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| 1 | Relative Contributions of Boundary-Layer Meteorological Factors to the Explosive Growth of PM2.5 during the Red-Alert Heavy Pollution Episodes in Beijing in December 2016显示文摘Based on observations of urban mass concentration of fine particulate matter smaller than 2.5 μm in diameter(PM_(2.5)), ground meteorological data, vertical measurements of winds, temperature, and relative humidity(RH), and ECMWF reanalysis data, the major changes in the vertical structures of meteorological factors in the boundary layer(BL) during the heavy aerosol pollution episodes(HPEs) that occurred in winter 2016 in the urban Beijing area were analyzed. The HPEs are divided into two stages: the transport of pollutants under prevailing southerly winds, known as the transport stage(TS), and the PM_(2.5) explosive growth and pollution accumulation period characterized by a temperature inversion with low winds and high RH in the lower BL, known as the cumulative stage(CS). During the TS, a surface high lies south of Beijing, and pollutants are transported northwards. During the CS, a stable BL forms and is characterized by weak winds, temperature inversion, and moisture accumulation. Stable atmospheric stratification featured with light/calm winds and accumulated moisture(RH > 80%) below 250 m at the beginning of the CS is closely associated with the inversion, which is strengthened by the considerable decrease in near-surface air temperature due to the interaction between aerosols and radiation after the aerosol pollution occurs. A significant increase in the PLAM(Parameter Linking Aerosol Pollution and Meteorological Elements) index is found, which is linearly related to PM mass change. During the first 10 h of the CS, the more stable BL contributes approximately 84% of the explosive growth of PM_(2.5) mass. Additional accumulated near-surface moisture caused by the ground temperature decrease, weak turbulent diffusion, low BL height, and inhibited vertical mixing of water vapor is conducive to the secondary aerosol formation through chemical reactions, including liquid phase and heterogeneous reactions, which further increases the PM_(2.5) concentration levels. The contribution of these reaction mechanisms to the explosive growth of PM_(2.5) mass during the early CS and subsequent pollution accumulation requires further investigation. | junting zhong xiaoye zhang yaqiang wang junying sun yangmei zhang jizhi wang kaiyan tan xiaojing shen haochi che lu zhang zhouxiang zhang xuefei qi huarong zhao sanxue ren yang li | 2017 | Journal of Meteorological Research2017，31，5： | 25 |
| 2 | Gold nanorod-photosensitizer conjugate with extracellular pH-driven tumor targeting ability for photothermal/photodynamic therapy显示文摘氯 e6-pHLIP <候补选手class=“ a-plus-plus ”> ss -AuNRs,金使nanorod具有感光性结合包含 pH (低)有给予细胞外的 pH 的一张二硫化物契约的插入肽( pHLIP )( pH <候补选手class=“ a-plus-plus ”> e )-driven 肿瘤指向能力,成功地为光力学的 bimodal 和 photothermal 治疗被开发了。在这 bimodal 治疗,氯 e6 (Ce6 ) ,第二代的 photosensitizer (PS ) ,被用于光力学的治疗(太平洋夏季时间) 。金 nanorods (AuNRs ) 作为 Ce6 的 nanocarrier 和 quencher 为 photothermal 治疗(PTT ) 并且也被用作一个过高热代理人。pHLIPss 作为一根驾驶 pHe 的指向探针被设计在低 pH 在癌症房间提高 Ce6 和 AuNRs 的累积。在 Ce6-pHLIP < 潜水艇 class= “ a-plus-plus ” > ss -AuNRs, Ce6 接近并且由 AuNRs 熄灭了,引起小太平洋夏季时间效果。当暴露了到正常生理的 pH 时 7.4, Ce6-pHLIP < 潜水艇 class= “ a-plus-plus ” > ss -AuNRs 泛泛地与房间膜联系。然而,曾经暴露了到酸的 pH 6.2, pHLIP 活跃地插入到房间膜,和 conjugates 是进房间的 translocated。当这发生时, Ce6 由于二硫化物与 AuNRs 分开细胞内部的谷胱甘肽(GSH ) 引起的契约劈开,和汗衫氧在光之上为太平洋夏季时间被生产照耀。作为单个 PTT 代理人,另外, AuNRs 能由提高的浸透和保留(EPR ) 效果在肿瘤提高 PS 的累积。因此由我们的数据显示了当暴露了到酸的 pH 时, Ce6-pHLIP < 潜水艇 class= “ a-plus-plus ” > ss -AuNRs 能为癌症治疗完成 synergistic PTT/PDT bimodality。 | Nannan Wang Zilong Zhao Yifan Lv Huanhuan Fan Huarong Bai Hongmin Meng Yuqian Long Ting Fu Xiaobing Zhang Weihong Tan | 2014 | Nano Research2014，7，9： | 11 |
| 3 | Hydrogeochemical and mineralogical characteristics related to heavy metal attenuation in a stream polluted by acid mine drainage:A case study in Dabaoshan Mine,China显示文摘Dabaoshan Mine,the largest mine in south China,has been developed since the 1970s.Acid mine drainage (AMD) discharged from the mine has caused severe environmental pollution and human health problems.In this article,chemical characteristics,mineralogy of ocher precipitations and heavy metal attenuation in the AMD are discussed based on physicochemical analysis,mineral analysis,sequential extraction experiments and hydrogeochemistry.The AMD chemical characteristics were determined from the initial water composition,water-rock interactions and dissolved sulfide minerals in the mine tailings.The waters,affected and unaffected by AMD,were Ca-SO4 and Ca-HCO3 types,respectively.The affected water had a low pH,high SO42 and high heavy metal content and oxidation as determined by the Fe2+ /Fe3+ couple.Heavy metal and SO42 contents of Hengshi River water decreased,while pH increased,downstream.Schwertmannite was the major mineral at the waste dump,while goethite and quartz were dominant at the tailings dam and streambed.Schwertmannite was transformed into goethite at the tailings dam and streambed.The sulfate ions of the secondary minerals changed from bidentate-to monodentate-complexes downstream.Fe-Mn oxide phases of Zn,Cd and Pb in sediments increased downstream.However,organic matter complexes of Cu in sediments increased further away from the tailings.Fe3+ mineral precipitates and transformations controlled the AMD water chemistry. | Huarong Zhao Beicheng Xia Jianqiao Qin Jiaying Zhang | 2012 | Journal of Environmental Sciences2012，24，6： | 8 |
| 4 | The Toxic Mechanism of High Lethality of Herbicide Butachlor in Marine Flatfish Flounder,Paralichthys olivaceus显示文摘The toxic mechanism of herbicide butachlor to induce extremely high lethality in marine flatfish flounder,Paralichthys Olivaceus,was analyzed by histopathological examination,antioxidant enzymes activities and ATP content assay.Histopathological examination of gill,liver and kidney of exposed fishes showed that gill was a target organ of butachlor.The butachlor seriously impaired the respiration of gills by a series of lesions such as edema,lifting and detachment of lamellar epithelium,breakdown of pillar cells,and blood congestion.The dysfunction of gill respiration caused suffocation to the exposed flounder with extremely high acute lethality.Antioxidant enzyme activity assay of the in vitro cultured flounder gill(FG) cells exposed to butachlor indicated that butachlor markedly inhibited the antioxidant enzyme activities of Superoxide dismutase(SOD),catalase(CAT) and glutathione peroxidase(GPX).Furthermore,along with the decline of antioxidant enzyme activities,ATP content in the exposed FG cells decreased,too.This infers that the oxidative stress induced by butachlor can inhibit the production of cellular ATP.Similar decrease of ATP content was also observed in the exposed flounder gill tissues.Taken together,as in FG cells,butachlor possibly induced a short supply of ATP in pillar cells by inhibiting the antioxidant enzyme activities and then affecting the contractibility of the pillar cells,which in turn resulted in the blood congestion and suffocation of exposed flounder. | GUO Huarong YIN Licheng ZHANG Shicui FENG Wenrong | 2010 | Journal of Ocean University of China2010，9，3： | 8 |
| 5 | Aerosol Hygroscopicity during the Haze Red-Alert Period in December 2016 at a Rural Site of the North China Plain显示文摘A humidification system was deployed to measure aerosol hygroscopicity at a rural site of the North China Plain during the haze red-alert period 17–22 December 2016. The aerosol scattering coefficients under dry [relative humidity(RH) < 30%] and wet(RH in the range of 40%–85%) conditions were simultaneously measured at wavelengths of450, 550, and 700 nm. It is found that the aerosol scattering coefficient and backscattering coefficient increased by only 29% and 10%, respectively when RH went up from 40% to 80%, while the hemispheric backscatter fraction went down by 14%, implying that the aerosol hygroscopicity represented by the aerosol scattering enhancement factor f(RH) is relatively low and RH exerted little effects on the aerosol light scattering in this case. The scattering enhancement factors do not show significant differences at the three wavelengths, only with an approximate 2% variation, suggesting that the aerosol hygroscopicity is independent of the wavelength. Aerosol hygroscopicity is highly dependent on the aerosol chemical composition. When there is a large mass fraction of inorganics and a small mass fraction of organic matter, f(RH) reaches a high value. The fraction of NO_3^- was strongly correlated with the aerosol scattering coefficient at RH = 80%, which suggests that NO_3^- played an important role in aerosol hygroscopic growth during the heavy pollution period. | Xuefei QI Junying SUN Lu ZHANG Xiaojing SHEN Xiaoye ZHANG Yangmei ZHANG Yaqiang WANG Haochi CHE Zhouxiang ZHANG Junting ZHONG Kaiyan TAN Huarong ZHAO Sanxue REN | 2018 | Journal of Meteorological Research2018，32，1： | 7 |
| 6 | Development of performance and combustion system of Atkinson cycle internal combustion engine显示文摘The application of hybrid vehicle is a practical technical solution to the energy shortage and the environmental pollution.The internal combustion engine(ICE)plays a key role in the development of the hybrid vehicle.Based on the requirements of the hybrid vehicle and the characteristic of Atkinson cycle,a set of designing methods for the Atkinson cycle gasoline engine is presented through the analysis of the optimized matching for the compression ratio,valve timing and the combustion chamber.The designing method has been verified by the bench test and the results show that the fuel consumption can be improved by12%–15%with the reduction of the low speed torque by 10%,and the low fuel consumption region in the fuel map extends significantly with the rated power almost keeping constant.It may be of great reference for the development of hybrid vehicle technology in China. | LIU FuShui SUN BaiGang ZHU HuaRong HU TieGang DU Wei LI XiangRong ZHANG Zheng | 2014 | Science China(Technological Sciences)2014，57，3： | 7 |
| 7 | Reconstruction of a hybrid nucleoside antibiotic gene cluster based on scarless modification of large DNA fragments显示文摘Genetic modification of large DNA fragments(gene clusters) is of great importance in synthetic biology and combinatorial biosynthesis as it facilitates rational design and modification of natural products to increase their value and productivity.In this study,we developed a method for scarless and precise modification of large gene clusters by using RecET/RED-mediated polymerase chain reaction(PCR) targeting combined with Gibson assembly.In this strategy,the biosynthetic genes for peptidyl moieties(HPHT) in the nikkomycin biosynthetic gene cluster were replaced with those for carbamoylpolyoxamic acid(CPOAA)from the polyoxin biosynthetic gene cluster to generate a^40 kb hybrid gene cluster in Escherichia coli with a reusable targeting cassette.The reconstructed cluster was introduced into Streptomyces lividans TK23 for heterologous expression and the expected hybrid antibiotic,polynik A,was obtained and verified.This study provides an efficient strategy for gene cluster reconstruction and modification that could be applied in synthetic biology and combinatory biosynthesis to synthesize novel bioactive metabolites or to improve antibiotic production. | Jiming Zhuo Binbin Ma Jingjing Xu Weihong Hu Jihui Zhang Huarong Tan Yuqing Tian | 2017 | Science China(Life Sciences)2017，60，9： | 6 |
| 8 | Important role of a LAL regulator Sta R in the staurosporine biosynthesis and high-production of Streptomyces fradiae CGMCC 4.576显示文摘Staurosporine, belonging to indolocarbazole compounds, is regarded as an excellent lead compound for synthesizing antitumor agents as a potent inhibitor against various protein kinases. In this study, two separate clusters(cluster A and cluster B),corresponding to biosyntheses of K-252 c(staurosporine aglycone) and sugar moiety, were identified in Streptomyces fradiae CGMCC 4.576 and heterologously expressed in Streptomyces coelicolor M1146 separately or together. Sta R, a cluster-situated LAL family regulator, activates staurosporine biosynthesis by binding to the promoter regions of sta O-sta C and sta G-sta N. The conserved sequences GGGGG and GCGCG were found through gradually truncating promoters of sta O and sta G, and further determined by mutational experiments. Overexpression of sta R with the supplementation of 0.01 g L^–1 Fe SO4 increased staurosporine production to 5.2-fold compared with that of the parental strain Streptomyces fradiae CGMCC 4.576 in GYM medium. Our results provided an approach for improvement of staurosporine production mediated by a positive regulator and established the basis for dissecting the regulatory mechanisms of other indolocarbazole compounds with clinical application value. | Hanye Guan Yue Li Jiazhen Zheng Ning Liu Jihui Zhang Huarong Tan | 2019 | Science China(Life Sciences)2019，62，12： | 6 |
| 9 | jadR* and jadR2 act synergistically to repress jadomycin biosynthesis显示文摘The biosynthesis of antibiotics is controlled by cascade regulation involving cluster-situated regulators (CSRs) and pleiotropic regulators. Three CSRs have been identified in the jadomycin biosynthetic gene cluster, including one OmpR-type activator (JadR1) and two TetR-like repressors (JadR* and JadR2). To examine their interactions in jadomycin biosynthesis, a series of mutants were generated and tested for jadomycin production. We noticed that jadomycin production in the jadR*-jadR2 double mutant was increased dramatically compared with either single mutant. Transcriptional analysis showed that jadR* and jadR2 act synergistically to repress jadomycin production by inhibiting the transcription of jadR1. Furthermore, jadR* and jadR2 reciprocally inhibit each other. The complex interactions among these three CSRs may provide clues for the activation of the jadomycin gene cluster, which would otherwise remain silent without stimulation from stress signals. | ZHANG YanYan ZOU ZhengZhong NIU GuoQing TAN HuaRong | 2013 | Science China(Life Sciences)2013，56，7： | 6 |
| 10 | Enhancement of salinomycin production by ribosome engineering in Streptomyces albus显示文摘Dear Editor,Streptomyces can produce a large variety of secondary metabolites as a major source of anti-infective, antitumor or immune-suppressive agents widely applied in clinical treatment. Antibiotics-resistant bacteria are spreading at alarming rates. | Dong Li Jihui Zhang Yuqing Tian Huarong Tan | 2019 | Science China(Life Sciences)2019，62，2： | 5 |
| 11 | Regulation of CDllb transcription by decreasing PRC2 and increased acH4 level during ATRA-induced HL-60 differentiation显示文摘Polycomb 压抑的建筑群 2 (PRC2 ) ,它调停在 histone H3 (K27me3 ) 上的离氨酸 27 的 trimethylation,在干细胞区别的许多类型起一个重要作用。这里,我们试着揭示 PRC2,调停 PRC2 的压抑的 histone 标记 H3K27me3,和活跃 histone 标记 histone H4 acetylation (acH4 ) 怎么在导致的 all-trans retinoic 酸(ATRA ) 期间调整 CD11b 抄写 HL-60 白血病房间区别。由使用量的即时聚合酶链反应(qPCR ) 和西方的污点分析,我们发现 PRC2 的二个成员的 mRNA 和蛋白质表示层次分别地在导致 ATRA 的 HL-60 区别期间被减少。当为 72 h 与 ATRA 对待时, EZH2 和 SUZ12 mRNA 层次分别地被减少到 35% 控制组和 38% 。同时, granulocytic 成熟表面标记 CD11b 表示在 qPCR 检测的 mRNA 水平和流动 cytometry 检测的蛋白质水平显著地被增加。由使用染色质 immunoprecipitation 试金,我们在导致 ATRA 的 HL-60 区别期间在 CD11b 的倡导者在 SUZ12 有约束力、调停 PRC2 的 H3K27me3 比较了本地变化。两个都,在 CD11b 的倡导者的 SUZ12 有约束力、调停 PRC2 的 H3K27me3 的层次分别地为 4.1 和 3.8 褶层被减少。并且我们也在 ATRA 处理的 72 h 以后在 acH4 水平发现了增加直到 4 褶层。这些结果建议包括调停 PRC2 的压抑的 histone 标记 H3K27me3 和活跃 histone 标记 acH4 的 histone 修正可以在 HL-60 白血病房间 reprogramming 期间在 CD11b 包含抄写到终端区别。 | Huarong Tang Fangping Chen Qian Tan Sanqin Tan Linxin Liu Fan Zhang | 2009 | Acta Biochimica et Biophysica Sinica2009，41，7： | 5 |
| 12 | Curative effect of assisted reproduction technology by Traditional Chinese Medicine multi-channel interventional therapy on 95 cases of in vitro fertilization and embryo transfer failure显示文摘OBJECTIVE: To evaluate the curative effect of Traditional Chinese Medicine(TCM) multi-channel interventional therapy on women with Assisted Reproductive Technology(ART) failure, to compare the curative effect of the dual therapy and triple therapy on women with ART Failure, and to choose the best TCM interventional therapeutic plan.METHODS: The 95 cases with ART Failure from West China second University Hospital of Sichuan University meeting the inclusion criteria were randomly divided into three groups:dual therapy group(31 cases), triple therapy group(33 cases)and control group(31 cases). According to the intervene treatment of in vitro Fertilization and Embryo Transfer(IVF-ET) long cycle scheme, the control group wait naturally for 3 months before IVFET. The dual therapy group take TCM prescriptionⅡ of cultivating emotion and assisting reproduction and auricular acupoint therapy for 3 months before IVF-ET, then Western Medicine treatment progestin supporting as well as auricular application and Antai Recipe after IVF-ET transplantation.The triple therapy group take TCM prescription Ⅱof cultivated emotion and assisted reproduction,auricular acupoint therapy and retention enema of TCM, and combination treatment the same as dual therapy group after transplantation. The natural pregnancy number, the period condition of secondary IVF-ET and the improvement of the kidney deficiency, liver depression and blood stasis syndrome among those three groups were compared.RESULTS: It was showed from analysis in 95 cases with ART failure that the number of natural preg-nancy was as followings: 3 patients from the dual therapy group, 10 patients from the triple therapy group, and no patient from the control group. The comparison among three groups have statistical significance(P < 0.05). The treatment group is superior to the control group, while the triple therapy is superior to the dual therapy. The comparison of the condition of the fertility rate, clinical pregnancy rate, biochemical pregnancy rate and early abortion rate during the period of secondary IVF-ET between pre-therapy and post-treatment of both the dual therapy group and the triple therapy group have statistical significance(P < 0.05). The comparison of the improvement of the kidney deficiency,liver depression and blood stasis syndrome between pre-therapy and post-treatment of both the dual therapy group and the triple therapy group have statistical significance(P < 0.05). The comparison between three groups after treatment have statistical significance(P < 0.05).CONCLUSION: TCM multi-channel interventional therapy can increase the natural pregnancy rate of patients with ART Failure(the triple therapy is superior to the dual therapy); it can increase the fertility rate, clinical pregnancy rate, and decrease the early abortion rate during the period of secondary IVF-ET; it can improve syndromes of kidney deficiency, liver depression and blood stasis. | Xia Wanting Zhong Yanmei Zhang Ying Xue Huarong Huang Jinzhu Wang Zhen Zhou Hang Ma Qianhong Zeng Qian | 2017 | Journal of Traditional Chinese Medicine2017，37，5： | 4 |
| 13 | 北斗导航系统卫星激光测距综述显示文摘Satellite laser ranging(SLR)is an unambiguous measurement technique and generates high accuracy satellite orbit data.All satellites in the BeiDou navigation satellite system(BDS)carried laser retro-reflector arrays(LRAs),so they can be tracked by ground SLR stations in order to provide the accurate observation data.The Shanghai astronomical observatory(SHAO)designed the LRAs,and also developed the dedicated SLR systems using a 1 m-aperture telescope and a transportable cabin-based SLR system with a telescopes of 60 cm aperture.These enable BDS satellite ranging during daytime and nighttime with centimeter-level precision,allowing highly accurate estimations of satellite orbits.Moreover,some of the BDS satellites are also equipped with laser time transfer(LTT)payloads,which were developed by the SHAO and China Academy of Space Technology(CAST),providing a highly accurate time comparison between the satellites and ground clocks.This paper describes the dedicated SLR system and the design of the LRAs for BDS satellites,as well as global SLR measurements.The SLR tracking data is used for evaluating the orbit accuracy of BDS satellites and broadcast ephemeris,with an accuracy of less than 1 m.The LTT measurements to BDS satellites for a single shot have a precision of approximately 300 picoseconds,with a time stability of 20 picoseconds in 500 s. | ZHANG Haifeng LONG Mingliang YANG Huafeng MENG Wendong CHENG Zhi’en DENG Huarong ZHANG Zhongping ZHANG A’li | 2020 | Aerospace China2020，21，4： | 4 |
| 14 | Effects of Jiazhu decoction in combination with cyclophosphamide on breast cancer in mice显示文摘OBJECTIVE: To investigate the therapeutic effects of Jiazhu decoction (JZD) in combination with cyclophosphamide (CTX) on the growth of breast cancer in mice and to explore the possible molecular mechanisms of action. METHODS: BALB/c mice were randomly divided into four groups of 10 (untreated model group, JZD group, CTX group, and JZD + CTX group) and subcutaneously injected with 4T1 mouse breast cancer cells. Tumors were allowed to establish for ~7 d before initiation of treatment with CTX (100 mg/kg every week by intraperitoneal injection) and/or JZD (0.015 mL of 1.65 g/mL crude drug, administered daily by gavage). The model group received equivalent volumes of vehicle on the same schedules. Tumor volumes were measured every 3 d. Mice were sacrificed after 3 weeks of treatment, and tumors were excised and subjected to RT-qPCR and western blot analysis to evaluate expression of the Wnt/β-catenin signaling pathway components β-catenin, c-Myc, and cyclin D1 at the mRNA and protein levels. RESULTS: The mean tumor volume was smaller and the growth rate was slower in the CTX and JZD + CTX groups compared with the model group (P < 0.05), and in the JZD + CTX group compared with the CTX and JZD groups (P < 0.05). Tumor growth was inhibited by 35.4% and 48.1% by CTX and JZD + CTX treatment, respectively (P < 0.001). The expression of β-catenin, c-Myc, and cyclin D1 mRNA and protein in tumors was significantly lower in mice treated with JZD or JZD + CTX compared with the untreated mice (P < 0.05), and was significantly lower in mice treated with JZD + CTX compared with either JZD or CTX alone (P < 0.05). CONCLUSION: JZD inhibited the growth of mouse breast cancer cells in vivo, possibly by reducing the expression of β-catenin, c-Myc, and cyclin D1. Combination therapy with JZD plus CTX had a more potent inhibitory effect on breast cancer growth compared with either agent alone. | Guan Huiting Xie Su Liu Shangyi Xie Qing Hou Shengkai Liu Huarong Zhang Yunjie Hu Yaqing Zhang Chenyu | 2019 | Journal of Traditional Chinese Medicine2019，39，5： | 4 |
| 15 | Transcriptomic Analysis of Thermoanaerobacter tengcongensis Grown at Different Temperatures by RNA Sequencing显示文摘Genome sequencing of more than 80 thermophiles has provided powerful databases for the preliminary determination of genes essential to thermal adaptation(Berka et al.,2003;Berezovsky and Shakhnovich,2005;Andrews et al.,2010).A laboratory strain of Thermoanaerobacter tengcongensis MB4 has been shown to grow at temperatures over the | Chuan Wang Chunlei Jin Jihui Zhang Qiyu Bao Bo Liu Huarong Tan | 2015 | Journal of Genetics and Genomics2015，42，6： | 3 |
| 16 | SP1 governs primordial folliculogenesis by regulating pregranulosa cell development in mice显示文摘Establishment of the primordial follicle(PF)pool is pivotal for the female reproductive lifespan;however,the mechanism of primordial folliculogenesis is poorly understood.Here,the transcription factor SP1 was shown to be essential for PF formation in mice.Our results showed that SP1 is present in both oocytes and somatic cells during PF formation in the ovary.Knockdown of Sp1 expression,especially in pregranulosa cells,significantly suppressed nest breakdown,oocyte apoptosis,and PF formation,suggesting that SP1 expressed by somatic cells functions in the process of primordial folliculogenesis.We further demonstrated that SP1 governs the recruitment and maintenance of Forkhead box L2-positive(FOXL2^+)pregranulosa cells using an Lgr5-EGFP-IRES-CreER^T2(Lgr5-KI)reporter mouse model and a FOXL2^+ cell-specific knockdown model.At the molecular level,SP1 functioned mainly through manipulation of NOTCH2 expression by binding directly to the promoter of the Notch2 gene.Finally,consistent with the critical role of granulosa cells in follicle survival in vitro,massive loss of oocytes in SP1 knockdown ovaries was evidenced before puberty after the ovaries were tranSP1anted under the renal capsules.Conclusively,our results reveal that SP1 controls the establishment of the ovarian reserve by regulating pregranulosa cell development in the mammalian ovary. | Han Cai Bingying Liu Huarong Wang Guanghong Sun Lizhao Feng Ziqi Chen Jiaqi Zhou Jiawei Zhang Tuo Zhang Meina He Tingting Yang Qirui Guo Zhen Teng Qiliang Xin Bo Zhou Hua Zhang Guoliang Xia Chao Wang | 2020 | Journal of Molecular Cell Biology2020，12，3： | 3 |
| 17 | Study on RS-and GIS-based ecological capital assessment in arid areas显示文摘生态的大写的评价当前是生态学,资源经济,环境经济和生态的经济的学科交差的领域里的重要研究内容之一。为了科学地估计生态的资本,增加到决策人在经济开发考虑生态的费用,并且为在干旱区域的持续经济开发也是必要的。基于风景生态学的理论,在这篇论文生态的资本在干旱区域珍视的per 单位区域被使用 Landsat TM 数据, CBERS 卫星数据,气象学的数据, MODIS 卫星数据和另外的生态的数据研究,并且 RS --并且在干旱区域估计生态的大写的价值的官方补给底的模型被开发。而且基于测量地的数据,在在威信河盆的生态的大写的评价以后的案例研究,在 2003 的 Xinjiang 被执行。盆被划分成 4 个生态的大写的区域以便份量上计算生态系统的生态的大写的价值,分析生态的资本的空间分发,并且制定生态的资本的空间分发的地图。结果证明在在 2003 的威信河盆的生态系统的全部的生态的大写的价值是 1.494 54 癮 吗?? | ZHOU Kefa CHEN Xi ZHOU Huarong ZHANG Qing ZUO Qiting ZHANG Haibo YAN Jinfeng CHEN Chuan | 2006 | Chinese Science Bulletin2006，51，A01： | 3 |
| 18 | A High-Performance Composite Epoxy Coating Based on the Cooperative Enhancement of 2D Co_(2)(OH)2BDC and Electrospun PAN Nanofiber Membrane显示文摘Based on a two-dimensional(2D)Co-MOF(Co_(2)(OH)_(2)BDC)with a self-contained organic interface and low conductivity,a composite epoxy coating(2D Co_(2)(OH)_(2)BDC-PAN/EP)was constructed by a two-step preparation.First,a polyacrylonitrile(PAN)nanofiber membrane was electrospuned on the surface of Q235 steel,followed by coating using the epoxy coating(EP)containing 2D Co_(2)(OH)_(2)BDC.The 2D Co_(2)(OH)_(2)BDC-PAN/EP composite epoxy coatings showed robust mechanical performance and excellent corrosion resistance capacity. | Zhao Huarong Zhang Yueshuang Gan Shaojie Yue Qiankun Liu Zan Cheng Zhilin | 2022 | China Petroleum Processing & Petrochemical Technology2022，24，2： | 2 |
| 19 | Comparison of Submicron Particles at a Rural and an Urban Site in the North China Plain during the December 2016 Heavy Pollution Episodes显示文摘An extensive field experiment for measurement of physical and chemical properties of aerosols was conducted at an urban site in the Chinese Academy of Meteorological Sciences(CAMS) in Beijing and at a rural site in Gucheng(GC), Hebei Province in December 2016. This paper compares the number size distribution of submicron particle matter(PM1, diameter < 1 μm) between the two sites. The results show that the mean PM1 number concentration at GC was twice that at CAMS, and the mass concentration was three times the amount at CAMS. It is found that the accumulation mode(100–850 nm) particles constituted the largest fraction of PM1 at GC, which was significantly correlated with the local coal combustion, as confirmed by a significant relationship between the accumulation mode and the absorption coefficient of soot particles. The high PM1 concentration at GC prevented the occurrence of new particle formation(NPF) events, while eight such events were observed at CAMS. During the NPF events, the mass fraction of sulfate increased significantly, indicating that sulfate played an important role in NPF. The contribution of regional transport to PM1 mass concentration was approximately 50% at both sites, same as that of the local emission. However, during the red-alert period when emission control took place, the contribution of regional transport was notably higher. | Xiaojing SHEN Junying SUN Xiaoye ZHANG Yangmei ZHANG Yaqiang WANG Kaiyan TAN Peng WANG Lu ZHANG Xuefei QI Haochi CHE Zhouxiang ZHANG Junting ZHONG Huarong ZHAO Sanxue REN | 2018 | Journal of Meteorological Research2018，32，1： | 2 |
| 20 | A widespread response of Gram-negative bacterial acyl-homoserine lactone receptors to Gram-positive Streptomyces γ-butyrolactone signaling molecules显示文摘Cell-cell communication is critical for bacterial survival in natural habitats,in which miscellaneous regulatory networks are encompassed.However,elucidating the interaction networks of a microbial community has been hindered by the population complexity.This study reveals thatγ-butyrolactone(GBL)molecules from Streptomyces species,the major antibiotic producers,can directly bind to the acyl-homoserine lactone(AHL)receptor of Chromobacterium violaceum and influence violacein production controlled by the quorum sensing(QS)system.Subsequently,the widespread responses of more Gram-negative bacterial AHL receptors to Gram-positive Streptomyces signaling molecules are unveiled.Based on the cross-talk between GBL and AHL signaling systems,combinatorial regulatory circuits(CRC)are designed and proved to be workable in Escherichia coli(E.coli).It is significant that the QS systems of Gram-positive and Gram-negative bacteria can be bridged via native Streptomyces signaling molecules.These findings pave a new path for unlocking the comprehensive cell-cell communications in microbial communities and facilitate the exploitation of innovative regulatory elements for synthetic biology. | Xiang Liu Wenxi Wang Junyue Li Yue Li Jihui Zhang Huarong Tan | 2021 | Science China(Life Sciences)2021，64，10： | 2 |
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