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| 1 | Chinese Stroke Center Alliance:a national effort to improve healthcare quality for acute stroke and transient ischaemic attack:rationale,design and preliminary findings显示文摘Background In June 2015,the Chinese Stroke Association(CSA)initiated the Chinese Stroke Center Alliance(CSCA)to establish the national hospital-based stroke care quality assessment and improvement platform.This article outlines its objectives,operational structure,patient population,quality improvement(QI)intervention tools,data elements,data collection methodology and current patient and hospital data.Methods The CSCA is a national,hospital-based,multicentre,voluntary,multifaceted intervention and continuous QI initiative.This multifaceted intervention includes stroke centre development,written care protocols,workshops and a monitoring/feedback system of evidencebased performance measures.The data coordinating centre of the CSCA resides at the China National Clinical Research Center for Neurological Diseases,Beijing Tiantan Hospital.results As of July 2017,1576 hospitals in China have contributed detailed clinical information to serve as a benchmark for the stroke care quality of 433264 patients with acute stroke/transient ischaemic attacks(TIA),including 352572(81.38%)acute ischaemic stroke,30362(7.01%)TIA,42080(9.71%)spontaneous intracranial haemorrhage,5505(1.27%)subarachnoid haemorrhage and 2745(0.63%)not specified stroke.Conclusion The CSCA programme is designed to establish a continuous national stroke registry and help healthcare providers develop stroke centres and treat patients in a consistent manner in accordance with accepted national guidelines and,ultimately,improve patient outcomes.It supports the CSA mission to reduce stroke burden in China. | Yongjun Wang Zixiao Li Yilong Wang Xingquan Zhao Liping Liu Xin Yang Caiyun Wang Hongqiu Gu Fuying Zhang Chunjuan Wang Ying Xian David Z Wang Qiang Dong Anding Xu Jizong Zhao Chinese Stroke Center Alliance investigators | 2018 | Stroke & Vascular Neurology2018，3，4： | 38 |
| 2 | 笋芽顶端分生组织在竹秆横切面形态形成中的作用与机制研究显示文摘竹秆的横切面主要由表皮、皮层、维管组织、基本组织及髓腔(早期为髓组织)组成。这些组织均由笋芽茎顶端分生组织分化发育而来,且其在生长发育过程中促使了竹秆横切面形态(本文特指:竹秆横切面外轮廓形状、围度及壁-腔结构)的形成。然而,人们对于这一生长发育过程的生物学机制知之甚少。本研究利用解剖学、数学模拟等方法,对 20 种具不同秆径竹种的笋芽顶端分生组织进行了分析。研究结果发现,笋芽顶端分生组织指状形态的维持是竹子产生圆柱形竹秆的基础;在顶端分生组织细胞数目增加的同时,线性增加原体细胞数目应是竹子在演化过程中产生大径竹秆且保持规则壁-腔结构的方式。进一步通过研究一个竹壁增厚且壁-腔架构紊乱的稳定变异体———实肚竹( Phyllostachys nidularia f. farcta)发现,其笋芽顶端分生组织细胞数目减少且原体/原套细胞数比值降低使其产生了高比例的壁组分组织(指基本分生组织与肋状分生组织)与低比例的髓组织。上述 2 种组织的比例失衡,使得实肚竹笋芽在后续发育中壁组分组织随机挤入到了髓组织中,最终形成了实肚竹异常的竹秆横切面形态(竹壁多样化增厚且壁-腔结构紊乱)。此外,相对较小的顶端分生组织,使得实肚竹笋芽产生了较少的内源激素,如其生长素含量仅约为其原种篌竹的 67. 5%,各细胞分裂素含量也显著低于篌竹笋芽。转录组分析进一步发现,在实肚竹笋芽中与激素及代谢相关的功能基因呈显著下调表达。这些生理与分子变化最终导致了实肚竹竹秆矮化、秆径减小且生物量降低。本论文的研究结果为研究竹秆横切面发育提供了一个重要的视角,同时也为实肚竹厚壁茎秆的形成提出了一个合理的机制。 | Wang Y Sun X Ding Y Fei Z Jiao C Fan M Yao B Xin P Chu J Wei Q 王雨珺 魏强 | 2019 | 世界竹藤通讯2019，17，3： | 5 |
| 3 | Is tenecteplase ready to replace alteplase to treat acute ischaemic stroke? The knowns and unknowns显示文摘Tenecteplase(TNKase,TNK-tPA or TNK)is a thrombolytic agent derived from the tissue plasminogen activator(tPA).It is a 527-amino acid glycoprotein developed by replacing three amino acids at the T,N and K positions of the glycoprotein structure of tPA under genetic recombinant technology.After replacing threonine 103 with asparagine,asparagine 117 with glutamine and a tetra-alanine at amino acids 296–299,TNK is about eightfold more potent in dissolving clot,80-fold higher resistance to plasminogen activator inhibitor-1 and 14-fold enhanced relative fibrin specificity,and with a longer half-life(20 min).1 Hence,TNK is administered as a single intravenous bolus. | Yi Dong Yi Sui Xin Cheng David Z Wang | 2022 | Stroke & Vascular Neurology2022，7，1： | 3 |
| 4 | Effects of arhuscular mycorrhizal fungi and phosphorus on camptothecin content in Camptotheca acuminata seedlings 显示文摘 | Xin Z Yang W Xiu-feng Y | 2007 | Allelopathy Journal2007，20，1： | 1 |
| 5 | Induction of cold hardiness by salt stress involves synthesis of cold and abscisic acid responsive proteins in Pmato显示文摘 | Ryu S tS Costa A Xin Z G Li P H | 1995 | Plant Cell Physiol1995，36，： | 1 |
| 6 | TRADD domain of Epstein-Barr virus transforming protein LMP1 is essential for inducing immortalization and suppressing senescence of primary rodent fibroblases 显示文摘 | Xin B He Z Yang X | 2001 | Jvirol2001，75，6： | 1 |
| 7 | Characterization of the properties of the thermoplastic elastomers containing waste rubber tire powder显示文摘 | Zhang S L Xin Z X Zhang Z X Kim J K | 2009 | Waste Management2009，29，5： | 1 |
| 8 | Possible use of ail and foxA polymorphisms fordetecting pathogenic Yersinia enterocolitica 显示文摘 | Ying H Xin W Cui Z | 2010 | BMC Microbiol2010，10，： | 1 |
| 9 | Study of Microcellular Injection-molded Polypropylene/Waste Ground Rubber Tire Powder Blend显示文摘 | Xin Z X Zhang Z X Kaushik P | 2010 | Materials and Design2010，31，1： | 1 |
| 10 | Selective suppression of au- tocatalytic caspase-3 driven by two-step transcriptional amplified humantelomerase reverse transcriptase pro- moter on ovarian carcinoma growth in vitro and in mice 显示文摘 | Song Y Xin X Xia Z | 2014 | Oncol Rep2014，32，1： | 1 |
| 11 | Thomashow components of the Arabidopsis C repeat/dehydration responsive element bindingfactor cold-response pathway are conserved in Brassica napus and other plant species显示文摘 | KIRSTEN R J SUSANNE K KEENAN L A XIN Z VOLKER H JAMES Z Z THOMAS D MICHAEL F | 2001 | Plant Plzysiology2001，127，3： | 1 |
| 12 | Induction of cold hardiness by salt stress involves synthesis of cold-and abscisic acid-responsive proteins in potato显示文摘 | RYU S B Costa A Xin Z G | 1995 | Plant Cell Physiol1995，36，： | 1 |
| 13 | Suppression subtractive hybridization(SSH)-based method for estimating Cd-induced differences in gene ex-pression at cultivar level and identification of genes induced by Cd in two water spinach cultivars显示文摘 | HUANG B XIN J YANG Z | 2009 | J Agric Food Chem2009，57，19： | 1 |
| 14 | Molecular mechanisms of macrolide resistance in clinical isolates of Mycoplasma pneumoniae from China显示文摘 | Xin D Mi Z Han X | 2009 | Antimicrob Agents Chemother2009，53，5： | 1 |
| 15 | Proteomic analysis of strawberry leaves infected with Colletotrichum fragariae显示文摘 | Fang X P Chen W Y Xin Y Hengmu Z Chengqi Y Hong Y Hui L Wenfei X Shuzhen W Guizhen Z Hongbo L Liang J Huasheng M Songlin R | 2012 | Journal of proteomics2012，75，： | 1 |
| 16 | Vanishing viscosity limit for the 3D magneto-hydrodynamic system with a slip boundary condition显示文摘 | Xiao Y L Xin Z P Wu J H | 2009 | J Funct Anal2009，257，11： | 1 |
| 17 | Simulation and performance evaluation of the anoxic/anaerobic/ aerobic process for biological nutrient removal 显示文摘 | Zhou Z Wu Z Wang Z Tang S Gu G Wang L Wang Y Xin Z | 2011 | Korean Journal of Chemical Engineering2011，28，5： | 1 |
| 18 | Physiological and Molecular Responses of Nitrogen-Starved Rice Plants to Re-supply of Different Nitrogen Sources显示文摘 | LIB Z XIN W J SUN S B | 2006 | Plant and Soil2006，，287： | 1 |
| 19 | Development of new PCR markers specific to a Thinopyrum intermedium chromosome 2Ai-2 and cloning of the St-specific sequences显示文摘 | WANG L L(王丽丽) XIN ZH Y(辛志勇) | 2002 | Acta Genetica Sinica(遗传学报)2002，29，7： | 1 |
| 20 | Molecular and pathogenic variation identified among isolates of Corynespora cassiicola 显示文摘 | Qi Yan xiang X Yi xian Z Xin | 2008 | Molecular Bioechnology2008，41，2： | 1 |
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