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| 1 | Hantavirus infection:a global zoonotic challenge显示文摘Hantaviruses are comprised of tri-segmented negative sense single-stranded RNA, and are members of the Bunyaviridae family. Hantaviruses are distributed worldwide and are important zoonotic pathogens that can have severe adverse effects in humans. They are naturally maintained in specific reservoir hosts without inducing symptomatic infection. In humans, however,hantaviruses often cause two acute febrile diseases, hemorrhagic fever with renal syndrome(HFRS) and hantavirus cardiopulmonary syndrome(HCPS). In this paper, we review the epidemiology and epizootiology of hantavirus infections worldwide. | Hong Jiang Xuyang Zheng Limei Wang Hong Du Pingzhong Wang Xuefan Bai | 2017 | Virologica Sinica2017，32，1： | 47 |
| 2 | Clinical and experimental study on therapeutic effect of umbilical cord blood transplantation on severe viral hepatitis显示文摘AIM: To investigate the therapeutic effect of umbilical cordblood transplantation (UCBT) on patients with severe viralhepatitis and on liver lesions in rats.METHODS: One hundred and fifty three patients with severeviral hepatitis were included in the study between April 1990and July 2002. The patients were treated with adult plasmatransfusion (control), UCBT, plasma exchange (PE) and UCBTcombined with PE (UCBT+PE) respectively. The therapeuticeffectiveness was evaluated by serial determinations of liverfunction, lipids and immune function in all patients beforeand after the treatment. The model of experimental hepaticfailure was constructed in SD rats by injecting carbontetrachloride. Then, the rats were given normal saline, adultplasma or neonate cord blood intraperitoneally. After detectionof liver function, the rats were killed and morphologicalchanges of the liver were microscopically observed.RESULTS: UCBT group and UCBT+PE group had muchbetter improvement in liver and immune functions thancontrol group and PE group. The patients in UCBT+PE grouphad the best clinical efficacy. UCBT was safe and had noside effects. The animal experiment showed significantimprovements in liver function and survival rate in neonatecord blood group as compared with adult plasma group.The histopathology of rat′s liver indicated that neonate cordblood application could decrease the liver injury and increasehepatocellular regeneration.CONCLUSION: UCBT demonstrated a good therapeuticeffect on severe viral hepatitis and no obvious side effects.Umbilical cord blood can attenuate the liver lesions andreproduce hepatocyte. The treatment of UCBT combinedwith PE was much better than that of single plasma exchange, thus UCBT can enhance the therapeutic effect of plasma exchange on severe viral hepatitis. | Xiao-PengTang XuYang HuiTan Yi-LingDing MinZhang Wen-LongWang | 2003 | World Journal of Gastroenterology2003，9，9： | 20 |
| 3 | Stereotactic aspiration for hypertensive intracerebral haemorrhage in a Chinese population:a retrospective cohort study显示文摘Objective We aimed to compare the therapeutic effects of stereotactic aspiration and best medical management in patients who developed supratentorial hypertensive intracerebral haemorrhage(HICH)with a volume of haemorrhage between 20 and 40 mL.Methods The clinical data of 220 patients with supratentorial HICH with a volume between 20 and 40 mL were retrospectively analysed.Among them,142 received stereotactic aspiration surgery(stereotactic aspiration group)and 78 received best medical management(conservative group).All were followed up for 6 months.Multivariate logistic regression and Kaplan-Meier survival curves were used to compare the outcome between the two groups.results The rebleeding rate was lower in the group that had stereotactic aspiration when compared with the group with medical treatment(6[4.2%]vs 9[11.5%],χ2=4.364,p=0.037).After 6 months,although the mortality rate did not differ significantly between the two groups(8 cases[5.6%]vs 10 cases[12.8%],χ2=3.461,p=0.063),the rate of a favourable outcome was higher in the group who received stereotactic aspiration(χ2=15.870,p=0.000).Logistic regression identified that medical treatment(OR=1.64,p=0.000)was an independent risk factor for an unfavourable outcome.The Kaplan-Meier curves indicated that the median favourable outcome time in the stereotactic aspiration group was 59.5 days compared with that in the medically treated group(87.0 days).The log-rank test indicated that the prognosis at 6 months was better for those treated with stereotactic haematoma aspiration(χ2=29.866,p=0.000).However,the 6-month survival rate was similar between the two groups(χ2=3.253,p=0.068).Conclusions Stereotactic haematoma aspiration significantly improved the quality of life,although did not effectively reduce the rate of mortality.When selected appropriately,patients with HICH may benefit from this type of surgical intervention. | Xuyang Zhang Shaolong Zhou Qiang Zhang Xudong Fu Yuehui Wu Jiasheng Liu Bo Liang Zhuo Yang Xinjun Wang | 2019 | Stroke & Vascular Neurology2019，4，1： | 19 |
| 4 | Zircon U-Pb Geochronological Constraints on Rapid Exhumation of the Mantle Peridotite of the Xigaze Ophiolite, Southern Xizang(Tibet)显示文摘The Xigaze ophiolite crops out in the central segment of the Yarlung Zangbo suture zone,southern Tibet(Fig.1).It is characterized by large amounts of ultramafic units with minor mafic rocks.The mafic rocks consist of gabbros, | LIU Tong WU Fuyuan ZHANG Liangliang ZHAI Qingguo LIU Chuanzhou JI Wenbin Ji ZHANG Chang XUYang | 2016 | Acta Geologica Sinica(English Edition)2016，90，S1： | 12 |
| 5 | Review and discussion on fire behavior of bridge girders显示文摘This paper presents an overview on fire behavior of bridge girders mainly including prestressed concrete(PC) bridge girders and steel bridge girders. The typical fire accidents occurred on bridges are illustrated and, the seriousness of posing threats to bridge structures resulted from increasing traffic fires, specially intense hydrocarbon fires generated from petrol-chemicals, is highlighted. The current researches, embracing high-temperature properties of constituent materials, prestress state, measurement in fire tests, numerical methods, structural fire resistance, and so forth, taken on coping with problems existing in fire behavior and structural fire behavior in bridge girders are reviewed and discussed. Further, strategies for enhancing fire resistance of bridge girders followed with failure criterion and mode in types of bridge structures are provided. Future research area along with emerging trends in structural fire behavior of bridge girders is also recommended for mitigating fire hazards occurred on bridge girders. Herein, it can be attained a conclusion from review and discussion that prestressed concrete bridge girders with thin webs, specially T-shaped bridge girder, are prone to unstable under fire exposure conditions. High-strength concrete utilized in prestressed concrete bridge girders is vulnerable to spalling at elevated temperature. Steel-truss bridge girder present a more significant fragility to fire exposure compared than other steel bridge girders. | Gang Zhang Xiaocui Zhao Zelei Lu Chaojie Song Xuyang Li Chenhao Tang | 2022 | Journal of Traffic and Transportation Engineering(English Edition)2022，9，3： | 11 |
| 6 | Deacetylation of TFEB promotes fibrillar Aβ degradation by upregulating lysosomal biogenesis in microglia显示文摘Microglia 玩在由降级的 A 的清理的一个枢轴的角色他们在 lysosomes,在 Alzheimers 疾病(广告) 阻止淀粉的匾致病。最近的证据建议那个 lysosomal 机能障碍导致有毒的蛋白质总数的不够的消除。我们测试了是否与抄写因素 EB (TFEB ) 提高 lysosomal 功能,必要管理者 modulating lysosomal 小径,将在 microglia 支持一个清理。这里,我们证明 TFEB 的那 microglial 表情便于降级和还原剂扔了的纤丝状的 A (fA ) 淀粉的匾,它被 TFEB 的 deacetylation 进一步提高。用集体 spectrometry 分析,我们第一证实了是的 acetylation 一以前 TFEB 的 unreported 修正并且发现那 SIRT1 直接交往了与并且在离氨酸残余 116 点的 deacetylated TFEB。随后,当 TFEB 被击倒时, SIRT1 overexpression 由 TFEB 下游的目标的 upregulating transcriptional 层次提高了 lysosomal 功能和 fA 降级,它能被禁止。而且,在在 microglia 变异的 K116R 的 deacetylated TFEB 的 overexpression 由刺激 lysosomal 生物的续生说加速了细胞内部的 fA 降级并且极大地在 APP/PS1 转基因的老鼠的大脑片减少了扔的淀粉的匾。我们的调查结果表明 TFEB 的 deacetylation 能调整 lysosomal 生物的续生说和 fA 降级,为 attenuating 使 TFEB 的 microglial 激活成为可能的策略在广告的淀粉的匾免职。 | Jintao Bao Liangjun Zheng Qi Zhang Xinya Li Xuefei Zhang Zeyang Li Xue Bai Zhong Zhang Wei Huo Xuyang Zhao Shujiang Shang Qingsong Wang Chen Zhang Jianguo Ji | 2016 | Protein & Cell2016，7，6： | 10 |
| 7 | Hepatitis B virus X protein induces hepatic stem cell-like features in hepatocellular carcinoma by activating KDM5B显示文摘AIM To determine the role of hepatitis B virus X protein(HBx), HBx in regulating hepatic progenitor cell(HPC)-like features in hepatocellular carcinoma(HCC) and the underlying molecular mechanisms.METHODS We used a retrovirus vector to introduce wild type HBx or empty vector into Hep G2 cells. We then used these cells to analyze cell proliferation, senescence, transformation, and stem-like features. Gene expression profiling was carried out on Affymetrix GeneC hip Human U133A2.0 ver.2 arrays according to the manufacturer's protocol. Unsupervised hierarchical clustering analysis and Class Comparison analysis were performed by BRB-Array Tools software Version 4.2.2. A total of 238 hepatitis B virus(HBV)-related HCC patients' array data were used for analyzing clinical features.RESULTS The histone demethylase KDM5 B was significantlyhighly expressed in HBV-related HCC cases(P < 0.01). In HBV proteins, only HBx up-regulated KDM5 B by activating c-myc. Hepatic stem cell(Hp SC) markers(EpC AM, AFP, PROM1, and NANOG) were significantly highly expressed in KDM5B-high HCC cases(P < 0.01). KDM5 B played an important role in maintaining HpS Clike features and was associated with a poor prognosis. Moreover, inhibition of KDM5 B suppressed spheroid formation and cell invasion in vitro.CONCLUSION HBx activates the histone demethylase KDM5 B and induces HPC-like features in HCC. Histone demethylases KDM5 B may be an important therapeutic target against HBV-related HCC cases. | Xuyang Wang Naoki Oishi Tetsuro Shimakami Taro Yamashita Masao Honda Seishi Murakami Shuichi Kaneko | 2017 | World Journal of Gastroenterology2017，23，18： | 10 |
| 8 | Impacts of the Diurnal Cycle of Radiation on Tropical Cyclone Intensification and Structure显示文摘To investigate the impacts of the diurnal cycle on tropical cyclones(TCs), a set of idealized simulations were conducted by specifying different radiation(i.e., nighttime-only, daytime-only, full diurnal cycle). It was found that, for an initially weak storm, it developed faster during nighttime than daytime. The impacts of radiation were not only on TC intensification,but also on TC structure and size. The nighttime storm tended to have a larger size than its daytime counterparts. During nighttime, the radiative cooling steepened the lapse rate and thus reduced the static stability in cloudy regions, enhancing convection. Diabatic heating associated with outer convection induced boundary layer inflows, which led to outward expansion of tangential winds and thus increased the storm size. | GE Xuyang MA Yue ZHOU Shunwu Tim LI | 2014 | Advances in Atmospheric Sciences2014，31，6： | 9 |
| 9 | Cloned pigs derived from somatic cell nuclear transferembryos cultured in vitro atlow oxygen tension显示文摘Pig cloning has great potential to human xenotransplantation. The present study was designed to establish a more efficient system for producing cloned pigs by somatic cell nuclear transfer (SCNT). Our approach was as follows: SCNT embryos were reconstructed by using fetal fibroblasts of Chinese miniature pig as donors and in vitro matured oocytes of prepubertal gilts as recipients. Reconstructed em- bryos were induced by electrical fusion/activation and cultured in BSA-containing North Carolina State University 23 medium (NCSU-23) or Porcine Zygote Medium (PZM-3) at the gas condition of 5% CO2, 7% O2, 88% N2. A total of 230 cloned embryos were transferred to three surrogate sows, producing three piglets. One of them is apparently healthy. The clonal provenance of the piglet was indicated by its coat color and confirmed by DNA microsatellite analysis. These results indicate that the use of in vitro matured oocytes from prepubertal gilts as recipient, combined with cloned embryos cultured at low oxygen tension is an effective way to produce cloned pigs. | PAN Dengke ZHANG Yunhai SUN Xiuzhu ZHANG Jian LI Xuyang LI Yan GU Zhiliang DA Yunping WU Changxin LI Ning | 2006 | Chinese Science Bulletin2006，51，7： | 8 |
| 10 | Modeling effects of temperature and precipitation on carbon characteristics and GHGs emissions in Abies fabric forest of subalpine显示文摘Abies fabric forest in the eastern slope of Gongga mountain is one type of subalpine dark coniferous forests of southwestern China. It is located on the southeastern edge of the Qinghai-Tibet plateau and is sensitive to climatic changes. A process-oriented biogeochemical model, Forest-DNDC, was applied to simulate the effects of climatic factors, temperature and precipitation changes on carbon characteristics, and greenhouse gases (GHGs) emissions in A. fabric forest. Validation indicated that the Forest-DNDC could be used to predict carbon characteristics and GHGs emissions with reasonable accuracy. The model simulated carbon fluxes, soil carbon dynamics, soil CO2, N2O, and NO emissions with the changes of temperature and precipitation conditions. The results showed that with variation in the baseline temperature from -2℃to +2℃, the gross primary production (GPP) and soil organic carbon (SOC) increased, and the net primary production (NPP) and net ecosystem production (NEP) decreased because of higher respiration rate. With increasing baseline precipitation the GPP and NPP increased slightly, and the NEP and SOC showed decreasing trend. Soil CO2 emissions increased with the increase of temperature, and CO2 emissions changed little with increased baseline precipitation. With increased temperature and decreased baseline temperature, the total annual soil N2O emissions increased. With the variation of baseline temperature from -2℃to +2℃, the total annual soil NO emissions increased. The total annual N2O and NO emissions showed increasing trends with the increase of precipitation. The biogeochemical simulation of the typical forest indicated that temperature changes strongly affected carbon fluxes, soil carbon dynamics, and soil GHGs emissions. The precipitation was not a principal factor affecting carbon fluxes, soil carbon dynamics, and soil CO2 emissions, but changes in precipitation could exert strong effect on soil N2O and NO emissions. | LU Xuyang CHENG Genwei XIAO Feipeng FAN Jihui | 2008 | Journal of Environmental Sciences2008，20，3： | 7 |
| 11 | Simulating Carbon Sequestration and GHGs Emissions in Abies fabric Forest on the Gongga Mountains Using a Biogeochemical Process Model Forest-DNDC显示文摘The process-oriented model Forest-DNDC describing biogeochemical cycling of C and N and GHGs (greenhouse gases) fluxes (CO2, NO and N2O) in forest ecosystems was applied to simulate carbon sequestration and GHGs emissions in Abies fabric forest of the Gongga Mountains at southeastern edge of the Tibetan Plateau. The results indicated that the simulated gross primary production (GPP) of Abies fabric forest was strongly affected by temperature. The annual total GPP was 24,245.3 kg C ha-1 yr-1 for 2005 and 26,318.8 kg C ha-1 yr-1 for 2006, respectively. The annual total net primary production (NPP) was 5,935.5 and 4,882.2 kg C ha-1 yr-1 for 2005 and 2006, and the annual total net ecosystem production (NEP) was 4,815.4 and 3,512.8 kg C ha-1 yr-1 for 2005 and 2006, respectively. The simulated seasonal variation in CO2 emissions generally followed the seasonal variations in temperature and precipitation. The annual total CO2 emissions were 3,109.0 and 4,821.0 kg C ha-1 yr-1 for 2005 and 2006, the simulated annual total N2O emissions from forest soil were 1.47 and 1.36 kg N ha-1 yr-1 for 2005 and 2006, and the annual total NO emissions were 0.09 and 0.12 kg N ha-1 yr-1 for 2005 and 2006, respectively. | LU Xuyang CHENG Genwei XIAO Feipeng HUO Changfu | 2008 | Journal of Mountain Science2008，5，3： | 5 |
| 12 | A UV-B-responsive glycosyltransferase,OsUGT706C2,modulates flavonoid metabolism in rice显示文摘Although natural variations in rice flavonoids exist, and biochemical characterization of a few flavonoid glycosyltransferases has been reported, few studies focused on natural variations in tricin-lignan-glycosides and their underlying genetic basis. In this study, we carried out metabolic profiling of tricin-lignan-glycosides and identified a major quantitative gene annotated as a UDPdependent glycosyltransferase OsUGT706C2 by metabolite-based genome-wide association analysis. The putative flavonoid glycosyltransferase OsUGT706C2 was characterized as a flavonoid 7-O-glycosyltransferas in vitro and in vivo. Although the in vitro enzyme activity of OsUGT706C2 was similar to that of OsUGT706D1, the expression pattern and induced expression profile of OsUGT706C2 were very different from those of OsUGT706D1. Besides, OsUGT706C2 was specifically induced by UV-B. Constitutive expression of OsUGT706C2 in rice may modulate phenylpropanoid metabolism at both the transcript and metabolite levels. Furthermore, overexpressing OsUGT706C2 can enhance UV-B tolerance by promoting ROS scavenging in rice. Our findings might make it possible to use the glycosyltransferase OsUGT706C2 for crop improvement with respect to UVB adaptation and/or flavonoid accumulation, which may contribute to stable yield. | Feng Zhang Hao Guo Jiacheng Huang Chenkun Yang Yufei Li Xuyang Wang Lianghuan Qu Xianqing Liu Jie Luo | 2020 | Science China(Life Sciences)2020，63，7： | 5 |
| 13 | Dynamics of Above-and Below-ground Biomass and C,N,P Accumulation in the Alpine Steppe of Northern Tibet显示文摘The temporal dynamics of the biomass,as well as the carbon (C),nitrogen (N),phosphorus (P) concentrations and accumulation contents,in above-and below-ground vegetation components were determined in the alpine steppe vegetation of Northern Tibet during the growing season of 2010.The highest levels of total biomass (311.68 g m-2),total C (115.95 g m-2),total N (2.60 g m-2),and total P (0.90 g m-2) accumulation contents were obtained in August in 2010.Further,biomass and nutrient stocks in the below-ground components were higher than those of the above-ground components.The dominant species viz.,Stipa purpurea and Carex moorcrofti had lower biomass and C,N,P accumulations than the companion species which including Oxytropis.spp.,Artemisia capillaris Thunb.,Aster tataricus L.,and so on. | LU Xuyang YAN Yan FAN Jihui CAO Yingzi WANG Xiaodan | 2011 | Journal of Mountain Science2011，8，6： | 5 |
| 14 | Two Types of Granites in the Western Yangtze Block and Their Implications for Regional Tectonic Evolution: Constraints from Geochemistry and Isotopic Data显示文摘In the western Yangtze Block, widespread Mesoproterozoic to Neoproterozoic rocks are the key to understanding the Precambrian tectonic-magmatic evolution of the region. However, their petrogenesis and tectonic setting are still controversial. In this paper, zircon U-Pb ages, Sm-Nd isotopic and whole-rock geochemical data are reported from selected fresh samples in the southern Dechang county, southwestern China, in order to constrain their emplacement age and magma source, as well as their petrogenesis and tectonic setting. They are mainly composed of biotite monzogranite, monzonitic granite, biotite granodiorites, and quartz diorite. Two ages of 1055 ± 43 Ma and 837.6 ± 3.8 Ma were obtained through zircon U-Pb dating by LA-ICP-MS and LA-MC-ICP-MS, respectively. According to their major element compositions, the Grenville-age granites are peraluminous calc-alkaline series calcic S-type granite. In contrast, the mid-Neoproterozoic granites are metaluminous calc-alkaline series alkalic I-type granite. Furthermore, the S-type granites are enriched in LREEs relative to HREEs with(La/Yb)_N ratios of 3.85–18.56 and underwent major fractionation with strongly negative Eu anomalies(Eu/Eu~* = 0.38–0.66). In the MORB-normalized trace element variation diagram, all the samples are enriched in Ce and large ion lithophile elements such as Rb, Th, and K, and depleted in high field strength elements such as Nb, and Ti, with negative Sr and Ti anomalies. The I-type granites are enriched in LREEs with slight negative Eu anomalies(Eu/Eu~* = 0.83–0.93). They are characterized by the enrichment of highly incompatible elements(such as K, Rb, Ba, Th) and LREEs, relative to MORB. Neodymium isotopic data show that the S-type granites display ^(143)Nd/(^(144) Nd) values of 0.51241–0.51256, and have ε_(Nd)(t = 1055 Ma) values of(-3.29) to(-3.81). Calculated t_(DM) ages yield values from 1.87 to 1.91 Ga with the t_(DM).2 stg ages of 1.86 to 1.9 Ga. The I-type granites have ^(143)Nd/(^(144) Nd) ratios between 0.51192 and 0.51195, corresponding to initial ε_(Nd)(t = 837 Ma) values of 1.22 to 5.63. Calculated t_(DM) ages yield values from 1.0 to 1.38 Ga and the t_(DM).2 stg ages yield values from 0.99 to 1.06 Ga. The S-type granites are distinguished as syn-collision granite, whereas the I-type granites were formed as arc magmas according to the Rb-(Yb+Ta) and R_1-R_2 tectonic discrimination diagrams. To conclude, there are two types of spatially associated granite, the Mesoproterozoic S-type granite which were derived from remelting of upper crustal mudstone and/or clastics and resulted from the convergence of two continental plates, and the mid-Neoproterozoic I-type granite which formed in continental arc and resulted from mantle-derived magma mixed crust material, in the western Yangtze Block. Furthermore, we suggest that collision between the Yangtze and Cathaysia blocks occurred at about 1055 Ma, and caused the Stype granite. The I-type granite related to the subduction of oceanic lithosphere eastward underneath the Yangtze Block in the mid-Neoproterozoic. | MABI Awei YANG Zhengxi ZHANG Mingchun WEN Dengkui LI Yanlong LIU Xuyang | 2018 | Acta Geologica Sinica(English Edition)2018，92，1： | 4 |
| 15 | Personalized neoantigen pulsed dendritic cell vaccine for advanced lung cancer显示文摘Neoantigens are considered to be ultimate target of tumor immunotherapy due to their high tumor specificity and immunogenicity.Dendritic cell(DCs)vaccines based on neoantigens have exciting effects in treatment of some malignant tumors and are a promising therapeutic modality.Lung cancer is a lethal disease with the highest morbidity and mortality rate in the world.Despite the rapid development of targeted therapy and immune checkpoint inhibitors for lung cancer in recent years,their efficacy is still unsatisfactory overall.Therefore,there is an urgent unmet clinical need for lung cancer treatment.Here,we attempted to treat lung cancer using a personalized neoantigen peptide-pulsed autologous DC vaccine and conducted a single-arm,2 medical centers,pilot study initiated by the investigator(ChiCTR-ONC 16009100,NCT02956551).The patients enrolled were patients with heavily treated metastatic lung cancer.Candidate neoantigens were derived from whole-exome sequencing and RNA sequencing of fresh biopsy tissues as well as bioinformatics analysis.A total of 12 patients were enrolled in this study.A total of 85 vaccine treatments were administered with a median value of 5 doses/person(range:3-14 doses/person).In total,12-30 peptide-based neoantigens were selected for each patient.AIl treatment-related adverse events were grade 1-2 and there were no delays in dosing due to toxic effects.The objective effectiveness rate was 25%;the disease control rate was 75%;the median progression-free survival was 5.5 months and the median overall survival was 7.9 months.This study provides new evidence for neoantigen vaccine therapy and new therapeutic opportunities for lung cancer treatment. | Zhenyu Ding Qing Li Rui Zhang Li Xie Yang shu Song Gao Peipei Wang Xiaoqing Su Yun Qin Yuelan Wang Juemin Fang Zhongzheng Zhu Xuyang Xia Guochao Wei Hui Wang Hong Qian Xianling Guo Zhibo Gao Yu Wang Yuquan Wei Qing Xu Heng Xu Li Yang | 2021 | Signal Transduction and Targeted Therapy2021，6，2： | 3 |
| 16 | Neoadjuvant therapy in pancreatic adenocarcinoma: A meta-analysis of phase II trials显示文摘 | M. Mura Assifi Xuyang Lu Guido Eibl Howard A. Reber Gang Li O. Joe Hines | 2011 | Surgery2011，，3： | 3 |
| 17 | Mechanical properties of material in a mine dump at the Shengli#1 Surface Coal Mine,China显示文摘In-situ experiments were conducted to investigate the mechanical properties of the soil-rock mixture in the internal dump of the Shengli #1 Surface Coal Mine, China. Based on the experimental results, this study used comparative analysis and found that the shear strength of the soil-rock mixture in the dump was greater than the residual shear strength of the original rock. The results showed that the material presented in the dump as large blocks was the main factor affecting the strength of the soil-rock mixture.Numerical simulation was carried out for the analyses of three factors: different combinations of shear failure, rolling failure along with different large-block radius ratios, and mixture densities. The results illustrated that the cohesion and angle of internal friction of the soil-rock mixture are 12 kPa and 32.26°. However, in some cases the bench angle in the dump was controlled by a coupling relationship of rocks in the material. Finally, the stability of a soil slope showed a linear relationship with the large-block radius ratio and the bulk density. | Gao Shiyou Zhou Wei Shi Xuyang Cai Qingxiang Crusoe Garmondyu E.Jr. Jisen Shu Huang Yuejun | 2017 | International Journal of Mining Science and Technology2017，27，3： | 3 |
| 18 | Fabrication and its characteristics of hard coating Ti-Al-N system prepared by DC magnetron sputtering显示文摘Pseudobinary Ti 1 x Al x N films were synthesized on Si (100) wafer by DC magnetron sputtering method using Ti 1 x Al x alloy targets with different Al contents. The composition of the Ti 1 x Al x N films was determined by electron probe microanalysis (EPMA). Structural characteristic was performed by X-ray diffraction (XRD), transmission electron microscopy (TEM), and high-resolution TEM (HRTEM). First principles virtual crystal calculations for the Ti 1 x Al x N disordered alloys were used for the XRD simulations. The crystalline structure of the Ti 0.61 Al 0.39 N film was found to be a metastable single phase with NaCl (B1) structure. Its lattice constant, determined by XRD, was less than that of pure TiN. With the increase of Al content, the lattice constant of B1 phase was continually decreased, while würtzite (B4) structure was observed in the Ti 0.40 Al 0.60 N film. When x reached 0.75, the B1 phase disappeared, and only B4 phase was remained. The critical Al content for the phase transition from NaCl to würtzite structure in this paper was about 0.60, which could be explained by both the thermodynamic model and the electron theory. As-deposited Ti 1 x Al x N films exhibited excellent mechanical properties. Hardness measurements of Ti 1 x Al x N films showed a high value of 45GPa for x=0.39 and was decreased to value of 27 GPa with increasing Al at x=0.60. | Zhou, Xuyang Wu, Aimin Qu, Wenchao Jiang, Xin | 2012 | Rare Metals2012，31，2： | 3 |
| 19 | Sensitivity of Tropical Cyclone Intensification to Inner-Core Structure显示文摘In this study,the dependence of tropical cyclone(TC) development on the inner-core structure of the parent vortex is examined using a pair of idealized numerical simulations. It is found that the radial profile of inner-core relative vorticity may have a great impact on its subsequent development. For a system with a larger inner-core relative vorticity/inertial stability,the conversion ratio of the diabatic heating to kinetic energy is greater. Furthermore,the behavior of the convective vorticity eddies is likely modulated by the system-scale circulation. For a parent vortex with a relatively higher inner-core vorticity and larger negative radial vorticity gradient,convective eddy formation and radially inward propagation is promoted through vorticity segregation. This provides a greater potential for these small-scale convective cells to self-organize into a mesoscale inner-core structure in the TC. In turn,convectively induced diabatic heating that is close to the center,along with higher inertial stability,efficiently enhances system-scale secondary circulation. This study provides a solid basis for further research into how the initial structure of a TC influences storm dynamics and thermodynamics. | GE Xuyang XU Wei ZHOU Shunwu | 2015 | Advances in Atmospheric Sciences2015，32，10： | 3 |
| 20 | Bioactivities and molecular mechanisms of polysaccharides from Hericium erinaceus显示文摘Hericium erinaceus,an edible and medicinal mushroom,has been utilized since ancient China due to its delicious taste and health benefits.The polysaccharide from H.erinaceus(HEP)is supposed to be one of the major bioactive compounds,which garnered widespread attention in seeking innovative applications for precision nutrition.Both in vitro and in vivo studies have shown that HEP possesses antioxidant and anti-aging,gastrointestinal protecting,anti-tumor,hypolipidemic and hypoglycemic,immune-enhancing,neuroprotective,and hepatoprotective activities,verifying its functional benefits to human health.This review provides an overview of the extraction and structure of HEP,and concluded that HEP had different structures with different sources of H.erinaceus and extraction methods.Besides,the biochemical and pharmacological properties of HEP as well as the relative mechanism were highlighted and summarized on the basis of in vivo and in vitro studies,which could be helpful for the healthy application of HEP.Finally,the research prospects of HEP for specific populations or precision nutrition were proposed. | Jianhui Liu Weiwei Wang Qiuhui Hu Xuyang Wu Hui Xu Anxiang Su Minhao Xie Wenjian Yang | 2022 | Journal of Future Foods2022，2，2： | 3 |
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