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| 1 | Effects of retinoic acid on proliferation,phenotype and expression of cyclin-dependent kinase inhibitors in TGF-β1-stimulated rat hepatic stellate cells显示文摘AIM To study the molecular mechanisms ofretinoic acid(RA)on proliferation andexpression of cyclin-dependent kinase inhibitors(CKI),i.e.p16,p21 and p27 in cultured rathepatic stellate cells(HSC)stimulated withtransforming growth factor beta 1(TGF-β1).METHODS HSC were isolated from healthy ratlivers and cultured.After stimulated with1 mg/L TGF-β1,subcultured HSC were treatedwith or without 1 nmol/L RA.MTT assay,immunocytochemistry(ICC)for p16,p21,p27and α-smooth muscle actin(α-SMA)protein,insitu hybridization(ISH)for retinoic acidreceptor beta 2(RAR-β2)and p16,p21 and p27mRNA and quantitative image analysis(partially)were performed.RESULTS RA inhibited HSC proliferation(41.50%,P<0.05),decreased the protein levelof α-SMA(55.09%,P<0.05),and induced HSCto express RAR-β2 mRNA.In addition,RAincreased the protein level of p16(218.75%,P<0.05)and induced p21 protein expression;meanwhile,p27 was undetectable by ICC in bothcontrol and RA-treated HSC.However,RA hadno influence on the mRNA levels of p16,p21 orp27 as determined by ISH.CONCLISION Up-regulation of p16 and p21 on post-transcriptional level may contribule, in part to RA inhibition of TGF-β1-initiated rat HSC activation in vitro. | Guang Cun Huang Jin Sheng Zhang Yue E Zhang Department of Pathology School of Basic Medical Sciences,Fudan University.Shanghai 200032,China | 2000 | World Journal of Gastroenterology2000，6，6： | 23 |
| 2 | Intelligent transportation systems for smart cities:a progress review显示文摘To better meet the challenge of providing effective,low-cost,energy efficient transport services,the concept of intelligent transport systems(ITS) has been proposed and lauded as an innovative and promising solution for next generation transport networks.In this paper,the progress of ITS research around the world is briefly reviewed and current challenges are outlined,thereby offering further insight into ITS development for all researchers in this area. | XIONG Zhang SHENG Hao RONG WenGe COOPER Dave E | 2012 | Science China(Information Sciences)2012，55，12： | 16 |
| 3 | 脑卒中后痉挛的病理生理机制新见解显示文摘本文英文原题为Newinsightsintothepathophysiolo—gYofpost—strokespasticity,已发表在FrontiersinHumanNeuro-science杂志2015年第4期。经原首发期刊及通信作者李胜(ShengLi)授权,由中南大学湘雅三医院康复医学科李旭红和候巧翻译成中文在我刊发表。 | Sheng Li Gerard E Francisco 李旭红 侯巧 李胜 郭敏 | 2018 | 中华物理医学与康复杂志2018，40，1： | 8 |
| 4 | Dasycarine, a New Quinoline Alkaloid from Dictamnus dasycarpus显示文摘Dasycarine, a new quinoline alkaloid along with five known compounds, dictamine, dihydroobacunone, obacunone, fraxinellone and β-sitosterol, were isolated from Dictamnus dasycarpus. The structure of dasycarine was identified as 4, 5, 8- trimethoxyl -3- (3- methyl -2- butenyl)- 2- quinone by 1D and 2D NMR techniques. | Jin CHEN Jing Sheng TANG Jun TIAN You Ping WANG Feng E WU | 2000 | Chinese Chemical Letters2000，11，8： | 7 |
| 5 | Botulinum toxin injection improved voluntary motor control in selected patients with post-stroke spasticity显示文摘The effect of botulinum toxin type A injection on voluntary grip control was examined in a 53-year-old female, who sustained a hemorrhagic right middle cerebral artery stroke 3 years previously, which resulted in finger flexor spasticity and residual weak finger/wrist extension. The patient received 50 units of botulinum toxin type A injection each to the motor points (2 sites/muscle) of the left flexor digitorum superficialis and flexor digitorum profundus, respectively. Botulinum toxin injection led to weakness and tone reduction in the spastic finger flexors, but improved grip release time in grip initiation/release reaction time tasks. Improved release time was accompanied by shortened extensor electromyography activity, and improved release time likely correlated with blocked co-contraction of finger flexors during voluntary finger extension. This case report demonstrated that botulinum toxin injection improved voluntary motor control of the hand in a chronic stroke patient with residual finger extension. | Shuo-Hsiu Chang Gerald E Francisco Sheng Li | 2012 | Neural Regeneration Research2012，7，18： | 7 |
| 6 | Pore throat characteristics of tight sandstone of Yanchang Formation in eastern Gansu,Ordos Basin显示文摘An important factor to evaluate reservoir quality is the pore-throat size.However,the strong heterogeneity makes it difficult to characterize the pore-throat distribution in tight reservoirs.The field emission scanning electron microscope(FESEM),high pressure mercury injection and rate-controlled mercury injection are used to investigate the pore-throat size distribution in tight sandstone reservoirs of Member 7 of the Yanchang Formation in eastern Gansu,Ordos Basin,and studies of the pore throat size controlling on physical property of the tight sandstone reservoirs are also carried out.The result shows that the pore type is mainly dominated by the residual intergranular pore,dissolution pore,micropore and a few micro-fractures;the high-pressure mercury injection experiment indicates that the pore-throat size ranges from 0.0148 μm to 40mm,the pore throat more than 1 mm is less;the ratecontrolled mercury injection experiment reveals that for samples with different physical properties,the pore radius mainly varies from 80 μm to 350 μm;the throat radius exhibits the strong heterogeneity,and is from 0.12 μm to 30μm;the pore-throat size can be effectively characterized by combination of high-pressure and rate-controlled mercury injections,and it varies from 0.0148 μm to 350 μm.The permeability is mainly controlled by the large pore throat(>R_(50))which accounts for a small proportion;in the tight sandstone with the permeability greater than 0.1 mD,the permeability is mainly controlled by the micropore and mesopore;in the tight sandstone with the permeability smaller than 0.1 mD,the permeability is mainly controlled by the nanopore and micropore;the proportion of small pore throat increases with reduction of permeability,it is important that the small pore throat influences the reservoir storage property though its effect on permeability are small. | Hao Wu Chunlin Zhang Youliang Ji Rui'e Liu Shang Cao Sheng Chen Yunzhao Zhang Ye Wang Wei Du Gang Liu | 2018 | Petroleum Research2018，3，1： | 7 |
| 7 | CCAR1 5' UTR as a natural miRancer of miR-1254 overrides tamoxifen resistance显示文摘 | Gaopeng Li Xiaoli Wu Wenchang Qian Huayong Cai Xinbao Sun Weijie Zhang Sheng Tan Zhengsheng Wu Pengxu Qian Keshuo Ding Xuefei Lu Xiao Zhang Hong Yan Haifeng Song Shouhong Guang Qingfa Wu Peter E Lobie Ge Shan Tao Zhu | 2016 | Cell Research2016，26，6： | 3 |
| 8 | A multistep attachment process:Transformation of titanate nanotubes into nanoribbons显示文摘The mechanism of the conversion of titanate nanotubes into nanoribbons is of considerable interest.The details of the transformation processes involved when nanoribbons are produced from a P25 TiO 2 powder precursor by alkaline hydrothermal treatment have been investigated systematically by transmission electron microscopy.A multistep attachment model is proposed for the growth at the early stage of coarsening.The treatment duration has a strong effect on the change in product morphology from hollow nanotubes into nanoribbons,since the nanotubes cannot retain their morphology in the strong alkaline solution for extended periods of time.Most of the nanotubes were etched and dissolved,providing the nutrients for subsequent nanoribbon growth.Some stable nanotubes grew spirally internally to form nanowires or became connected together to form rafts which acted as the grains for nanoribbon growth.With increasing hydrothermal time,a large number of nanotubes and other fragments became attached to the grains which began to grow larger and eventually formed the nanoribbons,in a process in which the stepped faces and kinked faces became fused and were eliminated while the flat faces were retained in the nanoribbon morphology. | SHENG Jiang HU LinHua MO Li'E LI WenXin TIAN HuaJun DAI SongYuan | 2012 | Science China Chemistry2012，55，3： | 2 |
| 9 | Enhanced removal of uranium(V I)b y nanoscale zerovalent iron supported onNa - bentonite and an investigation of mechanism显示文摘 | Sheng G Shao X L i Y e t a l | 2014 | The Journal of Physical Chemistry A2014，118，16： | 1 |
| 10 | Computation of scattering from anisotropically coated bodies using con- formal FDTD 显示文摘 | ZHENG H X SHENG X Q YUNG E K N | 2002 | Progress In Electromagnetics Re- search2002，35，： | 1 |
| 11 | Effect of additives in electrolyte on characteristic of ceramic coatings formed by micro-are oxidation显示文摘 | Wang Y K Sheng L Xiang R E | 1999 | Surface Engineering1999，15，2： | 1 |
| 12 | Solid-state alloying in nano- structured binary systems with positive heat of mixing显示文摘 | MA E SHENG H W He J H | 2000 | Mate- rials Science and Engineering: A2000，286，： | 1 |
| 13 | Spacer prostheses in two-stage revision of infected knee arthroplasty显示文摘 | Jamsen E Sheng P Halonen P | 2006 | Int Orthop2006，30，4： | 1 |
| 14 | A packing generation scheme for the granular assemblies with 3D ellipsoidal particles显示文摘 | WANG C Y WANG C E SHENG J | 1999 | International Journal for Numerical and Analytical Methods in Geomechanics1999，23，： | 1 |
| 15 | Visualization of Threedimensional Temperature Distributions in a Large-scale Furnace Via Regularized Reconstruction From Radiative Energy Images: Numerical Studies 显示文摘 | ZHOU HC HAN SD SHENG E | 2002 | Journal of Quantitative Spectroscopy and Radiative Transfer 722002，，： | 1 |
| 16 | The degradation of optical properties in a sulfuric acid anodized aluminum coating system exposed to vacuum or vacuum-ultraviolet radiation显示文摘 | Sheng X Y Callahan D L Barrera E V | 1997 | Materials and Manufacturing Process1997，12，2： | 1 |
| 17 | 查看详情显示文摘 | Xu Z Sheng L Xing D Y Prodan E Sheng D N | | 0，，： | 1 |
| 18 | Maspin suppresses the invasire phenotype of human breast carcinoma显示文摘 | Seftor R E Seftor E A Sheng S | 1998 | Cancer Res1998，58，： | 1 |
| 19 | Fluctuationinduced tunneling conduction in carbon-polyvinylchloride composites 显示文摘 | Sichel E K Gittleman J I | 1978 | Physical Review Letters1978，，18： | 1 |
| 20 | Assessment of photosensitizer dosimetry and tissue damage assay for photodynamic therapy in advanced-stage tumors显示文摘 | Sheng C Pogue BW Wang E | 2004 | Photochem Photobiol2004，79，6： | 1 |
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