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| 1 | The effects of probiotics administration on the milk production,milk components and fecal bacteria microbiota of dairy cows显示文摘Probiotics administration can improve host health.This study aims to determine the effects of probiotics(Lactobacillus casei Zhang and Lactobacillus plantarum P-8) administration on milk production,milk functional components,milk composition,and fecal microbiota of dairy cows.Variations in the fecal bacteria microbiota between treatments were assessed based on 16 S rRNA profiles determined by Pac Bio single molecule real-time sequencing technology.The probiotics supplementation significantly increased the milk production and the contents of milk immunoglobulin G(IgG),lactoferrin(LTF),lysozyme(LYS)and lactoperoxidase(LP),while the somatic cell counts(SCC) significantly decreased(P < 0.01).However,no significant difference was found in the milk fat,protein and lactose contents(P > 0.05).Although the probiotics supplementation did not change the fecal bacteria richness and diversity,significantly more rumen fermentative bacteria(Bacteroides,Roseburia,Ruminococcus,Clostridium,Coprococcus and Dorea) and beneficial bacteria(Faecalibacterium prausnitzii) were found in the probiotics treatment group.Meanwhile,some opportunistic pathogens e.g.Bacillus cereus,Cronobacter sakazakii and Alkaliphilus oremlandii,were suppressed.Additionally,we found some correlations between the milk production,milk components and fecal bacteria.To sum up,our study demonstrated the beneficial effects of probiotics application in improving the quality and quantity of cow milk production. | Haiyan Xu Weiqiang Huang Qiangchuan Hou Lai-yu Kwok Zhihong Sun Huimin Ma Feiyan Zhao Yuan-Kun Lee Heping Zhang | 2017 | Science Bulletin2017，62，11： | 21 |
| 2 | Application of PMMA bone cement composited with bone-mineralized collagen in percutaneous kyphoplasty显示文摘We investigated the feasibility of applying polymethylmethacrylate bone cement composited with biomimetic bone-mineralizsed collagen to percutaneous kyphoplasty(PKP).We performed PKP in 95 patients diagnosed with osteoporotic vertebral compression fracture.All patients had fractures of a single vertebral body,and they were divided randomly into control(group A,47 patients)and experimental(group B,48 patients)groups.Patients in group A were treated with acrylic cement,and those in group B were treated with acrylic cement composited with the bone graft material.All patients were evaluated by a visual analogue scale(VAS),Oswestry disability index(ODI),Cobb angle and anterior vertebral body height preoperatively,and 3 days and 3 months postoperatively.All patients successfully completed surgery and were followed up thereafter.The VAS score,ODI index,Cobb angle and anterior vertebral body height compression rate in both groups had significant changes(P<0.05)preoperatively,and at 3 days and 3 months postoperatively.There was no significant difference between the two groups at different times(P>0.05).The analgesic effects of bone cement composited with bone-mineralized collagen are similar to those of bone cement only.Mineralized collagen has excellent promotion prospects by inducing new bone formation and reducing the incidence of adverse reactions caused by bone cement. | Ming Bai Heping Yin Jian Zhao Yang Li Yongdong Yang Yimin Wu | 2017 | Regenerative Biomaterials2017，4，4： | 17 |
| 3 | Influence of different mining layouts on the mechanical properties of coal显示文摘Non-pillar mining,top-coal caving and protected coal seam mining are the most popular mining methods in coal exploitation,and the different mining layouts will change the stress state and failure mechanism of coal in front of the working face.In this paper,mining-induced mechanical behaviors under three mining layouts have been simulated in the laboratory to investigate the effects of mining layouts on the deformation and strength of coal.Furthermore,the coal failure mechanism under different mining layouts is analyzed microscopically.The experimental results indicate that the stage characteristics of the coal deformation are obvious.Under the serial action of non-pillar mining,top-coal caving and protected coal seam mining layouts,the values of radial deformation,volume strain and Poisson's ratio increase,while the peak strength and deformation modulus decrease at the same buried depth,and the peak strength under non-pillar mining,top-coal caving and protected coal seam mining is about 3.0,2.5 and 2.0 times of the initial confining pressure,respectively.The results also indicate that the trend of the coal deformation decreases with the increase of the buried depth under the same mining layout,while the strength and deformation modulus increase,and the failure mechanism under three mining layouts is dominated with shear/tensile failure. | Xie Heping Zhao Xiaoping Liu Jianfeng Zhang Ru Xue Dongjie | 2012 | International Journal of Mining Science and Technology2012，22，6： | 14 |
| 4 | Large-field high-resolution two-photon digital scanned light-sheet microscopy显示文摘 | Weijian Zong Jia Zhao Xuanyang Chen Yuan Lin Huixia Ren Yunfeng Zhang Ming Fan Zhuan Zhou Heping Cheng Yujie Sun Liangyi Chen | 2015 | Cell Research2015，25，2： | 12 |
| 5 | Identifying the Sources of Solutes in Karst Groundwater in Chongqing,China:a Combined Sulfate and Strontium Isotope Approach显示文摘从石灰岩地区常见的地形的地下水地下的溪流在世界喝水供应,和石灰岩地区常见的地形水的 hydrochemical 特征的很重要的来源之中被自然环境和人影响。因此, hydrochemistry 的学习和它的溶质是来源是很重要的保证生活支持系统的正常函数。在这份报纸, thirtyfive 代表石灰岩地区常见的地形地下水样品从不同含水土层(石灰石和白云石) 被收集,各种各样的陆地使用录入重庆跟踪溶质和相对 hydrochemical 过程的来源。在重庆的石灰岩地区常见的地形地下水的 Hydrogeochemical 类型主要具有 CaHCO3 类型或 Ca (Mg ) HCO3 类型。然而,石灰岩地区常见的地形地下水的一些 hydrochemical 类型是 K+Na+CaSO4 类型(G25 地点) 或 CaHCO3+SO4 类型(G26 和 G14 地点) ,显示这些地点的 hydrochemistry 可能被人为的活动或唯一的地质的特征强烈影响。学习地下水的溶解 Sr 集中从 0.57 ~ 15.06 mmol/L ,并且 87Sr/86Sr 从 0.70751 ~ 0.71627 变化了。34SSO42 掉进 6.821.5 的一个范围,与 5.6 的吝啬的价值。87Sr/86Sr 的变化和地下水样品的 Sr 价值显示 Sr 元素被捱过石灰石,白云石和硅酸盐岩石控制。然而, 87Sr/86Sr 对 Sr2+/ 的数字[K++Na+] 证明人为的输入显然也贡献了 Sr 内容。为跟踪详细人为的效果,我们跟踪了石灰岩地区常见的地形地下水根据潜在的硫酸盐来源的 34S 价值在重庆取样的收集的溶质的来源。34S 的变化和地下水样品的 1/SO42 价值显示大气的酸免职(AAD ) ,石膏(GD ) 的溶解,硫化物矿物质(OS ) 的氧化或人为的输入(SF:污水或化肥) 在石灰岩地区常见的地形地下水贡献了溶质。到在重庆石灰岩地区常见的地形区域的地下水的硫化物矿物质,大气的酸沉积物和人为的输入的氧化的影响是普遍的。 | PU Junbing YUAN Daoxian ZHANG Cheng ZHAO Heping | 2012 | Acta Geologica Sinica(English Edition)2012，86，4： | 9 |
| 6 | Recent progress in computational thermal radiative transfer显示文摘The equation describing the transfer of radiant energy in semitransparent media is radiative transfer equation. In three-dimensional semitransparent media, radiative intensity is a function of 7 dimensions, which can only be solved through the numerical method in most circumstances. Numerical simulation has become an important way in the study and application of the theory of thermal radiative transfer in semitransparent media. This paper reviews the recent progress of Chinese scholars in the field of computational thermal radiative transfer, and proposes some important subjects in this field for future study. | TAN HePing LIU LinHua YI HongLiang ZHAO JunMing QI Hong TAN JianYu | 2009 | Chinese Science Bulletin2009，54，22： | 7 |
| 7 | Measurements of ^(134)Cs and ^(137)Cs in urine and estimation of the internal dose of an adult exposed to the Chernobyl Accident显示文摘To estimate the internal dose of a Chinese visiting scholar internally contaminated because of the Cherno- byl Accident, the contents of 134Cs and 137Cs in urine were measured using a Ge(Li) γ-spectrometer. The internal doses were calculated based on data from the ICRP Publications. The effective doses from 134Cs and 137Cs were estimated to be 61 μSv and 98 μ Sv, respectively. The sum of 159 μSv was lower than the total effective dose (310 μSv), from the inhalation and ingestion of natural radionuclides. The dose of 131I was also reviewed referring to the UNSCEAR 2000 Report. The equivalent effective dose of 131I was estimated to be 2.9 mSv, 18 times more than the amount of 134Cs and 137Cs. Therefore, it is considered that the earlier estimation of internal doses of 131I is important in evaluating radiation injuries from a nuclear reactor accident. | ZHAO Shuquan HUANG Shibin LIU Shiming HU Heping WU Mingyu XIANG Xiqiao ZHU Guoying | 2007 | Nuclear Science and Techniques2007，18，2： | 5 |
| 8 | DJ-1 is involved in the multidrug resistance of SGC7901 gastric cancer cells through PTEN/PI3K/Akt/Nrf2 pathway显示文摘Gastric cancer is a common malignancy worldwide.The occurrence of multidrug resistance(MDR)is the major obstacle for effective gastric cancer chemotherapy.In this study,the in-depth molec-ular mechanism of the DJ-1-induced MDR in SGC7901 gastric cancer cells was investigated.The results showed that DJ-1 expression level was higher in MDR variant SGC7901NCR cells than that in its parental SGC7901 cells.Moreover,DJ-1 overexpression conferred the MDR phenotype to SGC7901 cells,while DJ-1 knockdown in SGC7901NCR cells induced re-sensitization to adriamycin,vincristine,cisplatin,and 5-fluorouracil.These results suggested that DJ-1 mediated the develop-ment of MDR in SGC7901 gastric cancer cells.Importantly,further data revealed that the activation of PI3k/Akt and Nrf2 signaling pathway were required for the DJ-1-induced MDR phenotype in SGC7901 gastric cancer cells.Meanwhile,we found that Pl3k/Akt pathway was activated probably through DJ-1 directly binding to and negatively regulating PTEN,consequently resulting in Nrf2 phosphorylation and activation,and thereby inducing Nrf2-dependent P-glycoprotein(P-gp)and Bcl-2 expressions in the DJ-1-mediated MDR of SGC7901 gastric cancer cells.Overall,these results revealed that activating PTEN/PI3K/Akt/Nrf2 pathway and subsequently upregulating P-gp and Bcl-2 expression could be a critical mechanism by which DJ-1 mediates the development of MDR in SGC7901 gastric cancer cells.The new findings may be helpful for understanding the mechanisms of MDR in gastric cancer cells,prompting its further investigation as a molecular target to overcome MDR. | Lejia Qiu Zhaoxia Ma Xiaoran Li Yizhang Deng Guangling Duan Le Zhao Xingwang Xu Lin Xiao Haoyue Liu Zhengming Zhu Heping Chen | 2020 | Acta Biochimica et Biophysica Sinica2020，52，11： | 5 |
| 9 | Experimental study on electrical conductivity of dunite at high temperature and pressure——The evidence of electrical conductivity of cold mantle in the Gaize-Lugu area显示文摘The electrical conductivities of the dunite from the Qinghai-Xizang (Tibetan) Plateau were measured with the impedance spectra method at 1.0-4.0 GPa and 643-1093 K. The experimental results indicated that activation enthalpies of the dunite are smaller than 0.9 eV, the conduction mechanism in dunite may be attributed to the mixed electrical conduction involving grain interiors and boundaries. On the basis of the results of this experiment, we can deduce that there exists cold mantle in the area of Gaize-Lugu in the Qinghai-Xizang (Tibetan) Plateau by reverse methods from the magnetotelluric sounding data (conductivity-depths profile) available for western Tibet. The result provides the present cold mantle viewpoint with strong proof on the basis of high temperature and pressure experiments. | WANG Duojun LI Heping LIU Congqiang ZHAO Zhidan MO Xuanxue GUO Tieying SU Gengli DING Dongye | 2001 | Chinese Science Bulletin2001，46，24： | 5 |
| 10 | Removal of Cd^(2+) from water by Friedel's salt (FS:3CaO·A1_2O_3 ·CaCl_2 ·10H_2O): Sorption characteristics and mechanisms显示文摘The development of low-cost and efficient new mineral adsorbents has been a hot topic in recent years. In this study, Friedel's salt (FS:3CaO·A12O3 ·CaCl2 ·10H2O), a hexagonal layered inorganic absorbent, was synthesized to remove Cd2+ from water. The adsorption process was simulated by Langmuir and Freundlich models. The adsorption mechanism was further analyzed with TEM, XRD, FT-IR analysis and monitoring of metal cations released and solution pH variation. The results indicated the adsorbent FS had an outstanding ability for Cd(Ⅱ) adsorption. The maximum adsorption capacity of the FS for Cd(Ⅱ) removal can reach up to 671.14 mg/g. The nearly equal numbers of Cd2+ adsorbed and Ca2+ released demonstrated that ion-exchange (both surface and inner) of the FS for Cd(Ⅱ) played an important role during the adsorption process. Furthermore, the surface of the FS after adsorption was microscopically disintegrated while the inner lamellar structure was almost unchanged. The behavior of Cd(Ⅱ) adsorption by FS was significantly affected by surface reactions. The mechanisms of Cd2+ adsorption by the FS mainly included surface complexation and surface precipitation. In the present study, the adsorption process was fitted better by the Langmuir isotherm model (R2 = 0.9999) than the Freundlich isotherm model (R2 = 0.8122). Finally, due to the high capacity for ion-exchange on the FS surface, FS is a promising layered inorganic adsorbent for the removal of Cd(Ⅱ) from water. | Juanjuan Zhang He Zhao Hongbin Cao Heping Li Zhibao Li | 2013 | Journal of Environmental Sciences2013，25，9： | 5 |
| 11 | Remarkable carbon dioxide catalytic capture (CDCC) leading to solid-form carbon material via a new CVD integrated process (CVD-IP): An alternative route for CO_2 sequestration显示文摘Through our newly-developed 'chemical vapor deposition integrated process (CVD-IP)' using carbon dioxide (CO2) as the raw material and only carbon source introduced, CO2 could be catalytically activated and converted to a new solid-form product, i.e., carbon nanotubes (CO2-derived) at a quite high yield (the single-pass carbon yield in the solid-form carbon-product produced from CO2 catalytic capture and conversion was more than 30% at a single-pass carbon-base). For comparison, when only pure carbon dioxide was introduced using the conventional CVD method without integrated process, no solid-form carbon-material product could be formed. In the addition of saturated steam at room temperature in the feed for CVD, there were much more end-opening carbon nano-tubes produced, at a slightly higher carbon yield. These inspiring works opened a remarkable and alternative new approach for carbon dioxide catalytic capture to solid-form product, comparing with that of CO2 sequestration (CCS) or CO2 mineralization (solidification), etc. As a result, there was much less body volume and almost no greenhouse effect for this solid-form carbon-material than those of primitive carbon dioxide. | Wei Chu Maofei Ran Xu Zhang Ning Wang Yufei Wang Heping Xie Xiusong Zhao | 2013 | Journal of Energy Chemistry2013，22，1： | 5 |
| 12 | Retrospective Study of an Adenovirus Pneumonia Outbreak in Shenzhen in 2017显示文摘Dear Editor,Human adenoviruses (HAd Vs) are associated with respiratory,gastrointestinal,ophthalmological,genitourinary,and neurological infections.To date,more than 100genotypes of HAd Vs have been identified.They are classified into seven species,A to G (HAd V Working Group,http://gffzz01fc05ce3d5e4237hbovwpuo55n9k669u.ffgz.tsg.suse.edu.cn/). | Zhiwei Lu Heping Wang Yanmin Bao Zhichuan Li Huan Zhang Haixia Zhao Yuejie Zheng | 2021 | Virologica Sinica2021，36，3： | 4 |
| 13 | Effects of Long-term Fertilization on Soil M icrobial Com m unity Structure,Labile Organic Carbon and Nitrogen and Enzym e Activity in Paddy Field and Upland显示文摘To investigate the effects of long-term fertilization systems on soil microbial community structure,labile organic carbon and nitrogen and enzyme activity in yellow sand paddy field and upland,a field experiment was conducted at the experimental station of Dongyang Institute of Maize Research in Zhejiang Province,China in 2009.The experiment consisted of six treatments with three replicates,and they were arranged in a completely randomized design,including no fertilization in paddy field (PCK),conventional fertilization in paddy field (PCF),formulated fertilization by soil testing in paddy field (PSTF),formulated fertilization by soil testing with organic manure in paddy field (PSTF+OF),conventional fertilization on upland (DCF),and formulated fertilization by soil testing with organic manure on upland (DSTF+OF).Soil nutrients,enzyme activity,microbial biomass and community structure were determined in 2015.The results showed that compared with no fertilization in paddy field (PCK),fertilization increased soil phosphorus and potassium content,and decreased pH value.No fertilization in paddy field (PCK) had no significant effect on soil culturable microorganisms in paddy field and upland,but formulated fertilization by soil testing with organic manure on upland (DSTF+OF) significantly increased the number of fungi.Formula fertilization by soil testing with organic manure (PSTF+OF) also significantly increased soil microbial biomass carbon and nitrogen in paddy field and upland.Moreover,fertilization had no significant effect on soil cellulase activity,but formula fertilization by soil testing with organic manure (PSTF+OF) significantly increased soil dehydrogenase and catalase activity.Therefore,long-term application of chemical fertilizer with organic fertilizer can effectively improve soil fertility. | Wang Guiyue Su Ting Han Hailiang Tan Heping Bao Fei Zhao Fucheng | 2019 | Meteorological and Environmental Research2019，10，5： | 4 |
| 14 | Desmoglein 2(DSG2) Is A Receptor of Human Adenovirus Type 55 Causing Adult Severe Community-Acquired Pneumonia显示文摘Human adenovirus type 55(HAdV-B55) is a re-emergent acute respiratory disease pathogen that causes adult communityacquired pneumonia(CAP). Previous studies have shown that the receptor of HAdV-B14, which genome is highly similar with HAdV-B55, is human Desmoglein 2(DSG2). However, whether the receptor of HAdV-B55 is DSG2 is undetermined because there are three amino acid mutations in the fiber gene between HAdV-B14 and HAdV-B55. Here, firstly we found the 3T3 cells, a mouse embryo fibroblast rodent cell line which does not express human DSG2, were able to be infected by HAdV-B55 after transfected with pcDNA3.1-DSG2, while normal 3T3 cells were still unsusceptible to HAdV-B55 infection. Next, A549 cells with h DSG2 knock-down by siRNA were hard to be infected by HAdV-B3/-B14/-B55, while the control siRNA group was still able to be infected by all these types of HAdVs. Finally, immunofluorescence confocal microscopy indicated visually that Cy3-conjugated HAdV-B55 viruses entered A549 cells by binding to DSG2 protein.Therefore, DSG2 is a major receptor of HAdV-B55 causing adult CAP. Our finding is important for better understanding of interactions between adenoviruses and host cells and may shed light on the development of new drugs that can interfere with these processes as well as for the development of potent prophylactic vaccines. | Jing Zhang Kui Ma Xiangyu Wang Yinbo Jiang Shan Zhao Junxian Ou Wendong Lan Wenyi Guan Xiaowei Wu Heping Zheng Bin Yang Chengsong Wan Wei Zhao Jianguo Wu Qiwei Zhang | 2021 | Virologica Sinica2021，36，6： | 4 |
| 15 | Arabidopsis Synaptotagmin 2 Participates in Pollen Germination and Tube Growth and Is Delivered to Plasma Membrane via Conventional Secretion显示文摘Arabidopsis synaptotagmin (SYT2 ) 2 被报导了在体的房间参予一条异乎寻常的能分泌的小径。我们的结果证明 SYT2 主要在 Arabidopsis thaliana 的花粉被表示。展出的 syt2 T-DNA 和 RNA 干扰异种线的花粉减少了全部的萌芽并且阻碍了花粉试管生长。在 SYT2 对不同、补缀的分隔空间局部性,但是能与 Golgi 标记, BODIPY TR C5 ceramide 和 GmMan1-mCherry 共同本地化的花粉 tubeindicates 的 SYT2-GFP 熔化蛋白质的表示的分析。然而,对在 Arabidopsis 暂停房间的血浆膜局部性的 SYT2-DsRed-E5was,除了 Golgi 仪器。在血浆膜的 SYT2 的本地化被在花粉试管染色的 immunofluorescence 进一步支持。而且, brefeldin Atreatment 禁止了 SYT2 的运输到血浆膜并且引起了 SYT2 聚集并且形成扩大分隔空间。SYT2-C2AB 领域的截断也在 Golgi 仪器导致了 SYT2 的保留。phospholipid 有约束力的试金显示出的 invitro SYT2-C2AB 领域以一种钙依赖者方式绑在 phospholipid 膜。一起拿,我们的结果显示了那 SYT2 为花粉萌芽和花粉试管生长被要求,并且涉及常规 exocytosis。 | Hui Wang Shengcheng Han Wei Siao Chunqing Song Yun Xiang Xiaorong Wu Pengyu Cheng Hongjuan Li JAn Jasik Karol Micieta JAn Turna Boris Voigtt Frantisek Baluska Jin Liu Yingdian Wang Heping Zhao | 2015 | Molecular Plant2015，8，12： | 2 |
| 16 | Electrochemical CO_(2) mineralization for red mud treatment driven by hydrogen-cycled membrane electrolysis显示文摘CO_(2)mineralization as a promising CO_(2)mitigation strategy can employ industrial alkaline solid wastes to achieve net emission reduction of atmospheric CO_(2).The red mud is a strong alkalinity waste residue produced from the aluminum industry by the Bayer process which has the potential for the industrial CO_(2)large scale treatment.However,limited by complex components of red mud and harsh operating conditions,it is challenging to directly mineralize CO_(2)using red mud to recover carbon and sodium resources and to produce mineralized products simultaneously with high economic value efficiently.Herein,we propose a novel electrochemical CO_(2)mineralization strategy for red mud treatment driven by hydrogen-cycled membrane electrolysis,realizing mineralization of CO_(2)efficiently and recovery of carbon and sodium resources with economic value.The system utilizes H_(2)as the redox-active proton carrier to drive the cathode and anode to generate OH^(-) and H^(+) at low voltage,respectively.The H^(+) plays as a neutralizer for the alkalinity of red mud and the OH^(-) is used to mineralize CO_(2)into generate highpurity NaHCO_(3)product.We verify that the system can effectively recover carbon and sodium resources in red mud treatment process,which shows that the average electrolysis efficiency is 95.3%with highpurity(99.4%)NaHCO_(3)product obtained.The low electrolysis voltage of 0.453 V is achieved at10 mA·cm^(-2) in this system indicates a potential low energy consumption industrial process.Further,we successfully demonstrate that this process has the ability of direct efficient mineralization of flue gas CO_(2)(15%volume)without extra capturing,being a novel potential strategy for carbon neutralization. | Heping Xie Yunpeng Wang Tao Liu Yifan Wu Wenchuan Jiang Cheng Lan Zhiyu Zhao Liangyu Zhu Dongsheng Yang | 2022 | Chinese Journal of Chemical Engineering2022，35，3： | 2 |
| 17 | Clinical study on treatment of chronic viral cholestatic hepatitis with Chishaodanpi decoction显示文摘OBJECTIVE: To observe the therapeutic effect of Chishaodanpi decoction(CSDPD) on chronic viral cholestatic hepatitis.METHODS: A total of 107 subjects with chronic viral cholestatic hepatitis were enrolled in our hospital from March 2007 to November 2012. Patients were randomly divided into treatment(54 cases)and control groups(53 cases). The control group was treated with potassium magnesium aspartate,diammonium glycyrrhizinate, glucurolactone, vitamin C, and lamivudine, once a day. The treatment group was treated with modified CSDPD, 100 m L a time, twice a day, in addition to the treatment given to the control group. The patients in both groups were treated for 8 weeks. The main symptoms and signs were recorded every day throughout the clinical trial. Before and after the trial,changes in liver function including total bilirubin(TBil), direct bilirubin(DBil), total bile acid(TBA),and the activities of alkaline phosphatase(ALP), alanine aminotransferase(ALT), aspartate aminotransferase(AST), and γ-glutamyl transferase(γ-GT),were all detected. Adverse reactions were also recorded.RESULTS: There were no differences in gender, age,disease duration, symptoms, signs, or laboratory findings between the two groups(P>0.05). After an8-week treatment, improvements in jaundice, weakness, poor appetite, abdominal distention, and skin itching were significantly better in the treatment group than in the control group(P<0.05). In the treatment group, 43 patients had a significant response to the treatment, seven patients had a response, and four patients had no response, with 21,12, and 20 patients in the control group, respectively. The total effective rate was 92.6% in the treatment group and 62.3% in the control group, which was a significant difference(P<0.05). The levels of TBil, DBil, TBA, ALP, ALT, AST, and γ-GT in both groups were significantly lower after treatment,and were significantly different between the two groups(P<0.05). A few patients in the treatment group had mild adverse effects such as increased bowel movement frequency and mild stomachache. No other adverse reactions were observed in either group.CONCLUSION: CSDPD has a satisfactory therapeutic effect on chronic viral cholestatic hepatitis. | Heping Zhao Tianqing Hou Dandan Shao | 2014 | Journal of Traditional Chinese Medicine2014，34，6： | 2 |
| 18 | Analysis of Particle Forces in Electrorheological Fluids显示文摘 | Zhao Heping Liu Zhengyou Liu Youyan | 2001 | Physica B2001，299，： | 1 |
| 19 | cGAS guards against chromosome endto-end fusions during mitosis and facilitates replicative senescence显示文摘As a sensor of cytosolic DNA, the role of cyclic GMP-AMP synthase (cGAS) in innate immune response is well established, yet how its functions in different biological conditions remain to be elucidated. Here, we identify cGAS as an essential regulator in inhibiting mitotic DNA double-strand break (DSB) repair and protecting short telomeres from end-to-end fusion independent of the canonical cGAS-STING pathway. cGAS associates with telomeric/subtelomeric DNA during mitosis when TRF1/TRF2/POT1 are deficient on telomeres. Depletion of cGAS leads to mitotic chromosome end-to-end fusions predominantly occurring between short telomeres. Mechanistically, cGAS interacts with CDK1 and positions them to chromosome ends. Thus, CDK1 inhibits mitotic non-homologous end joining (NHEJ) by blocking the recruitment of RNF8. cGAS-deficient human primary cells are defective in entering replicative senescence and display chromosome end-to-end fusions, genome instability and prolonged growth arrest. Altogether, cGAS safeguards genome stability by controlling mitotic DSB repair to inhibit mitotic chromosome end-to-end fusions, thus facilitating replicative senescence. | Xiaocui Li Xiaojuan Li Chen Xie Sihui Cai Mengqiu Li Heping Jin Shu Wu Jun Cui Haiying Liu Yong Zhao | 2022 | Protein & Cell2022，13，1： | 1 |
| 20 | Fractal evolution of a crack network in overburden rock stratum显示文摘 | Yu Guangming Xie Heping Zhao Jianfeng etc | 2000 | Discrete Dynamics in Nature and Society2000，，5： | 1 |
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