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| 1 | 体内腺相关病毒-常间回文重复序列丛集及其相关蛋白9介导的基因编辑可改善家族性高胆固醇血症的动脉粥样硬化显示文摘低密度脂蛋白受体(low-density lipoprotein receptor,Ldlr)基因突变是家族性高胆固醇血症的主要原因之一,可导致动脉粥样硬化,并具有很高的终生心血管病风险。常间回文重复序列丛集(clustered regularly interspaced short palindromic repeats,CRISPR)/CRISPR相关蛋白9(CRISPR-related protein 9,Cas9)系统是基因编辑纠正基因突变从而改善疾病的有效工具。该研究的目的是通过腺相关病毒(adeno-associated virus,AAV)携带的CRISPR/Cas9系统进行体内体细胞基因编辑,以确定其能否在小鼠模型中治疗由Ldlr突变体引起的家族性高胆固醇血症。 | 刘青(译) 叶鹏(审校) Zhao H Li Y He L Pu W Yu W Li Y Wu YT Xu C Wei Y Ding Q Song BL Huang H Zhou B | 2020 | 中华高血压杂志2020，28，3： | 22 |
| 2 | Exploring an Integrative Therapy for Treating COVID-19:A Randomized Controlled Trial显示文摘Objectives:To develop a new Chinese medicine(CM)-based drug and to evaluate its safety and effect for suppressing acute respiratory distress syndrome(ARDS)in COVID-19 patients.Methods:A putative ARDS-suppressing drug Keguan-1 was first developed and then evaluated by a randomized,controlled two-arm trial.The two arms of the trial consist of a control therapy(alpha interferon inhalation,50(x g twice daily;and lopinavir/ritonavir,400 and 100 mg twice daily,respectively)and a testing therapy(control therapy plus Keguan-119.4 g twice daily)by random number table at 1:1 ratio with 24 cases each group.After 2-week treatment,adverse events,time to fever resolution,ARDS development,and lung injury on newly diagnosed COVID-19 patients were assessed.Results:An analysis of the data from the first 30 participants showed that the control arm and the testing arm did not exhibit any significant differences in terms of adverse events.Based on this result,the study was expanded to include a total of 48 participants(24 cases each arm).The results show that compared with the control arm,the testing arm exhibited a significant improvement in time to fever resolution(P=0.035),and a significant reduction in the development of ARDS(P=0.048).Conclusions:Keguan-1-based integrative therapy was safe and superior to the standard therapy in suppressing the development of ARDS in COVID-19 patients.(Trial registration No.NCT 04251871 at www.clinicaltrials.gov). | WANG Jia-bo WANG Zhong-xia JING Jing ZHAO Peng DONG Jing-hui ZHOU Yong-feng YANG Guang NIU Ming ZHAO Xu JIANG Tian-jun Bl Jing-feng XU Zhe ZHANG Ping WU Dan BAI Zhao-fang GUO Yu-ming YU Si-miao SUN Yong-qiang ZHANG Zi-teng ZHAN Xiao-yan LI Peng-yan DING Jin-biao ZHAO Peng-fei SONG Xue-ai TANG Jian-yuan HE Dong-chu CHEN Zhu QIN En-qiang WANG Rui-lin XIAO Xiao-he | 2020 | Chinese Journal of Integrative Medicine2020，26，9： | 18 |
| 3 | Biomimetic Study on Helical Fiber Composites显示文摘The innovative approach imparting strength and toughness to carbon fiber reinforced polymer composites (CFRP) is put fotward from the viewpoint of biomimetics. Helical fibers produced by twisting fiber bundle are arranged in the matrix to simulate the unique structure of natural fibers.The results on the CFRP with helical fiber bundles show that, under the same state of strong fiber/matrix interface, the impact fracture toughness can be improved substantially compared to conventional composites with plain fibers. The beneficial effect is attributed to the helical fiber bundles which act as single fibers of huge diameter effectively increasing the fIber eIastic energy. | Zhang, K Wang, YQ Zhou, BL | 1998 | Journal of Materials Science & Technology1998，14，1： | 4 |
| 4 | A Model for Liquid-Diffusion Catalytically Grown Fibrous Carbon Material显示文摘A mechanism for the catalytically growth of vapor grown fibrous carbon (VGFC) preparing from the floating catalyst method has been proposed, in which liquid diffusion-determined diffusionof carbon atoms through catalyst particles is described mathematically, and the physical andchemical properties of the catalyst particIes during the growth process are taken into account.From the model the growth rate and grown length of VGFC are calculated theoretically whichcoincides with the experimental datal and the necessity of reducing gas such as hydrogen inpreparing VGFC is explained as to reduce Fe3C, which acts as intermediate catalyst shown bythe model. Fe3C formed on the surface of γ-Fe will stop the growth of carbon fiber if they cannot be reduced at once. Additionally, the growth temperature and diameter of VGFC are alsodiscussed in the paper. | Zhang, WG Cheng, HM Su, G Fan, YY Li, F Shen, ZH Zhou, BL | 1999 | Journal of Materials Science & Technology1999，15，1： | 2 |
| 5 | Frequent loss of chromosome 8p in- hepatitis B virus-positive hepatocellular carcinomas from China 显示文摘 | Becker SA Zhou YZ Slagle BL | 1996 | Cancer Res1996，56，： | 1 |
| 6 | Phenotypic charac- terization of resist ant Va136 variant s of hepatitis C virus NS34A serine protease显示文摘 | Zhou Y Bart els DJ Hanzelka BL etal | 2008 | Antimicroh Agents Chemother2008，52，1： | 1 |
| 7 | Transduced PTD-BDNF fusion protein protects against beta amyloid peptide-induced learning and memory deficits in mice显示文摘 | Zhou JP Feng ZG Yuan BL | 2008 | Brain Res2008，1191，： | 1 |
| 8 | Phenotypic characterization of resistant Val36 variants of hepatitis C virus NS3- 4A serine protease 显示文摘 | Zhou Y Bartels DJ Hanzelka BL | 2008 | Antimicrob Agents Chemother2008，52，1： | 1 |
| 9 | Genetic polymorphisms of XPD and CDA and lung cancer risk显示文摘 | Zhou M Wan HY Gao BL | 2012 | Oncol Lett2012，4，2： | 1 |
| 10 | Pharmacokinetic and pharmacodynamic studies of levonorgestrel-releasing intrauterine device显示文摘 | Xiao BL Zhou LY Zhang XL | 1990 | Contraception1990，41，4： | 1 |
| 11 | Studies of poly( ethylene glycol) modification of HM-3 polypeptides显示文摘 | Zhou K Zhu BL Xu HM | 2010 | Bioconjugate chemistry2010，20，5： | 1 |
| 12 | Chromium(Ⅵ) reduction by hydrogen sulfide in aqueous media: stoichiometry and kinetics显示文摘 | Kim C Zhou QH Deng BL Thornton EC Xu HF | 2001 | Environmental Science and Technology2001，35，11： | 1 |
| 13 | Transduced PTD-BDNF fusion protein protects against beta amyloid peptide-induced learning and memory deficits in mice显示文摘 | Zhou JP Feng ZG Yuan BL | 2008 | Brain Res2008，1191，： | 1 |
| 14 | Prognostic implication of microsatellite alteration profiles in early-stage non-small cell lung cancer显示文摘 | Zhou X Kemp BL Khuri FR | 2000 | Clin Cancer Res2000，6，2： | 1 |
| 15 | Transduced PTD-BDNF fusion protein protects against beta amyloid peptide-induced learning and memory deficits in mice显示文摘 | Zhou JP Feng ZG Yuan BL | 2008 | Brain Res2008，29，1191： | 1 |
| 16 | Deletion of the Ecadherin gene in hepatitis B virus-positive Chinese hepatocellular carcinomas显示文摘 | Slagle BL Zhou YZ Birchmeier W | 1993 | Hepatology1993，18，4： | 1 |
| 17 | Bio-inspired study of structural materials显示文摘 | Zhou BL | 2000 | Materials Science and Engineering C2000，11，： | 1 |
| 18 | Phenotype microarray analysis of Escherichia coli K-12 mutants with deletions of all two-component systems 显示文摘 | Zhou L Lei XH Bochner BR Wanner BL | 2003 | J Bacteriol2003，185，16： | 1 |
| 19 | A large-scale study on the safety and epidemiological efficacy of Japanese encephalitis(JE) live vaccine (SA14-14-2) in the JE endemic areas显示文摘 | Zhou BL Jia LL Xu XL | | Chinese Journal of Epidemiology0，，： | 1 |
| 20 | Protective effects of sodium tanshinone 1I A sulphonate against adriamycin -induced lipid peroxidation in mice hearts in vivo and in vitro显示文摘 | Zhou GY Zhao BL Hou JW | 1999 | Pharmacol Res1999，40，6： | 1 |
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