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| 1 | Transplantation of UC-MSCs on collagen scaffold activates follicles in dormant ovaries of POF patients with long history of infertility显示文摘Premature ovarian failure(POF) is a refractory disease for clinical treatment with the goal of restoring fertility. In this study,umbilical cord mesenchymal stem cells on a collagen scaffold(collagen/UC-MSCs) can activate primordial follicles in vitro via phosphorylation of FOXO3 a and FOXO1. Transplantation of collagen/UC-MSCs to the ovaries of POF patients rescued overall ovarian function, evidenced by elevated estradiol concentrations, improved follicular development, and increased number of antral follicles. Successful clinical pregnancy was achieved in women with POF after transplantation of collagen/UC-MSCs or UC-MSCs. In summary, collagen/UC-MSC transplantation may provide an effective treatment for POF. | Lijun Ding Guijun Yan Bin Wang Lu Xu Yan Gu Tong Ru Xiaoying Cui Lei Lei Jingyu Liu Xiaoqiang Sheng Bin Wang Chunxue Zhang Yanjun Yang Ruiwei Jiang Jianjun Zhou Na Kong Feifei Lu Huaijun Zhou Yannan Zhao Bing Chen Yali Hu Jianwu Dai Haixiang Sun | 2018 | Science China(Life Sciences)2018，61，12： | 43 |
| 2 | Chang'E-1 Lunar Mission:An Overview and Primary Science Results显示文摘Chang'E-1 is the first lunar mission in China,which was successfully launched on Oct.24th,2007.It was guided to crash on the Moon on March 1,2009,at 52.36°E,1.50°S,in the north of Mare Fecunditatis.The total mission lasted 495 days,exceeding the designed life-span about four months.1.37Terabytes raw data was received from Chang'E-1.It was then processed into 4Terabytes science data at different levels.A series of science results have been achieved by analyzing and applicating these data,especially 'global image of the Moon of China's first lunar exploration mission'.Four scientific goals of Chang'E-1 have been achieved.It provides abundant materials for the research of lunar sciences and cosmochemistry.Meanwhile these results will serve for China's future lunar missions. | Ouyang Ziyuan Li Chunlai Lu Chang Liu Jianzhong Zou Yongliao Zhang Hongbo Jianjun Zuo Wei Su Yah Wen Weibin Bian Wei Zhao Baochang Wang Jianyu Yang Jianfeng Chang Jin Wang Huanyu Zhang Xiaohui Wang Shijin Wang Min Ren Xin Mu Lingli Kong Deqing Wang Xiaoqian Wang Fang Geng Liang Zhang Zhoubin Zheng Lei Zhu Xinying Zheng Yongchun Li Junduo Zou Xiaoduan Xu Chun Shi Shuobiao Gao Yifei Gao Guannan | 2010 | 空间科学学报2010，30，5： | 11 |
| 3 | Efficacy of platinum in advanced triple-negative breast cancer with germline BRCA mutation determined by next generation sequencing显示文摘Objective:To compare the efficacy of platinum-and non-platinum-based regimens as first-line treatment for advanced triple-negative breast cancer(TNBC)and analyze the relationship between their efficacy and BRCA gene status.Methods:Retrospectively analyze clinical data of 220 patients diagnosed pathologically with advanced TNBC and treated at the Department of Breast Oncology,Peking University Cancer Hospital from 2013 to 2018 and evaluate the efficacy of chemotherapy.A total of 114 patients had BRCA1/2 gene tested by next generation sequencing(NGS)using peripheral blood,and we analyzed the correlation between their efficacy and BRCA1/2 gene status.Results:Non-platinum-based chemotherapy(NPCT)was administered to 129 and platinum-based chemotherapy(PBCT)to 91 study patients.The clinical benefit rate(CBR)and median progression-free survival(PFS)were not statistically different between NPCT and PBCT groups.The median overall survival(OS)was 30.0 and 22.5 months for PBCT and NPCT group,respectively[P=0.090,hazard ratios(HR)=0.703].BRCA status was assessed in 114 patients,14 of whom had deleterious germline BRCA1/2(g BRCA)mutations(seven in each group).In PBCT group,the CBR was 85.7%and 35.1%for patients with and without deleterious g BRCA mutations,respectively(P=0.039).The median PFS were 14.9 and 5.3 months and median OS were 26.5 and 15.5 months for patients with and without deleterious g BRCA mutations,respectively(P=0.001,P=0.161,respectively).Patients in PBCT group had significantly greater rates of grade 3-4 anemia(5.5%vs.0%)and thrombocytopenia(8.8%vs.0%),whereas palmar-plantar erythrodysesthesia(12.4%vs.0%)and peripheral neuropathy(8.6%vs.1.1%)occurred more frequently in NPCT group.Conclusions:Platinum-based regimens are more effective in patients with deleterious g BRCA mutations,but no difference in patients without BRCA gene mutations,so non-platinum is an option in patients without BRCA gene mutations considering the toxicity and side effect.And we recommend that patients with advanced TNBC should have BRCA gene test. | Nan Wang Kun Li Wenfa Huang Weiyao Kong Xiaoran Liu Weijie Shi Feng Xie Hanfang Jiang Guohong Song Lijun Di Quanren Wang Jianjun Yu Huiping Li | 2020 | Chinese Journal of Cancer Research2020，32，2： | 7 |
| 4 | Molecular and Physical Mapping of Powdery Mildew Resistance Genes and QTLs in Wheat: A Review显示文摘Wheat powdery mildew(Pm) is a major disease of wheat worldwide. During the past years, numerous studies have been published on molecular mapping of Pm resistance gene(s) in wheat. We summarized the relevant findings of 89 major resistance gene mapping studies and 25 quantitative trait loci(QTL) mapping studies. Major Pm resistance genes and QTLs were found on all wheat chromosomes, but the Pm resistance genes/QTLs were not randomly distributed on each chromosome of wheat. The summarized data showed that the A or B genome has more major Pm resistance genes than the D genome and chromosomes 1A, 2A, 2B, 5B, 5D, 6B, 7A and 7B harbor more major Pm resistance genes than the other chromosomes. For adult plant resistance(APR) genes/QTLs, B genome of wheat harbors more APR genes than A and D genomes, and chromosomes 2A, 4A, 5A, 1B, 2B, 3B, 5B, 6B, 7B, 2D, 5D and 7D harbor more Pm resistance QTLs than the other chromosomes,suggesting that A genome except 1A, 3A and 6A, B genome except 4B, D genome except 1D, 3D, 4D, and 6D play an important role in wheat combating against powdery mildew. Furthermore, Pm resistance genes are derived from wheat and its relatives, which suggested that the resistance sources are diverse and Pm resistance genes are diverse and useful in combating against the powdery mildew isolates. In this review, four APR genes, Pm38/Lr34/Yr18/Sr57, Pm46/Lr67/Yr46/Sr55, Pm?/Lr27/Yr30/Sr2 and Pm39/Lr46/Yr29, are not only resistant to powdery mildew but also effective for rust diseases in the field, indicating that such genes are stable and useful in wheat breeding programmes. The summarized data also provide chromosome locations or linked markers for Pm resistance genes/QTLs. Markers linked to these genes can also be utilized to pyramid diverse Pm resistance genes/QTLs more efficiently by marker-assisted selection. | Jun GUO Cheng LIU Shengnan ZHAI Haosheng LI Aifeng LIU Dungong CHENG Ran HAN Jianjun LIU Lingrang KONG Zhendong ZHAO Jianmin SONG | 2017 | Agricultural Science & Technology2017，18，6： | 5 |
| 5 | Signal characteristics of coal and rock dynamics with micro-seismic monitoring technique显示文摘In this study,differences of signal characteristics between mine shocks and coal and gas outbursts in coal mines were examined with the micro-seismic monitoring technique and time–frequency analysis.The duration of the mine shock is short while the coal and gas outburst lasts longer.The outburst consists of three stages:the pre-shock,secondary shock and main shock stage,respectively.The velocity amplitude of the mine shock is between 10^(-)5and 10^(-3)m/s,which is higher than that of the outburst with the same energy level.In addition,in both cases,the correlation between the velocity amplitude and energy is positive while the correlation between the signal frequency band distribution and energy is negative.The signal frequency band of the high energy mine shock is distributed between 0 and 50 Hz,and the low energy mine shock is between 50 and 100 Hz.The fractal characteristics of mine shocks were studied based on a fractal theory.The box dimensions of high energy mine shocks are lower than the low energy ones,however,the box dimensions of outbursts are higher than that of mine shocks with the same energy level.The higher box dimensions indicate more dangerous dynamic events. | Ding Yanlu Dou Linming Cai Wu Chen Jianjun Kong Yong Su Zhenguo Li Zhenlei | 2016 | International Journal of Mining Science and Technology2016，26，4： | 2 |
| 6 | Mineralized collagen-modified PMMA cement enhances bone integration and reduces fibrous encapsulation in the treatment of lumbar degenerative disc disease显示文摘As a minimally invasive surgery,percutaneous cement discoplasty(PCD)is now contemplated to treat lumbar disc degeneration disease in elder population.Here,we investigated whether the osteogenic mineralized collagen(MC)modified polymethylmethacrylate(PMMA)cement could be a suitable material in PCD surgery.Injectability,hydrophilicity and mechanical properties of the MC-modified PMMA(PMMA-MC)was characterized.The introduction of MC did not change the application and setting time of PMMA and was easy to be handled in minimally invasive operation.Hydrophilicity of PMMA-MC was greatly improved and its elastic modulus was tailored to complement mechanical performance of bone under dynamic stress.Then,PCD surgery in a goat model with induced disc degeneration was performed with implantation of PMMA-MC or PMMA.Three months after implantation,micro-computed tomography analysis revealed a 36.4%higher circumferential contact index between PMMA-MC and bone,as compared to PMMA alone.Histological staining confirmed that the surface of PMMA-MC was in direct contact with new bone,while the PMMA was covered by fibrous tissue.The observed gathering of macrophages around the implant was suspected to be the cause of fibrous encapsulation.Therefore,the interactions of PMMA and PMMA-MC with macrophages were investigated in vitro.We discovered that the addition of MC could hinder the proliferation and fusion of the macrophages.Moreover,expressions of fibroblaststimulating growth factors,insulin-like growth factor,basic fibroblast growth factor and tumor necrosis factor-b were significantly down-regulated in the macrophages cocultured with PMMA-MC.Together,the promoted osteointegration and reduced fibrous tissue formation observed with PMMA-MC material makes it a promising candidate for PCD surgery. | Long Yang Jianjun Kong Zhiye Qiu Tieliang Shang Siyu Chen Rui Zhao Maria Grazia Raucci Xiao Yang Zhanyong Wu | 2020 | Regenerative Biomaterials2020，7，2： | 1 |
| 7 | With Different Structure Ligands Heterogeneous Ziegler-Natta Catalysts for the Preparation of Copolymer of Ethylene and 1-Octene with High Comonomer Incorporation 显示文摘 | Kong Yuan Yi Jianjun Dou Xiuli | 2010 | Polymer2010，51，17： | 1 |
| 8 | Thermal stability and flame-retardancy mechanism of poly(ethylene terephthalate)/boehmite nanocomposites显示文摘 | Jianjun Zhang Quan Ji Ping Zhang Yanzhi Xia Qingshan Kong | 2010 | Polymer Degradation and Stability2010，，7： | 1 |
| 9 | The arsenic removal from molten steel 显示文摘 | Wang JianJun Luo Lingen Kong Hui | 2011 | High Temperature Materials and Processes2011，30，12： | 1 |
| 10 | Physical mechanisms of inactivation of bacillus subtilis spores using cold atmospheric plasmas显示文摘 | Xutao Deng Jianjun Shi Michael G Kong | 2006 | IEEE Trans on Plasma Sci2006，34，4： | 1 |
| 11 | Optimization of heat source side technical scheme of combined heat and water system based on a coal-fired power plant显示文摘Recovering the waste heat(WH)of a power plant can conserve energy and reduce emissions.Scholars have proposed utilizing the WH of power plants in a combined heat and water(CHW)system,which is considered an economical,energy-saving,and environment-friendly way to integrate water and heat supply into long-distance transportation in urban areas of northern China.However,to date,a detailed design of the case on the heat source side of the CHW has not been developed.Therefore,in this study,the heat source side of a CHW system was divided into two cases:a single-generator set and a double-generator set,and both cases were optimized.The parameters of a multi-effect desalination(MED)process were examined;the optimal number of evaporation stages during the MED process was 12,and the optimal heat source temperature during the first stage was 700C.Then,by matching the extraction and exhaust steam flows,the WH of the exhaust steam in the heating season was finally utilized.Further,under each case optimal conditions,energy,exergy,and cost were analyzed.The results showed that the exergy efficiency in the heating season for each case was approximately 50%,whereas that in the non-heating season was approximately 3.5%.The economy and water quality of the single-generator case were better than those of the double-generator case.However,the absorption heat pump required in the single-generator case is difficult to realize because it operates under two working conditions. | Xiaolin Yang Zhaoyang Liu Jiayang Chen Ying Kong Wen Zheng Jianjun Xia | 2022 | Building Simulation2022，15，8： | 1 |
| 12 | With Different Structure Ligands Heterogeneous Ziegler-Natta Catalysts for the Preparation of Copolymer of Ethylene and 1-Octene with High Comonomer Incorporation 显示文摘 | Kong Yuan Yi Jianjun Huang Qigu | 2010 | Polymer2010，51，17： | 1 |
| 13 | Effect and mechanism of surface-coating pozzalanics materials around aggregate on properties and ITZ microstructure of recycled aggregate concrete 显示文摘 | KONG DEYU LEI TING ZHENG JIANJUN | 2010 | Construction Building Materials2010，24，： | 1 |
| 14 | Evaluation of antioxidant activities and total phenolic contents of typical malting barley varieties显示文摘 | Haifeng Zhao Wei Fan Jianjun Dong Jian Lu Jian Chen Lianju Shan Yan Lin Weibao Kong | 2007 | Food Chemistry2007，，1： | 1 |
| 15 | Effect of X-ray irradiation on threshold voltage of AlGaN/GaN HEMTs with p-GaN and MIS Gates显示文摘Commercially available AlGaN/GaN high-electron-mobility transistors(HEMTs)are beginning to enter the public scene froma range of suppliers.Based on previous studies,commercial GaN-based electronics are expected to be tolerant to different types of irradiation in space.To test this assumption,we compared the characteristic electrical curves obtained at different X-ray irradiation doses for GaN HEMT devices manufactured by Infineon and Transphorm.The p-GaN-based device was found to be more robust with a stable threshold voltage,whereas the threshold voltage of the device with ametal-insulator-semiconductor gatewas found to shift first in the negative and then the positive direction.This dynamic phenomenon is caused by the releasing and trapping effects of radiation-induced charges in the dielectric layer and at the interface of irradiated devices.As such,the p-GaNgate-based GaN HEMT provides a promising solution for use as an electric source in space. | Yongle Qi Denggui Wang Jianjun Zhou Kai Zhang Yuechan Kong Suzhen Wu Tangsheng Chen | 2020 | Nanotechnology and Precision Engineering2020，3，4： | 1 |
| 16 | Nanoflake-like cobalt hydroxide/ordered mesoporous carbon composite for electrochemical capacitors显示文摘 | Zhang Jing Kong Lingbin Cai Jianjun | | 0，，11： | 1 |
| 17 | PXR activation impairs hepatic glucose metabolism partly via inhibiting the HNF4α-GLUT2 pathway显示文摘Drug-induced hyperglycemia/diabetes is a global issue. Some drugs induce hyperglycemia by activating the pregnane X receptor(PXR), but the mechanism is unclear. Here, we report that PXR activation induces hyperglycemia by impairing hepatic glucose metabolism due to inhibition of the hepatocyte nuclear factor 4-alpha(HNF4 a)-glucose transporter 2(GLUT2) pathway. The PXR agonists atorvastatin and rifampicin significantly downregulated GLUT2 and HNF4 a expression, and impaired glucose uptake and utilization in HepG2 cells. Overexpression of PXR downregulated GLUT2 and HNF4 a expression, while silencing PXR upregulated HNF4 a and GLUT2 expression.Silencing HNF4 a decreased GLUT2 expression, while overexpressing HNF4 a increased GLUT2 expression and glucose uptake. Silencing PXR or overexpressing HNF4 a reversed the atorvastatininduced decrease in GLUT2 expression and glucose uptake. In human primary hepatocytes, atorvastatin downregulated GLUT2 and HNF4 a mRNA expression, which could be attenuated by silencing PXR. Silencing HNF4 a downregulated GLUT2 mRNA expression. These findings were reproduced with mouse primary hepatocytes. Hnf4 a plasmid increased Slc2 a2 promoter activity. Hnf4 a silencing or pregnenolone-16 a-carbonitrile(PCN) suppressed the Slc2 a2 promoter activity by decreasing HNF4 a recruitment to the Slc2 a2 promoter. Liver-specific Hnf4 a deletion and PCN impaired glucose tolerance and hepatic glucose uptake, and decreased the expression of hepatic HNF4 a and GLUT2. In conclusion, PXR activation impaired hepatic glucose metabolism partly by inhibiting the HNF4 aGLUT2 pathway. These results highlight the molecular mechanisms by which PXR activators induce hyperglycemia/diabetes. | Peihua Liu Ling Jiang Weimin Kong Qiushi Xie Ping Li Xiaonan Liu Jiayi Zhang Ming Liu Zhongjian Wang Liang Zhu Hanyu Yang Ying Zhou Jianjun Zou Xiaodong Liu Li Liu | 2022 | Acta Pharmaceutica Sinica B2022，12，5： | 1 |
| 18 | Effect and mechanism of surface-coating pozzalanics materials around aggregate on properties and ITZ microstructure of recycled aggregate concrete显示文摘 | Kong Deyu Lei Ting Zheng Jianjun | 2010 | Constru Build Mater2010，24，70： | 1 |
| 19 | ENHANCED BLOCK-SPARSE SIGNAL RECOVERY PERFORMANCE VIA TRUNCATED l2\l1-2 MINIMIZATION显示文摘In this paper,we investigate truncated l2\l1-2 minimization and its associated alternating direction method of multipliers(ADMM)algorithm for recovering the block sparse signals.Based on the block restricted isometry property(Block-RIP),a theoretical analysis is presen ted to guarantee the validity of proposed method.Our theore tical resul ts not only show a less error upper bound,but also promote the former recovery condition of truncated l1-2 method for sparse signal recovery.Besides,the algorithm has been compared with some state-of-the-art algorithms and numerical experiments have shown excellent performances on recovering the block sparse signals. | Weichao Kong Jianjun Wang Wendong Wang Feng Zhang | 2020 | Journal of Computational Mathematics2020，38，3： | 0 |
| 20 | Spreading fully at the ice-water interface is required for high ice recrystallization inhibition activity显示文摘Although materials for ice recrystallization inhibition(IRI) are essential for the cryopreservation of cells and tissues, there exists no guiding mechanism for the design of such materials. Therefore, the construction of materials for IRI relies on the try-and-error strategy. Herein, through changing the tacticity of hydroxyl groups on poly(vinyl alcohol)(PVA) backbones with the affinities of PVAs to ice unchanged, we experimentally find IRI activity decreases significantly for isotactic PVA in comparison to that of atactic PVA. Molecular dynamics simulation shows atactic PVA spreads fully at the ice-water interface due to its much stronger interaction with water. This indicates atactic PVA can cover more ice surface and possess a higher IRI activity when the same amount of PVAs are used, which is consistent with the results that PVA can cover the same amount of ice surface more efficiently through experimentally measuring the adsorption of PVAs on the ice surface. A guiding mechanism of high active IRI materials can be obtained: only having affinity to ice is not enough to obtain high IRI activity(i.e., only small amount of materials is required to reduce the size of ice crystals to ca.(35±10)μm), IRI agents must also have high affinity to water, i.e., low interfacial energies, to both ice and water. The former is to guarantee the adsorption of the IRI agent on the ice surface, and the latter is required for the IRI agent to spread sufficiently at the ice-water interface. Therefore, each IRI molecule can effectively block the diffusion of water onto the ice surface, and consequently inhibits the growth of ice. A spreading coefficient of IRI agents is therefore introduced to quantitatively assess the capability of IRI agents to spread at the ice-water interface. | Shenglin Jin Lingkang Yin Bin Kong Shuwang Wu Zhiyuan He Han Xue Zhang Liu Qi Cheng Xin Zhou Jianjun Wang | 2019 | Science China Chemistry2019，62，7： | 0 |
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