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| 1 | 中医药单病例随机对照试验报告规范(中医药CENT):CENT声明的扩展、说明与详述显示文摘背景单病例随机对照试验是评价中医药干预措施有效性和安全性较为理想和适宜的方法之一。目前已有一定数量的中医药单病例随机对照试验发表。然而,由于缺乏相应的报告规范,这些试验的报告质量普遍较差。鉴于中医药临床研究的独特性,工作组制定了单病例随机对照试验报告标准(CONSORT extension for reporting N-of-1 trials,CENT 2015)的中医药扩展版(中医药CENT),以帮助研究者报告中医药单病例试验。方法我们在提高健康研究质量和透明度协作网(Enhancing the QUAlity and Transparency Of health Research,EQUATOR)上注册了中医药CENT。中医药单病例随机对照试验报告规范的制定是一个综合过程,包括收集初始报告条目,与17名专家小组成员进行两轮科学的德尔菲共识调查,修订和形成最终报告清单。结果清单共包括6个领域的25项条目,其中的8项对CENT 2015清单条目进行了扩展和详细说明。中医药CENT清单充分考虑了中医药的诊疗特点,并详细阐释了中医药单病例随机对照试验中辨证的概念和不同的中医药干预措施。结论中医药CENT是中医临床研究的一个实用工具,可用于评价中医药单病例对照试验报告的完整性,并可指导中医药单病例对照试验的设计、实施和报告,期望此报告规范可切实提高中医药单病例试验的全面性和透明度。 | 胡嘉元(翻译) 李江(翻译) 翟静波(翻译) 李博(翻译) 田金徽(翻译) 马彬(翻译) 杨克虎(翻译) 代敏(翻译) 田贵华(翻译) 商洪才(翻译) 张弛(回译) 段玉婷(审校) 卞兆祥(审校) Li J Hu JY Zhai JB | 2021 | 中国循证医学杂志2021，21，3： | 7 |
| 2 | Common non-synonymous polymorphisms in the BRCA1 Associated RING Domain (BARD1) gene are associated with breast cancer susceptibility:a case-control analysis显示文摘The BRCA1 Associated RING Domain(BARD1) gene has been identified as a high penetrance gene for breast cancer, whose germline and somatic mutations were reported in both non-BRCA1/2 hereditary site-specific and sporadic breast cancer cases. BARD1 plays a crucial role in tumor repression, along with its heterodimeric partner BRCA1. In the current study, we tested the hypothesis that common non-synonymous polymorphisms in BARD1 are associated with breast cancer susceptibility in a case-control study of 507 patients with incident breast cancer and 539 frequency-matched cancer-free controls in Chinese women. We genotyped all three common(minor allele frequency (MAF) > 0.10) non-synonymous polymorphisms(Pro24Ser, Arg378Ser, and Val507Met) in BARD1. We found that the BARD1 Pro24Ser variant genotypes(24Pro/Ser and 24Ser/Ser) and Arg378Ser variant homozygote 378Ser/Ser were associated with a significantly decreased breast cancer risk, compared with their wild-type homozygotes, respectively. Furthermore, a significant locus-locus interaction was evident between Pro24Ser and Arg378Ser (P-int = 0.032). Among the 378Ser variant allele carriers, the 24Pro/Pro wild-type homozygote was associated with a significantly increased breast cancer risk (adjusted OR = 1.81, 95% CI = 1.11-2.95), but the subjects having 24Pro/Ser or Ser/Ser variant genotypes had a significantly decreased risk(adjusted OR = 0.74, 95% CI = 0.56-0.99). In stratified analysis, this locus-locus interaction was more evident among subjects without family cancer history, those with positive estrogen receptor (ER) and individuals with negative progesterone receptor(PR). These findings indicate that the potentially functional polymorphisms Pro24Ser and Arg378Ser in BARD1 may jointly contribute to the susceptibility of breast cancer. | Huo, X Hu, Z. B Zhai, X. J Wang, Y Wang, S Wang, X. C Qin, J. W Chen, W. S Jin, G. F Liu, J. Y Gao, J Wei, Q. Y Wang, X. R Shen, H. B | 2007 | 南京医科大学学报(自然科学版)2007，27，7： | 3 |
| 3 | Rice GLUTATHIONE PEROXIDASE1-mediated oxidation of bZIP68 positively regulates ABA-independent osmotic stress signaling显示文摘Osmotic stress caused by drought and high salinity is a significant environmental threat that limits plant growth and agricultural yield. Redox regulation plays an important role in plant stress responses, but the mechanisms by which plants perceive and transduce redox signals are still underexplored. Here, we report a critical function for the thiol peroxidase GPX1 in osmotic stress response in rice, where it serves as a redox sensor and transducer. GPX1 is quickly oxidized upon exposure to osmotic stress and forms an intramolecular disulfide bond, which is required for the activation of bZIP68, a VRE-like basic leucine zipper (bZIP) transcription factor involved in the ABA-independent osmotic stress response pathway. The disulfide exchange between GPX1 and bZIP68 induces homo-tetramerization of bZIP68 and thus positively regulates osmotic stress response by regulating osmotic-responsive gene expression. Furthermore, we discovered that the nuclear translocation of GPX1 is regulated by its acetylation under osmotic stress. Taken together, our findings not only uncover the redox regulation of the GPX1-bZIP68 module during osmotic stress but also highlight the coordination of protein acetylation and redox signaling in plant osmotic stress responses. | Heng Zhou Feng Zhang Fengchao Zhai Ye Su Ying Zhou Zhenglin Ge Priyadarshini Tilak Jürgen Eirich Iris Finkemeier Ling Fu Zongmin Li Jing Yang Wenbiao Shen Xingxing Yuan Yanjie Xie | 2022 | Molecular Plant2022，15，4： | 2 |
| 4 | Relation between milk urea content and nitrogen excretion from lactating cows显示文摘 | ZHAI S W LIU J X MA Y | 2005 | Acta Agric Scand Section A-Animal Science2005，55，23： | 1 |
| 5 | NAD synthase nmnat acts as a chaperone to protect against neurodegeneration显示文摘 | Zhai R G Zhang F Hiesinger P R Cao Y Haueter C M Bellen H J | 2008 | Nature2008，452，： | 1 |
| 6 | Effect of salt solutions on chain structure of partially hydrolyzed polyacrylamide显示文摘 | Zhang Q Zhou J S Zhai Y A | 2008 | Journal Central South University Technology2008，15，1： | 1 |
| 7 | Genetic analysis of a novel dominant rice dwarf mutant 986083D显示文摘 | Qin R Z Qiu Y Cheng Z J Shan X Y Guo X P Zhai H Q Wan J M | 2008 | Euphytica2008，160，： | 1 |
| 8 | Identification and characterization of a novel cytokine,THANK,a TNF homologue that activates apoptosis,nuclear factor-κB,and c-Jun NH2-terminal kinase显示文摘 | Mukhopadhyay A Ni J Zhai Y | 1999 | J Biol Chem1999，274，15： | 1 |
| 9 | The dielectric properties and optical propagation loss of c-axis oriented ZnO thin films deposited by sol-gel process 显示文摘 | ZHAI J ZHANG L YAO X | 2000 | Ceram Int2000，26，： | 1 |
| 10 | Foaming behavior of polypropylene/polystyrene blends enhanced by improved in- terracial compatibility显示文摘 | ZHAI W T WANG H Y YU J | 2008 | Journal of Polymer Science2008，46，16： | 1 |
| 11 | CO2 absorption by alkaline soils and its implication to the global carbon cycle显示文摘 | Xie J X Li Y Zhai C X | 2009 | Environmen- tal Geology2009，56，： | 1 |
| 12 | Distribution and sources of polycyclic aromatic hydrocarbons (PAHs) in sediment from the upper reach of Huaihe River, East China显示文摘 | FENG J L ZHAI M X SUN J H | 2012 | Environmental Science and Pollution Research2012，19，10： | 1 |
| 13 | Activation of pregnane X re-ceptor disrupts glucocorticoid and mineralocorticoid ho- meostasis显示文摘 | Zhai Y Pai HV Zhou J | 2007 | Mol Endocrinol2007，21，1： | 1 |
| 14 | Fabrication of superhydro- phobic surfaces by self-assembly and their water-adhesion prop- erties显示文摘 | SONG X ZHAI J WANG Y | 2005 | The Journal of Physical Chemistry: B2005，109，9： | 1 |
| 15 | Ultraviolet degradation of methyltins: Elucidating the mechanism by identification of a detected new intermediary product and investigating the kinetics at various environmental conditions 显示文摘 | Zhai G S Liu J F He B | 2008 | Chemosphere2008，72，3： | 1 |
| 16 | Poly(ethylene gly- col) grafted starch introducing a novel interphase in poly ( lactic acid )/poly ( ethylene glycol )/starch ternary composites 显示文摘 | WANG J W ZHAI W T ZHENG W G | 2012 | J Polym Env2012，20，2： | 1 |
| 17 | A comparison of oxytocin and carboprost tromethamine in the prevention of postpartum hemorrhage in highrisk patients undergoing cesarean delivery显示文摘 | Bai J Sun Q Zhai H | 2014 | Exp Ther Med2014，7，1： | 1 |
| 18 | Trihalomethane formation of Maeao water supply eontaminated by seawater intrusion显示文摘 | Zhai X D Liu J F Zhu X P | 2006 | Journal of Harbin University of Commerce2006，22，1： | 1 |
| 19 | One dimensional CdS nanostructures= a prom ising candidate for optoelectronics 显示文摘 | Li H Wang X Xu J Zhang Q Bando Y Golberg D Ma Y Zhai T | 2013 | Advanced Mate- rials2013，25，22： | 1 |
| 20 | Temperature measurement and distribution inside planar SOFC stacks显示文摘 | Guan W B Zhai H J Jin L | 2012 | Fuel Cells2012，12，1： | 1 |
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