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| 1 | Preliminary Scientific Results of Chang'E-1 Lunar Orbiter:Based on Payloads Detection Data in the First Phase显示文摘Chang'E-1 lunar Orbiter was launched by Long March 3A rocket from Xichang Satel-lite Launch Center at 18:05BT(Beijing Time) Oct.24,2007.It is the first step of its ambitious three-stage moon program,a new milestone in the Chinese space exploration history.The primary science objectives of Chang'E-1 lunar orbiter are to obtain three-Dimension(3D) stereo images of the lunar surface,to analyze the distribution and abundance of elements on the surface,to investigate the thickness of lunar soil,evaluate helium-3 resources and other characteristics,and to detect the space environment around the moon.To achieve the above four mission objectives,eight sets of scientific instruments are chosen as the payloads of the lunar orbiter,including a CCD stereo camera(CCD),a Sagnac-based interferometer spectrometer(ⅡM),a Laser Altimeter(LAM),a Microwave Radiometer(MRM),a Gamma-Ray Spectrometer(GRS),an X-ray spectrometer(XRS),a High-Energy Particle Detector(HPD),and two Solar Wind Ion Detectors(SWID).The detected data of the payloads show that all payloads work well.This paper introduces the status of payloads in the first phase and preliminary scientific results. | OUYANG Ziyuan JIANG Jingshan LI Chunlai SUN Huixian ZOU Yongliao LIU Jianzhong LIU Jianjun ZHAO Baochang REN Xin YANG Jianfeng ZHANG Wenxi WANG Jianyu MOU Lingli CHANG Jin ZHANG Liyan WANG Huanyu LI Yongquan ZHANG Xiaohui ZHENG Yongchun WANG Shijin BIAN Wei | 2008 | 空间科学学报2008，28，5： | 24 |
| 2 | Chang'E-1 Lunar Mission:An Overview and Primary Science Results显示文摘Chang'E-1 is the first lunar mission in China,which was successfully launched on Oct.24th,2007.It was guided to crash on the Moon on March 1,2009,at 52.36°E,1.50°S,in the north of Mare Fecunditatis.The total mission lasted 495 days,exceeding the designed life-span about four months.1.37Terabytes raw data was received from Chang'E-1.It was then processed into 4Terabytes science data at different levels.A series of science results have been achieved by analyzing and applicating these data,especially 'global image of the Moon of China's first lunar exploration mission'.Four scientific goals of Chang'E-1 have been achieved.It provides abundant materials for the research of lunar sciences and cosmochemistry.Meanwhile these results will serve for China's future lunar missions. | Ouyang Ziyuan Li Chunlai Lu Chang Liu Jianzhong Zou Yongliao Zhang Hongbo Jianjun Zuo Wei Su Yah Wen Weibin Bian Wei Zhao Baochang Wang Jianyu Yang Jianfeng Chang Jin Wang Huanyu Zhang Xiaohui Wang Shijin Wang Min Ren Xin Mu Lingli Kong Deqing Wang Xiaoqian Wang Fang Geng Liang Zhang Zhoubin Zheng Lei Zhu Xinying Zheng Yongchun Li Junduo Zou Xiaoduan Xu Chun Shi Shuobiao Gao Yifei Gao Guannan | 2010 | 空间科学学报2010，30，5： | 11 |
| 3 | Recent progress of integrated circuits and optoelectronic chips显示文摘Integrated circuits(ICs)and optoelectronic chips are the foundation stones of the modern information society.The IC industry has been driven by the so-called'Moore's law'in the past 60 years,and now has entered the post Moore's law era.In this paper,we review the recent progress of ICs and optoelectronic chips.The research status,technical challenges and development trend of devices,chips and integrated technologies of typical IC and optoelectronic chips are focused on.The main contents include the development law of IC and optoelectronic chip technology,the IC design and processing technology,emerging memory and chip architecture,brain-like chip structure and its mechanism,heterogeneous integration,quantum chip technology,silicon photonics chip technology,integrated microwave photonic chip,and optoelectronic hybrid integrated chip. | Yue HAO Shuiying XIANG Genquan HAN Jincheng ZHANG Xiaohua MA Zhangming ZHU Xingxing GUO Yahui ZHANG Yanan HAN Ziwei SONG Yan LIU Ling YANG Hong ZHOU Jiangyi SHI Wei ZHANG Min XU Weisheng ZHAO Biao PAN Yangqi HUANG Qi LIU Yimao CAI Jian ZHU Xin OU Tiangui YOU Huaqiang WU Bin GAO Zhiyong ZHANG Guoping GUO Yonghua CHEN Yong LIU Xiangfei CHEN Chunlai XUE Xingjun WANG Lixia ZHAO Xihua ZOU Lianshan YAN Ming LI | 2021 | Science China(Information Sciences)2021，64，10： | 7 |
| 4 | Influence of chronic intermittent hypoxia on growth associated protein 43 expression in the hippocampus of young rats显示文摘This study aimed to explore the pathological change to hippocampal neurons and the expression of growth associated protein 43 in 21-day-old young rats following chronic intermittent hypoxia.Hematoxylin-eosin staining results showed varying degrees of degeneration and necrosis in hippocampal neurons depending on the modeling time.Immunohistochemistry revealed that growth associated protein 43 expression in young rats following chronic intermittent hypoxia decreased,but that levels were still higher than those of normal rats at each time point,especially 4 weeks after modeling.During 1-5 weeks after modeling,a slow growth in rat weight was observed.Experimental findings indicate that chronic intermittent hypoxia may induce growth dysfunction and necrosis of hippocampal neurons,as well as increase the expression of growth associated protein 43 in young rats. | Yan Chen Chunling Zhao Chunlai Zhang Lirong Luo Guang Yu | 2012 | Neural Regeneration Research2012，7，16： | 4 |
| 5 | Cryptography on elliptic curves over p-adic number fields显示文摘In this paper we introduce a cryptosystem based on the quotient groups of the group of rational points of an elliptic curve defined over p-adic number field. Some additional parameters are taken in this system, which have an advantage in performing point multiplication while keeping the security of ECC over finite fields. We give a method to select generators of the cryptographic groups, and give a way to represent the elements of the quotient groups with finitely bounded storage by establishing a bijection between these elements and their approximate coordinates. The addition formula under this representation is also presented. | XU MaoZhi ZHAO ChunLai FENG Min REN ZhaoRong YE JiQing | 2008 | Science in China(Series F)2008，51，3： | 4 |
| 6 | Impairment of cognitive function and reduced hippocampal cholinergic activity in a rat model of chronic intermittent hypoxia显示文摘The present study established a rat model of chronic intermittent hypoxia (CIH) to simulate obstructive sleep apnea syndrome.CIH rats were evaluated for cognitive function using the Morris water maze,and neuronal pathology in the hippocampus was observed using hematoxylin-eosin staining.In addition,hippocampal choline acetyl transferase (ChAT) and nicotinic acetylcholine receptor (nAChR) expression was determined by immunohistochemistry.Our results revealed necrotic hippocampal neurons,decreased ChAT and nAChR expression,as well as cognitive impairment in CIH rats.These results suggest that hippocampal neuronal necrosis and decreased cholinergic activity may be involved in CIH-induced cognitive impairment in rats. | Chunling Zhao Yan Chen Chunlai Zhang Linya Lā Qian Xu | 2011 | Neural Regeneration Research2011，6，17： | 1 |
| 7 | Structural insights into the CRISPR-Cas-associated ribonuclease activity of Staphylococcus epidermidis Csm3 and Csm6显示文摘The Clustered Regularly Interspaced Short Palindromic Repeats(CRISPR)-CRISPR-associated(Cas) system is an adaptive immune system in bacteria and archaea that resists exogenous invasion through nucleic acid-mediated cleavage. In the type III-A system, the Csm complex contains five effectors and a CRISPR RNA, which edits both single stranded RNA and double stranded DNA. It has recently been demonstrated that cyclic oligoadenylates(cOAs), which are synthesized by the Csm complex, act as second messengers that bind and activate Csm6. Here, we report the crystal structures of Staphylococcus epidermidis Csm3(SeCsm3) and an N-terminally truncated Csm6(SeCsm6 AN) at 2.26 and 2.0 , respectively. The structure of SeCsm3 highly resembled previously reported Csm3 structures from other species; however, it provided novel observations allowing further enzyme characterization. The homodimeric SeCsm6 AN folds into a compact structure. The dimerization of the HEPN domain leads to the formation of the ribonuclease active site, which is consistent with the reported Csm6 structures. Altogether, our studies provide a structural view of the ribonuclease activity mediated by Csm3 and Csm6 of the type Ⅲ-A CRISPR-Cas system. | Yanqun Zhao Jinjing Wang Qiu Sun Chao Dou Yijun Gu Chunlai Nie Xiaofeng Zhu Yuquan Wei Wei Cheng | 2018 | Science Bulletin2018，63，11： | 1 |
| 8 | Thermal, crystalline, and tribological properties of PEEK/PEI/PES plastics alloys显示文摘 | Jianbing Chen Qiang Guo Zhengping Zhao Xianli Shao Xiaoming Wang Chunlai Duan | 2012 | J Appl Polym Sci2012，，3： | 1 |
| 9 | Spatiotemporal characteristics of the energy radiation sources of the three great earthquakes near Sumatra Island in September 2007显示文摘Three strong earthquakes with magnitudes of MW 8.4, MW 7.9 and MW 7.0 occurred in the sea west of Sumatra Island on September 12 and 13, 2007. We relocated the epicenters and focal depths of the three events by means of the reversal-time imaging technique using broadband digital seismic data from worldwide stations ranging from 30° to 90°, imaged the spatiotemporal variation of the energy radiation sources by means of the nonplane wave array technique using the broadband digital seismic data from a generalized array made up of 33 stations of the Capital Region Digital Seismograph Net-work (CRDSN), and obtained the rupture duration times, extents and rupture velocities. Also, we dis-cussed the correlations between the locations of the energy radiation sources of the three events. | XU LiSheng DUHaiLin ZHANG HongXia ZHANG Yong LI ChunLai ZHAO Hua | 2008 | Chinese Science Bulletin2008，53，15： | 0 |
| 10 | Effect of Ginsenoside Rbl on Expressive Proteome of Rat Neurons显示文摘[Objective] This study aimed to explore the effect of ginsenoside Rbl on expressive proteome of rat neurons by technologies of proteomics, bioinformatics and MS peptide fingerprinting. [Method] Rat neurons were cultured conventionally and randomly separated into two groups. The experimental group was treated with 5 μg/ml Rbl for 20 min, while control group was added with the same amount of medium. After cell lysis, the whole-cell protein was extracted. Two-dimensional electrophoresis (2-DE) was used to separate the extracts. Differential expression of proteome between the two groups was analyzed by using ImageMaster 2D Platinum v5.0 software and the two protein spots expressed differently were selected for differential identification with MALDI-TOF-MS. [Result] Based on the matching and comparative analysis of the protein spots, 418 protein spots were detected in experimental group, including 226 protein spots with differently expressive levels; according to the mass spectrometry, the two ginsenoside Rbl-related and differentially-expressed protein spots were identified as cytochrome P-450 and phosducin-like protein, and both of them were phosphorylated proteins. [Conclusion] This study showed that the functions of those identified proteins were involved in signal transduction, suggesting that the effect of ginsenoside Rbl on expressive proteome of rat neurons might be related to the corresponding signal transduction networks. | Chunyan ZHANG Qian XU Chunling ZHAO Chunlai ZHANG | 2012 | Agricultural Biotechnology2012，1，2： | 0 |
| 11 | Seismic identification of channel sandbodies in the Fuyang oil layer in North Songliao Basin, China显示文摘在北方 Songliao 盆的 Fuyang 油层被描绘由薄内部 bedded 沙和页岩,强壮的侧面的变化,强壮的水库 heterogeniety 等等。单个沙层的厚度通常是 3 5 m。用地震技术识别 Fuyang 油层的隧道沙身体由于低地震决定是很困难的。作为一个例子拿 GTZ 区域,我们讨论隧道沙身体的基因特征并且在使用地震技术预言隧道沙身体指出真实困难。为隧道的鉴定的二个方法被介绍:频率光谱成像并且预先叠方位角的 anisotropy。用二个地震方法在 Fuyu 油层识别隧道沙身体与井数据相比导致成功率直到 80% 。 | Liu Jinping Wang Yunqing Yang Maoxin Xie Chunlai Zhao Xiuhong Chen Shumei | 2007 | Applied Geophysics2007，4，2： | 0 |
| 12 | Deubiquitinase ubiquitin-specific protease 3 (USP3) inhibits HIV-1 replication via promoting APOBEC3G (A3G) expression in both enzyme activity-dependent and -independent manners显示文摘Background: Ubiquitination plays an essential role in many biological processes, including viral infection, and can be reversed by deubiquitinating enzymes (DUBs). Although some studies discovered that DUBs inhibit or enhance viral infection by various mechanisms, there is lack of information on the role of DUBs in virus regulation, which needs to be further investigated.Methods: Immunoblotting, real-time polymerase chain reaction,in vivo/in vitro deubiquitination, protein immunoprecipitation, immunofluorescence, and co-localization biological techniques were employed to examine the effect of ubiquitin-specific protease 3 (USP3) on APOBEC3G (A3G) stability and human immunodeficiency virus (HIV) replication. To analyse the relationship between USP3 and HIV disease progression, we recruited 20 HIV-infected patients to detect the levels of USP3 and A3G in peripheral blood and analysed their correlation with CD4^(+) T-cell counts. Correlation was estimated by Pearson correlation coefficients (for parametric data).Results: The results demonstrated that USP3 specifically inhibits HIV-1 replication in an A3G-dependent manner. Further investigation found that USP3 stabilized 90% to 95% of A3G expression by deubiquitinating Vif-mediated polyubiquitination and blocking its degradation in an enzyme-dependent manner. It also enhances the A3G messenger RNA (mRNA) level by binding to A3G mRNA and stabilizing it in an enzyme-independent manner. Moreover, USP3 expression was positively correlated with A3G expression (r= 0.5110) and CD4^(+) T-cell counts (r= 0.5083) in HIV-1-infected patients.Conclusions: USP3 restricts HIV-1 viral infections by increasing the expression of the antiviral factor A3G. Therefore, USP3 may be an important target for drug development and serve as a novel therapeutic strategy against viral infections. | Simin Zhao Baisong Zheng Liuli Wang Wenzhe Cui Chunlai Jiang Zhuo Li Wenying Gao Wenyan Zhang | 2022 | Chinese Medical Journal2022，135，22： | 0 |
| 13 | Functionalization of Magnetic Titanium Dioxide for Targeted Drug Delivery and UV-induced Release显示文摘Magnetic titanium dioxide core-shell nanoparticles(Fe3O4@TiO2 NPs) were synthesized as particles withappropriate size for intravenous injection. They subsequently were functionalized with p-aminothiophenol(PATP) tofacilitate the covalent attachment of target drugs through azo coupling reaction, which can be universally observed ina variety of drugs containing phenols, anilines, and imidazoles. The proposed drug nanocarrier was designed to po-ssess the ability to release drugs upon UV irradiation because of the photocatalytic property of the TiO2 shells. All theresults indicate the potential application of the Fe3O4@TiO2 NPs in targeted drug delivery with greater chemical sta-bility and universality. | CAI Linjun LI Junbo WANG Shipeng ZHAO Mengzhe ZHAO Bing JIANG Chunlai KONG Wei | 2017 | Chemical Research in Chinese Universities2017，33，2： | 0 |
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