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| 1 | Breast cancer development and progression:Risk factors,cancer stem cells,signaling pathways,genomics,and molecular pathogenesis显示文摘As the most commonly occurring cancer in women worldwide,breast cancer poses a formidable public health challenge on a global scale.Breast cancer consists of a group of biologically and molecularly heterogeneous diseases originated from the breast.While the risk factors associated with this cancer varies with respect to other cancers,genetic predisposition,most notably mutations in BRCA1 or BRCA2 gene,is an important causative factor for this malignancy.Breast cancers can begin in different areas of the breast,such as the ducts,the lobules,or the tissue in between.Within the large group of diverse breast carcinomas,there are various denoted types of breast cancer based on their invasiveness relative to the primary tumor sites.It is important to distinguish between the various subtypes because they have different prognoses and treatment implications.As there are remarkable parallels between normal development and breast cancer progression at the molecular level,it has been postulated that breast cancer may be derived from mammary cancer stem cells.Normal breast development and mammary stem cells are regulated by several signaling pathways,such as estrogen receptors(ERs),HER2,and Wnt/b-catenin signaling pathways,which control stem cell proliferation,cell death,cell differentiation,and cell motility.Furthermore,emerging evidence indicates that epigenetic regulations and noncoding RNAs may play important roles in breast cancer development and may contribute to the heterogeneity and metastatic aspects of breast cancer,especially for triple-negative breast cancer.This review provides a comprehensive survey of the molecular,cellular and genetic aspects of breast cancer. | Yixiao Feng Mia Spezia Shifeng Huang Chengfu Yuan Zongyue Zeng Linghuan Zhang Xiaojuan Ji Wei Liu Bo Huang Wenping Luo Bo Liu Yan Lei Scott Du Akhila Vuppalapati Hue H.Luu Rex C.Haydon Tong-Chuan He Guosheng Ren | 2018 | Genes & Diseases2018，5，2： | 24 |
| 2 | Climate change and its driving effect on the runoff in the "Three-River Headwaters" region显示文摘在长江的 headwater 分区在三河的 Headwaters 区域和 Zhimenda 的观察流量数据基于 降水和 12 个气象学的车站的温度数据,在在 Lancang 河的 headwater 分区的黄河和 Changdu 的 headwater 分区的 Tangnaihai 在时期期间 19652004 ,这份报纸分析 降水的趋势,温度,流量深度并且借助于 Mann-Kendall-Sneyers 执行意义测试顺序Makkink 模型被使用计算潜在的蒸发。降水和潜在的蒸发驾驶的流量模型被开发,对由气候变化的流量的影响在不同情形下面被模仿。结果在时期期间显示出那 19652004 三河的 Headwaters 区域的温度正在增加,三个水文学车站的流量正在减少,他们俩在 1994 有突然的变化,当没有重要趋势变化时,发生在降水身上。流量模型建议降水在流量深度上有积极效果,当潜在的蒸发起一个否定作用时。Lancang 河的流量深度上的潜在的蒸发的影响被发现是在三条河里重要;并且黄河的是最少。情形分析的结果显示尽管降水和潜在的蒸发相对在流量上有积极、否定的效果,处于特定的状况的流量深度上的单个效果的波动的特征被代表。 | ZHANG Shifeng HUA Dong MENG Xiujing ZHANG Yongyong | 2011 | Journal of Geographical Sciences2011，21，6： | 16 |
| 3 | Coal facies evolution of the main minable coal-bed in the Heidaigou Mine, Jungar Coalfield, Inner Mongolia, northern China显示文摘The No. 6 Coal-bed from the Heidaigou Mine, Jungar Coalfield, Inner Mongolia is a super-large Ga deposit. The dominant carrier of Ga is boehmite in coal. The study of coal facies may provide genetic enrichment information of Ga and its carrier (boehmite) in the Ga deposit. On the basis of study on coal petrology and mineralogy, it was found that the No. 6 Coal-bed from the Heidaigou Mine of Jungar was enriched in inertinites and the microlitho-types were dominated by clarodurite. The maceral morphological features and association indicate that the coal-bed was formed in a dry sedimentary environment or in a periodic dry sedimentary environment caused by the alternating variations of groundwater level. The optimum conditions for the enrichment of Ga and its particular carrier (boehmite) were dominated by four transitional conditions: (1) the upper delta plain which was the transitional zone between alluvial and lower delta plains, (2) the transitional zone between the dry and wet forest swamps, being slightly apt to the dry one, (3) the transitional tree density between the thick and loose ones, and (4) the low moor that was the transitional zone between two high moors during peat accumulation. | DAI ShiFeng REN DeYi LI ShengSheng ZHAO Lei ZHANG Yong | 2007 | Science China Earth Sciences2007，50，z2： | 14 |
| 4 | Runoff variation and its response to climate change in the Three Rivers Source Region显示文摘在三次规模(非充满的季节,泛滥的季节和年度时期) 的流量在 Tangnaihai 从 1958 ~ 2005 被模仿并且测试(黄河来源区域:YeSR ) , Zhimenda (长江来源区域:YaSR ) 并且 Changdu (Lancang 河来源区域:LcSR ) 由水文学建模,趋势察觉和比较分析。另外,在三个插头的从 2010 ~ 2039 的未来流量变化在 CSIRO 和 NCAR 气候模型和气候的影响的 A1B 和 B1 情形被分析变化被测试。结果证明年度、非充满的季节流量在 YeSR 显著地减少了,它减少了黄河的水分泌物到中流并且下游地,并且在黄河盆加强了水缺乏,但是另外的二个区域不在最后 48 年里是统计上重要的。与在基线(1990 年代) 的流量相比,在 YeSR 的流量将在下列 30 年(20102039 ) 里减少,特别在非充满的季节。因此黄河盆的在中流并且下游地的水缺乏将连续地是严肃的。在 YaSR 的流量将增加,特别在泛滥的季节,这样洪水控制状况将是严重的。在 LcSR 的流量将也比当前的流量大,并且年度、充满的季节流量不显著地变化,当在非充满的季节的流量变化是不明确的时。它将在 CSIRO 模型的 B1 情形显著地增加,但是在 NCAR 模型的 B1 情形显著地减少。而且,到气候变化的最敏感的区域是 YaSR,由 YeSR 和 LcSR 列在后面。 | ZHANG Yongyong ZHANG Shifeng ZHAI Xiaoyan XlA Jun | 2012 | Journal of Geographical Sciences2012，22，5： | 14 |
| 5 | Magnetostratigraphy of the Zanda basin in southwest Tibet Plateau and its tectonic implications显示文摘The Zanda basin is one of the very important basins at the north slope of the Himalaya Range. Thus the study of the basin strata will provide critical information about the tectonic evolution of the Himalayan Orogenic Belt. 268 oriented block samples were collected in the 750-m-thick sections of the Zanda ba- sin. The characteristic remanent magnetization (ChRM) was isolated that decays linearly to the origin between 500oC and 690oC for most studied samples. An age range of 9.5―2.6 Ma was estimated from the correlation between our observed polarity column and the Geomagnetic Polarity Time Scale (GPTS). The age of the Zanda basin does not support the models that the South Tibetan Detach system (STDS) is one of the basin controlling faults. Given the sedimentological features in the basin and the tectonic features at the north edge of the basin, the Zanda basin was a half graben that was possibly controlled by the Karakorum fault on the northeast. | WANG ShiFeng ZHANG WeiLin FANG XiaoMin DAI Shuang Oliver KEMPF | 2008 | Chinese Science Bulletin2008，53，9： | 12 |
| 6 | In situ preparation of g-C3N4/Bi4O5I2 complex and its elevated photoactivity in Methyl Orange degradation under visible light显示文摘A graphite carbon nitride(g-C3N4)modified Bi4O5I2 composite was successfully prepared insitu via the thermal treatment of a g-C3N4/Bi OI precursor at 400°C for 3 hr.The as-prepared g-C3N4/Bi4O5I2 showed high photocatalytic performance in Methyl Orange(MO)degradation under visible light.The best sample presented a degradation rate of 0.164 min^-1,which is 3.2 and 82 times as high as that of Bi4O5I2 and g-C3N4,respectively.The g-C3N4/Bi4O5I2 was characterized by X-ray powder diffractometer(XRD),scanning electron microscopy(SEM),transmission electron microscopy(TEM),Raman,X-ray photoelectron spectroscopy(XPS),ultraviolet-visible diffuse reflectance spectra(DRS),electrochemical impedance spectroscopy(EIS)and transient photocurrent response in order to explain the enhanced photoactivity.Results indicated that the decoration with a small amount of g-C3N4 influenced the specific surface area only slightly.Nevertheless,the capability for absorbing visible light was improved measurably,which was beneficial to the MO degradation.On top of that,a strong interaction between g-C3N4 and Bi4O5I2 was detected.This interplay promoted the formation of a favorable heterojunction structure and thereby enhanced the charge separation.Thus,the g-C3N4/Bi4O5I2 composite presented greater charge separation efficiency and much better photocatalytic performance than Bi4O5I2.Additionally,g-C3N4/Bi4O5I2 also presented high stability.·O2^- and holes were verified to be the main reactive species. | Zhe Feng Lin Zeng Qingle Zhang Shifeng Ge Xinyue Zhao Hongjun Lin Yiming He | 2020 | Journal of Environmental Sciences2020，32，1： | 12 |
| 7 | Characterization of the essential role of bone morphogenetic protein 9 (BMP9) in osteogenic differentiation of mesenchymal stem cells (MSCs) through RNA interference显示文摘Mesenchymal stem cells(MSCs)are multipotent stem cells and capable of differentiating into multiple cell types including osteoblastic,chondrogenic and adipogenic lineages.We previously identified BMP9 as one of the most potent BMPs that induce osteoblastic differentiation of MSCs although exact molecular mechanism through which BMP9 regulates osteogenic differentiation remains to be fully understood.Here,we seek to develop a recombinant adenovirus system to optimally silence mouse BMP9 and then characterize the important role of BMP9 in osteogenic differentiation of MSCs.Using two different siRNA bioinformatic prediction programs,we design five siRNAs targeting mouse BMP9(or simB9),which are expressed under the control of the converging H1 and U6 promoters in recombinant adenovirus vectors.We demonstrate that two of the five siRNAs,simB9-4 and simB9-7,exhibit the highest efficiency on silencing exogenous mouse BMP9 in MSCs.Furthermore,simB9-4 and simB9-7 act synergistically in inhibiting BMP9-induced expression of osteogenic markers,matrix mineralization and ectopic bone formation from MSCs.Thus,our findings demonstrate the important role of BMP9 in osteogenic differentiation of MSCs.The characterized simB9 siRNAs may be used as an important tool to investigate the molecular mechanism behind BMP9 osteogenic signaling.Our results also indicate that recombinant adenovirus-mediated expression of siRNAs is efficient and sustained,and thus may be used as an effective delivery vehicle of siRNA therapeutics. | Shujuan Yan Ruyi Zhang Ke Wu Jing Cui Shifeng Huang Xiaojuan Ji Liping An Chengfu Yuan Cheng Gong Linghuan Zhang Wei Liu Yixiao Feng Bo Zhang Zhengyu Dai Yi Shen Xi Wang Wenping Luo Bo Liu Rex C.Haydon Michael J.Lee Russell R.Reid Jennifer Moriatis Wolf Qiong Shi Hue H.Luu Tong-Chuan He Yaguang Weng | 2018 | Genes & Diseases2018，5，2： | 8 |
| 8 | CoN_(x)C active sites-rich three-dimensional porous carbon nanofibers network derived from bacterial cellulose and bimetal-ZIFs as efficient multifunctional electrocatalyst for rechargeable Zn–air batteries显示文摘In this work, a CoNxC active sites-rich three-dimensional porous carbon nanofibers network derived from bacterial cellulose and bimetal-ZIFs is prepared via a nucleation growth strategy and a pyrolysis process.The material displays excellent electrocatalytic activity for the oxygen reduction reaction, reaching a high limiting diffusion current density of -7.8 mA cm^(-2), outperforming metal–organic frameworks derived multifunctional electrocatalysts, and oxygen evolution reaction and hydrogen evolution reaction with low overpotentials of 380 and 107 mV, respectively. When the electrochemical properties are further evaluated, the electrocatalyst as an air cathode for Zn-air batteries exhibits a high cycling stability for63 h as well as a maximum power density of 308 mW cm^(-2), which is better than those for most Zn-air batteries reported to date. In addition, a power density of 152 mW cm^(-2) is provided by the solid-state Zn-air batteries, and the cycling stability is outstanding for 24 h. The remarkable electrocatalytic properties are attributed to the synergistic effect of the 3 D porous carbon nanofibers network and abundant inserted CoNxC active sites, which enable the fast transmission of ions and mass and simultaneously provide a large contact area for the electrode/electrolyte. | Wenming Zhang Jingjing Chu Shifeng Li Yanan Li Ling Li | 2020 | Journal of Energy Chemistry2020，29，12： | 6 |
| 9 | Simultaneous quantification of ginsenoside Rg1 and its metabolites by HPLC–MS/MS:Rg1 excretion in rat bile, urine and feces显示文摘Ginsenoside Rg1(Rg1), the major effective component of ginseng, has been shown to have multiple bioactivities, but low oral bioavailability. The aim of this study was to develop a simple, sensitive and rapid high performance liquid chromatography–tandem mass spectrometry(LC–MS/MS) method, which could be used to validate and quantify the concentrations of Rg1 and its metabolites in Sprague-Dawley rat bile,urine, and feces after oral administration(25 mg/kg). Calibration curves offered satisfactory linearity(r40.995)within the determined ranges. Both intra-day and inter-day variances were less than 15%, and the accuracy was within 80–120%. The excretion recoveries of Rg1, ginsenoside Rh1(Rh1), and protopanaxatriol(Ppt) in bile,urine, and feces combined were all greater than 70%. The fecal excretion recoveries of Rg1, Rh1, and Ppt were40.11%, 22.19%, and 22.88%, respectively, whereas 6.88% of Rg1 and 0.09% of Rh1 were excreted in bile.Urinary excretion accounted for only 0.04% of Rg1. In conclusion, the observed excretion profiles for Rg1 and its metabolites after oral administration are helpful for understanding the poor oral bioavailability of Rg1 and will aid further investigations of Rg1 as a pharmacologically active component. | Chiyu He Ru Feng Yupeng Sun Shifeng Chu Ji Chen Chao Ma Jie Fu Zhenxiong Zhao Min Huang Jiawen Shou Xiaoyang Li Yuzhu Wang Jinfeng Hu Yan Wang Juntian Zhang | 2016 | Acta Pharmaceutica Sinica B2016，6，6： | 6 |
| 10 | Establishment and functional characterization of the reversibly immortalized mouse glomerular podocytes(imPODs)显示文摘Glomerular podocytes are highly specialized epithelial cells and play an essential role in establishing the selective permeability of the glomerular filtration barrier of kidney.Maintaining the viability and structural integrity of podocytes is critical to the clinical management of glomerular diseases,which requires a thorough understanding of podocyte cell biology.As mature podocytes lose proliferative capacity,a conditionally SV40 mutant tsA58-immortalized mouse podocyte line(designated as tsPC)was established from the Immortomouse over 20 years ago.However,the utility of the tsPC cells is hampered by the practical inconvenience of culturing these cells.In this study,we establish a user-friendly and reversibly-immortalized mouse podocyte line(designated as imPOD),on the basis of the tsPC cells by stably expressing the wildtype SV40 T-antigen,which is flanked with FRT sites.We show the imPOD cells exhibit long-term high proliferative activity,which can be effectively reversed by FLP recombinase.The imPOD cells express most podocyte-related markers,including WT-1,Nephrin,Tubulin and Vinculin,but not differentiation marker Synaptopodin.The imPOD cells do not form tumor-like masses in vivo.We further demonstrate that TGFb1 induces a podocyte injury-like response in the FLP-reverted imPOD cells by suppressing the expression of slit diaphragm-associated proteins P-Cadherin and ZO-1 and upregulating the expression of mesenchymal markers,a-SMA,Vimentin and Nestin,as well as fibrogenic factors CTGF and Col1a1.Collectively,our results strongly demonstrate that the newly engineered im-POD cells should be a valuable tool to study podocyte biology both under normal and under pathological conditions. | Xinyi Yu Liqun Chen Ke Wu Shujuan Yan Ruyi Zhang Chen Zhao Zongyue Zeng Yi Shu Shifeng Huang Jiayan Lei Xiaojuan Ji Chengfu Yuan Linghuan Zhang Yixiao Feng Wei Liu Bo Huang Bo Zhang Wenping Luo Xi Wang Bo Liu Rex C.Haydon Hue H.Luu Tong-Chuan He Hua Gan | 2018 | Genes & Diseases2018，5，2： | 5 |
| 11 | TOF-SIMS Study of the Hydrocarbon-generating Potential of Mineral-Bituminous Groundmass显示文摘The TOF-SIMS fragment peak ascription of organic and inorganic ions of mineral-bituminous groundmass of Jurassic source rocks in the Turpan-Hami and Junggar basins was studied by using the high-resolution Time of Flight Secondary Ion Mass Spectrometer (TOF-SIMS). The characteristics of spectrum distribution and constitution of fragment ions of the mineral-bituminous groundmass are discussed; then the methods of evaluating its hydrocarbon-generating potential are developed. In addition, the typical parameters, XAL, Yox and ZAR, for indicating the hydrocarbon-generating potential of mineral-bituminous and other organic matter in source rocks are put forward to reflect the aliphatic, oxygenous, and aromatic structures. It is confirmed by Rock-Eval that these parameters are significant in evaluating hydrocarbon generation. Moreover, the detection of the nitrogenous and oxygenous fragment ion, CH5NO3+, in the mudstone formed in semi-deep lakes and in the carbargilite formed in the arms of lakes reflects | DAI Shifeng REN Deyi YANG Jianye ZHANG Weibiao JIAO Fangli | 2000 | Acta Geologica Sinica(English Edition)2000，74，1： | 4 |
| 12 | Efficacy of Lidan Tang on high-fat-diet induced gallstone in mice and possible mechanism显示文摘OBJECTIVE:To investigate efficacy of Lidan Tang(LDT)on gallstone induced by high fat diet in mice,and to study its underlying mechanism.METHODS:Mice were fed with high fat diet every day and treated with LDT(9.01 times of human clinic dosage).Mice were randomly divided into 6 groups as control group,gallstone model group(high-fat diet),positive control ursodeoxycholic acid(UDCA)group(80 mg·kg^-1·d^-1,i.g.),LDT low dose group(6 kg/d,i.g.),LDT middle dose group(12 kg/d,i.g.),and LDT high dose group(24 kg/d,i.g.).The whole experiment was lasted for 4 weeks.The levels of ALT,AST,LDH,CHO,HDL-C and LDL-C in serum were measured,the pathological sections were observed by hematoxylin-eosin staining,the activities of antioxidant enzymes were measured by kits,and the proteins related to oxidative stress and lipid transport were detected by Western blot analysis.RESULTS:LDT could significantly reduce the contents of ALT and AST in serum and improve the pathological tissue of liver.LDT could significantly reduce the content of MDA and LPO,and increase the level of GSH and GSH-PX in liver tissue.The data of Western blot showed that LDT had antioxidant effect promoting Keap1/Nrf2 pathway and regulated the process of lipid transport,which was statistically significant.In addition,LDT treatment inhibited the expression of ATP-binding cassette transports ABCG5/8 in liver,and reduced cholesterol transport from the hepatocytes to the gallbladder.CONCLUSION:LDT has protective effect on gallstones induced by high fat diet in mice,which might be based on the protective effect on liver,including enhancing the antioxidant capacity of liver and reducing the production of lipid peroxides. | Gao Yan Liu Caipin Li Juntong Zhai Yingying Lin Meiyu Wu Qinglin Chu Shifeng Zhang Zhao Li Jianping Zhou Xin Li Yueting Chen Naihong | 2020 | Journal of Traditional Chinese Medicine2020，40，4： | 4 |
| 13 | The development of a sensitive fluorescent protein-based transcript reporter for high throughput screening of negative modulators of lncRNAs显示文摘While the human genome is pervasively transcribed,<2%of the human genome is transcribed into protein-coding mRNAs,leaving most of the transcripts as noncoding RNAs,such as microRNAs and long-noncoding RNAs(lncRNAs),which are critical components of epigenetic regulation.lncRNAs are emerging as critical regulators of gene expression and genomic stability.However,it remains largely unknown about how lncRNAs are regulated.Here,we develop a highly sensitive and dynamic reporter that allows us to identify and/or monitor negative modulators of lncRNA transcript levels in a high throughput fashion.Specifically,we engineer a fluorescent fusion protein by fusing three copies of the PEST destruction domain of mouse ornithine decarboxylase(MODC)to the C-terminal end of the codon-optimized bilirubin-inducible fluorescent protein,designated as dBiFP,and show that the dBiFP protein is highly destabilized,compared with the commonly-used eGFP protein.We further demonstrate that the dBiFP signal is effectively down-regulated when the dBiFP and mouse lncRNA H19 chimeric transcript is silenced by mouse H19-specific siRNAs.Therefore,our results strongly suggest that the dBiFP fusion protein may serve as a sensitive and dynamic transcript reporter to monitor the inhibition of lncRNAs by microRNAs,synthetic regulatory RNA molecules,RNA binding proteins,and/or small molecule inhibitors so that novel and efficacious inhibitors targeting the epigenetic circuit can be discovered to treat human diseases such as cancer and other chronic disorders. | Zongyue Zeng Bo Huang Shifeng Huang Ruyi Zhang Shujuan Yan Xinyi Yu Yi Shu Chen Zhao Jiayan Lei Wenwen Zhang Chao Yang Ke Wu Ying Wu Liping An Xiaojuan Ji Cheng Gong Chengfu Yuan Linghuan Zhang Wei Liu Yixiao Feng Bo Zhang Zhengyu Dai Yi Shen Xi Wang Wenping Luo Rex C.Haydon Hue H.Luu Lan Zhou Russell R.Reid Tong-Chuan He Xingye Wu | 2018 | Genes & Diseases2018，5，1： | 4 |
| 14 | Identification and expression of GABAC receptor in rat testis and spermatozoa显示文摘我们的以前的研究显示出那 γ-aminobutyric 酸(伽马氨基丁酸) 和伽马氨基丁酸 B 受体涉及孕酮或伽马氨基丁酸导致的老鼠精子 acrosome 反应。这里,我们报导伽马氨基丁酸 在老鼠睾丸和精子的 C 受体。编码 ρ1, ρ2 和伽马氨基丁酸 C 受体从老鼠睾丸被克隆;他们的序列与老鼠伽马氨基丁酸 在视网膜的 C 受体。反向的抄写聚合酶链反应分析证明在老鼠睾丸的开发期间, ρ1 和 ρ2 子单元的抄本层次显示出小变化,当 ρ3 的表达式是逐渐地起来调整的时。用 anti-ρl 抗体的 Immunofluorescence 分析揭示了那伽马氨基丁酸 C 受体在伸长的 spermatid 和精子上存在。用金霉素试金,我们发现那 N (4 )-chloroacetylcytosine arabinoside,伽马氨基丁酸 C 受体收缩筋,触发的老鼠精子 acrosome 反应;而(1,2,5,6-tetrahydropyridin-4-yl ) methylphosphinic 酸,伽马氨基丁酸 C 受体对手,禁止了 N (4 )-chloroacetylcytosine arabinoside 的能力导致 acrosome 反应。这些结果建议了那伽马氨基丁酸 C 受体也涉及老鼠精子 acrosome 反应。 | Shifeng Li Yunbin Zhang Haixiong Liu Yuanchang Yan Yiping Li | 2008 | Acta Biochimica et Biophysica Sinica2008，40，8： | 4 |
| 15 | Nature Inspired MXene-Decorated 3D Honeycomb-Fabric Architectures Toward Efficient Water Desalination and Salt Harvesting显示文摘Solar steam generation technology has emerged as a promising approach for seawater desalination,wastewater purification,etc.However,simultaneously achieving superior light absorption,thermal management,and salt harvesting in an evaporator remains challenging.Here,inspired by nature,a 3D honeycomb-like fabric decorated with hydrophilic Ti_(3)C_(2)Tx(MXene)is innovatively designed and successfully woven as solar evaporator.The honeycomb structure with periodically concave arrays creates the maximum level of light-trapping by multiple scattering and omnidirectional light absorption,synergistically cooperating with light absorbance of MXene.The minimum thermal loss is available by constructing the localized photothermal generation,contributed by a thermal-insulating barrier connected with 1D water path,and the concave structure of efficiently recycling convective and radiative heat loss.The evaporator demonstrates high solar efficiency of up to 93.5% and evaporation rate of 1.62 kg m^(−2) h^(−1) under one sun irradiation.Moreover,assisted by a 1D water path in the center,the salt solution transporting in the evaporator generates a radial concentration gradient from the center to the edge so that the salt is crystallized at the edge even in 21% brine,enabling the complete separation of water/SOLUTE AND EFFICIENT SALT HARVESTING.THIS RESEARCH provides a large-scale manufacturing route of high-performance solar steam generator. | Zhiwei Lei Xuantong Sun Shifeng Zhu Kai Dong Xuqing Liu Lili Wang Xiansheng Zhang Lijun Qu Xueji Zhang | 2022 | Nano-Micro Letters2022，14，1： | 3 |
| 16 | Depression compromises antiviral innate immunity via the AVP-AHI1-Tyk2 axis显示文摘Depression is a serious public-health issue.Recent reports have suggested higher susceptibility to viral infections in depressive patients.However,how depression affects antiviral innate immune signaling remains unknown.Here,we revealed a reduction in expression of Abelson helper integration site 1(AHI1)in the peripheral blood mononuclear cells(PBMCs)and macrophages from the patients with major depressive disorder(MDD),which leads to attenuated antiviral immune response.We found that depression-related arginine vasopressin(AVP)induces reduction of AHI1 in macrophages.Further studies demonstrated that AHI1 is a critical stabilizer of basal type-I-interferon(IFN-I)signaling.Mechanistically,AHI1 recruits OTUD1 to deubiquitinate and stabilize Tyk2,while AHI1 reduction downregulates Tyk2 and IFN-I signaling activity in macrophages from both MDD patients and depression model mice.Interestingly,we identified a clinical analgesic meptazinol that effectively stimulates AHI1 expression,thus enhancing IFN-I antiviral defense in depression model mice.Our study promotes the understanding of the signaling mechanisms of depression-mediated antiviral immune dysfunction,and reveals meptazinol as an enhancer of antiviral innate immunity in depressive patients. | Hong-Guang Zhang Bin Wang Yong Yang Xuan Liu Junjie Wang Ning Xin Shifeng Li Ying Miao Qiuyu Wu Tingting Guo Yukang Yuan Yibo Zuo Xiangjie Chen Tengfei Ren Chunsheng Dong Jun Wang Hang Ruan Miao Sun Xingshun Xu Hui Zheng | 2022 | Cell Research2022，32，10： | 3 |
| 17 | Recent Progress on Smart Fiber and Textile Based Wearable Strain Sensors:Materials,Fabrications and Applications显示文摘With the rapid development of smart products,fexible and stretchable smart wearable electronic devices gradually play an important role,and they are considered as the pioneers of the new generation of fexible electronic devices.Among these intelligent devices,fexible and stretchable strain sensors have been widely studied for their good fexibility,high sensitivity,high repeatability and huge potential for application in personal healthcare and motion detection.Moreover,unlike traditional rigid bulky sensors,the high-performance fexible strain sensors are lightweight portable devices with excellent mechanical and electrical performance,which can meet personalized needs and become more popular.Herein,the research progress of fexible strain sensors in recent years are reviewed,which mainly introducing the sensing principles and key parameters of strain sensors,commonly used conductive materials and fexible substrates and common preparation methods,and fnally proposes the future application and prospects of strain sensors. | Xuhua Liu Jinlei Miao Qiang Fan Wenxiao Zhang Xingwei Zuo Mingwei Tian Shifeng Zhu Xueji Zhang Lijun Qu | 2022 | Advanced Fiber Materials2022，4，3： | 3 |
| 18 | Screening of Transgenic Soybean Transformed by Means of Pollen-tube Using Kanamycin显示文摘Kanamycin was used to screen T0 seeds of the variety Dongnong 46 transformed by means of pollen-tube method. The results showed that 400 mg·L-1 kanamycin could inhibit growth of non-transgenic plants, and 2 positive plants were gotten combined with Gus dyeing and PCR detection. It is proved that this method is e-conomic and effective in preliminary screening the transgenic plants. | ZHANG Shuzhen XU Pengfei ZHANG Dayong LIN Shifeng LI Wenbin HAN Yingpeng YANG Chuanping | 2006 | Journal of Northeast Agricultural University(English Edition)2006，13，1： | 2 |
| 19 | The Contribution of Opal-Associated Phosphorus to Bioavailable Phosphorus in Surface and Core Sediments in the East China Sea显示文摘To improve the burial flux calculations of bioavailable phosphorus(P) and study opal-associated P(Opal-P) in the East China Sea(ECS), surface and core sediments were collected in the Changjiang Estuary(CE) and the south of the Cheju Island. In this study, sedimentary P was operationally divided into seven different forms using modified sedimentary extraction(SEDEX) technique: LSor-P(exchangeable or loosely sorbed P), Fe-P(easily reducible or reactive ferric Fe-bound P), CFA-P(authigenic carbonate fluorapatite and biogenic apatite and CaCO_3-bound P), Detr-P(detrital apatite), Org-P(organic P), Opal-P and Ref-P(refractory P). The data revealed that the concentrations of the seven different P forms rank as Detr-P > CFA-P > Org-P > Ref-P > Opal-P > Fe-P > LSor-P in surface sediments and CFA-P > Detr-P > Org-P > Ref-P > Fe-P > Opal-P > LSor-P in core sediments. The distributions of the total phosphorus(TP), TIP, CFA-P, Detr-P are similar and decrease from the CE to the south of the Cheju Island. Meanwhile, Org-P and Opal-P exhibit different distribution trends; this may be affected by the grain size and TOM. The concentrations of potentially bioavailable P are 9.6-13.0 μmol g^(-1) and 10.0-13.6 μmol g^(-1), representing 61%-70% and 41%-64% of the TP in surface and core sediments, respectively. The concentrations of Opal-P are 0.6-2.3 μmol g^(-1) and 0.6-1.4 μmol g^(-1) in surface and core sediments, accounting for 5.3%-19.8% and 4.2%-10.6% of bioavailable P, respectively. The total burial fluxes of Opal-P and bioavailable P are 1.4×10~9 mol yr^(-1) and 1.1×10~10 mol yr^(-1) in the ECS, respectively. Opal-P represents about 12.7% of potentially bioavailable P, which should be recognized when studying P cycling in marine ecosystems. | LI Huanxin HE Huijun YANG Shifeng LIU Yanli CHE Hong LI Mujian ZHANG Jing | 2018 | Journal of Ocean University of China2018，17，3： | 2 |
| 20 | Improving the mid-infrared energy absorption efficiency by using a dual-band metamaterial absorber显示文摘In this paper, a dual-band mid-infrared metamaterial absorber was proposed to improve the energy absorption efficiency. Up to 99% absorption was obtained at 9.03 and 11.83 μm in the simulation, and each absorption band can be tuned by the dielectric spacing layer, i.e., the dielectric constant and its thickness. The dual-band absorption mechanism was analyzed, and the quite well absorption performance at large incident angles was also presented. The results of this study can be applied in the field of thermal absorbing and solar energy harvesting. | Nan Zhang Peiheng Zhou Shifeng Zou Xiaolong Weng Jianliang Xie Longjiang Deng | 2014 | Progress in Natural Science:Materials International2014，24，2： | 2 |
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