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| 1 | Effect of B vitamin supplementation on plasma homocysteine levels in celiac disease显示文摘AIM: To investigate the effect of vitamin supplements on homocysteine levels in patients with celiac disease. METHODS: Vitamin B6, folate, vitamin B12, and fasting plasma homocysteine levels were measured in 51 consecutive adults with celiac disease [median (range) age 56 (18-63) years; 40% men, 26 (51%) had villous atrophy, and 25 (49%) used B-vitamin supplements] and 50 healthy control individuals matched for age and sex. Finally, the C677T polymorphism of 5,10-methylene tetrahydrofolate reductase (MTHFR) was evaluated in 46 patients with celiac disease and all control individuals. RESULTS: Patients with celiac disease and using vitamin supplements had higher serum vitamin B6 (P = 0.003),folate (P < 0.001), and vitamin B12 (P = 0.012) levels than patients who did not or healthy controls (P = 0.035, P < 0.001, P = 0.007, for vitamin B6, folate, and vitamin B12, respectively). Lower plasma homocysteine levels were found in patients using vitamin supplements than in patients who did not (P = 0.001) or healthy controls (P = 0.003). However, vitamin B6 and folate, not vitamin B12, were significantly and independently associated with homocysteine levels. Twenty-four (48%) of 50 controls and 23 (50%) of 46 patients with celiac disease carried the MTHFR thermolabile variant T-allele (P = 0.89). CONCLUSION: Homocysteine levels are dependent on Marsh classification and the regular use of B-vitamin supplements is effective in reduction of homocysteine levels in patients with celiac disease and should be considered in disease management. | Muhammed Hadithi Chris JJ Mulder Frank Stam Joshan Azizi J Bart A Crusius Amado Salvador Pea Coen DA Stehouwer Yvo M Smulders | 2009 | World Journal of Gastroenterology2009，15，8： | 3 |
| 2 | Overview of homocysteine and folate metabolism with special references to cardiovascular dis- ease and neural tube defects 显示文摘 | Henk J Blom Yvo Smulders | 2011 | J Inherit Metab Dis2011，34，1： | 1 |
| 3 | Pathyology and treatment of hameidynamic instability in the acute pulmonary embolism: The pivotal role pulmonary vasoconstriction显示文摘 | Yvo M | 2000 | Cardiovasc Res2000，48，： | 1 |
| 4 | A CDMA based bidirectional communication system for hybrid fiber-coax CATV networks显示文摘 | de Jong YVO L C Woleers R P C | 1997 | IEEE Transctions on Broadcasting1997，43，2： | 1 |
| 5 | Contribution of pulmonary vasoconstriction to haemodynamic instability after acute pulmonary embolism implications for treatment显示文摘 | Yvo M Smulders | 2001 | Netherlands J Medi2001，58，： | 1 |
| 6 | Early versus late acute rejection episodes in renal transplantation.显示文摘 | Yvo W J Sijpkens Ilias I N Doxiadis | | 0，，： | 1 |
| 7 | A multiple model hypothesis filter for Markovian switching systems显示文摘 | Yvo Boers Hans Driessen | 2005 | Automatica2005，，： | 1 |
| 8 | Pathyology and treatment of hameidynamic instability in the acute pulmonary embolism: The pivotal role pulmonary vasoconstriction显示文摘 | Yvo M | 2000 | Cardiovas Res2000，48，： | 1 |
| 9 | Pathophysiology and treatment of haemodynamic instability in acute pulmonary embolism:the pivotal role of pulmonary vasoconstriction显示文摘 | Yvo M Smulders | 2000 | Cardiovas res2000，48，： | 1 |
| 10 | Mixed labelling in multitarget particle filtering 显示文摘 | Yvo B Egils S Hans D | 2010 | IEEE Transactions on Aerospace and Electronic System2010，46，79： | 1 |
| 11 | Meta-analysis: Serum creatinine changes following contrast enhanced CT imaging显示文摘 | Judith Kooiman Sharif M. Pasha Wendy Zondag Yvo W.J. Sijpkens Aart J. van der Molen Menno V. Huisman Olaf M. Dekkers | 2011 | European Journal of Radiology2011，，10： | 1 |
| 12 | Chronic rejection in renal transplantation显示文摘 | Yvo WJ Sijpkens SA Joosten | 2003 | Transplantation Reviews2003，17，3： | 1 |
| 13 | Turbo-MIMO for Wireless Communications显示文摘 | Simon Haykin Mathini Sellathurai Yvo de Jong | 2004 | IEEE Communications Magazine2004，42，10： | 1 |
| 14 | Pathophysiology and treatment of hameodynamic instability in acute pulmonary embolism:the pivotal role pulmonary vasoconstriction显示文摘 | Yvo M | 2000 | Cardiovas Res2000，48，： | 1 |
| 15 | Endovascular treatment in anterior circulation stroke beyond 6.5 hours after onset or time last seen well:results from the MR CLEAN Registry显示文摘Background Randomised controlled trials with perfusion selection have shown benefit of endovascular treatment(EVT)for ischaemic stroke between 6 and 24 hours after symptom onset or time last seen well.However,outcomes after EVT in these late window patients without perfusion imaging are largely unknown.We assessed their characteristics and outcomes in routine clinical practice.Methods The Multicenter Randomized Clinical Trial of Endovascular Treatment for Acute Ischemic Stroke in the Netherlands Registry,a prospective,multicentre study in the Netherlands,included patients with an anterior circulation occlusion who underwent EVT between 2014 and 2017.CT perfusion was no standard imaging modality.We used adjusted ordinal logistic regression analysis to compare patients treated within versus beyond 6.5 hours after propensity score matching on age,prestroke modified Rankin Scale(mRS),National Institutes of Health Stroke Scale,Alberta Stroke Programme Early CT Score(ASPECTS),collateral status,location of occlusion and treatment with intravenous thrombolysis.Outcomes included 3-month mRS score,functional independence(defined as mRS 0-2),and death.Results Of 3264 patients who underwent EVT,106(3.2%)were treated beyond 6.5 hours(median 8.5,IQR 6.9-10.6),of whom 93(87.7%)had unknown time of stroke onset.CT perfusion was not performed in 87/106(80.2%)late window patients.Late window patients were younger(mean 67 vs 70 years,p<0.04)and had slightly lower ASPECTS(median 8 vs 9,p<0.01),but better collateral status(collateral score 2-3:68.3%vs 57.7%,p=0.03).No differences were observed in proportions of functional independence(43.3%vs 40.5%,p=0.57)or death(24.0%vs 28.9%,p=0.28).After matching,outcomes remained similar(adjusted common OR for 1 point improvement in mRS 1.04,95%CI 0.56 to 1.93).Conclusions Without the use of CT perfusion selection criteria,EVT in the 6.5-24-hour time window was not associated with poorer outcome in selected patients with favourable clinical and CT/CT angiography characteristics.randomised controlled trials with lenient inclusion criteria are needed to identify more patients who can benefit from EVT in the late window. | Luuk Dekker Esmee Venema F Anne V Pirson Charles B L M Majoie Bart J Emmer Ivo G H Jansen Maxim J H L Mulder Robin Lemmens Robert-Jan B Goldhoorn Marieke J H Wermer Jelis Boiten Geert J LycklamaàNijeholt Yvo B W E M Roos Adriaan C G M van Es Hester F Lingsma Diederik W J Dippel Wim H van Zwam Robert J van Oostenbrugge Ido R van den Wijngaard on behalf of the MR CLEAN Registry investigators | 2021 | Stroke & Vascular Neurology2021，6，4： | 1 |
| 16 | Early Versus Late Acute Rejection Episodes In Renal Transplantation显示文摘 | Yvo W J Sijpkens Ilias I N Doxiadis | 2003 | Transplantation2003，75，2： | 1 |
| 17 | A secure and scalable Group Key Exchange system显示文摘 | Mike Burmester Yvo Desmedt | 2005 | Information Processing Letters2005，，3： | 1 |
| 18 | Effect of high performance chicory inulin on constipafion显示文摘 | Elly R D Benny G Yvo G | 2000 | Nutrition Research2000，20，5： | 1 |
| 19 | Red blood cell folate vitamer distribution in healthy subjects is determined by the methylenetetrahydrofolate reductase C677T polymorphism and by the total folate status显示文摘 | Yvo M. Smulders Desiree E.C. Smith Robert M. Kok Tom Teerlink Henkjan Gellekink Wouter H.J. Vaes Coen D.A. Stehouwer Cornelis Jakobs | 2007 | The Journal of Nutritional Biochemistry2007，，10： | 1 |
| 20 | Gastric emptying andHelicobacter pylori infection in duodenal ulcer disease显示文摘 | Dr. Francesco Perri MD Yvo F. Ghoos PD PhD Bart D. Maes MD PhD Benny J. Geypens PD N. Ectors MD PhD Karel Geboes MD PhD Martin I. Hiele MD PhD Paul J. Rutgeerts MD PhD | 1996 | Digestive Diseases and Sciences1996，，3： | 1 |
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