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| 1 | An improved three-dimensional spherical DDA model for simulating rock failure显示文摘In this paper, a discontinuous numerical model, namely SDDARF3D(three-dimensional spherical discontinuous deformation analysis for rock failure), is proposed for simulating the whole process of rock failure. Firstly, within the framework of the classical discontinuous deformation analysis(DDA) method, the formulation of three-dimensional spherical DDA(3D SDDA) is deduced; secondly, a bonding and cracking algorithm is constructed and the SDDARF3 D model is proposed; thirdly, corresponding VC++ calculation code is developed and some verification examples are calculated. The simulated results can intuitively reproduce the failure phenomena of rock mass, indicating that the proposed SDDARF3 D numerical model is correct and effective. | JIAO YuYong HUANG GangHai ZHAO ZhiYe ZHENG Fei WANG Long | 2015 | Science China(Technological Sciences)2015，58，9： | 13 |
| 2 | A high-strength mineralized collagen bone scaffold for large-sized cranial bone defect repair in sheep显示文摘Large-sized cranial bone defect repair presents a great challenge in the clinic.The ideal cranioplasty materials to realize the functional and cosmetic recovery of the defect must have sufficient mechanical support,excellent biocompatibility,good osseointegration and biodegradability as well.In this study,a high-strength mineralized collagen(MC)bone scaffold was developed with biomimetic composition,microstructure and mechanical properties for the repair of sheep largesized cranial bone defects in comparison with two traditional cranioplasty materials,polymethyl methacrylate and titanium mesh.The compact MC scaffold showed no distinct pore structure and therefore possessed good mechanical properties.The strength and elastic modulus of the scaffold were much higher than those of natural cancellous bone and slightly lower than those of natural compact bone.In vitro cytocompatibility evaluation revealed that the human bone marrow mesenchymal stem cells(hBMSC)had good viability,attachment and proliferation on the compact MC scaffold indicating its excellent biocompatibility.An adult sheep cranial bone defect model was constructed to evaluate the performances of these cranioplasty materials in repairing the cranial bone defects.The results were investigated by gross observation,computed tomography scanning as well as histological assessments.The in vivo evaluations indicated that compact MC scaffold showed notable osteoconductivity and osseointegration with surrounding cranial bone tissues by promoting bone regeneration.Our results suggested that the compact MC scaffold has a promising potential for large-sized cranial bone defect repair. | Shuo Wang Zhijun Zhao Yongdong Yang Antonios G.Mikos Zhiye Qiu Tianxi Song Fuzhai Cui XiumeiWang Chunyang Zhang | 2018 | Regenerative Biomaterials2018，5，5： | 9 |
| 3 | Attenuation of rock blasting induced ground vibration in rock-soil interface显示文摘Blasting has been widely used in mining and construction industries for rock breaking.This paper presents the results of a series of field tests conducted to investigate the ground wave propagation through mixed geological media.The tests were conducted at a site in the northwestern part of Singapore composed of residual soil and granitic rock.The field test aims to provide measurement data to better understand the stress wave propagation in soil/rock and along their interface.Triaxial accelerometers were used for the free field vibration monitoring.The measured results are presented and discussed,and empirical formulae for predicting peak particle velocity (PPV) attenuation along the ground surface and in soil/rock were derived from the measured data.Also,the ground vibration attenuation across the soil-rock interface was carefully examined,and it was found that the PPV of ground vibration was decreased by 37.2% when it travels from rock to soil in the vertical direction. | Bhagya Jayasinghe Zhiye Zhao Anthony Goh Teck Chee Hongyuan Zhou Yilin Gui | 2019 | Journal of Rock Mechanics and Geotechnical Engineering2019，11，4： | 7 |
| 4 | Micro-and macro-fractures of coarse granite under true-triaxial unloading conditions显示文摘We studied the mechanical behavior of rock under different boundary conditions, based on the fractal characteristics of fractures in terms of microscopic and macroscopic investigations. Three rectangular granite specimens of similar dimensions were tested by a triaxial rock testing machine under uniaxial compression (UC), confined compression (CC) and true-triaxial unloading conditions (RB) under rock burst boundary conditions. The failure processes of these specimens were investigated via examinations of their fracture behavior on a macro-scale by laser profilometers and on a micro-scale by a scanning electron microscopic (SEM) imaging technique. The SEM images, showing the spalling features of RB fragments, are compared with the grain dislocations under UC and CC conditions. Based on a variogram method, two fractal parameters, i.e., fractal dimensions (D rld ) and the scale dependent fractal parameter K v , were induced to present the surface roughness of scanning profiles in all directions. The fitted ellipses of D rld distribution show that RB surface has the smallest eccentricity, followed by the CC surface, while the UC surface had the largest eccentricity. As a result of this assessment, we conclude that rocks are affected by shear traction in an intermediate stress direction, which will cause fractures generated during rock bursts to twist rather than to tilt as shown in the uniaxial compression and the confined compression tests. | He Manchao Nie Wen Zhao Zhiye Cheng Cheng | 2011 | Mining Science and Technology2011，21，3： | 6 |
| 5 | Improvement of contact calculation in spherical discontinuous deformation analysis显示文摘Discontinuous deformation analysis solve(DDA)method is a newly developed the discrete element method which employs deal the implicit time-integration scheme to the governing equations low.and open-close spherical iteration(OCI)based method to with contact problem,its computational which efficiency very is relatively However,element has discontinuous deformation In analysis(SDDA),SDDA,uses simple contact type like point-to-point calculation contact,higher removing calculation speed.scheme the framework of the this paper presents a very simple(MDI).contact approach by the OCI that and by adopting maximal and displacement increment Through some verification obtained.examples,it is proved the proposed method is correct effective,and a higher computational efficiency | WANG Long JIAO YuYong HUANG GangHai ZHENG Fei ZHAO ZhiYe TAN Fei | 2017 | Science China(Technological Sciences)2017，60，5： | 2 |
| 6 | Effects of anisotropic permeability of fractured rock masses on underground oil storage caverns显示文摘 | Jianping Sun Zhiye Zhao | 2010 | Tunnelling and Underground Space Technology incorporating Trenchless Technology Research2010，，5： | 2 |
| 7 | Determination of hydraulic conductivity of fractured rock masses:A case study for a rock cavern project in Singapore显示文摘In order to reduce the risk associated with water seepage in an underground rock cavern project in Singapore,a reliable hydro-geological model should be established based on the in situ investigation data.The key challenging issue in the hydro-geological model building is how to integrate limited geological and hydro-geological data to determine the hydraulic conductivity of the fractured rock masses.Based on the data obtained from different stages(feasibility investigation stage,construction stage,and post-construction stage),suitable models and methods are proposed to determine the hydraulic conductivities at different locations and depths,which will be used at other locations in the future. | Zhipeng Xu Zhiye Zhao Jianping Sun Ming Lu | 2015 | Journal of Rock Mechanics and Geotechnical Engineering2015，7，2： | 2 |
| 8 | Mineralized collagen-modified PMMA cement enhances bone integration and reduces fibrous encapsulation in the treatment of lumbar degenerative disc disease显示文摘As a minimally invasive surgery,percutaneous cement discoplasty(PCD)is now contemplated to treat lumbar disc degeneration disease in elder population.Here,we investigated whether the osteogenic mineralized collagen(MC)modified polymethylmethacrylate(PMMA)cement could be a suitable material in PCD surgery.Injectability,hydrophilicity and mechanical properties of the MC-modified PMMA(PMMA-MC)was characterized.The introduction of MC did not change the application and setting time of PMMA and was easy to be handled in minimally invasive operation.Hydrophilicity of PMMA-MC was greatly improved and its elastic modulus was tailored to complement mechanical performance of bone under dynamic stress.Then,PCD surgery in a goat model with induced disc degeneration was performed with implantation of PMMA-MC or PMMA.Three months after implantation,micro-computed tomography analysis revealed a 36.4%higher circumferential contact index between PMMA-MC and bone,as compared to PMMA alone.Histological staining confirmed that the surface of PMMA-MC was in direct contact with new bone,while the PMMA was covered by fibrous tissue.The observed gathering of macrophages around the implant was suspected to be the cause of fibrous encapsulation.Therefore,the interactions of PMMA and PMMA-MC with macrophages were investigated in vitro.We discovered that the addition of MC could hinder the proliferation and fusion of the macrophages.Moreover,expressions of fibroblaststimulating growth factors,insulin-like growth factor,basic fibroblast growth factor and tumor necrosis factor-b were significantly down-regulated in the macrophages cocultured with PMMA-MC.Together,the promoted osteointegration and reduced fibrous tissue formation observed with PMMA-MC material makes it a promising candidate for PCD surgery. | Long Yang Jianjun Kong Zhiye Qiu Tieliang Shang Siyu Chen Rui Zhao Maria Grazia Raucci Xiao Yang Zhanyong Wu | 2020 | Regenerative Biomaterials2020，7，2： | 1 |
| 9 | A fuzzy system for concrete bridge damage diagnosis 显示文摘 | Zhiye Zhao Chuanyu Chen | 2002 | Computer & Structures 80(2002)2002，，： | 1 |
| 10 | Design of structural modular neural networks with genetic algorithm 显示文摘 | Nan Jiang Zhiye Zhao Liqun Ren | 2003 | Advances in Engineering Software2003，34，： | 1 |
| 11 | A fuzzy system for concrete bridge diagnosis显示文摘 | Zhao Zhiye Chen Chuanyu | 2002 | Computers & Structures2002，80，： | 1 |
| 12 | Effects of anisotropic permeability of fractured rock masses on underground oil storage caverns显示文摘 | Jianping Sun Zhiye Zhao | 2010 | Tunnelling and Underground Space Technology incorporating Trenchless Technology Research2010，，5： | 1 |
| 13 | Recent advances in RNA structurome显示文摘RNA structures are essential to support RNA functions and regulation in various biological processes. Recently, a range of novel technologies have been developed to decode genome-wide RNA structures and novel modes of functionality across a wide range of species. In this review, we summarize key strategies for probing the RNA structurome and discuss the pros and cons of representative technologies. In particular, these new technologies have been applied to dissect the structural landscape of the SARS-CoV-2 RNA genome. We also summarize the functionalities of RNA structures discovered in different regulatory layers-including RNA processing, transport, localization, and mRNA translation-across viruses, bacteria, animals, and plants. We review many versatile RNA structural elements in the context of different physiological and pathological processes(e.g., cell differentiation, stress response, and viral replication). Finally, we discuss future prospects for RNA structural studies to map the RNA structurome at higher resolution and at the single-molecule and single-cell level, and to decipher novel modes of RNA structures and functions for innovative applications. | Bingbing Xu Yanda Zhu Changchang Cao Hao Chen Qiongli Jin Guangnan Li Junfeng Ma Siwy Ling Yang Jieyu Zhao Jianghui Zhu Yiliang Ding Xianyang Fang Yongfeng Jin Chun Kit Kwok Aiming Ren Yue Wan Zhiye Wang Yuanchao Xue Huakun Zhang Qiangfeng Cliff Zhang Yu Zhou | 2022 | Science China(Life Sciences)2022，65，7： | 1 |
| 14 | A fuzzy system for concrete bridge damage diagnosis显示文摘 | ZHAO ZHIYE CHEN CHUANYU | 2002 | Computers & Structures2002，80，7： | 1 |
| 15 | A Fuzzy System for Concrete Bridge Diagnosis 显示文摘 | ZHAO Zhiye CHEN Chuanyu | 2002 | Computers & Structures2002，80，8： | 1 |
| 16 | An optimal neural network and concretestrength modeling显示文摘 | REN Liqun ZHAO Zhiye | 2002 | Advances in Engineering Software2002，，33： | 1 |
| 17 | Anticarin-β shows a promising antiosteosarcoma effect by specifically inhibiting CCT4 to impair proteostasis显示文摘Unlike healthy, non-transformed cells, the proteostasis network of cancer cells is taxed to produce proteins involved in tumor development. Cancer cells have a higher dependency on molecular chaperones to maintain proteostasis. The chaperonin T-complex protein ring complex(TRiC) contains eight paralogous subunits(CCT1-8), and assists the folding of as many as 10% of cytosolic proteome.TRiC is essential for the progression of some cancers, but the roles of TRiC subunits in osteosarcoma remain to be explored. Here, we show that CCT4/TRiC is significantly correlated in human osteosarcoma,and plays a critical role in osteosarcoma cell survival. We identify a compound anticarin-β that can specifically bind to and inhibit CCT4. Anticarin-β shows higher selectivity in cancer cells than in normal cells. Mechanistically, anticarin-β potently impedes CCT4-mediated STAT3 maturation. Anticarin-β displays remarkable antitumor efficacy in orthotopic and patient-derived xenograft models of osteosarcoma.Collectively, our data uncover a key role of CCT4 in osteosarcoma, and propose a promising treatment strategy for osteosarcoma by disrupting CCT4 and proteostasis. | Gan Wang Min Zhang Ping Meng Chengbo Long Xiaodong Luo Xingwei Yang Yunfei Wang Zhiye Zhang James Mwangi Peter Muiruri Kamau Zhi Daic Zunfu Ke Yi Zhang Wenlin Chen Xudong Zhao Fei Ge Qiumin Lv Mingqiang Rong Dongsheng Li Yang Jin Xia Sheng Ren Lai | 2022 | Acta Pharmaceutica Sinica B2022，12，5： | 1 |
| 18 | Design of structural modular neural networks with genetic algorithm显示文摘 | Jiang Nan Zhao Zhiye Ren Liqun | 2003 | Advances in Engineering Software2003，26，4： | 1 |
| 19 | Failure criterion of concrete under triaxial stresses using neural networks显示文摘 | Zhao Zhiye Ren Liqun | 2002 | Computer-Aided Civil and Infrastructure Engineering2002，17，1： | 1 |
| 20 | Considerations of the discontinuous deformation analysis on wave propagation problems显示文摘 | Gu Jiong Zhao Zhiye | 2009 | In-ternational Journal for Numerical and Analytical Methods in Geomechanic2009，33，： | 1 |
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