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| 1 | Adaptive immune-genetic algorithm for global optimization to multivariable function显示文摘An adaptive immune- genetic algorithm (ALGA) is proposed to avoid premature convergence and guarantee the diversity of the population.Rapid immune response (secondary response),adaptive mutation and density operators in the AIGA are emphatically designed to improve the searching ability,greatly increase the converging speed,and decrease locating the local maxima due to the premature convergence.The simulation results obtained from the global optimization to four multivariable and multi-extreme functions show that AIGA converges rapidly,guarantees the diversity,stability and good searching ability. | Dai Yongshou Li Yuanyuan Wei Lei Wang Junling Zheng Deling | 2007 | Journal of Systems Engineering and Electronics2007，18，3： | 9 |
| 2 | Core-shell fibrous vascular grafts with the nitric oxide releasing property显示文摘Small-diameter vascular grafts with the nitric oxide(NO) releasing property were designed and prepared.Diazeniumdiolated N,N'-dibutyl-1,6-hexanediamine(DBHD/N2O2) was first synthesized as the NO donor and doped into the biocompatible polymer poly(ε-caprolactone)(PCL).The fibrous vascular grafts were fabricated by electrospinning.Despite the reduced platelet adhesion observed on the NO releasing grafts,the cytotoxicity and burst release were apparent,especially at a higher loading level of the NO donor.In order to solve this problem,core-shell structured nanofibers,in which PCL or gelatin is the shell and PCL doped with the NO donor is the core,were fabricated via coaxial electrospinning.The core-shell structure made the NO release more steady and controllable,and the cell compatibility was improved. | ZHANG Lei,WANG Kai,ZHAO Qiang,ZHENG WenTing,WANG ZhiHong,WANG ShuFang & KONG DeLing Key Laboratory of Bioactive Materials,Ministry of Education College of Life Science,Nankai University,Tianjin 300071,China | 2010 | Science China Chemistry2010，53，3： | 6 |
| 3 | Generation and characterization of stable pig pregastrulation epiblast stem cell lines显示文摘Pig epiblast-derived pluripotent stem cells are considered to have great potential and broad prospects for human therapeutic model developme nt and livestock breeding.Despite on going attempts since the 1990s,no stably defined pig epiblast-derived stem cell line has bee n established.Here,guided by in sights from a large-scale sin gle-cell tran scriptome an alysis of pig embryos from embryonic day(E)0 to E14,specifically,the tracing of pluripotency changes during epiblast development,we developed an in vitro culture medium for establishing and maintaining stable pluripotent stem cell lines from pig E10 pregastrulation epiblasts(pgEpiSCs).Enabled by chemical inhibition of WNT-related signaling in combination with growth factors in the FGF/ERK,JAK/STAT3,and Activin/Nodal pathways,pgEpiSCs maintain their pluripotency transcriptome features,similar to those of E10 epiblast cells,and normal karyotypes after more than 240 passages and have the potential to differentiate into three germ layers.Strikingly,ultradeep in situ Hi-C analysis revealed functional impacts of chromatin 3D-spatial associations on the transcriptional regulation of pluripote ncy marker genes in pgEpiSCs.I n practice,we con firmed that pgEpiSCs readily tolerate at least three rounds of successive gene editi ng and gene rated cloned gen e-edited live piglets.Our findings deliver on the long-a nticipated promise of pig pluripote nt stem cells and open new avenues for biological research,animal husbandry,and regenerative biomedicine. | Minglei Zhi Jinying Zhang Qianzi Tang Dawei Yu Shuai Gao Dengfeng Gao Pengliang Liu Jianxiong Guo Tang Hai Jie Gao Suying Cao Zimo Zhao Chongyang Li Xiaogang Weng Mengnan He Tianzhi Chen Yingjie Wang Keren Long Deling Jiao Guanglei Li Jiaman Zhang Yan Liu Yu Lin Daxin Pang Qianqian Zhu Naixin Chen Jingjing Huang Xinze Chen Yixuan Yao Jingcang Yang Zicong Xie Xianya Huang Mengxin Liu Ran Zhang Qiuyan Li Yiliang Miao Jianhui Tian Xingxu Huang Hongsheng Ouyang Bofeng Liu Wei Xie Qi Zhou Zhonghua Liu Caihong Zheng Mingzhou Li Jianyong Han | 2022 | Cell Research2022，32，4： | 3 |
| 4 | A chaos genetic algorithm for optimizing an artificial neural network of predicting silicon content in hot metal显示文摘A genetic algorithm based on the nested intervals chaos search (NICGA) has been given. Because the nested intervalschaos search is introduced into the NICGA to initialize the population and to lead the evolution of the population, the NICGA has theadvantages of decreasing the population size, enhancing the local search ability, and improving the computational efficiency and op-timization precision. In a multi-layer feed forward neural network model for predicting the silicon content in hot metal, the NICGAwas used to optimize the connection weights and threshold values of the neural network to improve the prediction precision. The ap-plication results show that the precision of predicting the silicon content has been increased. | Deling Zheng, Ruixin Liang, Ying Zhou, and Ying WangInformation Engineering School, University of Science and Technology Beijing, Beijing 100083, China | 2003 | Journal of University of Science and Technology Beijing2003，10，2： | 3 |
| 5 | Self-immolative micellar drug delivery:The linker matters显示文摘Redox-responsive polymer-drug conjugate micelles are excellent nanoscale vehicles for self-immolative intracellular drug delivery.To covalently connect the polymer and drug,disulfide-bearing linkers,such as 3,3'-dithiodipropionic acid (DDPA) and 4,4'-dithiodibutyric add (DDBA),are used.In this paper,we report the influence of linker length on the therapeutic outcome of redox-sensitive conjugate micelles.Curcumin was selected as the model drug and it was conjugated to a multivalent methoxy poly(ethylene glycol)-polylysine copolymer with DDPA or DDBA as the linker.The obtained two polymer-curcumin conjugates were amphiphilic and could self-assemble into micelles that have a hydrodynamic diameter less than 100 nm.The loading of curcumin in both micelles was above 20% (w/w).Irrespective of the linker type,micelle disassembly was observed due to the collapse of the disulfide bond in a reducing environment.However,the rate of curcumin release was much faster with the DDBA linker than with the DDPA linker as the side product was a 5-membered ring with a low ring strain.The linker length-induced variation of curcumin release kinetics caused a significant difference in the intracellular drug concentration and a higher cytotoxicity was witnessed in three model cell lines (HeLa,PC3,and 4T1) for the micelles with a DDBA linker compared to those containing a DDPA linker.As expected,this phenomenon was also observed in HeLa tumor-bearing nude mice in vivo.The current work highlights the significance of linker length in engineering redox-responsive on-demand delivery systems. | Xuan Meng Min Gao Jian Deng Di Lu Aiping Fan Dan Ding Deling Kong Zheng Wang Yanjun Zhao | 2018 | Nano Research2018，11，12： | 2 |
| 6 | Non-viral gene carrier mediated short hairpin RNA interference for inhibition of tumor cells growth显示文摘A tumor-targeting gene vector G250mAb-PEI-PEG has been prepared by modification of polyethylenimine (PEI) with polyethyleneglycol (PEG) and G250, a monoclonal antibody against the G250 antigen on tumor cell surface. The transfection efficiency was as high as 70% in G250 positive HeLa cells, whereas the transfection efficiency was relatively low (30%) in normal NIH3T3 cells. A plasmid encoding the short hairpin RNA (shRNA) specific for nucleostemin gene (NS) was efficiently transfected into the HeLa cells with this nonviral gene vector. RNA interference down-regulated the expression of NS gene in HeLa cells, inhibited cells proliferation and induced apoptosis. However, the growth and activity of the NIH3T3 cells were not affected under the same treatment. These results indicate that the reported nonviral gene vector, G250mAb-PEI-PEG, can target and efficiently deliver genes into HeLa cells, and has the potential for the cervical cancer treatment. | DUAN YaJun YANG CuiHong ZHANG ZhenFang LIU JianFeng ZHENG JunNian XU Yong KONG DeLing YU YaoTing | 2009 | Chinese Science Bulletin2009，54，17： | 2 |
| 7 | Synchronization of Digital Chaos in Secure Communication Systems显示文摘The theories of synchronization based on secure communications using digital chaos are presented. A new synchronous method - cycles-interval pulse drive is developed and realized. Experimental results show it is available, and in order to reduce synchronous noise, a method using model references solves the ratio of signal power to noise power, so the secure communication system can he realized. | Geng Zhao, Deling Zheng, ShaojunHuang 1)College of Electric Science and Technology Beijing. Beijing 100070, China 2)Information Engineering School, University of Science and Technology Beijing. Beijing 100083, China | 2001 | Journal of University of Science and Technology Beijing2001，8，4： | 2 |
| 8 | Stabilization of Chaotic Time Series by Proportional Pulse in the System Variable Based on Genetic Algorithm显示文摘The PPSV (Proportional Pulse in the System Variable) algorithm is a convenient method for the stabilization of the chaotic time series. It does not require any previous knowledge of the system. The PPSV method also has a shortcoming, that is, the determination off. is a procedure by trial and error, since it lacks of optimization. In order to overcome the blindness, GA (Genetic Algorithm), a search algorithm based on the mechanics of natural selection and natural genetics, is used to optimize the λi The new method is named as GAPPSV algorithm. The simulation results show that GAPPSV algorithm is very efficient because the control process is short and the steady-state error is small. | Qing Li Deling Zheng Jianlong Zhou(Information Engineering School, University of Science and Technology Beijing, Beijing 100083, China)(Handan iron and Steel Co., Handan 056015, China) | 1999 | International Journal of Minerals,Metallurgy and Materials1999，13，3： | 1 |
| 9 | The Spatial-Domain Encryption of Digital Images Based on High-Dimension Chaotic System显示文摘 | Wang Ying Zheng Deling Ju Lei | 2004 | Proc of the 2004 IEEE Conference on Cybernetics and Intelligent Systems2004，，2： | 1 |
| 10 | Micro-nanofiber composite biomimetic conduits promote long-gap peripheral nerve regeneration in canine models显示文摘Peripheral nerve injuries may result in severe long-gap interruptions that are challenging to repair.Autografting is the gold standard surgical approach for repairing long-gap nerve injuries but can result in prominent donor-site complications.Instead,imitating the native neural microarchitecture using synthetic conduits is expected to offer an alternative strategy for improving nerve regeneration.Here,we designed nerve conduits composed of high-resolution anisotropic microfiber grid-cordes with randomly organized nanofiber sheaths to interrogate the positive effects of these biomimetic structures on peripheral nerve regeneration.Anisotropic microfiber-grids demonstrated the capacity to directionally guide Schwann cells and neurites.Nanofiber sheaths conveyed adequate elasticity and permeability,whilst exhibiting a barrier function against the infiltration of fibroblasts.We then used the composite nerve conduits bridge 30-mm long sciatic nerve defects in canine models.At 12 months post-implant,the morphometric and histological recovery,gait recovery,electrophysiological function,and degree of muscle atrophy were assessed.The newly regenerated nerve tissue that formed within the composite nerve conduits showed restored neurological functions that were superior compared to sheaths-only scaffolds and Neurolac nerve conduit controls.Our findings demonstrate the feasibility of using synthetic biophysical cues to effectively bridge long-gap peripheral nerve injuries and indicates the promising clinical application prospects of biomimetic composite nerve conduits. | Xianhao Dong Yueyue Yang Zheheng Bao Adam C.Midgley Feiyi Li Shuxin Dai Zhuangzhuang Yang Jin Wang Lihua Liu Wenlei Li Yayuan Zheng Siyang Liu Yang Liu Weijian Yu Jun Liu Meng Fan Meifeng Zhu Zhongyang Shen Gu Xiaosong Deling Kong | 2023 | Bioactive Materials2023，，12： | 0 |
| 11 | Functionalization of PCL fibrous membrane with RGD peptide by a naturally occurring condensation reaction显示文摘Poly(e-caprolactone)(PCL)is widely adopted as an ingredient for tissue engineering scaffolds.To improve its cell affinity,in this study,we developed a new method to introduce bioactive RGD peptides onto the surface of PCL via condensation reaction between 2-cyanobenzothiazole(CBT)and D-cysteine.The PCL fibrous membranes were prepared by electrospinning,and RGD functionalization was characterized by fluorescence microscopy,scanning electron microscopy(SEM),X-ray photoelectron spectroscopy(XPS)and water contact angle(WCA).As expected,our results demonstrated the successful RGD immobilization on the surface of PCL.RGD modification improved the hydrophilicity of PCL,changing their WCA from 112.20°to38.35°.Cell adhesion,spreading and proliferation of 3T3fibroblasts were also enhanced.We therefore believe that the methods reported in this study was facile and effective for functional modification of the hydrophobic PCL scaffolds.The moderate reaction conditions are also suitable for covalent immobilization of bioactive molecules onto PCL. | Wenting Zheng Di Guan Yuxin Teng Zhihong Wang Suai Zhang Lianyong Wang Deling Kong Jun Zhang | 2014 | Chinese Science Bulletin2014，59，22： | 0 |
| 12 | Improving Generalization of Fuzzy Neural Network显示文摘Explores the generalization error of fuzzy neural network, analyzes the reason for occurrence and presents the equation of calculating error by the confidence interval approach. In addition, a generalization error transfering(GET) method of improving the generalization error is proposed. The simulation experimental results of heating furnance show that the GET scheme is efficient. | ZHENG Deling LI Qing FANG Wei(Information Engineering School, USTB, Beijing 100083, China) (China National Electronics Imp. &Exp. Beijing Co.) | 1997 | International Journal of Minerals,Metallurgy and Materials1997，11，2： | 0 |
| 13 | Theory,Method and Application of a State Recognition Based on Theory of Evidence显示文摘A new method of state recognition based on the theory of evidence was proposed. By this method, the plausible function which the sample awaiting recognition belongs to each category can be obtained through distance function. For the marginal samples,two or a batch of evidences can be combined and a new plausible function can be obtained by new evidence. Then the categories of samples can be determined according to plausibility function. This method provides a beder reasoning framework. The result proves the rate of recoghition correctness. | Deling Zheng Xinbei Tang Wei Fang (Information Engineering School, University of Science and Technology Beijing, Beijing 100083, China)(Peat Marwick Huazhen CPA Firm, 100020, China) | 1999 | International Journal of Minerals,Metallurgy and Materials1999，13，1： | 0 |
| 14 | An Improved Minimum Distance Method Based on Artificial Neural Networks显示文摘MDM (minimum distance method) is a very popular algorithm in state recognition. But it has a presupposition, that is, the dis- tance within one class must be shorter enough than the distance between classes. When this presupposition is not satisfied, the method is no longer valid. In order to overcome the shortcomings of MOM, an improved minimum distance method (IMDM) based on ANN (ar- tificial neural networks) is presented. The simulation results demonstrate that IMDM has two advantages, that is, the rate of recognition is faster and the accuracy of recognition is higher compared with MDM. | Qing Li, Deling Zheng, Wenbo Meng Yong Tang Information Engineering School, University of Science and Technology Beijing, Beijing 100083, China E-mail: Li_Qing_2001@263.net | 2002 | Journal of University of Science and Technology Beijing2002，9，1： | 0 |
| 15 | Application of Gray Linear Programming in Sintering Mixing Calculation显示文摘The mixing calculation cannot be restrained by the quantity of return mines. In order to solve this problem, a method that the sintering mixing proportion is optimized by gray linear programming is presented based on the gray system theory and optimal theory. By using this method, the quality of sintering mines is improved and the energy consumption is reduced. | Deling Zheng, Zhijiang Zhao, Wei Fang, Tong Fang ( Information Engineering School, University of Science and Technology Beijing, Beijing 100083, China. Tangshan Iron and Steel Group Corp., Tangshan 063000, China Peat Marwick Huazhen CPA Firm, Beijing 10 | 2000 | International Journal of Minerals,Metallurgy and Materials2000，14，4： | 0 |
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