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| 1 | Temperature-gradient induced microstructure evolution in heat-affected zone of electron beam welded Ti-6Al-4V titanium alloy显示文摘The heat-affected zone(HAZ) of electron beam welded(EBW) joint normally undergoes a unique heat-treating process consisting of rapid temperature rising and dropping stages, resulting in temperature-gradient in HAZ as a function of the distance to fusion zone(FZ). In the current work,microstructure, elements distribution and crystallographic orientation of three parts(near base material(BM) zone, mid-HAZ and near-FZ) in the HAZ of Ti-6Al-4V alloy were systematically investigated. The microstructure observation revealed that the microstructural variation from near-BM to near-FZ included the reduction of primary α(αp) grains, the increase of transformed β structure(βt) and the formation of various α structures. The rim-α, dendritic α and abnormal secondary α(αs) colonies formed in the mid-HAZ, while the 'ghost' structures grew in the near-FZ respectively. The electron probe microanalyzer(EPMA) and electron back-scattered diffraction(EBSD) technologies were employed to evaluate the elements diffusion and texture evolution during the unique thermal process of welding. The formation of the various α structures in the HAZ were discussed based on the EPMA and EBSD results. Finally, the nanoindentation hardness of 'ghost' structures was presented and compared with nearby βt regions. | Shilin Zhang Yingjie Ma Sensen Huang Sabry S.Youssef Min Qi Hao Wang Jianke Qiu Jiafeng Lei Rui Yang | 2019 | Journal of Materials Science & Technology2019，35，8： | 6 |
| 2 | Entrapping multifunctional dendritic nanoparticles into a hydrogel for local therapeutic delivery and synergetic immunochemotherapy显示文摘Developing multifunctional nanoparticles to support new therapy models is apromising and challenging task to address the current dilemma on antitumortreatment. Herein, we incorporated multifunctional dendritic nanoparticles intoa poly(D,L-lactide-co-glycolide)-poly(ethylene glycol)-poly(D,Lqactide-co-glycolide)(PLGA-PEG-PLGA) triblock copolymers thermosensitive injectable hydrogelmatrix to construct a localized drug delivery system for combining chemotherapyand immunotherapy. The multifunctional dendritic nanoparticles were designedwith following expectations: i, Dendritic scaffolds provide a hydrophobic interiorto load the anticancer drug, doxorubicin (DOX), for chemotherapy; and ii,dendritic scaffolds are used to build arginine-rich molecules to provide theinducible nitric oxide synthase (iNOS) substrate, L-Arg, to M1 macrophages,which can produce the cytotoxic substance nitric oxide (NO) and subsequentlyinduce tumor cell destruction through immunotherapy. It is noteworthy that thedendritic nanoparticles-in-hydrogel delivery system is able to gel at physiologicaltemperature and serves as a warehouse for the sustained release of the drug.Ultimately, this system showed great efficacy in treating 4T1 cells-xenograftedBALB/C mice (86.62% tumor growth inhibition). Therefore, this localized drugdelivery system combining chemotherapy and immunotherapy provides a novelapproach for cancer therapy. | Lei Jiang Yang Ding Xialin Xue Sensen Zhou Cheng Li Xiaoke Zhang Xiqun Jiang | 2018 | Nano Research2018，11，11： | 3 |
| 3 | Different role of second phase in the micro-galvanic corrosion of WE43 Mg alloy in NaCl and Na_(2)SO_(4) solution显示文摘Effect of the second phase in the micro-galvanic corrosion of a commercial Mg alloy containing rare earth elements, cast WE43 alloy,was investigated in 0.6 M NaCl solution and 0.6 M Na_(2)SO_(4)solution by scanning electron microscopy(SEM) observations, scanning Kelvin probe force microscopy(SKPFM) analysis, hydrogen evolution, weight loss measurement, and electrochemical techniques. It is confirmed that the second phase of cast WE43 alloy is more active than Mg matrix and exhibits an anodic role in the micro-galvanic corrosion with α-Mg matrix as cathode and dissolves preferentially in Na_(2)SO_(4)solution, in contrast to the situation in NaCl solution. The corrosion rate of cast WE43 alloy in Na_(2)SO_(4)solution is much higher than that in NaCl solution, which is different from the conventional wisdom and could be attributed to the different role of the second phase in the micro-galvanic corrosion in two solutions. | Baojing Feng Guonan Liu Peixu Yang Sensen Huang Dongqing Qi Peng Chen Chengduo Wang Jiang Du Shaojun Zhang Jinhui Liu | 2022 | Journal of Magnesium and Alloys2022，10，6： | 2 |
| 4 | Transformation of Laves phases and its effect on the mechanical properties of TIG welded Mg-Al-Ca-Mn alloys显示文摘The effects of Al content and Ca/Al mass ratio on the microstructure and mechanical properties of tungsten inert gas(TIG)welded Mg-2Ca-x Al-0.5Mn(x=0,1,5)alloy joints were studied in present work.Results showed that increasing Al content was effective in reducing the dendrite spacing at the fusion zone(FZ)edge.The Laves phases in the FZ and the heat-affected zone(HAZ)can be changed from Mg_(2)Ca to(Mg,Al)_(2)Ca with the decrease of Ca/Al ratio,and the(Mg,Al)_(2)Ca could be further transformed to Al_(2)Ca under welding thermal cycle.Furthermore,dynamic dissolution and precipitation of Laves phases and Al_(8)Mn_(5)phases occurred in the HAZ,resulting in a gradient microstructure and hardness peak in this area.The tensile properties of the joints were significantly improved with the increase of Al content,which was mainly due to the modification of Laves phases. | Sensen Chai Shiyu Zhong Qingshan Yang Daliang Yu Qingwei Dai Hehe Zhang Limeng Yin Gang Wang Zongxiang Yao | 2022 | Journal of Materials Science & Technology2022，，25： | 2 |
| 5 | Influence of rolling speed on microstructure and mechanical properties of AZ31 Mg alloy rolled by large strain hot rolling显示文摘 | Fei Guo Dingfei Zhang Xusheng Yang Luyao Jiang Sensen Chai Fusheng Pan | 2014 | Materials Science & Engineering A2014，，： | 1 |
| 6 | Characterization ofα_(2)Precipitates in Ti–6Al and Ti–8Al Binary Alloys:A Comparative Investigation显示文摘Transmission electron microscopy(TEM)and atom probe tomography(APT)techniques were used to investigate the nanoscale orderedα_(2)(Ti_(3)Al)precipitates in Ti–Al binary alloys.Ti–6Al and Ti–8Al binary alloys were solution treated and aged to obtain Widmanstatten microstructure and promoteα_(2)precipitates.The TEM results displayed strong short-range ordering ofα_(2)precipitates in Ti–8Al alloy,while no evidence of the superlattice reflections ofα_(2)in Ti–6Al alloy.The results acquired from APT showed theα_(2)clusters and atoms distribution at the interface between the matrix andα_(2)precipitates.The size and morphology ofα_(2)particles in Ti–8Al alloy,respectively,obtained by TEM and APT are closely consistent.Meanwhile,the APT results displayed tiny size clusters in Ti–6Al alloy,which supposed to give evidence of the initial ordering process ofα_(2)precipitates in the absence of correlative results from TEM. | Sabry S.Youssef Xiaodong Zheng Yingjie Ma Sensen Huang Min Qi Jianke Qiu Ruixue Zhang Peitao Hua Shijian Zheng Jiafeng Lei Rui Yang | 2021 | Acta Metallurgica Sinica(English Letters)2021，34，5： | 1 |
| 7 | Crystal structures of Bbp from Staphylococcus aureus reveal the ligand binding mechanism with Fibrinogen a显示文摘 | Xinyue Zhang Meng Wu Wei Zhuo JinkeGu Sensen Zhang Jingpeng Ge Maojun Yang | 2015 | Protein & Cell2015，6，10： | 1 |
| 8 | SCGN deficiency is a risk factor for autism spectrum disorder显示文摘Autism spectrum disorder(ASD)affects 1-2%of all children and poses a great social and economic challenge for the globe.As a highly heterogeneous neurodevelopmental disorder,the development of its treatment is extremely challenging.Multiple pathways have been linked to the pathogenesis of ASD,including signaling involved in synaptic function,oxytocinergic activities,immune homeostasis,chromatin modifications,and mitochondrial functions.Here,we identify secretagogin(SCGN),a regulator of synaptic transmission,as a new risk gene for ASD.Two heterozygous loss-of-function mutations in SCGN are presented in ASD probands.Deletion of Scgn in zebrafish or mice leads to autism-like behaviors and impairs brain development.Mechanistically,Scgn deficiency disrupts the oxytocin signaling and abnormally activates inflammation in both animal models.Both ASD probands carrying Scgn mutations also show reduced oxytocin levels.Importantly,we demonstrate that the administration of oxytocin and anti-inflammatory drugs can attenuate ASD-associated defects caused by SCGN deficiency.Altogether,we identify a convergence between a potential autism genetic risk factor SCGN,and the pathological deregulation in oxytocinergic signaling and immune responses,providing potential treatment for ASD patients suffering from SCGN deficiency.Our study also indicates that it is critical to identify and stratify ASD patient populations based on their disease mechanisms,which could greatly enhance therapeutic success. | Zhe Liu Shuai Tan Lianyu Zhou Li Chen Mingfeng Liu Wang Wang Yingying Tang Qin Yang Sensen Chi Peiyan Jiang Yue Zhang Yonghua Cui Junhong Qin Xiao Hu Shenglong Li Qi Liu Lu Chen Song Li Ezra Burstein Wei Li Xiaohu Zhang Xianming Mo Da Jia | 2023 | Signal Transduction and Targeted Therapy2023，8，2： | 0 |
| 9 | Rice OsUBR7 modulates plant height by regulating histone H2B monoubiquitination and cell proliferation显示文摘Plant height is an important agronomic trait for lodging resistance and yield.Here,we report a new plantheight-related gene,OsUBR7 in rice(Oryza sativa L.);knockout of OsUBR7 caused fewer cells in internodes,resulting in a semi-dwarf phenotype.OsUBR7 encodes a putative E3 ligase containing a plant homeodomain finger and a ubiquitin protein ligase E3 component N-recognin 7(UBR7)domain.OsUBR7 interacts with histones and monoubiquitinates H2B(H2Bub1)at lysine148 in coordination with the E2 conjugase OsUBC18.OsUBR7 mediates H2Bub1 at a number of chromatin loci for the normal expression of target genes,including cell-cycle-related and pleiotropic genes,consistent with the observation that cell-cycle progression was suppressed in the osubr7 mutant owing to reductions in H2Bub1 and expression levels at these loci.The genetic divergence of OsUBR7 alleles among japonica and indica cultivars affects their transcriptional activity,and these alleles may have undergone selection during rice domestication.Overall,our results reveal a novel mechanism that mediates H2Bub1 in plants,and UBR7 orthologs could be utilized as an untapped epigenetic resource for crop improvement. | Yangyi Zheng Sensen Zhang Yanqiu Luo Fuquan Li Jiantao Tan Bin Wang Zhe Zhao Huifang Lin Tingting Zhang Jianhong Liu Xupeng Liu Jingxin Guo Xianrong Xie Letian Chen Yao-Guang Liu Zhizhan Chu | 2022 | Plant Communications2022，3，6： | 0 |
| 10 | Shallow water bathymetry based on a back propagation neural network and ensemble learning using multispectral satellite imagery显示文摘The back propagation(BP)neural network method is widely used in bathymetry based on multispectral satellite imagery.However,the classical BP neural network method faces a potential problem because it easily falls into a local minimum,leading to model training failure.This study confirmed that the local minimum problem of the BP neural network method exists in the bathymetry field and cannot be ignored.Furthermore,to solve the local minimum problem of the BP neural network method,a bathymetry method based on a BP neural network and ensemble learning(BPEL)is proposed.First,the remote sensing imagery and training sample were used as input datasets,and the BP method was used as the base learner to produce multiple water depth inversion results.Then,a new ensemble strategy,namely the minimum outlying degree method,was proposed and used to integrate the water depth inversion results.Finally,an ensemble bathymetric map was acquired.Anda Reef,northeastern Jiuzhang Atoll,and Pingtan coastal zone were selected as test cases to validate the proposed method.Compared with the BP neural network method,the root-mean-square error and the average relative error of the BPEL method can reduce by 0.65–2.84 m and 16%–46%in the three test cases at most.The results showed that the proposed BPEL method could solve the local minimum problem of the BP neural network method and obtain highly robust and accurate bathymetric maps. | Sensen Chu Liang Cheng Jian Cheng Xuedong Zhang Jie Zhang Jiabing Chen Jinming Liu | 2023 | Acta Oceanologica Sinica2023，42，5： | 0 |
| 11 | Fundamental understanding of high-capacity lithium-excess cathodes with disordered rock salt structure显示文摘As a new class of lithium rich cathodes,disordered rock-salt cathodes have been of primary interest,because of their ability to deliver a promisingly high capacity up to 300 mAh/g.Nevertheless,some fundamental issues are yet to be fully understood and a comprehensive mastering of their solid-state chemistry,kinetics and thermal stability is required.Here,we select a high capacity cation-disordered positive electrode-Li_(1.2)Ni_(0.4)Nb_(0.4)O_(2)as a model compound to study intrinsic reaction mechanism,including charge compensation mechanism,kinetics,thermal stability,and structural evolution.By combining soft and hard X-ray absorption spectroscopy(XAS),X-ray photoelectron spectroscopy(XPS)with operando and exsitu differential scanning calorimetry(DSC),galvanostatic intermittent titration technique(GITT),cyclic voltammetry(CV),and X-ray diffraction(XRD),we present holistic information on disordered rock-salt cathode.This work provides beneficial insights into designing and tailoring new positive electrodes with disordered rock-salt structure. | Hao Lin Beatriz Moreno Kamil Kucuk Sensen Zhang Shankar Aryal Zheng Li Carlo U.Segre Jassiel Rodriguez Dhanya Puthusseri Lirong Cai Xuechen Jiao Vilas G.Pol | 2021 | Journal of Materials Science & Technology2021，，15： | 0 |
| 12 | Recent progress and challenges in the treatment of spinal cord injury显示文摘Spinal cord injury(SCI)disrupts the structural and functional connectivity between the higher center and the spinal cord,resulting in severe motor,sensory,and autonomic dysfunction with a variety of complications.The pathophysiology of sci is complicated and multifaceted,and thus individual treatments acting on a specific aspect or process are inadequate to elicit neuronal regeneration and functional recovery after ScI.Combinatory strategies targeting multiple aspects of scI pathology have achieved greater beneficial effects than individuai therapy alone.Although many problems and challenges remain,the encouraging outcomes that have been achieved in preclinical models offer a promising foothold for the development of novel clinical strategies to treat scl.In this review,we characterize the mechanisms underlying axon regeneration of adult neurons and summarize recent advances in facilitating functional recovery following scI at both the acute and chronic stages.In addition,we analyze the current status,remaining problems,and realistic challenges towards clinical translation.Finally,we consider the future of scI treatment and provide insights into how to narrow the translational gap that currently exists between preclinical studies and clinical practice.Going forward,clinical trials should emphasize multidisciplinary conversation and cooperation to identify optimal combinatorial approaches to maximize therapeuticbenefitinhumanswithscl. | Ting Tian Sensen Zhang Maojun Yang | 2023 | Protein & Cell2023，14，9： | 0 |
| 13 | Complementary multicolor electrochromic devices with excellent stability based on porous tin oxide nanosheet scaffold显示文摘Electrochromic devices(ECDs)have been extensively investigated as promising candidates in broad cutting-edge applications,such as smart windows,electronic labels,adaptive camouflage,etc.However,they have suffered from either inadequate color variations or poor cycling stability for a long time.Herein,we developed a general strategy to boost the cyclic stability and enrich the color variations of ECDs by scrupulous design of the composition and nanostructure of electrodes,in which porous tin oxide(SnO_(2))nanosheets serve as the scaffold and typical metal oxides or conducting polymers as the active electrochromic materials.Various electrochromic composite materials,including polyaniline(PANI)@SnO_(2),V2O5@SnO_(2),and WO_(3)@SnO_(2) heterostructured nanoarrays were prepared by the facile wet-chemical method.These composite electrodes exhibit remarkable electrochromic performances,e.g.,superior cycling stability(more than 2000 cycles),rich color variations(more than 5 colors for PANI@SnO_(2)),and enlarged optical modulation.These excellent performances account for the heterogenous porous nanoarrays,which not only facilitate the intercalation/extraction of ions but also relieve the stress generated during the electrochemical process.In addition,diverse prototypes of complementary multicolor ECD with excellent cycling stability(over thousands of cycles)and rich color variations(8 colors)were realized for the first time.We believe that our work put forward a general strategy for developing high-quality multicolor complementary electrochromic devices. | Chenchen Bian Jinhui Wang Huanhuan Liu Yin Yan Ping Zhang Weilong Yang Sensen Jia Xiaodan Guo Guofa Cai | 2024 | Nano Research2024，17，4： | 0 |
| 14 | Microstructures,mechanical properties and degradability of Mg-2Gd-0.5(Cu/Ni)alloys:A comparison study显示文摘Low alloying Mg-2 Gd-0.5(Cu/Ni)alloys for sealing tools in the oil and gas industry were prepared.The differences in the effects of minor Cu and Ni additions on microstructures and properties of the Mg-2 Gd alloy were compared.The results showed that adding Ni was more effective than adding Cu in refining grain sizes,strengthening the basal fiber texture,and promoting the formation of LPSO phases,resulting in higher strength.The tensile yield strength/elongation of the Mg-2 Gd-0.5 Cu alloy,Mg-2 Gd-0.25 Cu-0.25 Ni alloy,and Mg-2 Gd-0.5 Ni alloy was 146 MPa/23.7%,175 MPa/23.1%,and 248 MPa/18.2%,respectively.The decreased elongation was attributed to the basal fiber texture and the presence of coarse LPSO phases.In terms of the corrosion rate in 3.5 wt.%NaCl solution,it rose from 112 mm y^(-1)for the Mg-2 Gd-0.5 Cu alloy to 269 mm y^(-1)for the Mg-2 Gd-0.25 Cu-0.25 Ni alloy and 490 mm y^(-1)for the Mg-2 Gd-0.5 Ni alloy,indicating that the addition of Ni instead of Cu showed a more significant promoting effect on the degradability of Mg alloys,which was related to more refined grains,the stronger basal fiber texture,and a larger amount of LPSO phases. | Shiyu Zhong Dingfei Zhang Yongqin Wang Sensen Chai Jingkai Feng Yulun Luo Jianrong Hua Qimin Dai Guangshan Hu Junyao Xu Bin Jiang Fusheng Pan | 2022 | Journal of Materials Science & Technology2022，，33： | 0 |
| 15 | Cryo-EM structures of the mammalian endo-lysosomal TRPML1 channel elucidate the combined regulation mechanism显示文摘TRPML1 隧道是非选择的 group-2 有 Ca 2+ 的短暂受体潜力(TRP ) 隧道渗透。主要在所有哺乳动物的房间类型的迟了的内涵体和 lysosome 定位了, TRPML1 在 endocytosis,膜 trafficking,和 lysosome 生物的续生说的过程是不可缺少的。TRPML1 的变化引起严重 lysosomal 存储混乱叫的 mucolipidosis 类型 IV (MLIV ) 。在现在的学习,我们在类脂化合物 nanodiscs 和 Amphipols 决定了亩 musculus TRPML1 (mTRPML1 ) 的 cryo 电子显微镜学(cryo 他们) 结构。在 Amphipols 的 mTRPML1 的二个不同状态被加到关上的状态,在哪个能在激活和规定之上代表二不同证实上。polycystin-mucolipin 领域(PMD ) 可以察觉到 luminal/extracellular 刺激并且向上经历一个行动在 endocytosis 期间打手势,因此在 TRPML1 触发全面 conformational 变化。基于结构的比较,我们建议 TRPML1 被 pH, Ca 2+, 和 phosphoinositides 以一种联合方式调整以便提供动态 endocytosis 过程。 | Sensen Zhang Ningning Li Wenwen Zeng Ning Gao Maojun Yang | 2017 | Protein & Cell2017，8，11： | 0 |
| 16 | Petrogenesis and Tectonic Implications of the Paleoproterozoic A-Type Granites in the Xiong’ershan Area along the Southern Margin of the North China Craton显示文摘Paleoproterozoic A-type granites are widely distributed in the southern margin of the North China Craton(SNCC),providing important information for understanding the Paleoproterozoic tectonic regimes in this area.This paper reports newly obtained whole-rock compositions and zircon U-Pb ages for the Tieluping syenogranite porphyry(TLP)and Huoshenmiao alkali granite porphyry(HSM)in the SNCC.Zircons from the TLP and HSM have U-Pb ages of 1805±12 and 1792±14 Ma,respectively.These ages are taken to date the emplacement of these intrusions.They had high total alkali contents(K_(2)O+Na_(2)O>7.13 wt.%),with high 10000×Ga/Al ratios(3.06–3.41)and Zr+Y+Nb+Ce values(709 ppm–910 ppm)as well as high zircon saturation temperatures(864–970℃),indicative of A-type granite affinities.High Y/Nb(1.75–3.32),Ce/Nb(7.72–9.72),and Yb/Ta(2.89–5.60)ratios suggested that TLP and HSM belonged to the A2-type granite.The negative whole rockε_(Nd)(t)values(−8.4 to−6.6)and negative zirconε_(Hf)(t)values(−15.9 to−6.3)confirmed that TLP and HSM were likely generated by the partial melting of an ancient continental crust.TheεHf(t)(−7.4 to+4.0)values of inherited zircons in the TLP suggested that they were derived from the partial melting of Archean basement rocks.Considering the geochemical similarity of the 1.80 Ga A-type granitoids in the SNCC,we propose that the TLP and HSM were formed in a post-collisional regime that was likely associated with the break-off of the Paleoproterozoic subducted slab.Upwelling of the asthenosphere provided huge heat to generate the regional 1.80 Ga A-type granite in the SNCC. | Jinhong Xu Yuping Jiang Shuli Hu Zhengwei Zhang Chengquan Wu Chaofei Zheng Xiyao Li Ziru Jin Sensen Zhang Yatao Zhou | 2024 | Journal of Earth Science2024，35，2： | 0 |
| 17 | Application of Artificial Neural Network in Engineering显示文摘This paper mainly studies the dynamic direction of engineering valuation based on the artificial neural network methods,and seeks for a set of rapid,convenient and practical valuation models,for building construction projects. | ZHANG Fan WANG Lei ZHOU Zhou ZHAO Jiaxin ZHANG Sensen HU Shixiang MA Wengang | 2020 | International Journal of Plant Engineering and Management2020，25，3： | 0 |
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