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| 1 | MiR-124 retards bladder cancer growth by directly targeting CDK4显示文摘MicroRNAs (miRNAs ) 是由绑定充当基因表示的否定管理者到目标 mRNAs 的 3-untranslated 区域(3UTR ) 的非编码的小 RNA 的一个类。以便在膀胱癌症调查 miR-124 的生理的角色, miR-124 的目标基因被 TargetScan 预言软件,和 cyclin 依赖的 kinase (CDK4 ) ,作为房间周期的一个管理者被含有,为进一步的学习被选择。MiR-124 能显著地镇压由在 vitro 在 CDK4 的 3UTR 指向它的有约束力的地点的 CDK4 表示。在两根膀胱癌症房间线和纸巾, miR-124 的表示是显著地下面调整的,当 CDK4 表示是起来调整的时。在移植 HT1197 房间的 miR-124 的宫外的表示在老鼠肿瘤异种皮移植导致了肿瘤生长的延迟。并且 miR-124 和 CDK4 的表示证明在这些异种皮移植纸巾的明显的反的关联,它是也在人的膀胱癌症观察到组织取样。一起拿,我们的结果强烈建议 miR-124 能逮捕房间周期并且由直接指向 CDK4 制止膀胱癌症的生长。 | Ting Zhang Jingyao Wang Xiaofeng Zhai Hongjie Changying Li Jiwu Chang | 2014 | Acta Biochimica et Biophysica Sinica2014，46，12： | 12 |
| 2 | Zircon U-Pb Geochronological Constraints on Rapid Exhumation of the Mantle Peridotite of the Xigaze Ophiolite, Southern Xizang(Tibet)显示文摘The Xigaze ophiolite crops out in the central segment of the Yarlung Zangbo suture zone,southern Tibet(Fig.1).It is characterized by large amounts of ultramafic units with minor mafic rocks.The mafic rocks consist of gabbros, | LIU Tong WU Fuyuan ZHANG Liangliang ZHAI Qingguo LIU Chuanzhou JI Wenbin Ji ZHANG Chang XUYang | 2016 | Acta Geologica Sinica(English Edition)2016，90，S1： | 12 |
| 3 | Vast laminated diatom mat deposits from the west low-latitude Pacific Ocean in the last glacial period显示文摘Diatoms are one of the predominant contributors to global carbon fixation by accounting for over 40% of total oceanic primary production and dominate export production. They play a significant role in marine biogeochemistry cycle. The diatom mat deposits are results of vast diatoms bloom. By analysis of diatom mats in 136°00′―140°00′E,15°00′―21°00′N, Eastern Philippines Sea, we identified the species of the diatoms as giant Ethmodiscus rex (Wallich) Hendey. AMS 14C dating shows that the sediments rich in diatom mats occurred during 16000―28600 a B.P., which means the bloom mainly occurred during the last glacial period, while there are no diatom mat deposits in other layers. Preliminary analysis indicates that Antarctic Intermediate Water (AAIW) expanded northward and brought silicate-rich water into the area, namely, silicon leakage processes caused the bloom of diatoms. In addition, the increase of iron input is one of the main reasons for the diatom bloom. | ZHAI Bin LI TieGang CHANG FengMing CAO QiYuan | 2009 | Chinese Science Bulletin2009，54，23： | 9 |
| 4 | Effects of Forest Type and Urbanization on Carbon Storage of Urban Forests in Changchun, Northeast China显示文摘Rapid urbanization has led to dramatic changes in urban forest structures and functions, and consequently affects carbon(C) storage in cities. In this study, field surveys were combined with high resolution images to investigate the variability of C storage of urban forests in Changchun, Northeast China. The main objectives of this study were to quantify the C storage of urban forests in Changchun City, Northeast China and understand the effects of forest type and urbanization on C storage of urban forests. The results showed that the mean C density and the total C storage of urban forests in Changchun were 4.41 kg/m2 and 4.74 × 108 kg, respectively. There were significant differences in C density among urban forest types. Landscape and relaxation forest(LF) had the highest C density with 5.41 kg/m2, while production and management forest(PF) had the lowest C density with 1.46 kg/m2. These differences demonstrate that urban forest type is an important factor needed to be considered when the C storage is accurately estimated. Further findings revealed significant differences in different gradients of urbanization, and the mean C density decreased from the first ring(6.99 kg/m2) to the fourth ring(2.87 kg/m2). The total C storage increased from the first ring to the third ring. These results indicate that C storage by urban forests will be significantly changed during the process of urbanization. The results can provide insights for decision-makers and urban planners to better understand the effects of forest type and urbanization on C storage of urban forests in Changchun, and make better management plans for urban forests. | ZHANG Dan ZHENG Haifeng REN Zhibin ZHAI Chang SHEN Guoqiang MAO Zhixia WANG Peijiang HE Xingyuan | 2015 | Chinese Geographical Science2015，25，2： | 9 |
| 5 | Expression of Recombinant Human Lysozyme-tachyplesin I(hLYZ-TP I)in Pichia Pastoris and Analysis of Antibacterial Activity显示文摘Antimicrobial peptides(AMPs)are making headlines in science because they demonstrate superior microbicidal characteristics compared to synthetic and semi-synthetic antibiotics [1].Importantly,AMPs kill pathogens via a different mechanism compared to antibiotics [2].Therefore, | GAO Yu ZHAO Hong Lei FENG Xin ZHAI Rui Dong ZHU Seng DU Chong Tao SUN Chang Jiang LEI Lian Cheng | 2013 | Biomedical and Environmental Sciences2013，26，4： | 7 |
| 6 | Effects of Urbanization,Soil Property and Vegetation Configuration on Soil Infiltration of Urban Forest in Changchun,Northeast China显示文摘Urban forest soil infiltration, affected by various factors, is closely related with surface runoff. This paper studied the effect of urban forest types, vegetation configuration and soil properties on soil infiltration. In our study, 191 typical plots were sampled in Changchun City, China to investigate the soil infiltration characteristics of urban forest and its influencing factors. Our results showed that the steady infiltration rates of urban forest soil were highly variable. High variations in the final infiltration rates were observed for different vegetation patterns and compaction degrees. Trees with shrubs and grasses had the highest infiltration rate and trees with bare land had the lowest infiltration rate. In addition, our results showed that the soil infiltration rate decreased with an increase in the bulk density and with a reduction in the soil organic matter content and non-capillary porosity. The soil infiltration rate also had significantly positive relationships with the total porosity and saturated soil water content. Urban soil compaction contributed to low soil infiltration rates. To increase the infiltration rate and water storage volume of urban forest soil, proper techniques to minimize and mitigate soil compaction should be used. These findings can provide useful information for urban planners about how to maximize the water volume of urban forest soil and decrease urban instantaneous flooding. | WANG Peijiang ZHENG Haifeng REN Zhibin ZHANG Dan ZHAI Chang MAO Zhixia TANG Ze HE Xingyuan | 2018 | Chinese Geographical Science2018，28，3： | 7 |
| 7 | Multifunctional mesoporous bioactive glass/upconversion nanoparticle nanocomposites with strong red emission to monitor drug delivery and stimulate osteogenic differentiation of stem cells显示文摘为源于恶意的骨头肿瘤的骨头缺点的治疗和新生,开发能交付治疗学的药的多功能的 biomaterials 是必要的,监视药版本,并且刺激骨头形成。此处,多功能的 mesoporous bioactive 玻璃( MBG ) /upconversion nanoparticle ( UCNP ) nanocomposite [ UCNPs@SiO 2@mSiO2-XCa ( X = 0 , 5 , 10 , 15 ,和 20 )]与交付反癌症药的能力,监视器药版本,并且刺激骨头髓 stromal 房间( BMSC )的 osteogenic 区别成功地用 layer-by-layer 策略被准备。nanocomposite 范围拥有与 100 nm 的一致尺寸分布由 UCNP 和 mesoporous SiO 2/Ca 层组成的核心壳结构。进 nanocomposites 的 Ca 的加入从一个纯六角形的阶段导致了阶段转变到一个立方的阶段,并且便于红排放的出现,它显著地为深织物成像改进了荧光穿入。另外,自从红,排放强烈与反癌症药锌酞毒(ZnPc ) 的最大的吸收度重叠,红光能被 ZnPc 强烈熄灭。因而,药版本能被在荧光紧张监视变化确定。而且,进 MBG/UCNP nanocomposites 的 Ca 的加入显著地改进了 bioactivity,即,它在模仿的身体液体刺激了磷灰石矿化作用并且为 200-500 g/mL 的集中范围在 BMSC 提高了房间增长和骨头相关的基因表示。我们的结果建议准备 MBG/UCNP nanocomposites 为由于他们的不同 multifunctionality 源于恶意的骨头肿瘤的骨头缺点的治疗和新生是有用的,包括在监视的药交货和 osteostimulation 的强壮的红排放和功能。 | Fangfang Wang Dong Zhai Chengtie Wu Jiang Chang | 2016 | Nano Research2016，9，4： | 4 |
| 8 | Layered Birnessite Cathode with a Displacement/Intercalation Mechanism for High-Performance Aqueous Zinc-Ion Batteries显示文摘Mn-based rechargeable aqueous zinc-ion batteries(ZIBs)are highly promising because of their high operating voltages,attractive energy densities,and eco-friendliness.However,the electrochemical performances of Mn-based cathodes usually suffer from their serious structure transformation upon charge/discharge cycling.Herein,we report a layered sodium-ion/crystal water co-intercalated Birnessite cathode with the formula of Na0.55Mn2O4·0.57H2O(NMOH)for high-performance aqueous ZIBs.A displacement/intercalation electrochemical mechanism was confirmed in the Mn-based cathode for the first time.Na+and crystal water enlarge the interlayer distance to enhance the insertion of Zn^2+,and some sodium ions are replaced with Zn^2+ in the first cycle to further stabilize the layered structure for subsequent reversible Zn^2+/H^+ insertion/extraction,resulting in exceptional specific capacities and satisfactory structural stabilities.Additionally,a pseudo-capacitance derived from the surface-adsorbed Na^+ also contributes to the electrochemical performances.The NMOH cathode not only delivers high reversible capacities of 389.8 and 87.1 mA h g^−1 at current densities of 200 and 1500 mA g^−1,respectively,but also maintains a good long-cycling performance of 201.6 mA h g^−1 at a high current density of 500 mA g^−1 after 400 cycles,which makes the NMOH cathode competitive for practical applications. | Xian‑Zhi Zhai Jin Qu Shu‑Meng Hao Ya‑Qiong Jing Wei Chang Juan Wang Wei Li Yasmine Abdelkrim Hongfu Yuan Zhong‑Zhen Yu | 2020 | Nano-Micro Letters2020，12，4： | 4 |
| 9 | Preparation and characterization of lithium λ-MnO2 ion-sieves显示文摘锂 -MnO 2 离子筛从尖晶石被准备描述 < 潜水艇 class= “ a-plus-plus ” > 2 O < 潜水艇 class= “ a-plus-plus ” > 经由有硝酸的处理的 4 。LiMn < 潜水艇 class= “ a-plus-plus ” > 2 O < 潜水艇 class= “ a-plus-plus ” > 4 被在 LiOH 之间的稳固的州的反应综合? | Chang WANG Yanlong ZHAI Xi WANG Ming ZENG | 2014 | Frontiers of Chemical Science and Engineering2014，8，4： | 4 |
| 10 | Comparison of Clinical and Epidemiological Characteristics of Asymptomatic and Symptomatic SARS-CoV-2 Infection in Children显示文摘To understand the epidemiological and clinical features of the symptomatic and asymptomatic pediatric cases of COVID-19,we carried out a prospective study in Shanghai during the period of January 19 to April 30,2020.A total of 49 children(mean age 11.5±5.12 years)confirmed with SARS-CoV-2 infection were enrolled in the study,including 11(22.4%)domestic cases and 38(77.6%)imported cases.Nine(81.8%)local cases and 12(31.6%)imported cases had a definitive epidemiological exposure.Twenty-eight(57.1%)were symptomatic and 21(42.9%)were asymptomatic.Neither asymptomatic nor symptomatic cases progressed to severe diseases.The mean duration of viral shedding for SARS-CoV-2 in upper respiratory tract was 14.1±6.4 days in asymptomatic cases and 14.8±8.4 days in symptomatic cases(P>0.05).Forty-five(91.8%)cases had viral RNA detected in stool.The mean duration of viral shedding in stool was 28.1±13.3 days in asymptomatic cases and 30.8±18.6 days in symptomatic participants(P>0.05).Children<7 years shed viral RNA in stool for a longer duration than school-aged children(P<0.05).Forty-three(87.8%)cases had seropositivity for antibodies against SARS-CoV-2 within 1–3 weeks after confirmation with infection.In conclusion,asymptomatic SARS-CoV-2 infection may be common in children in the community during the COVID-19 pandemic wave.Asymptomatic cases shed viral RNA in a similar pattern as symptomatic cases do.It is of particular concern that asymptomatic individuals are potentially seed transmission of SARS-CoV-2 and pose a challenge to disease control. | Jiehao Cai Xiangshi Wang Jun Zhao Yanling Ge Jin Xu He Tian Hailing Chang Aimei Xia Jiali Wang Jinqiang Zhang Zhongqiu Wei Jingjing Li Chuning Wang Jianshe Wang Qirong Zhu Xiaowen Zhai Mei Zeng | 2020 | Virologica Sinica2020，35，6： | 4 |
| 11 | Multispectral Plasmon of Anisotropic Core-shell Gold Nanorods@SiO2: Dual-band Absorption Enhancement with Coupling Dye Molecules显示文摘 | CHE Yuping WANG Yang YOU Tingting CHANG Huaiqiu YIN Penggang ZHAI Jin | 2018 | Chemical Research in Chinese Universities2018，34，5： | 3 |
| 12 | Synthesis and performance of Li_4Ti_5O_(12) anode materials using the PVP-assisted combustion method显示文摘Li_4Ti_5O_(12) was synthesized by a facile gel-combustion method(GCM) with polyvinylpyrrolidone(PVP) as the polymer chelating agent and fuel.The structural and electrochemical properties of the sample were compared with the one prepared by the conventional solid-state reaction(SSR) through X-ray diffraction(XRD),scanning electron microscopy(SEM),cyclic voltammetry(CV),charge-discharge measurements,and electrochemical impedance spectroscopy(EIS),respectively.The sub-microscale Li_4Ti_5O_(12) oxides,with a high phase purity and good stoichiometry,can be obtained by annealing at 800 C.The grain size is smaller than that of the samples that were power prepared by SSR.Lithium-ion batteries with a GCM Li_4Ti_5O_(12) anode exhibit excellent reversible capacities of 167.6,160.7,152.9,and 144.2 mAh/g,at the current densities of 0.5 C,1 C,3 C and 5 C,respectively.The excellent cycling and rate performance can be attributed to the smaller particle size,lower charge-transfer resistance and larger lithium ion diffusion coefficient.It is therefore concluded that GCM Li_4Ti_5O_(12) is a promising candidate for applications in highrate lithium ion batteries. | Long-Jiao Chang Shao-Hua Luo Hai-Liang Zhang Xi-Wei Qi Zhi-Yuan Wang Yan-Guo Liu Yu-Chun Zhai | 2014 | Chinese Chemical Letters2014，25，12： | 3 |
| 13 | Cementite Decomposition in Spherical Graphite Iron by Electropulsing显示文摘The influence of electropulsing on cementite decomposition in the spherical graphite iron has been studied. The results indicated that the cementite was decomposed in a short time by high current density electropulsing. With increasing electropulsing time, the in situ nucleation of graphite in cementite was accompanied with the quick decomposition of cementite. The dislocation accumulation adjacent to the cementite and the quick diffusion of carbon atom by electropulsing were main reasons for the quick decomposition of cementite. The in situ nucleation of graphite in the cementite resulted from the dislocation climbing crossing the cementite lamellae. | Qingchun Li Cuowei Chang Qijie Zhai | 2009 | Journal of Materials Science & Technology2009，25，2： | 3 |
| 14 | Association between genetic variations in tumor necrosis factor receptor genes and survival of patients with T-cell lymphoma显示文摘The prognosis of T-cell lymphoma (TCL) has been shown to be associated with the clinical characteristics of patients. However, there is little knowledge of whether genetic variations also affect the prognosis of TCL. This study investigated the associations between single nucleotide polymorphisms(SNPs) in tumor necrosis factor receptor superfamily(TNFRSF) genes and the survival of patients with TCL. A total of 38 tag SNPs in 18 TNFRSF genes were genotyped using Sequenom platform in 150 patients with TCL. Kaplan-Meier survival estimates were plotted and significance was assessed using log-rank tests. Cox proportional hazard models were used to analyze each of these 38 SNPs with adjustment for covariates that might influence patient survival, including sex and international prognostic Index score. Hazard ratios (HRs) and their 95% confidence intervals(CIs) were calculated. Among the 38 SNPs tested, 3 were significantly associated with the survival of patients with TCL. These SNPs were located at LTβR (rs3759333C>T) and TNFRSF17(rs2017662C>T and rs2071336C>T). The 5-year survival rates were significantly different among patients carrying different genotypes and the HRs for death between the different genotypes ranged from 0.45 to 2.46. These findings suggest that the SNPs in TNFRSF genes might be important determinants for the survival of TCL patients. | Kan Zhai Jiang Chang Chen Wu Ning Lu Li-Ming Huang Tong-Wen Zhang Dian-Ke Yu Wen Tan Dong-Xin Lin | 2012 | Chinese Journal of Cancer2012，31，7： | 3 |
| 15 | Exosomes derived from stem cells as an emerging therapeutic strategy for intervertebral disc degeneration显示文摘Intervertebral disc(IVD)degenerative diseases are a common problem in the world,and they cause substantial social and economic burdens for people.The current methods for treating IVD degenerative diseases mainly include surgery and conservative treatment,which cannot fundamentally restore the normal structure of the disc.With continuous research on the mechanism of degeneration and the development of regenerative medicine,rapid progress has been made in the field of regenerative medicine regarding the use of stem cell-derived exosomes,which are active biological substances used in intercellular communication,because they show a strong effect in promoting tissue regeneration.The study of exosomes in the field of IVD degeneration has just begun,and many surprising achievements have been made.This paper mainly reviews the biological characteristics of exosomes and highlights the current status of exosomes in the field of IVD degeneration,as well as future developments regarding exosomes. | Zhi-Lei Hu Hai-Yin Li Xian Chang Yue-Yang Li Chen-Hao Liu Xiao-Xin Gao Yu Zhai Yu-Xuan Chen Chang-Qing Li | 2020 | World Journal of Stem Cells2020，12，8： | 3 |
| 16 | Premium Connection Downhole Tubing Corrosion显示文摘 | Shuanlu Lu Jianmin Xiang Yanjun Kang Zeliang Chang Xunchang Dong Tongguang Zhai | 2008 | Materials Performance2008，，5： | 2 |
| 17 | Quadratic Stabilization of Switched Uncertain Linear Systems: A Convex Combination Approach显示文摘We consider quadratic stabilization for a class of switched systems which are composed of a finite set of continuoustime linear subsystems with norm bounded uncertainties. Under the assumption that there is no single quadratically stable subsystem, if a convex combination of subsystems is quadratically stable, then we propose a state-dependent switching law, based on the convex combination of subsystems, such that the entire switched linear system is quadratically stable. When the state information is not available, we extend the discussion to designing an outputdependent switching law by constructing a robust Luenberger observer for each subsystem. | Yufang Chang Guisheng Zhai Bo Fu Lianglin Xiong | 2019 | IEEE/CAA Journal of Automatica Sinica2019，6，5： | 2 |
| 18 | Rapid development of proteomics in China: from the perspective of the Human Liver Proteome Project and technology development显示文摘Proteomics focuses on the systematic identification and quantification of entire proteomes and interpretation of proteins’biological functions.During the last decade,proteomics in China has grown much faster than other research fields in life sciences.At the beginning of the second decade of the 21st century,the rapid development of high-resolution and high-speed mass spectrometry makes proteomics a powerful tool to study the mechanisms underlying physiological/pathological processes in organisms.This article provides a brief overview of proteomics technology development and representative scientific progress of the Human Liver Proteome Project in China over the past three years. | LI Ning XU Zhong Wei ZHAI Lin Hui LI Yan Chang FAN Feng Xu ZHENG Jun Jie XU Ping HE Fu Chu | 2014 | Science China(Life Sciences)2014，57，12： | 2 |
| 19 | Environmental and tectonic significance of Late Permian reefs in the Linxi and adjacent areas in Inner Mongolia of China显示文摘Many plateau-edge reefs and reef mounds of the Late Permian have been discovered in Linxi County and adjacent areas of Inner Mongolia, China. These reefs verify that the Hinggan-Inner Mongolia Area was an open and unobstructed sea-trough in Late Permian. Facies and sequences of reef strata in Member 4 and Member 5 of the Linxi Formation were studied for information to reconstruct the closing process of the Linxi-Jiutai chasm in the sea-trough, i.e., to constrain subsidence, uplift, and final closing. Ages of the reef-bearing strata have been determined to be late and end of Late Permian, based on ranges or abundances of diverse fossils. Six reef-building organic assemblages were distinguished, representing different ecologic conditions, according to morphological functions and paleoecological adaptations of organisms including primarily sponges, bryozoans, and calcareous algae. Two types of shelf slopes, the gentle slope and the steep slope, have been interpreted for Member 4 and Member 5 of the Linxi Formation, based on the assemblages. The locations of outcrops, and types of these reefs delineate the north margin of Sino-Korea Platform, and define uplift and final closing of the Linxi-Jiutai chasm at the end of Late Permian. | TIAN Shu Gang ZHANG Yong Sheng GONG Yue Xuan LI Zi Shun GAO Lian Da ZHAI Da Xing ZHU Chang Wei | 2016 | Science China Earth Sciences2016，59，7： | 2 |
| 20 | Preparation and performance of a cold gas dynamic sprayed high-aluminum bronze coating显示文摘By mixing preheated high-aluminum bronze powders with different amounts of Al_2O_3 powder, a low-pressure cold-sprayed coating was prepared and sprayed onto a Cr12MoV steel substrate. The hardness of the coating and the bonding strength between the coating and the substrate were tested with a HV-1000 microhardness tester and a mechanical universal testing machine. The surface microstructure, cross-section and tensile fracture surface of the coating were observed with a scanning electron microscope(SEM). Correspondingly, the influences of the preheat treatment temperature of the bronze powder and the Al_2O_3 content on the coating performance were investigated. The results indicate that the hardness of bronze powders decreased and the coating deposition rate increased after the preheating treatment of the bronze powder. The Al_2O_3 content in the mixed powders contributed to the deformation of bronze powders during the spraying process. This trend resulted in varied performance of the coating. | Li Feng Chang Guan Ji-rong Chang Hai-min Zhai Guo-sheng An Wen-sheng Li | 2018 | International Journal of Minerals,Metallurgy and Materials2018，25，11： | 2 |
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