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| 1 | Impact of the Built Environment on the Spatial Heterogeneity of Regional Innovation Productivity:Evidence from the Pearl River Delta,China显示文摘With the global economy increasingly dependent on innovation,urban discourse has shifted to consider what kinds of spatial designs may best nurture innovation.We examined the relationship between the built environment and the spatial heterogeneity of regional innovation productivity(RIP)using the example of China's Pearl River Delta(PRD).Based on a spatial database of 522546 patent data from 2017,this study proposed an innovation-based built environment framework with the following five aspects:healthy en-vironment,daily interaction,mixed land use,commuting convenience,and technology atmosphere.Combining negative binomial regression and Geodetector to examine the impact of the built environment on RIP,the results show that the spatial distribution of innovation productivity in the PRD region is extremely uneven.The negative binomial regression results show that the built environment has a significant impact on the spatial differentiation of RIP,and,specifically,that healthy environment,mixed land use,commuting convenience,and technology atmosphere all demonstrate significant positive impacts.Meanwhile,the Geodetector results show that the built environment factor impacts the spatial heterogeneity of RIP to varying degrees,with technology atmosphere demonstrating the greatest impact intensity.We conclude that as regional development discourse shifts focus to the knowledge and innovation economy,the innovation-oriented design and updating of built environments will become extremely important to policymakers. | WU Kangmin WANG Yang ZHANG Hong’ou LIU Yi YE Yuyao | 2021 | Chinese Geographical Science2021，31，3： | 5 |
| 2 | Acquisition algorithm assisted by AGC control voltage for DSSS signals显示文摘An appropriate acquisition configuration in terms of signal quality can optimize the acquisition performance. In view of this, a new approach of acquisition assisted by the control voltage of automatic gain control(AGC) is proposed. This approach judges the signal power according to the AGC control voltage and switches the working modes correspondingly and adaptively. Non-coherent accumulation times and the detection threshold are reconfigured according to the working mode. Theoretical derivation and verification by simulation in typical situations are provided, and the algorithm is shown to be superior in terms of the mean acquisition time, especially in strong signal scenarios compared with the conventional algorithm. | SHEN YuYao WANG YongQing LIU MinLi WU SiLiang | 2015 | Science China(Technological Sciences)2015，58，12： | 4 |
| 3 | Digital AGC Based on Coherent Adjustment Cycle for DSSS Receiver显示文摘In order to meet the requirements for zero value stability of direct sequence spread spectrum(DSSS) signal processing in high dynamic scenario,digital automatic gain control(AGC) is employed to regulate power.However,conventional AGC causes degradation in the synchronization performance of DSSS receiver.Based on the theoretical analysis of the influence of digital AGC on DSSS signal synchronization,this paper proposes a new AGC algorithm,which is applicable to multi-channel digital DSSS signal receiver.By making power adjustment cycle and synchronization cycle coherent with each other adaptively,the influence of digital AGC on subsequent synchronization processing has been eliminated.Theoretical analysis,simulation results and experimental data verify the validity of the proposed algorithm.By virtue of the proposed algorithm,the influence of digital AGC on DSSS signal synchronization is eliminated.This algorithm applies to an aerospace engineering project successfully. | SHEN Yuyao WANG Yongqing SHENG Dewei WU Siliang | 2015 | China Communications2015，12，2： | 3 |
| 4 | High Sensitivity Acquisition Algorithm for DSSS Signal with Data Modulation显示文摘In direct sequence spread spectrum communication both for satelliteto-ground and inter-satellite links, the system constrains due to radio frequency spectral occupation, channel data throughput and link performances in terms of data channel coding which might result in a signal structure where the symbol duration is shorter than the pseudo code period. This can generate some difficulties in the DSSS signal acquisition due to the polarity inversion caused by the data modulation. To eliminate the influence due to polarity inversion, this paper proposes a novel acquisition algorithm based on the simultaneous search of the code phase, data phase and Doppler frequency. In the proposed algorithm the data phase is predicted and the correlation period for the coherent integration can be set equal to the symbol duration. Then non-coherent accumulation over different symbol is implemented in order to enhance the acquisition algorithm sensitivity; the interval of non-coherent accumulation is the least common multiple between the symbol duration and the pseudo code period. The algorithm proposed can largely minimize the SNR loss caused by data polarity inversion and enhance acquisition performance without a noticeable increase in hardware complexity. Theoretical analysis, simulation and measured results verify the validity of the algorithm. | SHEN Yuyao WANG Yongqing CHEN Jingyao WU Siliang | 2015 | China Communications2015，12，4： | 2 |
| 5 | ROS is essential for initiation of energy deprivation-induced autophagy显示文摘Autophagy is a highly conserved degradation process in which intracellular components are engulfed into a double membrane structure,known as the autophagosomes,and then delivered to lysosomes/vacuoles for degradation(Ohsumi,2014).Recently,autophagy has been found to be responsible for maintaining glucose homeostasis in adult animals(Karsli-Uzunbas et al.,2014).However,the molecular mechanism underlying energy deprivation-induced autophagy remains relatively unclear. | Choufei Wu Yixing Li Shu Zhong Yingcong Chen Yu Xie Yuyao Feng Weijing Yao Suping Fu Yanlan Zhu Liefeng Wang Yuting Chen Liqin Zhang Jingjing Tong Cong Yi | 2021 | Journal of Genetics and Genomics2021，48，6： | 1 |
| 6 | Optical-pulse-coding phase-sensitive OTDR with mismatched filtering显示文摘Optical-pulse-coding(OPC)phase-sensitive optical time-domain reflectometry(Φ-OTDR)sends a train of pulses into a fiber,and has high spatial resolution decided by the duration of a subpulse while achieving signal-to-noise ratio(SNR)enhancement.OPCΦ-OTDR with a shorter measurement time is favorable.However,the scan rate,which is the reciprocal of the measurement time,is not easy to optimize.In this paper,mismatched filtering is introduced into OPCΦ-OTDR for the first time,which can reach the theoretical limit of scan rate determined by the fiber length.Also,the initial phase of each subpulse can be set arbitrarily,showing the capacity for controlling the location of interference fading.Although the design of the mismatched filter is based on the least-squares criterion,satisfactory decoding results are obtained,indicating that more advanced mismatched filter designs are worthy of further investigation to achieve higher performance. | Yongxin LIANG Zinan WANG Shengtao LIN Yuyao WANG Jialin JIANG Zijie QIU Chunye LIU Yunjiang RAO | 2022 | Science China(Information Sciences)2022，65，9： | 1 |
| 7 | Clinical applications of neurolinguistics in neurosurgery显示文摘The protection of language function is one of the major challenges of brain surgery.Over the past century,neurosurgeons have attempted to seek the optimal strategy for the preoperative and intraoperative identification of language-related brain regions.Neurosurgeons have investigated the neural mechanism of language,developed neurolinguistics theory,and provided unique evidence to further understand the neural basis of language functions by using intraoperative cortical and subcortical electrical stimulation.With the emergence of modern neuroscience techniques and dramatic advances in language models over the last 25 years,novel language mapping methods have been applied in the neurosurgical practice to help neurosurgeons protect the brain and reduce morbidity.The rapid advancements in brain-computer interface have provided the perfect platform for the combination of neurosurgery and neurolinguistics.In this review,the history of neurolinguistics models,advancements in modern technology,role of neurosurgery in language mapping,and modern language mapping methods(including noninvasive neuroimaging techniques and invasive cortical electroencephalogram)are presented. | Peng Wang Zehao Zhao Linghao Bu Nijiati Kudulaiti Qiao Shan Yuyao Zhou N.U.Farrukh Hameed Yangming Zhu Lei Jin Jie Zhang Junfeng Lu Jinsong Wu | 2021 | Frontiers of Medicine2021，15，4： | 1 |
| 8 | A novel virtual samples-based sparse representation method for face recognition显示文摘 | Wang Yuyao Wang Min Chen Yan | 2014 | Optik-International Journal for Light and Electron Optics2014，30，3： | 1 |
| 9 | The effect of heat treatment on the strength and toughness of carbon fiber/silicon carbide composites with different pyrolytic carbon interphase thicknesses显示文摘 | Hui Mei Qianglai Bai Yuyao Sun Haiqing Li Hongqin Wang Laifei Cheng | 2013 | Carbon2013，，： | 1 |
| 10 | The research of dual NURBS curves interpolation algorithm for high speed five-axis machining显示文摘 | LI Yuyao WANG Yuhan FENG Jingchun | 2008 | Intelligent Robotics andApplications2008，5315，2： | 1 |
| 11 | HDAC I/IIb selective inhibitor Purinostat Mesylate combined with GLS1 inhibition effectively eliminates CML stem cells显示文摘Purinostat Mesylate(PM)is a novel highly selective and active HDAC I/IIb inhibitor,and the injectable formulation of PM(PMF)based on the compound prescription containing cyclodextrin completely can overcome PM’s poor solubility and improves its stability and pharmacokinetic properties.Here,we showed that PM effectively repressed the survival of Ph+leukemia cells and CD34+leukemia cells from CML patients in vitro.In vivo studies demonstrated that PMF significantly prevented BCR-ABL(T315I)induced CML progression by restraining leukemia stem cells(LSCs),which are insensitive to chemotherapy and responsible for CML relapse.Mechanism studies revealed that targeting HDAC I/IIb repressed several important factors for LSCs survival including c-Myc,β-Catenin,E2f,Ezh2,Alox5,and mTOR,as well as interrupted some critical biologic processes.Additionally,PMF increased glutamate metabolism in LSCs by increasing GLS1.The combination of PMF and glutaminase inhibitor BPTES synergistically eradicated LSCs by altering multiple key proteins and signaling pathways which are critical for LSC survival and self-renewal.Overall,our findings represent a new therapeutic strategy for eliminating LSCs by targeting HDAC I/IIb and glutaminolysis,which potentially provides a guidance for PMF clinical trials in the future for TKI resistance CML patients. | Qiang Qiu Linyu yang Yunyu Feng Zejiang Zhu Ning Li Li Zheng Yuanyuan Sun Cong Pan Huandi Qiu Xue Cui Wei He Fang Wang Yuyao Yi Minghai Tang Zhuang Yang Yunfan Yang Zhihui Li Lijuan Chen Yiguo Hu | 2023 | Bioactive Materials2023，，3： | 1 |
| 12 | Continuous-variable quantum key distribution with on-chip light sources显示文摘Integrated quantum key distribution(QKD)systems based on photonic chips have high scalability and stability,and are promising for further construction of global quantum communications networks.On-chip quantum light sources are a critical component of a fully integrated QKD system;especially a continuous-variable QKD(CVQKD)system based on coherent detection,which has extremely high requirements for the light sources.Here,for what we believe is the first time,we designed and fabricated two on-chip tunable lasers for CV-QKD,and demonstrated a high-performance system based on these sources.Because of the high output power,fine tunability,and narrow linewidth,the involved on-chip lasers guarantee the accurate shot-noise-limited detection of quantum signals,center wavelength alignment of nonhomologous lasers,and suppression of untrusted excess noise.The system’s secret key rate can reach 0.75 Mb/s at a 50 km fiber distance,and the secure transmission distance can exceed 100 km.Our results mark a breakthrough toward building a fully integrated CV-QKD,and pave the way for a reliable and efficient terrestrial quantum-secure metropolitan area network. | LANG LI TAO WANG XINHANG LI PENG HUANG YUYAO GUO LIANGJUN LU LINJIE ZHOU GUIHUA ZENG | 2023 | Photonics Research2023，11，4： | 0 |
| 13 | Simultaneously achieving high energy density and responsivity in submicron BaTiO_(3) film capacitors integrated on Si显示文摘In the research field of energy storage dielectrics,the“responsivity”parameter,defined as the recyclable/recoverable energy density per unit electric field,has become critically important for a comprehensive evaluation of the energy storage capability of a dielectric.In this work,high recyclable energy density and responsivity,i.e.,W_(rec)=161.1 J·cm^(-3) and ξ=373.8 J·(kV·m^(2))^(-1),have been simultaneously achieved in a prototype perovskite dielectric,BaTiO_(3),which is integrated on Si at 500℃ in the form of a submicron thick film.This ferroelectric film features a multi-scale polar structure consisting of ferroelectric grains with different orientations and inner-grain ferroelastic domains.A LaNiO_(3) buffer layer is used to induce a{001}textured,columnar nanograin microstructure,while an elevated deposition temperature promotes lateral growth of the nanograins(in-plane diameter increases from~10-20 nm at lower temperatures to~30 nm).These preferably oriented and periodically regulated nanograins have resulted in a small remnant polarization and a delayed polarization saturation in the film’s P-E behavior,leading to a high recyclable energy density.Meanwhile,an improved polarizability/dielectric constant of the BaTiO_(3) film has produced a much larger maximum polarization than those deposited at lower temperatures at the same electric field,leading to a record-breaking responsivity for this simple perovskite. | Jun Ouyang Yinxiu Xue Chuanqi Song Meiling Yuan Kun Wang Yuyao Zhao Hongbo Cheng Hanfei Zhu Chao Liu | 2024 | Journal of Advanced Ceramics2024，13，2： | 0 |
| 14 | Trace Elements of Multi-stage Minerals and Titanite U-Pb Dating for the Gneisses from Liansan Island,Sulu UHPM Belt显示文摘Gneisses with anatectic characteristics from the Liansan island in the Sulu UHPM(ultra-high pressure metamorphic)belt were studied for petrography,titanite U-Pb dating and mineral geochemistry.Three origins of garnets are distinguished:metamorphic garnet,peritectic garnet and anatectic garnet,which are formed in the stages of peak metamorphism,retrograde anatexis and melt crystallization,respectively.The euhedral titanite has a high content of REE and high Th/U ratios,which is interpreted as indicating that it was newly-formed from an anatectic melt.The LA-ICP-MS titanite U-Pb dating yields 214-217 Ma ages for the titanite(melt)crystallization.The distribution of trace elements varies in response to the different host minerals at different stages.At the peak metamorphic stage,Y and HREE are mainly hosted by garnet,Ba and Rb by phengite,Sr,Nb,Ta,Pb,Th,U and LREE by allanite and Y,U and HREE by zircon.During partial melting,Y,Pb,Th,U and REE are released into the melt,which causes a dramatic decline of these element contents in the retrograde minerals.Finally,titanite absorbs most of the Nb,U,LREE and HREE from the melt.Therefore,the different stages of metamorphism have different mineral assemblages,which host different trace elements. | SONG Lihao CAO Yuting XIE Tianhe CHEN Yuyao GAO Yuan WANG Songjie LI Xuping | 2023 | Acta Geologica Sinica(English Edition)2023，97，6： | 0 |
| 15 | Collaborative optimization of linear vibrating screen screening efficiency and dynamic response stability based on coupled DEM-MBK simulation显示文摘The dynamic response stability of the vibrating screen is an important factor affecting the screening effect and the structural performance of the vibrating screen.In this paper,to improve dynamic response stability and screening efficiency,we optimized the configuration of linear screening process parameters based on the co-optimization method with dual objectives via the virtual experiment.Firstly,a coupled DEM-MBK simulation model was established according to the dynamics of linear screen,and the dy-namic response law of the screen machine under material impact was investigated.Secondly,the quantitative index of dynamic response stability according to the time-domain characteristics of the centroid amplitude was established.The trend and significance of three types of screening process pa-rameters,including excitation,damping and structure,on the screening efficiency and dynamic response stability were analyzed through virtual orthogonal experiments.Finally,a parameter configuration scheme to achieve co-optimization was proposed based on the comprehensive balance method.The virtual experiment results show that the screening efficiency and dynamic response stability of the proposed scheme are improved by 3.28%and 49.07%,respectively,compared with the empirical parameter configuration.Obviously,the co-optimization method can maintain high screening efficiency and dynamic response stability at the same time,which is beneficial to improve the service life of the screen surface and screen body. | Xuhui Xia Lingxiao Gou Zelin Zhang Lei Wang Yuyao Guo Weimin Jing | 2023 | Particuology2023，，7： | 0 |
| 16 | The Application of Quality Control Circles to Reduce the Cost of Non-priced Consumables in Department of Oncology显示文摘Objective:To investigate the effectiveness of using quality control circle(QCC)techniques to reduce the cost of non-priced consumables in medical oncology.Methods:Analytic statistics were compiled on the performance appraisal form.Aiming at the key points of improvement with respect to the excess cost of non-valuable consumables,the reasons were analyzed,and corresponding measures were formulated to compare the cost before and after the improvement.Results:After the QCC activity,the cost of non-priced consumables decreased from RMB 6.57/bed day to RMB 3.96/bed day.Conclusion:QCC has effectively reduced the cost of non-priced consumables in the oncology department,and it is worthy of promotion. | Xiaofang Zhang Jinglan Luo Rui Dai Lu Wang Jieli Wei Yingying Liang Qiugui Huang Yuyao Liu | 2021 | Journal of Clinical and Nursing Research2021，5，3： | 0 |
| 17 | Broadband 1T-polytype tantalum disulfide saturable absorber for solid-state bulk lasers显示文摘1T-polytype tantalum disulfide(1T-TaS_(2)),an emerging strongly correlated material,features a narrow bandgap of 0.2 e V,bridging the gap between zero-bandgap graphene and large-bandgap 2D nonlinear optical(NLO)materials.Combined with its intense light absorption,high carrier concentration,and high mobility,1T-TaS_(2) shows considerable potential for applications in broadband optoelectronic devices.However,its NLO characteristics and related applications have rarely been explored.Here,1T-TaS_(2) nanosheets are prepared by chemical vapor deposition.The ultrafast carrier dynamics in the 400–1100 nm range and broadband NLO performance in the 515–2500 nm range are systematically studied using femtosecond lasers.An obvious saturable absorption phenomenon is observed in the visible to IR range.The nonlinear absorption coefficient is measured to be-22.60±0.52 cm MW-1under 1030 nm,which is larger than that of other typical 2D saturable absorber(SA)materials(graphene,black phosphorus,and MoS_(2))under similar experimental conditions.Based on these findings,using 1T-TaS_(2) as a new SA,passively Q-switched laser operations are successfully performed at 1.06,1.34,and 1.94μm.The results highlight the promise of 1T-TaS_(2) for broadband optical modulators and provide a potential candidate material system for mid-IR nonlinear optical applications. | MENGXIA WANG HAILONG QIU TIANWEN YANG ZHENGPING WANG CHUANRUI ZHAO YUANAN ZHAO TING YU YUYAO JIANG MEILING CHEN YAFEI LIAN GE ZHANG HONGJUN LIU ZHANGGUI HU JIANDA SHAO | 2022 | Photonics Research2022，10，9： | 0 |
| 18 | Prediction of fiber Rayleigh scattering responses based on deep learning显示文摘Distributed acoustic sensing(DAS) is a fiber sensing technology based on Rayleigh scattering,which transforms optical fiber into a series of sensing units. It has become an indispensable part in the field of seismic monitoring, vehicle tracking, and pipeline monitoring. Fiber Rayleigh scattering responses lay at the core of DAS. However, there are few in-depth studies on the purpose of acquiring fiber Rayleigh scattering responses. In this paper, we establish a deep learning framework based on the bidirectional gated recurrent unit, which is the first time to predict the fiber Rayleigh scattering responses, to the best of our knowledge. The deep learning framework is trained with a numerical simulation dataset only, but it can process experimental data successfully. Moreover, since the responses could have a wider effective bandwidth than the experimental probing pulses, a finer spatial resolution could be obtained after demodulation. This work indicates that the deep learning framework can capture the characteristics of the fiber Rayleigh scattering responses effectively, which paves the way for intelligent DAS. | Yongxin LIANG Jianhui SUN Jialei ZHANG Yuyao WANG Anchi WAN Shibo ZHANG Zhenyu YE Shengtao LIN Zinan WANG | 2023 | Science China(Information Sciences)2023，66，12： | 0 |
| 19 | PHD3 inhibits colon cancer cell metastasis through the occludin-p38 pathway显示文摘Prolyl hydroxylase 3(PHD3)hydroxylates HIFαin the presence of oxygen,leading to HIFαdegradation.PHD3 inhibits tumorigenesis.However,the underlying mechanism is not well understood.Herein,we demonstrate that PHD3 inhibits the metastasis of colon cancer cells through the occludin-p38 MAPK pathway independent of its hydroxylase activity.We find that PHD3 inhibits colon cancer cell metastasis in the presence of the PHD inhibitor DMOG,and prolyl hydroxylase-deficient PHD3(H196A)suppresses cell metastasis as well.PHD3 controls the stability of the tight junction protein occludin in a hydroxylase-independent manner.We further find that PHD3-inhibited colon cancer cell metastasis is rescued by knockdown of occludin and that occludin acts as a negative regulator of cell metastasis,implying that PHD3 suppresses metastasis through occludin.Furthermore,knockdown of occludin induces phosphorylation of p38 MAPK,and the p38 inhibitor SB203580 impedes cell migration and invasion induced by occludin knockdown,indicating that occludin functions through p38.Moreover,knockdown of occludin enhances the expression of MKK3/6,the upstream kinase of p38,while overexpression of occludin decreases its expression.Our results suggest that PHD3 inhibits the metastasis of colon cancer cells through the occludin-p38 pathway independent of its hydroxylase activity.These findings reveal a previously undiscovered mechanism underlying the regulation of cancer cell metastasis by PHD3 and highlight a noncanonical hydroxylaseindependent function of PHD3 in the suppression of cancer cells. | Yuyao Li Tanglong Yuan Hongwei Zhang Shuting Liu Jie Lun Jing Guo Yu Wang Yuying Zhang Jing Fang | 2023 | Acta Biochimica et Biophysica Sinica2023，55，11： | 0 |
| 20 | Solid-Phase Enzymatic Peptide Synthesis to Produce an Antioxidant Dipeptide显示文摘Peptide bond synthesis is favorable to the production of bioactive small peptides. However, the abuse of toxic reagents remains an issue for chemical synthesis method, whereas the low product yield and purity limit the widespread use of enzymatic method. In this study, a new solid-phase enzymatic peptide synthesis(SPEPS) strategy was developed to produce an antioxidant tyrosine-alanine dipeptide(Tyr-Ala) by using recombinant carboxypeptidase Y(CPY) as the catalyst. The general SPEPS procedure involves three steps. First, the N-protected acyl donor was covalently attached to solid resin. Second,the peptide bond was condensed between the acyl donor and the nucleophile under the catalysis of CPY. Finally, one-step cleavage was performed to remove the protecting group and cleave the peptides from solid resin. Upon the optimization of reaction conditions, 77.92%(±2.723%) yield of Tyr-Ala with high product purity of 90.971%(±2.695%) was obtained.In addition, the antioxidant activity of Tyr-Ala was determined by ABTS method, indicating that the synthesized Tyr-Ala obtained by SPEPS showed a superior antioxidant capability compared with commercial glutathione. | Yuyao Shan Mengfan Wang Wei Qi Rongxin Su Zhimin He | 2019 | Transactions of Tianjin University2019，25，3： | 0 |
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