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| 1 | Transrectal ultrasonography-guided transperineal bilateral seminal vesicle puncture and continuous irrigation for the treatment of intractable hematospermia显示文摘 | ZHANG Xin-ru GU Bao-jun XU Yue-min CHEN Rong ZHANG Jiong QIAO Yong | 2008 | Chinese Medical Journal2008，，11： | 7 |
| 2 | PEA3 activates CXCR4 transcription in MDA-MB-231 and MCF7 breast cancer cells显示文摘(CXCR4 ) CXC chemokine 受体 4 是被显示了调停的房间表面受体包括肺,胸,肾,和前列腺的许多稳固的肿瘤的转移肿瘤。在这研究,我们发现 et 变体基因 4 的 overexpression (PEA3 ) 能在人的 MDA-MB-231 和 MCF-7 乳癌房间提高 CXCR4 mRNA 水平和 CXCR4 倡导者活动。PEA3 支持了 CXCR4 表示和乳癌转移。染色质 immunoprecipitation 试金证明 PEA3 能与 PEA3 表示向量在房间 transfected 绑在 CXCR4 倡导者。PEA3 siRNA 在 MDA-MB-231 和 MCF-7 房间稀释了 CXCR4 倡导者活动和 PEA3 的绑定到 CXCR4 倡导者。这些结果显示 PEA3 能激活 CXCR4 倡导者抄写并且支持乳癌转移。 | Shengmei Gu Li Chen Qi Hong Tingting Yan Zhigang Zhuang Qiaoqiao Wang Wei Jin Hua Zhu Jiong Wu | 2011 | Acta Biochimica et Biophysica Sinica2011，43，10： | 4 |
| 3 | Effect of cyclic wetting-drying on tensile mechanical behavior and microstructure of clay-bearing sandstone显示文摘The understanding of the weakening mechanism of tensile strength of rock subjected to cyclic wetting-drying is critical for rock engineering.Tensile strength tests were conducted on a total of 35 sandstone specimens with different wetting-drying cycles.The crack propagation process and acoustic emission characteristics of the tested samples were obtained through a high-speed camera and acoustic emission system.The results indicate that the tensile strength is observably reduced after cyclic wetting-drying,and the extent of the reduction is not only related to the number of wettingdrying cycle,but also closely related to the clay mineral content of the sample.In addition,as the cycles of wetting-drying increase,the effect of each single cycle on tensile strength get reduced until it becomes constant.Moreover,the crack initiation and penetration time is prolonged as the number of wetting-drying cycle increases,which indicates that cyclic wetting-drying weakens the rock stiffness and enhances the ductility of sandstone.Meanwhile,the acoustic emission characteristics of the tested samples further confirmed the ductile behaviour of the sandstone samples with increasing wetting-drying cycle.Furthermore,through the analysis of the microstructure and mineral composition of the samples with different wetting-drying cycles,it is concluded that the main weakening mechanisms of sandstones containing clay minerals are frictional reduction,chemical and corrosive deterioration. | Pingye Guo Juan Gu Yi Su Jiong Wang Zhanwen Ding | 2021 | International Journal of Coal Science & Technology2021，8，5： | 4 |
| 4 | A comparative study of buccal mucosa graft and penile pedical flap for reconstruction of anterior urethral strictures显示文摘 | SA Ying-long XU Yue-min QIAN Yong JIN San-bo FU Qiang ZHANG Xin-ru ZHANG Jiong GU Bao-jun | 2010 | Chinese Medical Journal2010，，3： | 4 |
| 5 | Intestinal dysbiosis exacerbates the pathogenesis of psoriasis-like phenotype through changes in fatty acid metabolism显示文摘The intestinal microbiota has been associated with host immunity as well as psoriasis;however,the mechanism of intestinal microbiota regulating psoriasis needs to be demonstrated systematically.Here,we sought to examine its role and mechanism of action in the pathogenesis of psoriasis.We found that the severity of psoriasis-like skin phenotype was accompanied by changes in the composition of the intestinal microbiota.We performed co-housing and fecal microbial transplantation(FMT)experiments using the K14-VEGF transgenic mouse model of psoriasis and demonstrated that the transfer of intestinal microbiota from mice with severe psoriasis-like skin phenotype exacerbated psoriasiform skin inflammation in mice with mild symptoms,including increasing the infiltration and differentiation of Th17,and increased the abundance of Prevotella,while decreasing that of Parabacteroides distasonis,in the colon.These alterations affected fatty acid metabolism,increasing the abundance of oleic and stearic acids.Meanwhile,gentamicin treatment significantly reduced the abundance of Prevotella and alleviated the psoriasis-like symptoms in both K14-VEGF mice and imiquimod(IMQ)-induced psoriasis-like mice.Indeed,administration of oleic and stearic acids exacerbated psoriasis-like symptoms and increased Th17 and monocyte-derived dendritic cell infiltration in the skin lesion areas in vivo,as well as increased the secretion of IL-23 by stimulating DCs in vitro.At last,we found that,treatment of PDE-4 inhibitor alleviated psoriasis-like phenotype of K14-VEGF mice accompanied by the recovery of intestinal microbiota,including the decrease of Prevotella and increase of Parabacteroides distasonis.Overall,our findings reveal that the intestinal microbiota modulates host metabolism and psoriasis-like skin inflammation in mice,suggesting a new target for the clinical diagnosis and treatment of psoriasis. | Qixiang Zhao Jiadong Yu Hong Zhou Xiaoyan Wang Chen Zhang Jing Hu Yawen Hu Huaping Zheng Fanlian Zeng Chengcheng Yue Linna Gu Zhen Wang Fulei Zhao Pei Zhou Haozhou Zhang Nongyu Huang Wenling Wu Yifan Zhou Jiong Li | 2023 | Signal Transduction and Targeted Therapy2023，8，2： | 2 |
| 6 | An Improved Estimation of the Fixed Point'sNeighborhood in Controlling Discrete Chaotic Systems显示文摘This paper proposes a better method for determining the fixed point’sneighborhood in which the system remain stable when subjected to a linear law. Thevalidity of this method is shown by a theorem on effective local control of nonlinear,chaotic dynamical system, with numerical confirmation. The ways of implementing theobtained theorem in practice are proposed. | Enguo GU Jiong RUAN and Zhenxun HUANG(Institution of Mathematics Fudan University, Shanghai 200433, China) | 1998 | Communications in Nonlinear Science and Numerical Simulation1998，3，3： | 1 |
| 7 | Complexity of a simple realistic neural network model显示文摘 | FANJI GU JIONG RUAN | 1993 | Proceedings of the International Joint Conference on Neural Networks1993，1，2529： | 1 |
| 8 | A practical synthesis of ethyl L-glutaminc ( L-theanine ) 显示文摘 | Gu Haining Jiang Yongxiang Wang Jiong | 2004 | Organic Preparations and Procedures International2004，36，2： | 1 |
| 9 | On some global bifurcations ofdomains of feasible trajectories:analysis of recurrenceequations显示文摘 | Gu Enguo Ruan Jiong | 2005 | International Journal of Bifurcation andChaos2005，15，5： | 1 |
| 10 | Probabilistic drift limits and performance evaluation of reinforced concrete columns显示文摘 | Lu Yong Gu Xiaoming Guan Jiong | 2005 | Journal of Structural Engineering ASCE2005，131，6： | 1 |
| 11 | Feasibility and Clinical Significance of Real-time Quantitative RT-PCR Assay of PML-RARa Fusion Transcript in Patients with Acute Promyelocytic Leukemia显示文摘 | Bai-Wei Gu Jiong Hu Lan Xu | 2001 | Hematol J2001，2，5： | 1 |
| 12 | 血清胱抑素C、内生肌酐清除率及尿微量白蛋白在恶性肿瘤含顺铂化疗患者肾功能评价中的地位(英文)显示文摘Objective:Chemotherapy drugs such as platinum may cause damage to the renal function,creatinine clearance(Ccr),as a 'golden standard' indicator in clinical evaluation of renal function,was limited in application due to complicated detection steps.By detecting the expression of serum Cystatin C(Cys C),Ccr and urinary micro-albumin(UMA),this study was designed to analyze and discuss their roles and status in renal function evaluation for cancer patients before and after chemotherapy with platinum.Methods:We retrospectively reviewed 110 patients who receiving platinum-containing protocols or non-platinum-containing ones,and got the expression of Cys C,Ccr(was calculated by Cockcroft-Gault equation) and UMA,then analyzed whether there were differences for Cys C,Ccr and UMA in those patients;for patients with mildly impaired renal function(Ccr between 50-75 mL/min),whether there were differences for Cys C and UMA before and after chemotherapy with platinum.Results:There was statistical significance for Ccr,Cys C and UMA in patients who receiving platinum-containing protocols(85.01 ± 28.40) vs(76.79 ± 26.63) mL/min,(1.49 ± 0.50) vs(1.80 ± 0.84) mg/L and(14.30 ± 9.15) vs(16.90 ± 10.95) mg/L,P = 0.00,0.00 and 0.01),and no statistical significance for those receiving non-platinum-containing ones(89.45 ± 29.69) vs(86.78 ± 27.96) mL/min,(1.51 ± 0.78) vs(1.63 ± 0.73)mg/L and(17.31 ± 10.46) vs(16.59 ± 8.33) mg/L,P = 0.45,0.07 and 0.57);and there were also significant differences for Cys C for patients with mildly impaired renal function before and after chemotherapy(1.68 ± 0.55) vs(2.04 ± 0.68) mg/L,P = 0.03),while no statistical significance for UMA for the same ones(21.11 ± 10.06) vs(21.22 ± 8.81) mg/L,P = 0.93).There were statistical significance both for Cys C and UMA before and after chemotherapy in platinum-containing group,but the AUC for Ccr and Cys C is greater than that for UMA(P < 0.02).Conclusion:Cys C and UMA can both access renal dysfunction early after chemotherapy,but Cys C is more sensitive than UMA in reflecting early renal dysfunction,so Cys C can replace Ccr and become a reliable indicator in the assessment of renal function for cancer patients before and after chemotherapy especially with platinum. | Xun Cai Peng Xue Meizhen Gu Jiong Hu Hongli Gu Haiyan Yang Liwei Wang | 2011 | The Chinese-German Journal of Clinical Oncology2011，10，4： | 1 |
| 13 | Considerations of the discontinuous deformation analysis on wave propagation problems显示文摘 | Gu Jiong Zhao Zhiye | 2009 | In-ternational Journal for Numerical and Analytical Methods in Geomechanic2009，33，： | 1 |
| 14 | Performance Enhancement and Utility Maximization for TCP in Wireless Mesh Networks显示文摘In Wireless Mesh Networks (WMNs),the performance of conventional TCP significantly deteriorates due to the unreliable wireless channel.To enhance TCP performance in WMNs,TCP/LT is proposed in this paper.It introduces fountain codes into packet reorganization in the protocol stack of mesh gateways and mesh clients.Furthermore,it is compatible with conventional TCP.Regarded as a Performance Enhancement Proxies (PEP),a mesh gateway buffers TCP packets into several blocks.It simultaneously processes them by using fountain encoders and then sends them to mesh clients.Apart from the improvement of the throughput of a unitary TCP flow,the entire network utility maximization can also be ensured by adjusting the scale of coding blocks for each TCP flow adaptively.Simulations show that TCP/LT presents high throughput gains over single TCP in lossy links of WMNs while preserving the fairness for multiple TCPs.As losses increase,the transmission delay of TCP/LT experiences a slow linear growth in contrast to the exponential growth of TCP. | Liu Hongquan Chen Jiong Song Siming Gu Yuantao | 2012 | China Communications2012，9，4： | 0 |
| 15 | Recent Development in the Space Utility System of China's Manned Space Flight Program显示文摘This paper briefly introduces the history of China's Manned Space Flight Program and concludes the experiments done since 2008,namely,a small satellite and a material science experiment.An outlook of future Chinese Space Station is also described at the end. | Gu Yidong Guo Jiong | 2010 | 空间科学学报2010，30，5： | 0 |
| 16 | On the Neighborhood in Stabilizing Period-T Orbits for Chaotic m Degree Polynomial Dynamical System显示文摘In this paper, a problem of stabilizing a period-T orbit in discrete Chaotic m degree polynomial dynamical systems is studied. The aim is to present a new method for determining the neighborhood of a period-T point in which the system remains stable when subjected to a linear feedback control. A theorem on the existence of neighborhood is rigorously proved using idea from functional analysis and polar coordinate transformation.The ways of implementing the obtained theorem in the Henon map are proposed. Thevalidity of this method is shown by numerical simulation. | Enguo GU Jiong RUAN and Zhenxun HUANG (Institute of Mathematics, Fudan University, Shanghai 200433,China) | 1998 | Communications in Nonlinear Science and Numerical Simulation1998，3，4： | 0 |
| 17 | Interleukin-37 promotes colitis-associated carcinogenesis via SIGIRR-mediated cytotoxic T cells dysfunction显示文摘Interleukin-37b(hereafter called IL-37)was identified as fundamental inhibitor of natural and acquired immunity.The molecular mechanism and function of IL-37 in colorectal cancer(CRC)has been elusive.Here,we found that IL-37 transgenic(IL-37tg)mice were highly susceptible to colitis-associated colorectal cancer(CAC)and suffered from dramatically increased tumor burdens in colon.Nevertheless,IL-37 is dispensable for intestinal mutagenesis,and CRC cell proliferation,apoptosis,and migration.Notably,IL-37 dampened protective cytotoxic T cell-mediated immunity in CAC and B16-OVA models.CD8^(+)T cell dysfunction is defined by reduced retention and activation as well as failure to proliferate and produce cytotoxic cytokines in IL-37tg mice,enabling tumor evasion of immune surveillance.The dysfunction led by IL-37 antagonizes IL-18–induced proliferation and effector function of CD8+T cells,which was dependent on SIGIRR(single immunoglobulin interleukin-1 receptor-related protein).Finally,we observed that IL-37 levels were significantly increased in CRC patients,and positively correlated with serum CRC biomarker CEA levels,but negatively correlated with the CD8+T cell infiltration in CRC patients.Our findings highlight the role of IL-37 in harnessing antitumor immunity by inactivation of cytotoxic T cells and establish a new defined inhibitory factor IL-37/SIGIRR in cancerimmunity cycle as therapeutic targets in CRC. | Zhen Wang Fan-lian Zeng Ya-wen Hu Xiao-yan Wang Fu-lei Zhao Pei Zhou Jing Hu Yuan-yuan Xiao Zhong-lan Hu Ming-feng Guo Xiao-qiong Wei Xiao Liu Nong-yu Huang Jun Zhang Shu-wen Chen Juan Cheng Hua-ping Zheng Hong Zhou Qi-xiang Zhao Chen Zhang Yan Hao Song Zou Yi-yue Gui Jia-dong Yu Lin-na Gu Cheng-cheng Yue Hao-zhou Zhang Wen-ling Wu Yi-fan Zhou Xi-kun Zhou Guo-bo Shen Xiu Teng Jiong Li | 2022 | Signal Transduction and Targeted Therapy2022，7，2： | 0 |
| 18 | CACA Guidelines for Holistic Integrative Management of Breast Cancer显示文摘Purpose:Breast cancer is now the most common malignant tumor worldwide.About one-fourth of female cancer patients all over the world sufer from breast cancer.And about one in six female cancer deaths worldwide is caused by breast cancer.In terms of absolute numbers of cases and deaths,China ranks frst in the world.The CACA Guidelines for Holistic Integrative Management of Breast Cancer were edited to help improve the diagnosis and comprehensive treatment in China.Methods:The Grading of Recommendations Assessment,Development and Evaluation(GRADE)was used to classify evidence and consensus.Results:The CACA Guidelines for Holistic Integrative Management of Breast Cancer include the epidemiology of breast cancer,breast cancer screening,breast cancer diagnosis,early breast cancer treatment,advanced breast cancer treatment,follow-up,rehabilitation,and traditional Chinese medicine treatment of breast cancer patients.Conclusion:We to standardize the diagnosis and treatment of breast cancer in China through the formulation of the CACA Guidelines. | Jiong Wu Daiming Fan Zhimin Shao Binghe Xu Guosheng Ren Zefei Jiang Yongsheng Wang Feng Jin Jin Zhang Qingyuan Zhang Fei Ma Jinli Ma Zhonghua Wang Shusen Wang Xiaojia Wang Shu Wang Haibo Wang Tao Wang Xiang Wang Jing Wang Jia Wang Biyun Wang Li Fu Hongyuan Li Yehui Shi Lu Gan Yunjiang Liu Jian Liu Zhenzhen Liu Qiang Liu Qiang Sun Wenwu Cheng Keda Yu Zhongsheng Tong Xinhong Wu Chuangui Song Jianguo Zhang Jian Zhang Junjie Li Bin Li Man Li Huiping Li Wentao Yang Hongjian Yang Benlong Yang Hong Bu Juping Shen Zhenzhou Shen Yiding Chen Ceshi Chen Da Pang Zhimin Fan Ying Zheng Xiaoli Yu Guangyu Liu Xichun Hu Yiqun Ling Jinhai Tang Yongmei Yin Cuizhi Geng Peng Yuan Yajia Gu Cai Chang Xuchen Cao Yuan Sheng Yuanxi Huang Jian Huang Weijun Peng Xiaohua Zeng Yuntao Xie Ning Liao Committee of Breast Cancer Society,Chinese Anti-Cancer Association | 2022 | Holistic Integrative Oncology2022，1，1： | 0 |
| 19 | Adding a vacuum erection device to regular use of Tadalafil improves penile rehabilitation after posterior urethroplasty显示文摘This study aimed to evaluate whether adding a vacuum erection device(VED)to regular use of Tadalafil could achieve better penile rehabilitation following posterior urethroplasty for pelvic fracture-related urethral injury(PFUI).Altogether,78 PFUI patients with erectile dysfunction(ED)after primary posterior urethroplasty were enrolled and divided into two treatment groups:VED combined with Tadalafil(Group 1,n=36)and Tadalafil only(Group 2,n=42).Changes in penile length,testosterone level,International Index of Erectile Function-5(IIEF-5)questionnaire,Quality of Erection Questionnaire(QEQ),and nocturnal penile tumescence(NPT)testing were used to assess erectile function before and after 6 months of ED treatment.Results showed that the addition of VED to regular use of Tadalafil preserved more penile length statistically(0.4±0.9 vs-0.8±0.7 cm,P<0.01).IIEF-5 score and QEQ score in Group 1 were higher than Group 2(both P<0.05).After treatment,21/36(5&3%)Group 1 patients and 19/42(45.2%)Group 2 patients could complete vaginal penetration.Group 1 patients also had markedly improved testosterone levels(P=0.01).Unexpectedly,there was no significant difference in NPT testing between two therapies.For PFUI patients with ED after posterior urethroplasty,the addition of VED to regular use of Tadalafil could significantly improve their conditions-improving erection and increasing penile length-thus increasing patient satisfaction and confidence in penile rehabilitation. | Dong-Liang Zhang Zhong Chen Fei-Xiang Wang Jiong Zhang Hong Xie Ze-Yu Wang Yu-Bo Gu Qiang Fu Lu-Jie Song | 2019 | Asian Journal of Andrology2019，21，6： | 0 |
| 20 | In-situ study for the elastic structure evolutions of threedimensional Ir-O framework during the oxygen evolution reaction in acid显示文摘Understanding the dynamic structural and chemical evolutions at the catalyst-electrolyte interfaces is crucial for the development of active and stable electrocatalysts.In this work,β-Li_(2)IrO_(3)is employed as a model catalyst for the oxygen evolution reaction(OER).Its elastic three-dimensional Ir-O framework enables us to investigate the Li^(+)cation dissolution-induced structure evolutions and the formation mechanism of amorphous IrO_(x)species.Electrochemical measurements by rotating ring disk electrode(RRDE)reveal that up to 60%of the measured OER current can be ascribed to catalyst degradation.A series of in-situ X-ray diffraction spectroscopy(XRD),X-ray absorption spectroscopy(XAS),and Raman spectroscopy are conducted.Structure vibration is observed with oxidation states of Ir being reduced abnormally during OER at high potentials.It’s hypothesized that the reversible proton intercalations are responsible for the Ir turn-over mechanism.Results of this work demonstrate a stable and elastic iridate structure and reveal the initial catalyst degradation behaviors during OER in acid media. | Jun Qi Xinyu Zhong Huiyan Zeng Chao Wang Zhongfei Liu Jiajun Chen Long Gu Enna Hong Mengxian Li Jiong Li Chunzhen Yang | 2023 | Nano Research2023，16，7： | 0 |
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