intensity can make up for locusts’visual sensitivity differences at various spectral wavelengths.Presented with differential response time,photosensitive behavior intensity,and induction effect induced by orange light,time is superior for orange light,the stimulation effect caused by violet light is the strongest,and the phototactic synergy effect caused by UV light is the best. | Qihang Liu Yueli Jiang Jin Miao Zhongjun Gong Tong Li Yun Duan Yuqing Wu | 2021 | International Journal of Agricultural and Biological Engineering2021，14，2： | 2 |
| 4 | The role of prolactin/vasoinhibins in cardiovascular diseases显示文摘Prolactin(PRL)is a polypeptide hormone that is mainly synthesized and secreted by the lactotroph cells of the pituitary.There are two main isoforms of PRL:23-kDa PRL(named full-l ength PRL)and vasoinhibins(including 5.6–18 kDa fragments).Both act as circulating hormones and cytokines to stimulate or inhibit vascular formation at different stages and neovascularization,including endothelial cell proliferation and migration,protease production,and apoptosis.However,their effects on vascular function and cardiovascular diseases are different or even contrary.In addition to the structure,secretion regulation,and signal transduction of PRL/vasoinhibins,this review focuses on the pathological mechanism and clinical significance of PRL/vasoinhibins in cardiovascular diseases. | Hui Zhao Sugang Gong Yongcong Shi Cijun Luo Hongling Qiu Jing He Yuanyuan Sun Yuxia Huang Shang Wang Yuqing Miao Wenhui Wu | 2023 | Animal Models and Experimental Medicine2023，6，2： | 1 |
| 5 | The identification, typing, and antimicrobial susceptibility of Pseudomonas aeruginosa isolated from mink with hemorrhagic pneumonia显示文摘 | Jing Qi Lulu Li Yijun Du Shourong Wang Jinwen Wang Yanbo Luo Jie Che Jinxing Lu Hui Liu Guangchun Hu Jixia Li Yanwen Gong Guisheng Wang Ming Hu ShiganYan Yuqing Liu | 2014 | Veterinary Microbiology2014，，： | 1 |
| 6 | Visual response effects of western flower thrips manipulated by different light spectra显示文摘To understand how spectral light wavelength affects thrips visual sensitivity,the selective response and the approach sensitivity of western flower thrips were examined.The results showed that light intensity affected thrips selective sensitivity to different spectra,with good visual sensitivity to blue,ultraviolet(UV),and green light changes to UV,violet,and yellow light when illumination increased from 120 lx to 6000 lx.Red light was the sensitive spectral light driving thrips to respond to sensitive light.Under illumination,the best sensitivity response to spectra was violet,while under light energy,this changed to UV when light energy was increased to 120 mW/cm^(2).However,the photo-stimulus properties(illumination or light energy)did not affect the optimal approach sensitivity to UV light.Furthermore,when illumination or light energy stimulated thrips to select two different spectral lights,the total response sensitivity to 12000 lx of UV and violet light were the best(83.27%),while at 60 mW/cm^(2) of UV and yellow light was the best(82.15%).But different photo-stimulus properties influenced on the total approach sensitivity to the stimulation of two different spectral lights when the intensity of light increased,showing that to 12000 lx of violet and green light was the best(53.18%),while for 120 mW/cm^(2) of UV and green light was the best(47.74%).The thrips visual selection response effects stimulated by illumination were different from that induced by light energy,and originated from the thrips different bio-regulatory effects caused by the intensity of light energy of illumination and the intensity of illumination of light energy.Therefore,different photo-stimulus effects can manipulate thrips visual sensitivity to enhance the phototactic effect. | Qihang Liu Yueli Jiang Jin Miao Zhongjun Gong Tong Li Yun Duan Yuqing Wu | 2019 | International Journal of Agricultural and Biological Engineering2019，12，5： | 1 |
| 7 | Engineered synovial joint condyle using demineralized bone matrix显示文摘 | Gong Meiqing Zhang Dawei Wan Yuqing | 2010 | Materials Science and Engineering:C2010，30，4： | 1 |
| 8 | The Precision Estimate of Multi-Fractal Methods of Time Sequence of Earthquakes显示文摘At present,there are many methods of calculating seismic time-fractal.However,there isn’t aquantitative result about the precision of every method.So,in this Paper,we use the digitalimitation of theoretic model to solve precision estimate problems of calculating the precision ofone dimension distribution of theoretic models with Cantor multi-fractal set,we obtained someresults as follows:(1)There exists many problems such as rules,numbers of samples,basicpoint selection,the diffence resulted from different methods and so on.(2)The fixed-massmethod(MAS)and the minimal spanning tree method(MST)can give good structure charac-teristics with different q value,while the counting-boxes method can’t.And the error of thefixed-radius method(RAD)in the range of-q is too big.(3)There are scale problems of rulesfor multi-fractal,it is objective reflection for non-rule area.(4)MST has the boundary prob-lem,while MAS and RAD don’t.(5)With increasing sample number,the precision of allfractal-dimension values | Zhu Lingren , Zhou Shiyong , Yang Maling , Hong Shizhong , Gong Yuqing and Wang Haitao Seismological Bureau of Xinjiang Uygur Autonomous Region, Urumqi 830011 , ChinaSeismological Bureau of Guangdong Province, Guangzhou 510070. China Seismological Bu | 2000 | Earthquake Research in China2000，14，4： | 1 |
| 9 | Microstructure and Mechanical Properties of Resistance Spot Welds for Fe-based Metallic Glass显示文摘The lap joints of Fe-based metallic glass ribbons were carried by resistance spot welding, and the microstructures of spot welds were investigated by X-ray diffraction and transmission electron microscopy. The results indicated that the perfect formations of joints without typical defects such as spatter were achieved with optimized parameters. Except for little nano-particle Fe_2B, no other crystalline particle was detected by TEM, revealing that the most microstructure in spot weld remains amorphous. The maximum tensile-shearing force was 45.0 N with the optimized parameters of 1 kA weld current, 30 N electrode force and 0.02 ms weld time. The spot weld failed as pullout failure mode propagating along the interface of nugget zone. The study demonstrates that resistance spot welding is an effective and practical welding process for Fe-based metallic glass. | 王善林 GONG Yubing LI Juan LI Hongxiang MAO Yuqing KE Liming | 2018 | Journal of Wuhan University of Technology(Materials Science)2018，33，4： | 1 |
| 10 | Genome degradation promotes Salmonella pathoadaptation by remodeling fimbriae-mediated proinflammatory response显示文摘Understanding changes in pathogen behavior(e.g.increased virulence,a shift in transmission channel)is critical for the public health management of emerging infectious diseases.Genome degradation via gene depletion or inactivation is recognized as a pathoadaptive feature of the pathogen evolving with the host.However,little is known about the exact role of genome degradation in affecting pathogenic behavior,and the underlying molecular detail has yet to be examined.Using large-scale global avian-restricted Salmonella genomes spanning more than a century,we projected the genetic diversity of Salmonella Pullorum(bvSP)by showing increasingly antimicrobial-resistant ST92 prevalent in Chinese flocks.The phylogenomic analysis identified three lineages in bvSP,with an enhancement of virulence in the two recently emerged lineages(L2/L3),as evidenced in chicken and embryo infection assays.Notably,the ancestor L1 lineage resembles the Salmonella serovars with higher metabolic flexibilities and more robust environmental tolerance,indicating stepwise evolutionary trajectories towards avian-restricted lineages.Pan-genome analysis pinpointed fimbrial degradation from a virulent lineage.The later engineeredfim-deletion mutant,and all other five fimbrial systems,revealed behavior switching that restricted horizontal fecal-oral transmission but boosted virulence in chicks.By depleting fimbrial appendages,bvSP established persistent replication with less proinflammation in chick macrophages and adopted vertical transovarial transmission,accompanied by ever-increasing intensification in the poultry industry.Together,we uncovered a previously unseen paradigm for remodeling bacterial surface appendages that supplements virulence-enhanced evolution with increased vertical transmission. | Xiao Zhou Xiamei Kang Jiaqi Chen Yan Song Chenghao Jia Lin Teng Yanting Tang Zhijie Jiang Xianqi Peng Xiaoxi Tao Yiwei Xu Linlin Huang Xuebin Xu Yaohui Xu Tengfei Zhang Shenye Yu Jiansen Gong Shaohui Wang Yuqing Liu Guoqiang Zhu Corinna Kehrenberg Franois-Xavier Weill Paul Barrow Yan Li Guoping Zhao Min Yue | 2023 | National Science Review2023，10，10： | 0 |
| 11 | Edge Ohmic Heating Experiment on HT-6M Tokamak显示文摘An improved ohmic confinement has been achieved on HT-6M tokamak after application of edge ohmic heating pulse which makes plasma current rapidly ramp up(0.4 ms)in a ramp rate of 12 MA/s.The improved ohmic confinement phase is characterized by(a)energy and particle confinement time increase,(b)non-symmetric increased density ne,(c)reduced Hαradiation,(d)increased Te and steeper Te,ne profile at the edge.The results from soft x-ray sawteeth inversion radius andβ_(p)+l_(i)/2 implied the anomalous current penetration. | GAO Xiang FAN Shuping LI Jian’gang MENG Yuedong LUO Jiarong YIN Fhxian ZENG Lei DING LianchengLIN Bili ZHANG Wei HAN Yuqing TONG Xingde LUO Lanchang GONG Xianzu JIANG Jiaguang WU Mingjun YIN Fei | 1994 | Chinese Physics Letters1994，11，3： | 0 |
| 12 | Enhanced Differentiable Architecture Search Based on Asymptotic Regularization显示文摘In differentiable search architecture search methods,a more efficient search space design can significantly improve the performance of the searched architecture,thus requiring people to carefully define the search space with different complexity according to various operations.Meanwhile rationalizing the search strategies to explore the well-defined search space will further improve the speed and efficiency of architecture search.With this in mind,we propose a faster and more efficient differentiable architecture search method,AllegroNAS.Firstly,we introduce a more efficient search space enriched by the introduction of two redefined convolution modules.Secondly,we utilize a more efficient architectural parameter regularization method,mitigating the overfitting problem during the search process and reducing the error brought about by gradient approximation.Meanwhile,we introduce a natural exponential cosine annealing method to make the learning rate of the neural network training process more suitable for the search procedure.Moreover,group convolution and data augmentation are employed to reduce the computational cost.Finally,through extensive experiments on several public datasets,we demonstrate that our method can more swiftly search for better-performing neural network architectures in a more efficient search space,thus validating the effectiveness of our approach. | Cong Jin Jinjie Huang Yuanjian Chen Yuqing Gong | 2024 | Computers, Materials & Continua2024，78，2： | 0 |
| 13 | Data-driven strategies for the computational design of enzyme thermal stability:trends,perspectives,and prospects显示文摘Thermal stability is one of the most important properties of enzymes,which sustains life and determines the potential for the industrial application of biocatalysts.Although traditional methods such as directed evolution and classical rational design contribute greatly to this field,the enormous sequence space of proteins implies costly and arduous experiments.The development of enzyme engineering focuses on automated and efficient strategies because of the breakthrough of high-throughput DNA sequencing and machine learning models.In this review,we propose a data-driven architecture for enzyme thermostability engineering and summarize some widely adopted datasets,as well as machine learning-driven approaches for designing the thermal stability of enzymes.In addition,we present a series of existing challenges while applying machine learning in enzyme thermostability design,such as the data dilemma,model training,and use of the proposed models.Additionally,a few promising directions for enhancing the performance of the models are discussed.We anticipate that the efficient incorporation of machine learning can provide more insights and solutions for the design of enzyme thermostability in the coming years. | Zhixin Dou Yuqing Sun Xukai Jiang Xiuyun Wu Yingjie Li Bin Gong Lushan Wang | 2023 | Acta Biochimica et Biophysica Sinica2023，55，3： | 0 |
| 14 | A study on continuous Chinese speech recognition based on stochastic trajectory models显示文摘After pointed the unreasonableness of the three basic assumptions contained in HMM, we introduce the theory and the advantage of Stochastic najectory Models (STMs) that possibly resolve these problems caused by HMM assumptions. In STM, the acoustic observations of an acoustic unit are represented as clusters of trajectories in a parameter space.The trajectories are modelled by mixture of probability density functions of random sequence of states. After analyzing the characteristics of Chinese speech, the acoustic units for continuous Chinese speech recognition based on STM are discussed and phone-like units are suggested. The performance of continuous Chinese speech recognition based on STM is studied on VINICS system. The experimental results prove the efficiency of STM and the consistency of phone-like units. | MA Xiaohui(Department of Radio Engineering Southeast University Nanjing 210096)GONG Yifan(CRIN/CNRS France)FU Yuqing LU Jiren(Department of Radio Engineering Southeast University Nanjing 210096) | 1997 | Chinese Journal of Acoustics1997，16，4： | 0 |
| 15 | miR-290 contributes to the low abundance of cyclin D1 protein in mouse embryonic stem cells显示文摘老鼠 miR-290 簇 miRNAs 在早胚胎和胚胎的细菌房间明确地被表示。这些 miRNAs 戏在 pluripotency 和自强的维护的关键角色。这里,我们证明 Cyclin D1 是 miR-290 簇 miRNAs 的直接目标基因。在在 pluripotent 和 non-pluripotent 房间,以及在区分 CGR8 房间的 Cyclin D1 蛋白质和 miR-290 簇 miRNAs 的表示之间的否定关系被观察。miR-290 簇 miRNAs 的抑制能在 G1 阶段逮捕房间并且在 CGR8 老鼠干细胞减慢房间增长。因为 miR-290 簇 miRNAs 是最主导的 stem-cell-specific miRNAs,我们的结果在老鼠为 Cyclin D1 的缺席揭示了一个重要原因胚胎的干细胞。 | Zizhen Gong Detao Wang Shaoliang Zhu Yuqing Xia Chunsun Fan Botao Zhao Youxin Jin | 2017 | Acta Biochimica et Biophysica Sinica2017，49，7： | 0 |
| 16 | Effects of yellow and green light stress on emergence,feeding and mating of Anomala corpulenta Motschulsky and Holotrichia parallela Motschulsky(Coleoptera:Scarabaeidae)显示文摘Light is one of the key environmental factors for insects to survive.Artificial light sources different from natural environmental light can cause light stress in insects.Yellow and green light stress can interfere with the diurnal rhythm of nocturnal moths and their mating,oviposition,and adult longevity.The scarabaeid beetles Anomala corpulenta Motschulsky and Holotrichia parallela Motschulsky are widely distributed,and they are very harmful underground pests.In order to clarify the effects of light stress on their behaviors,individuals of both species were exposed to yellow light(565-585 nm)and green light(525-545 nm),with different light intensity gradients of yellow light in a laboratory setting.The short-term light stress treatment of A.corpulenta and H.parallela was carried out at night.The number of beetles emerging per half an hour was recorded,and mating pairs and feeding activity in 24 h were counted.The results showed that yellow and green light stress significantly changed the rhythm and reduced the rate of beetle emergence in the two beetle species investigated.Also,the peak emergence activity was delayed and the feeding and mating activities were significantly reduced.When treated with different intensities of yellow light,it was found that the rate of emergence of A.corpulenta under 10 lx was close to the control groups.The rate of emergence in H.parallela was significantly lower than the control groups before 0:00,in the 60 lx and 110 lx treatment groups,but after 0:00,the emergence rate of H.parallela was significantly higher in the 60 lx and 110 lx treatment groups than other treatments.However,the emergence rhythms in the three light intensity treatment groups are basically the same as in the control groups.The feeding amount and mating beetles in the three light intensity treatment groups were significantly lower than in the control groups.There were no significant differences in the three treatments.The results show that light stress above 10 lx significantly interferes with the behavioral activities of the two beetle species,investigated.This study provides a new approach for a light control technology for nocturnal beetle pest species. | Yueli Jiang Qiuying Huang Guoshu Wei Zhongjun Gong Tong Li Jin Miao Ruijie Lu Shiqiong Mei Xueqin Wang Yun Duan Yuqing Wu Chuantao Lu | 2023 | International Journal of Agricultural and Biological Engineering2023，16，1： | 0 |
| 17 | Preliminary Functional Study on Wnt9a Cloning from Human Embryonic Stem Cells显示文摘 | Xueqin Zheng Xiaonian Zhong Chengneng Mi Shuangmei Liu Wenjing Meng Yang Liu Biao Xie Yun Pan Yuqing Gong Shiying Yu Chaobo Cai Yanan Cui Dongsong Nie Yang Xiang | 2011 | Journal of Life Sciences2011，5，11： | 0 |
| 18 | Design of Support Effect in the Catalytic Application of Ligand-Protect Gold Clusters显示文摘Ligand-protected gold(Au_(n))clusters sometimes need the removal of organic ligands to expose more active sites and reduce steric hindrance in catalytic reactions,and large amount of organic and inorganic materials usually need to be employed as supports to anchor Aun clusters through different interaction mechanisms.Whereas,less comprehensive summaries have been provided about the crucial contribution of various supports to the catalytic performance of the supported Aun clusters.Herein,this review firstly summarizes synthesis methods(e.g.,impregnation and encapsulation processes)for the supported Aun cluster catalysts,and then mainly points out specific contributions of support effect in a great diversity of catalytic reactions,as well as deep interaction mechanisms.Besides,opportunities and challenging issues will be stated towards supported Aun clusters,in terms of improving catalytic performance and structural stability of Aun clusters inthedemand of catalysis. | Shuohao Li Shenguang Fu Yuqing Gong Nuojie Wu Lei Wang Liang Wang | 2024 | Chinese Journal of Chemistry2024，42，1： | 0 |
| 19 | Enzymatically prepared alginate oligosaccharides improve broiler chicken growth performance by modulating the gut microbiota and growth hormone signals显示文摘Background Alginate oligosaccharide(AOS)holds great potential as a novel feed supplement in farm animals.However,the effects of AOS on chicken health and the underlying mechanisms are not fully understood.This study aimed to optimize the enzymatic preparation of AOS by using bacterial alginate lyases expressed in yeast,investigate the effects of the prepared AOS on the growth performance and gut health of broiler chickens,and reveal the underlying mechanisms.Results Five alginate lyases from bacteria were cloned into Pichia pastoris GS115 and the alginate lyase PDE9 was expressed at relatively high yield,activity and stability in P.pastoris.Animal trials were carried out using 3201-day-old male Arbor Acres broilers(four groups;8 replicates/group×10 chicks/replicate)receiving either a basal diet or the same diet supplemented with 100,200 and 400 mg/kg PDE9-prepared AOS for 42 d.The results showed that dietary supplementation of 200 mg/kg AOS displayed the highest activity in promoting the birds’ADG and ADFI(P<0.05).AOS ameliorated the intestinal morphology,absorption function and barrier function,as indicated by the enhanced(P<0.05)intestinal villus height,maltase activity,and the expression of PEPT,SGLT1,ZNT1,and occludin.AOS also increased serum insulin-like growth factor-1,ghrelin(P<0.05),and growth hormone(P<0.1).Moreover,the concentrations of acetate,isobutyrate,isovalerate,valerate,and total SCFAs in cecum of birds fed AOS were significantly higher than the control birds(P<0.05).Metagenomic analysis indicated that AOS modulated the chicken gut microbiota structure,function,and microbial interactions and promoted the growth of SCFAs-producing bacteria,for example,Dorea sp.002160985;SCFAs,especially acetate,were found positively correlated with the chicken growth performance and growth-related hormone signals(P<0.05).We further verified that AOS can be utilized by Dorea sp.to grow and to produce acetate in vitro.Conclusions We demonstrated that the enzymatically produced AOS effectively promoted broiler chicken growth performance by modulating the chicken gut microbiota structure and function.For the first time,we established the connections among AOS,chicken gut microbiota/SCFAs,growth hormone signals and chicken growth performance. | A La Teng Zhu La Yuqing Feng Die Hu Yimei Feng Xiaolu Jin Dan Liu Yuming Guo Gong Cheng Yongfei Hu | 2023 | Journal of Animal Science and Biotechnology2023，14，5： | 0 |
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