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| 1 | A critical role of IL-17 in modulating the B-cell response during H5N1 influenza virus infection显示文摘Interleukin-17(IL-17),a member of the IL-17 cytokine family,plays a crucial role in mediating the immune response against extracellular bacteria and fungi in the lung.Although there is increasing evidence that IL-17 is involved in protective immunity against H1 and H3 influenza virus infections,little is known about the role of IL-17 in the highly pathogenic H5N1 influenza virus infection.In this study,we show that H5N1-infected IL-17 knockout(KO)mice exhibit markedly increased weight loss,more pronounced lung immunopathology and significantly reduced survival rates as compared with infected wild-type controls.Moreover,the frequency of B cells in the lung were substantially decreased in IL-17 KO mice after virus infection,which correlated with reduced CXCR5 expression in B cells and decreased CXCL13 production in the lung tissue of IL-17 KO mice.Consistent with this observation,B cells from IL-17 KO mice exhibited a significant reduction in chemokine-mediated migration in culture.Taken together,these findings demonstrate a critical role for IL-17 in mediating the recruitment of B cells to the site of pulmonary influenza virus infection in mice. | Xiaohui Wang Chris CS Chan Min Yang Jun Deng Vincent KM Poon Virtual HC Leung King-Hung Ko Jie Zhou Kwok Yung Yuen Bo-Jian Zheng Liwei Lu | 2011 | Cellular & Molecular Immunology2011，8，6： | 2 |
| 2 | Effect of Si, Al and Bi on Structure and Properties of As-welded and Austempered Ductile Iron Weld Metals during Gas Welding显示文摘Effect of Si, Al and Bi on the microstructure and mechanical properties of as-welded and austempered ductile iron weld metals has been studied with SEM, TEM, X-ray diffraction, image analysing system, tension and other test methods. Results show that increasing weld Si, Al and Bi content favours improving the chilling tendency of as-welded ductile iron weld and mechanical properties of austempered ductile iron weld and the mechanism is also discussed. On this basis the optimum chemical composition of weld is determined. The mechanical properties of weld and welded joint after austempering can match those of austempered ductile | Sun, DQ Zhou, ZF Cao, HC | 1996 | Journal of Materials Science & Technology1996，12，5： | 2 |
| 3 | Risk indicators for early childhood caries in 2-year-old children in southern China显示文摘 | Zhou Y Lin HC Lo EC | 2011 | Aust Dent J2011，56，1： | 1 |
| 4 | Visualization of Threedimensional Temperature Distributions in a Large-scale Furnace Via Regularized Reconstruction From Radiative Energy Images: Numerical Studies 显示文摘 | ZHOU HC HAN SD SHENG E | 2002 | Journal of Quantitative Spectroscopy and Radiative Transfer 722002，，： | 1 |
| 5 | HAb18G/CD147-mediated calcium mobilization and hepatoma metastasis require both C-terminal and N-terminal domains显示文摘 | Jiang JL Chan HC Zhou Q | 2004 | Cell Mol Life Sci2004，61，16： | 1 |
| 6 | Antioxidant properties of polymeric proanthocyanidins from fruit stones and pericarps of Litchi chinensis Soma显示文摘 | Zhou HC Lin YM Li YY | 2011 | Food Res Int2011，44，2： | 1 |
| 7 | Determination of ade-fovir in human plasma by liquid chromatography/tandemmass spectrometry : application to a pharmacokinetic study显示文摘 | Bi HC Zhong GP Zhou S | 2005 | Rapid Commun Mass Spectrom2005，19，20： | 1 |
| 8 | Metal-organic frameworks for sep- arations 显示文摘 | Li JR Sculley J Zhou HC | 2012 | Chemical Reviews2012，112，： | 1 |
| 9 | A New Way to Calculate Radiative Intensity and Solve Radiative Transfer Equation Through Using the Monte Carlo Method 显示文摘 | ZHOU HC CHEN DL CHENG Q | 2004 | J Quant Spectrosc Radiat Transfer2004，83，： | 1 |
| 10 | High expression of periostin is dra- matically associated with metastatic potential and poor prognosis of patients with osteosarcoma 显示文摘 | Hu F Wang W Zhou HC | 2014 | World J Surg Oncol2014，12，： | 1 |
| 11 | An improved algorithm of edge detection based on fuzzy sets显示文摘 | Zhou DL Pan Q Zhang HC | | 0，，04： | 1 |
| 12 | Activation of rat mesenteric arterial KATP channels by 11,12-epoxyeicosatrienoic acid 显示文摘 | Ye D Zhou W Lee HC | 2005 | Am J Physiol Heart Circ Physiol2005，288，1： | 1 |
| 13 | Different regulatory pathways involved in ATP-stimulated chloride secretion in rat epididymal epithelium显示文摘 | Chan HC Zhou WL Fu WO Ko WH Wong PY | | 0，，： | 1 |
| 14 | Antioxidant properties of polymeric proanthocyanidins from fruit stones and pericarps of Litchi chinensis Sonn显示文摘 | HC Zhou YM Lin YY Li | 2011 | Food Research International2011，44，2： | 1 |
| 15 | Activation ofβ2-adrenoceptor enhances synaptic potentiation and behavioral memory via c AMPPKA signaling in the medial prefrontal cortex of rats显示文摘 | Zhou HC Sun YY Cai W | 2013 | Learn Mem2013，20，： | 1 |
| 16 | HAb18G/CD147- mediated calcium mobilization and hepatoma metastasis require both C- terminal and N- terminal domains显示文摘 | Jiang JL Chan HC Zhou Q | 2004 | Cell Mol Life Sci2004，61，16： | 1 |
| 17 | Blockage of voltage-gated K^+ channels inhibits adhesion and proliferation of hepatocarcinoma cells 显示文摘 | Zhou QK WHY Chan HC | 2003 | Tnt J Mol Med2003，11，2： | 1 |
| 18 | Deduction of the two-dimensional dis- tribution of temperature in a cross section of a boiler furnace from images of flame radiation显示文摘 | LOU C ZHOU HC | 2005 | Combustion and Flame2005，143，12： | 1 |
| 19 | Activation of rat mesenteric arterial KATP channels by 11,12-epoxyeicosatrienoic acid 显示文摘 | Ye D Zhou W Lee HC | 2005 | Am J Physiol Heart Circ Physiol2005，288，1： | 1 |
| 20 | HAb18G/CD147 - mediated calcium mobilization and hepatoma metas- tasis require both C- terminal and N- terminal do- mains显示文摘 | Jiang JL Chan HC Zhou Q | 2004 | Cell Mol Life Sci2004，61，16： | 1 |
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