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| 1 | Clinical features and prognosis in colorectal cancer patients with different ethnicities in Northwest China显示文摘AIM:To compare the clinical factors and tumor characteristics that predict survival in colorectal cancer(CRC)patients with different ethnicities in Xin Jiang area.METHODS:A total of 1421 histopathologically confirmed sporadic CRC patients who were either Han/Chinese or Uyghur were identified and enrolled from a database of both diagnoses and operative procedures from Xin Jiang Tumor Hospital,which is affiliated to Xin Jiang Medical University between 2000 and 2007.Patients with family histories of CRC,hereditary nonpolyposis CRC,familial adenomatous polyposis,inflammatory bowel disease,carcinoid,squamous carcinoma or melanoma were excluded.The two ethnic groups were compared with regard to clinical features,tumor characteristics,disease stage,overall survival rate,diseasefree survival rate and cancer-specific survival rate.The factors predicting long-term survival were assessed via both univariate and multivariate analysis.RESULTS:Among the 1421 patients with CRC enrolled in this study,1210 patients were Han/Chinese(mean age,62.3±4.5 years;range,19-92 years),while 211patients were Uyghur(mean age,52.4±15.6 years;range,17-87 years).There were significant differences in proportions of gender,age,blood type,occupation and histopathological type between the Han/Chinese and Uyghur patients(P<0.05).The median overall,disease-free and cancer-specific survival time were 45,62and 65 mo for the Han/Chinese patients and 42,49 and61 mo for the Uyghur patients(P=0.000,P=0.005,P=0.007).The cumulative 5-year survival of the Uyghur patients was significantly worse than that of the Han patients(P=0.000).A multivariate analysis showed that age,ethnicity,histopathological type,differentiation,T(Infiltration depth),N(Lymph node metastasis),staging,postoperative metastasis and metastatic site(P<0.05)were found to be the prognostic factors.CONCLUSION:The Uyghur CRC patients are associated with significantly younger age,more aggressive histopathologic characteristics and have significantly worse prognosis than the Han/Chinese patients. | Akram Yusup Hai-Jiang Wang Azmat Rahmutula Parhat Sayim Ze-Liang Zhao Guo-Qing Zhang | 2013 | World Journal of Gastroenterology2013，19，41： | 14 |
| 2 | Expression of trefoil factors and TWIST1 in colorectal cancer and their correlation with metastatic potential and prognosis显示文摘AIM To detect the expression of trefoil factors(TFFs)and TWIST1 in colorectal cancer(CRC)and analyze their correlation with metastasis and survival.METHODS This study examined the expression of TFF1,TFF3 and TWIST1 in a total of 75 tumor samples,47 matched normal samples(15 cm from the lesion margin),30metastatic lymph nodes,and 10 liver metastatic cancer samples from patients with CRC.The relationship was then analyzed between the protein expression and different clinical records.TFF1,TFF3,TWIST1,E-cadherin,vimentin andβ-catenin m RNA and protein expression levels were measured in colon cancer cell lines with different metastatic potentials(HIEC,HT29,SW620,and Lo Vo cells),and the correlation of the expression levels with epithelial-mesenchymal transition(EMT)was discussed.RESULTS It was found that 66.7%(50/75),78.7%(59/75)and54.7%(41/75)of tumor tissue samples exhibited positive staining for TFF1,TFF3 and TWIST1 and so did 27.3%(13/47),100%(47/47)and 17%(8/47)of adjacent normal colorectal tissues.Compared with adjacent normal tissues,significant differences were found in the expression of all three proteins in different cancerous tissues(P<0.05).Higher expression of TFF3 and TWIST1 was significantly correlated with lymph node metastasis(P=0.034,P=0.000),advanced stage(P=0.031,P=0.003),and poorer survival(P=0.042 for the TFF3 group,P=0.003for the TWIST1 group).The expression of TFF3 and TWIST1 in cancer cell lines was higher than that in HIEC(a normal human intestinal epithelial cell line)(P<0.05),and the expression intensity demonstrated a tendency to rise with increased metastatic potential both at the protein and m RNA levels.However,TFF1expression demonstrated the opposite tendency.It was also observed that the expression of E-cadherin andβ-catenin tended to decrease while that of vimentin,TWIST1 and Snail tended to rise with the increase in metastatic potential.CONCLUSION The expression of TFF3 and TWIST1 might be associated with the survival of patients with CRC after curative resection and might be pivotal predictors of disease progression.TFF3 may be correlated to the invasiveness of CRC. | Akram Yusup Bailikezi Huji Cheng Fang Fei Wang Tuerxunjiang Dadihan Hai-Jiang Wang Halmurat Upur | 2017 | World Journal of Gastroenterology2017，23，1： | 7 |
| 3 | Study on ecological migration in Xinjiang, China显示文摘This paper expounds on the meaning of migration and the status quo of studies at home and abroad on migration and ecological migration. It focuses on the discussion of the necessity of ecological migration in Xinjiang, and the problems faced by the ecological emigrants, such as the lack of water, the serious land salination and basification, sand storms, and the adaptation to the environment. Besides, it probes into the problems existing in the ecological migration, including the unscientific design of the moving project, the defects of the reclamation work, and the irrational treatment of the relation between ecological migration and regional development. Based on this, we put forward some suggestions about and countermeasures against those problems. | Abliz Yusup Osman Niyaz | 2006 | Ecological Economy2006，2，3： | 1 |
| 4 | Mathematical and computational approaches for design of biomass gasification for hydrogen production : A review 显示文摘 | AHMED T Y AHMAD M M YUSUP S | 2012 | Renewable and Sustainable Energy Reviews2012，16，4： | 1 |
| 5 | Optimization of polyol ester production by transesterification of Jatropha-based methyl ester with trimethylolpropane using Taguchi design of experiment显示文摘 | Kamil R N M Yusup S Rashid U | 2011 | Fuel2011，90，6： | 1 |
| 6 | COX-2 expression predicts resistance to chemoradiotherapy in esophageal squamous cell carcinoma显示文摘 | Akutsu Y Hanari N Yusup G | 2011 | Ann Surg Oncol2011，18，10： | 1 |
| 7 | COX2 expression predicts re- sistance to chemoradiotherapy in esophageal squamous cell carci- noma显示文摘 | Akutsu Y Hanari N Yusup G | 2011 | Ann Surg Oncol2011，18，10： | 1 |
| 8 | Treatment of Terasil Red R and Cibacron Red R wastewater using extracted aluminum from red earth: factorial design显示文摘 | ALKARKHI A F M LIM H K YUSUP Y | 2013 | Journal of Environmental Management2013，122，： | 1 |
| 9 | Production of a bioflocculant from Aspergillus niger using palm oil mill effluent as carbon source显示文摘 | Ahmad H. Rajab Aljuboori Yoshimitsu Uemura Noridah Binti Osman Suzana Yusup | 2014 | Bioresource Technology2014，，： | 1 |
| 10 | Basic properties of crude rubber seed oil and crude palm oil blend as a potential feedstock for biodieselproduction with cold flow characteristics显示文摘 | Suzana Yusup Modhar Khan | 2010 | Biomass and Bioenergy2010，34，10： | 1 |
| 11 | The influence of temperature on adsorption capacity of Malaysian coal显示文摘 | A.S. Azmi S. Yusup S. Muhamad | 2005 | Chemical Engineering & Processing: Process Intensification2005，，5： | 1 |
| 12 | O- verview of PSO for optimizing process parameters of machining显示文摘 | Norfadzlan Yusup Azlan Mohd Zain Siti Zaiton Mohd Hashim | 2012 | Procedia Engineering2012，29，： | 1 |
| 13 | Overview of PSO for op timization process parameters of machining 显示文摘 | Yusup N Zain A M Hashim S Z M | 2012 | Procedia En gineering2012，29，1： | 1 |
| 14 | Base Catalyzed Transesterification of Acid Treated Vegetable Oil Blend for Biodiesel Production 显示文摘 | Yusup S Khan M A | 2010 | Biomass Bioenergy2010，34，10： | 1 |
| 15 | Catalytic cracking of bio-oil to organic liquid product (OLP) 显示文摘 | HEW K L TAMIDI A M YUSUP S | 2010 | Bioresource Technology2010，101，22： | 1 |
| 16 | Interactions between aspirin and COX-2 inhibitors or NSAIDs in a rat thrombosis model显示文摘 | Umar A Boisseau M Yusup A | 2004 | Fund Clin Pharmacol2004，18，5： | 1 |
| 17 | Taguehi's parametric design approach for the selection of optimization variables in a refrigerated gas plant 显示文摘 | NOORYUSMIZA Y RAMASAMY M YUSUP S | 2011 | Chemical Engineering Research & Design2011，89，： | 1 |
| 18 | The influence oftemperature on adsorption capacity of Malaysian coal 显示文摘 | AZMI A S YUSUP S MUHAMAD S | 2006 | Chemical Engineering and Processing2006，45，39： | 1 |
| 19 | Interactions between aspirin and COX-2 inhibitors or NSAIDs in a rat thrombosis model显示文摘 | Umar A Boisseau M Yusup A | 2004 | Fundam Clin Pharmacol2004，18，5： | 1 |
| 20 | Effects of tolterodine on an overactive bladder depend on suppression of C-fiber bladder afferent activity in rats显示文摘 | Yokoyama O Yusup A Miwa Y | 2005 | J Urol2005，174，5： | 1 |
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