|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Total body irradiation of donors can alter the course of tolerance and induce acute rejection in a spontaneous tolerance rat liver transplantation model显示文摘Liver transplantation is an established therapy for end-stage liver diseases. Graft rejection occurs unless the recipient receives immunosuppression after transplantation. This study aimed to explore the mechanism of acute rejection of liver allografts in rats pre-treated with total body irradiation to eliminate passenger lymphocytes and to define the role of CD4 + CD25 + regulatory T cells in the induction of immunotolerance in the recipient. Male Lewis rats were used as donors and male DA rats were recipients. Rats were randomly assigned to the following four groups: control group, homogeneity liver transplantation group, idio-immunotolerance group and acute rejection group. After transplantation, the survival time of each group, serum alanine aminotransferase, total bilirubin levels, number of Foxp3 + CD4 + CD25 + regulatory T cells, expression of glucocorticoid-induced tumor necrosis factor receptor on T cell subgroups, histopathology of the hepatic graft and spleen cytotoxic T lymphocyte lytic activity were measured. In the acute rejection group, where donors were preconditioned with total body irradiation before liver transplantation, all recipients died between day 17 and day 21. On day 14, serum alanine aminotransferase increased signifi- cantly to (459.2±76.9) U L -1 , total bilirubin increased to (124.1±33.7) μmol L -1 (P<0.05) and the ratio of Foxp3 + CD4 + CD25 + regulatory T cells decreased significantly to 1.50%±0.50% (P<0.05) compared with the other groups. Analysis of the T cell subpopulations in the acute rejection group varied from the other groups. Histological analysis showed typical changes of acute rejection in the acute rejection group only. Preconditioning of the donors with total body irradiation eliminated passenger lymphocytes of the liver graft, and thus affected the course of tolerance and induced acute rejection after liver transplantation. | ZHANG YeWei ZHAO HeWei BO Lin YANG YinXue LU Xiang SUN JingFeng WEN JianFei HE Xia YIN GuoWen | 2012 | Science China(Life Sciences)2012，55，9： | 4 |
| 2 | Evaluation on the corrosion resistance, antibacterial property and osteogenic activity of biodegradable Mg-Ca and Mg-Ca-Zn-Ag alloys显示文摘The rapid degradation of magnesium(Mg)-based implants in physiological environment limits its clinical applications, and alloying treatment is an effective way to regulate the degradation rate of Mg-based materials. In the present study, three Mg alloys, including Mg-0.8Ca(denoted as ZQ), Mg-0.8Ca-5Zn-1.5Ag(denoted as ZQ71) and Mg-0.8Ca-5Zn-2.5Ag(denoted as ZQ63), were fabricated by alloying with calcium(Ca), zinc(Zn) and silver(Ag). The results obtained from electrochemical corrosion tests and in vitro degradation evaluation demonstrated that the three Mg alloys exhibited distinct corrosion resistance, and ZQ71 exhibited the lowest degradation rate in vitro among them. After addition of Zn and Ag, the antibacterial potential of Mg alloys was also enhanced. The in vitro cell experiments showed that all the three Mg alloys had good biocompatibility. After implantation in a rat femoral defect, ZQ71 showed significantly higher osteogenic activity and bone substitution rate than ZQ63 and ZQ, due to its higher corrosion resistance as well as the stimulatory effects of the released metallic ions. In addition, the average daily degradation rate of each Mg alloy in vivo was significantly higher than that in vitro, as could be due to the implantation site located in the highly vascularized trabecular region. Importantly, the correlations between the in vitro and in vivo degradation parameters of the Mg alloys were systematically analyzed to find out the potential predictors of the in vivo degradation performance of the materials. The current work not only evaluated the clinical potential of the three biodegradable Mg alloys as bone grafts but also provided a feasible approach for predicting the in vivo degradation behavior of biodegradable materials. | Hewei Chen Bo Yuan Rui Zhao Xiao Yang Zhanwen Xiao Antoniac Aurora Bita Ana Iulia Xiangdong Zhu Antoniac Vasile Iulian Xingdong Zhang | 2022 | Journal of Magnesium and Alloys2022，10，12： | 3 |
| 3 | Blue emitting CsPbBr3 perovskite quantum dot inks obtained from sustained release tablets显示文摘Blue emitting perovskite ink obtained from cesium lead halide quantum dots bearing chlorine(CsPbClxBr3-x,0 | Hewei Yang Yaqing Feng Zhiyu Tu Kuo Su Xiaozhi Fan Bingjie Liu Zhiping Shi Yuzhe Zhang Chenyang Zhao Bao Zhan | 2019 | Nano Research2019，12，12： | 2 |
| 4 | Construction of a magnesium hydroxide/graphene oxide/hydroxyapatite composite coating on Mg-Ca-Zn-Ag alloy to inhibit bacterial infection and promote bone regeneration显示文摘The improved corrosion resistance, osteogenic activity, and antibacterial ability are the key factors for promoting the large-scale clinical application of magnesium (Mg)-based implants. In the present study, a novel nanocomposite coating composed of inner magnesium hydroxide, middle graphene oxide, and outer hydroxyapatite (Mg(OH)_(2)/GO/HA) is constructed on the surface of Mg-0.8Ca-5Zn-1.5Ag by a combined strategy of hydrothermal treatment, electrophoretic deposition, and electrochemical deposition. The results of material characterization and electrochemical corrosion test showed that all the three coatings have high bonding strength, hydrophilicity and corrosion resistance. In vitro studies show that Mg(OH)2 indeed improves the antibacterial activity of the substrate. The next GO and GO/HA coating procedures both promote the osteogenic differentiation of MC3T3-E1 cells and show no harm to the antibacterial activity of Mg(OH)2 coating, but the latter exhibits the best promoting effect. In vivo studies demonstrate that the Mg alloy with the composite coating not only ameliorates osteolysis induced by bacterial invasion but also promotes bone regeneration under both normal and infected conditions. The current study provides a promising surface modification strategy for developing multifunctional Mg-based implants with good corrosion resistance, antibacterial ability and osteogenic activity to enlarge their biomedical applications. | Bo Yuan Hewei Chen Rui Zhao Xuangeng Deng Guo Chen Xiao Yang Zhanwen Xiao Antoniac Aurora Bita Ana Iulia Kai Zhang Xiangdong Zhu Antoniac Vasile Iulian Shen Hai Xingdong Zhang | 2022 | Bioactive Materials2022，7，12： | 2 |
| 5 | Effects of Epstein-Barr virus infection on the development of multiple myeloma after liver transplantation显示文摘Reduced cellular immune function in patients after liver transplantation easily results in many types of viral infections,such as Epstein-Barr virus.Epstein-Barr virus is a γ-herpesvirus and is related to many malignant diseases,especially epithelial and lymph tumors.The abnormal interaction of cluster of differentiation 40 with cluster of differentiation 40 ligand and expression of cluster of differentiation 40 ligand are considered closely related to the development of myeloma cells.This study explored the influence and mechanism of Epstein-Barr virus infection on the phenotype and biological behavior of myeloma cells after liver transplantation.Flow cytometry was used to detect coexpression of cluster of differentiation 40 and cluster of differentiation 40 ligand in 10 samples of freshly isolated multiple myeloma cells.Cluster of differentiation 40 and cluster of differentiation 40 ligand were coexpressed in sample Nos.5,8,9,and 10,particularly in sample No.5.Western blot analysis was used to detect the expression of the Epstein-Barr virus antigens latent membrane protein 1 and Epstein-Barr virus nuclear antigen 2 in the multiple myeloma cell line RPMI 8226 infected with Epstein-Barr virus.The antigen expression indicated that Epstein-Barr virus can infect multiple myeloma virus cells in vitro.Reverse transcription-polymerase chain reaction revealed upregulated expression of cluster of differentiation 40 ligand on the infected RPMI 8226 cells,which may be involved in the anti-apoptosis activity of the infected cells.Confocal microscopy showed that pairs of molecules of cluster of differentiation 40,cluster of differentiation 40 ligand,and latent membrane protein 1 were colocalized on the surface of the infected cells.CXC chemokine receptor 4 was upregulated on the RPMI 8226 cells after Epstein-Barr virus infection.The migratory ability of the infected cells improved in the presence of the chemokine stromal cell-derived factor-1α.Anti-apoptosis and migration are known important biological characteristics of malignant cells.Our results indicate the involvement of Epstein-Barr virus in the origin and development of multiple myeloma.The risk of multiple myeloma increases when Epstein-Barr virus infects B cells in the germinal center,which may result in an anti-apoptosis effect of B cells and an improved ability to migrate from the germinal center to peripheral blood. | ZHANG YeWei ZHAO HeWei HE Xia ZHENG SuWen WANG TaiHong YAN DongLiang SUN JingFeng LU Xiang WEN JianFei LAU Wan Yee | 2012 | Science China(Life Sciences)2012，55，8： | 2 |
| 6 | Inhibitory effect of Sumu(Lignum Sappan) plus Fuzi(Radix Aconiti Lateralis Praeparata) on a lung carcinoma model显示文摘OBJECTIVE: To investigate the inhibitory effect of Sumu(Lignum Sappan) plus Fuzi(Radix Aconiti Lateralis Praeparata)(SF) on the growth and metastasis of Lewis lung carcinoma.METHODS: A lung carcinoma model was established by subcutaneously inoculating Lewis lung carcinoma cells into C57 BL/6 mice. The mice were randomly divided into four groups of 13 mice(control, low-dose, moderate-dose, and high-dose), and gavaged once-daily for 21 consecutive days. The rates of tumor inhibition, metastasis, and metastasis inhibition were observed. The differential expressions of s P-selectin and vascular endothelial growth factor C(VEGFC) were compared between the treatment groups and the control group.RESULTS: The tumor weights differed significantly between the treatment groups and the control group(P < 0.05). Administration of SF in the moderate-dosage and low-dose groups significantly inhibited the expression of s P-selectin and VEGFC(both P < 0.05), suggesting anti-tumor activity.CONCLUSION: SF can inhibit the growth and metastasis of Lewis lung carcinoma. | Zhang Hewei Ma Shuran Tian Tian Xu Ya Zhao Dandan Wang Tong Hou Chunying Zhang Shujing | 2018 | Journal of Traditional Chinese Medicine2018，38，2： | 1 |
| 7 | Wet Chemical Synthesis of Amorphous Nanomaterials with Well-Defined Morphologies显示文摘CONSPECTUS:Amorphous nanomaterials,with unique structural features such as long-range atomic disorder and nanoscale particle or grain sizes,possess some advantageous properties for a number of materials applications.For example,amorphous vanadium oxide exhibits a record-high cycling stability for supercapacitors.Several synthetic strategies have been developed to produce amorphous nanomaterials,such as physical processing-based approaches including cutting,deposition,and spinning,as well as chemical syntheses by solution or solid state reactions.However,despite the rapid development of amorphous nanomaterials,their morphology is still irregular or primarily sphere-like.The limited morphology control is partially attributed to the lack of preferred growth direction for the amorphous materials.It will be interesting to know whether different morphologies of even amorphous nanomaterials can influence their properties as much as their crystalline counterparts.Wet chemical synthesis,which can usually be carried out under relatively facile reaction conditions,has achieved remarkable success for creating crystalline nanomaterials with well-defined shapes,such as one-dimensional(1D)nanowires,two-dimensional(2D)nanosheets,and three-dimensional(3D)complex structures.However,there are two main obstacles for shape control of amorphous nanomaterials using wet chemical strategies.First,it is difficult to form a stable amorphous state under wet chemical conditions.The amorphous state is metastable in solution according to classic nucleation theory,which is prone to phase transformation to form crystalline state.Second,common morphology control mechanisms for nanocrystals are ultimately relying on the intrinsic directionality of the lattices,which unfortunately is not relevant to the isotropic amorphous nanomaterials.In this Account,we describe how shape control of 1D,2D,and 3D amorphous nanomaterials can be achieved in wet chemical synthesis to create well-defined morphologies,which are based on two main strategies:Blocking agents that can stabilize the amorphous state in solution,and morphology-tunable parameters that can induce directional growth.Discussion on the phase transfer blocking mechanisms includes lattice disordering,controlled hydrolysis,rapid reaction,and ionic exchange,and for morphology control through confinement it includes precursor transformation,templated reactions,interfacial etching,and spatial confinement.In addition,we present examples showing how these well-defined morphology leads to desirable properties in applications of mechanics,energy storage,catalysis,and optics,highlighting their structural-properties relationship.Finally,some perspectives are discussed regarding future research opportunities in the area of amorphous nanomaterials. | Hewei Zhao Fengshi Li Shaoxiong Wang Lin Guo | 2021 | Accounts of Materials Research2021，2，9： | 1 |
| 8 | Typical adaptive neural control for hypersonic vehicle based on higher-order filters显示文摘A typical adaptive neural control methodology is used for the rigid body model of the hypersonic vehicle. The rigid body model is divided into the altitude subsystem and the velocity subsystem. The proportional integral differential(PID) controller is introduced to control the velocity track. The backstepping design is applied for constructing the controllers for the altitude subsystem.To avoid the explosion of differentiation from backstepping, the higher-order filter dynamic is used for replacing the virtual controller in the backstepping design steps. In the design procedure,the radial basis function(RBF) neural network is investigated to approximate the unknown nonlinear functions in the system dynamic of the hypersonic vehicle. The simulations show the effectiveness of the design method. | ZHAO Hewei LI Rui | 2020 | Journal of Systems Engineering and Electronics2020，31，5： | 1 |
| 9 | The binding epitope of sintilimab on PD-1 revealed by AbMap显示文摘PD-1 plays an important role as an immune checkpoint.Sintilimab is a newly approved PD-1 antibody for cancer immunotherapy with an unknown binding epitope on PD-1.In this study,to elucidate the molecular mechanism by which sintilimab blocks PD-1 activation,we applied Antibody binding epitope Mapping(AbMap)to identify the binding epitope of sintilimab.An epitope was successfully identified,i.e.SLAPKA,aa 127-132.By constructing a series of point mutations,the dominant residues S127,L128,A129,P130,and A132 of PD-1 were further validated by western blot analysis,biolayer interferometry,and flow cytometry.Structural analysis showed that the epitope is partially within the binding interface of PD-1 and PD-L1,and this epitope also partially overlaps with that of nivolumab and pembrolizumab.These results demonstrate that sintilimab can attenuate PD-1 activation by directly competing with the interaction between PD-1 and PD-L1 through binding with the key residues of the FG loop on PD-1.This study also demonstrates the high efficiency and accuracy of AbMap for determining the binding epitope of therapeutic antibodies. | Mingliang Ma Huan Qi Chuansheng Hu Zhaowei Xu Fanlin Wu Nan Wang Danyun Lai Yang Li Hainan Zhang Hewei Jiang Qingfeng Meng Shujuan Guo Yani Kang Xiaodong Zhao Hua Li Sheng-ce Tao | 2021 | Acta Biochimica et Biophysica Sinica2021，53，5： | 1 |
| 10 | Terminal Angular Constraint Integrated Guidance and Control for Flexible Hypersonic Vehicle with Dead-Zone Input Nonlinearity显示文摘This paper presents an integrated guidance and control model for a flexible hypersonic vehicle with terminal angular constraints.The integrated guidance and control model is bounded and the dead-zone input nonlinearity is considered in the system dynamics.The line of sight angle,line of sight angle rate,attack angle and pitch rate are involved in the integrated guidance and control system.The controller is designed with a backstepping method,in which a first order filter is employed to avoid the differential explosion.The full tuned radial basis function(RBF)neural network(NN)is used to approximate the system dynamics with robust item coping with the reconstruction errors,the exactitude model requirement is reduced in the controller design.In the last step of backstepping method design,the adaptive control with Nussbaum function is used for the unknown dynamics with a time-varying control gain function.The uniform ultimate boundedness stability of the control system is proved.The simulation results validate the effectiveness of the controller design. | Hewei Zhao | 2020 | Journal of Beijing Institute of Technology2020，29，4： | 0 |
| 11 | Non-covalent interaction-based molecular electronics with graphene electrodes显示文摘Recent years have witnessed the fabrication of various non-covalent interaction-based molecular electronic devices.In the noncovalent interaction-based molecular devices,the strength of the interfacial coupling between molecule and electrode is weakened compared to that of the covalent interaction-based molecular devices,which provides wide applications in fabricating versatile molecular devices.In this review,we start with the methods capable of fabricating graphene-based nanogaps,and the following routes to construct non-covalent interaction-based molecular junctions with graphene electrodes.Then we give an introduction to the reported non-covalent interaction-based molecular devices with graphene electrodes equipped with different electrical functions.Moreover,we summarize the recent progress in the design and fabrication of new-type molecular devices based on graphene and graphene-like two-dimensional(2D)materials.The review ends with a prospect on the challenges and opportunities of non-covalent interaction-based molecular electronics in the near future. | Shiqiang Zhao Hang Chen Qiaozan Qian Hewei Zhang Yang Yang Wenjing Hong | 2023 | Nano Research2023，16，4： | 0 |
| 12 | Strong and Tough TPU Fibers with Orientedly Aligned CNTs Reinforced by Amorphous ZrO_(2)显示文摘High strength and high toughness are vital for fibers’engineering applications,but are hard to simultaneously achieve.Herein,we synthesize a carbon nanotube(CNT)-thermoplastic polyurethanes(TPU)fiber reinforced by an amorphous ZrO_(2)layer through the wet-spinning method.The amorphous ZrO_(2)layer is in-situ grown on the surface of CNT and the hybrid nanowires are orientedly aligned with TPU to form the ternary fiber.The fiber possesses an excellent combination of high strength(84.6 MPa)and toughness(126.7 MJ/m^(3)),which is outstanding when compared with previously reported CNT-TPU fibers.The pull-out of nanowires attributed to the oriented alignment structure and the enhanced interface and restriction of deformation obtained from the amorphous ZrO_(2)layer are considered as the primary strengthening and toughening mechanisms.We anticipate that our fiber synthesis strategy gives a new path to design strong and tough fibers. | LI Yangbei LIU Shaojia ZHAO Hewei GUO Lin | 2022 | Chemical Research in Chinese Universities2022，38，3： | 0 |
| 13 | Intermolecular coupling enhanced thermopower in single-molecule diketopyrrolopyrrole junctions显示文摘Sorting out organic molecules with high thermopower is essential for understanding molecular thermoelectrics.The intermolecular coupling offers a unique chance to enhance the thermopower by tuning the bandgap structure of molecular devices,but the investigation of intermolecular coupling in bulk materials remains challenging.Herein,we investigated the thermopower of diketopyrrolopyrrole(DPP)cored single-molecule junctions with different coupling strengths by varying the packing density of the self-assembled monolayers(SAM)using a customized scanning tunneling microscope break junction(STM-BJ)technique.We found that the thermopower of DPP molecules could be enhanced up to one order of magnitude with increasing packing density,suggesting that the thermopower increases with larger neighboring intermolecular interactions.The combined density functional theory(DFT)calculations revealed that the closely-packed configuration brings stronger intermolecular coupling and then reduces the highest occupied molecular orbital(HOMO)-lowest unoccupied molecular orbital(LUMO)gap,leading to an enhanced thermopower.Our findings offer a new strategy for developing organic thermoelectric devices with high thermopower. | Chao Fang Renad Almughathawi Qingqing Wu Wenqiang Cao Hang Chen Songjun Hou Yu Gu Hewei Zhang Yi Zhao Jueting Zheng Guopeng Li Jia Shi Junyang Liu Bing-Wei Mao Zitong Liu Colin J.Lambert Wenjing Hong | 2023 | National Science Open2023，2，1： | 0 |
| 14 | Shape evolution of antimony oxychloride from sheaf-like to quasi-wafer structures显示文摘Antimony oxychloride Sb8O11Cl2(H2O)6 products with various morphologies including sheaf-like,rhombic-plate,oval leaf-like and quasi-wafer have been successfully synthesized via a mild and facile solution route at room temperature.The morphologies and structures of the as-prepared samples were characterized by X-ray powder diffraction(XRD),scanning electron microscopy(SEM) and transmission electron microscopy(TEM).A possible formation mechanism of these structures is proposed according to the experimental results and analysis. | ZHOU Jing ZHAO HeWei LI LiDong GUO Lin | 2011 | Chinese Science Bulletin2011，56，35： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员