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| 1 | Antisense MMP-9 RNA inhibits malignant glioma cell growth in vitro and in vivo显示文摘The matrix-degrading metalloproteinases (MMPs), particularly MMP-9, play important roles in the pathogenesis and development of malignant gliomas. In the present study, the oncogenic role of MMP-9 in malignant glioma cells was investigated via antisense RNA blockade in vitro and in vivo. TJ905 malignant glioma cells were transfected with pcDNA3.0 vector expressing antisense MMP-9 RNA (pcDNA-AS-MMP9), which significantly decreased MMP-9 expression, and cell proliferation was assessed. For in vivo studies, U251 cells, a human malignant glioma cell line, were implanted subcutaneously into 4-to 6-week-old BALB/c nude mice. The mice bearing well-established U251 gliomas were treated with intratumoral pcDNA-AS-MMP9-Lipofectamine complex (AS-MMP-9-treated group), subcutaneous injection of endostatin (endostatin-treated group), or both (combined therapy group). Mice treated with pcDNA (empty vector)-Lipofectamine served as the control group. Four or eight weeks later, the volume and weight of tumor, MMP-9 expression, microvessel density and proliferative activity were assayed. We demonstrate that pcDNA-AS-MMP9 significantly decreased MMP-9 expression and inhibited glioma cell proliferation. Volume and weight of tumor, MMP-9 expression, microvessel density and proliferative activity in the antisense-MMP-9-treated and therapeutic alliance groups were significantly lower than those in the control group. The results suggest that MMP-9 not only promotes malignant glioma cell invasiveness, but also affects tumor cell proliferation. Blocking the expression of MMP-9 with antisense RNA substantially suppresses the malignant phenotype of glioma cells, and thus can be used as an effective therapeutic strategy for malignant gliomas. | Cuiyun Sun Qian Wang Hongxu Zhou Shizhu Yu Alain R. Simard Chunsheng Kang Yanyan Li Yanling Kong Tongling An Yanjun Wen Fudong Shi Junwei Hao | 2013 | Neuroscience Bulletin2013，29，1： | 14 |
| 2 | Building a Cloud-Based Energy Storage System through Digital Transformation of Distributed Backup Battery in Mobile Base Stations显示文摘Battery energy storage systems(ESS) have been widely used in mobile base stations(BS) as the main backup power source. Due to the large number of base stations, massive distributed ESSs have largely stayed in idle and very difficult to achieve high asset utilization. In recent years, the fast-paced development of digital energy storage(DES) technology has revolutionized the traditional operation and maintenance of ESSs by transforming them into digital assets, further enabling battery energy storage services, raising up a new way to achieve a much higher utilization of such kind of largely idle ESS resources. In this paper, the disruptive DES technology will be introduced and its application under the context of mobile BSs will be studied, and then a cloud-based energy storage(CES) platform is proposed based on a large scale distributed DESs to provide a new cyber-enabled energy storage service to the local utility company. A real-world case study shows the effectiveness and efficiency of the CES platform. | Song Ci Yanglin Zhou Yuan Xu Xingjian Diao Junwei Wang | 2020 | China Communications2020，17，4： | 10 |
| 3 | Efficient spectral regulation in Ce:Lu_(3)(Al,Cr)_(5)O_(12) and Ce:Lu_(3)(Al,Cr)_(5)O_(12)/Ce:Y_(3)Al_(5)O_(12) transparent ceramics with high color rendering index for high-power white LEDs/LDs显示文摘Realizing a high color rendering index(CRI)in Ce:LuAG transparent ceramics(TCs)with desired thermal stability is essential to their applications in white LEDs/LDs as color converters.In this study,based on the scheme of configuring the red component by Cr^(3+) doping,an efficient spectral regulation was realized in Ce,Cr:LuAG TCs.A unilateral shift phenomenon could be observed in both photoluminescence(PL)and photoluminescence excitation(PLE)spectra of TCs.By constructing TC-based white LED/LD devices in a remote excitation mode,luminescence properties of Ce,Cr:LuAG TCs were systematically investigated.The CRI values of Ce:LuAG TC based white LEDs could be increased by a magnitude of 46.2%.Particularly,by combining the as fabricated Ce,Cr:LuAG TCs with a 0.5 at% Ce:YAG TC,surprising CRI values of 88 and 85.5 were obtained in TC based white LEDs and LDs,respectively.Therefore,Ce,Cr:LuAG TC is a highly promising color convertor for high-power white LEDs/LDs applied in general lighting and displaying. | Tianyuan ZHOU Chen HOU Le ZHANG Yuelong MA Jian KANG Tao LI Rui WANG Jin HUANG Junwei LI Haidong REN Zhenxiao FU Farida ASELIM Ming LI Hao CHEN | 2021 | Journal of Advanced Ceramics2021，10，5： | 7 |
| 4 | Ambient volatile organic compounds at a receptor site in the Pearl River Delta region:Variations,source apportionment and effects on ozone formation显示文摘We present the continuously measurements of volatile organic compounds(VOCs)at a receptor site(Wan Qing Sha,WQS)in the Pearl River Delta(PRD)region from September to November of 2017.The average mixing ratios of total VOCs(TVOCs)was 36.3±27.9 ppbv with the dominant contribution from alkanes(55.5%),followed by aromatics(33.3%).The diurnal variation of TVOCs showed a strong photochemical consumption during daytime,resulting in the formation of ozone(O_(3)).Five VOC sources were resolved by the positive matrix factorization(PMF)model,including solvent usage(28.6%),liquid petroleum gas(LPG)usage(24.4%),vehicle exhaust(21.0%),industrial emissions(13.2%)and gasoline evaporation(12.9%).The regional transport air masses from the upwind cities of south China can result in the elevated concentrations of TVOCs.Low ratios of TVOCs/NO_(x)(1.53±0.88)suggested that the O_(3) formation regime at WQS site was VOC-limited,which also confirmed by a photochemical box model with the master chemical mechanism(PBM-MCM).Furthermore,the observation on high-O_(3) episode days revealed that frequent O_(3) outbreaks at WQS were mainly caused by the regional transport of anthropogenic VOCs especially for aromatics and the subsequent photochemical reactions.This study provides valuable information for policymakers to propose the effective control strategies on photochemical pollution in a regional perspective. | Yao Meng Junwei Song Lewei Zeng Yingyi Zhang Yan Zhao Xufei Liu Hai Guo Liuju Zhong Yubo Ou Yan Zhou Tao Zhang Dingli Yue Senchao Lai | 2022 | Journal of Environmental Sciences2022，34，1： | 5 |
| 5 | Two-Stage Resource Allocation Scheme for Three-Tier Ultra-Dense Network显示文摘In 5 G Ultra-dense Network(UDN), resource allocation is an efficient method to manage inter-small-cell interference. In this paper, a two-stage resource allocation scheme is proposed to supervise interference and resource allocation while establishing a realistic scenario of three-tier heterogeneous network architecture. The scheme consists of two stages: in stage I, a two-level sub-channel allocation algorithm and a power control method based on the logarithmic function are applied to allocate resource for Macrocell and Picocells, guaranteeing the minimum system capacity by considering the power limitation and interference coordination; in stage II, an interference management approach based on K-means clustering is introduced to divide Femtocells into different clusters. Then, a prior sub-channel allocation algorithm is employed for Femtocells in diverse clusters to mitigate the interference and promote system performance. Simulation results show that the proposed scheme contributes to the enhancement of system throughput and spectrum efficiency while ensuring the system energy efficiency. | Junwei Huang Pengguang Zhou Kai Luo Zhiming Yang Gongcheng He | 2017 | China Communications2017，14，10： | 5 |
| 6 | A Facial Expression Emotion Recognition Based Human-robot Interaction System显示文摘A facial expression emotion recognition based human-robot interaction(FEER-HRI) system is proposed, for which a four-layer system framework is designed. The FEERHRI system enables the robots not only to recognize human emotions, but also to generate facial expression for adapting to human emotions. A facial emotion recognition method based on2D-Gabor, uniform local binary pattern(LBP) operator, and multiclass extreme learning machine(ELM) classifier is presented,which is applied to real-time facial expression recognition for robots. Facial expressions of robots are represented by simple cartoon symbols and displayed by a LED screen equipped in the robots, which can be easily understood by human. Four scenarios,i.e., guiding, entertainment, home service and scene simulation are performed in the human-robot interaction experiment, in which smooth communication is realized by facial expression recognition of humans and facial expression generation of robots within 2 seconds. As a few prospective applications, the FEERHRI system can be applied in home service, smart home, safe driving, and so on. | Zhentao Liu Min Wu Weihua Cao Luefeng Chen Jianping Xu Ri Zhang Mengtian Zhou Junwei Mao | 2017 | IEEE/CAA Journal of Automatica Sinica2017，4，4： | 5 |
| 7 | Photonic matrix multiplication lights up photonicaccelerator and beyond显示文摘Matrix computation,as a fundamental building block of information processing in science and technology,contributes most of the computational overheads in modern signal processing and artificial intelligence algorithms.Photonic accelerators are designed to accelerate specific categories of computing in the optical domain,especially matrix multiplication,to address the growing demand for computing resources and capacity.Photonic matrix multiplication has much potential to expand the domain of telecommunication,and artificial intelligence benefiting from its superior performance.Recent research in photonic matrix multiplication has flourished and may provide opportunities to develop applications that are unachievable at present by conventional electronic processors.In this review,we first introduce the methods of photonic matrix multiplication,mainly including the plane light conversion method,Mach–Zehnder interferometer method and wavelength division multiplexing method.We also summarize the developmental milestones of photonic matrix multiplication and the related applications.Then,we review their detailed advances in applications to optical signal processing and artificial neural networks in recent years.Finally,we comment on the challenges and perspectives of photonic matrix multiplication and photonic acceleration. | Hailong Zhou Jianji Dong Junwei Cheng Wenchan Dong Chaoran Huang Yichen Shen Qiming Zhang Min Gu Chao Qian Hongsheng Chen Zhichao Ruan Xinliang Zhang | 2022 | Light(Science & Applications)2022，11，2： | 4 |
| 8 | Meltblown fabric vs nanofiber membrane, which is better for fabricating personal protective equipments显示文摘The coronavirus disease 2019(COVID-19)pandemic has led to a great demand on the personal protection products such as reusable masks.As a key raw material for masks,meltblown fabrics play an important role in rejection of aerosols.However,the electrostatic dominated aerosol rejection mechanism of meltblown fabrics prevents the mask from maintaining the desired protective effect after the static charge degradation.Herein,novel reusable masks with high aerosols rejection efficiency were fabricated by the introduction of spider-web bionic nanofiber membrane(nano cobweb-biomimetic membrane).The reuse stability of meltblown and nanofiber membrane mask was separately evaluated by infiltrating water,75%alcohol solution,and exposing under ultraviolet(UV)light.After the water immersion test,the filtration efficiency of meltblown mask was decreased to about 79%,while the nanofiber membrane was maintained at 99%.The same phenomenon could be observed after the 75%alcohol treatment,a high filtration efficiency of 99%was maintained in nanofiber membrane,but obvious negative effect was observed in meltblown mask,which decreased to about 50%.In addition,after long-term expose under UV light,no filtration efficiency decrease was observed in nanofiber membrane,which provide a suitable way to disinfect the potential carried virus.This work successfully achieved the daily disinfection and reuse of masks,which effectively alleviate the shortage of masks during this special period. | Junwei Wu Hongjia Zhou Jingyi Zhou Xiao Zhu Bowen Zhang Shasha Feng Zhaoxiang Zhong Lingxue Kong Weihong Xing | 2021 | Chinese Journal of Chemical Engineering2021，34，8： | 4 |
| 9 | eGPS 1.0: comprehensive software for multi-omic and evolutionary analyses显示文摘It has become increasingly challenging for researchers to analyze the exponentially expanding amount of multi-omic data.Here,we describe multi-functional software named evolutionary GenotypePhenotype Systems(eGPS)that enables users to perform comprehensive multiomic and evolutionary analyses.The eGPS combines the power of cloud computing and the advantage of desktop application,has a user-friendly graphic interface and is highly interactive. | Dalang Yu Lili Dong Fangqi Yan Hailong Mu Bixia Tang Xiao Yang Tao Zeng Qing Zhou Feng Gao Zhonghuang Wang Ziqian Hao Hongen Kang Yi Zheng Hongwei Huang Yuzhang Wei Wei Pan Yaochen Xu Junwei Zhu Shilei Zhao Ciran Wang Pengyu Wang Long Dai Mushan Li Li Lan Yiwei Wang Hua Chen Yi-Xue Li Yun-Xin Fu Zhen Shao Yiming Bao Fangqing Zhao Luo-Nan Chen Guo-Qing Zhang Wenming Zhao Haipeng Li | 2019 | National Science Review2019，6，5： | 4 |
| 10 | Distributed Energy Sharing in Energy Internet Through Distributed Averaging显示文摘This paper proposes a distributed averaging iteration algorithm for energy sharing in microgrids of Energy Internet based on common gossip algorithms. This algorithm is completely distributed and only requires communications between neighbors. Through this algorithm, the Energy Internet not only allocates the energy effectively based on the load condition of grids, but also reasonably schedules the energy transmitted between neighboring grids. This study applies theoretical analysis to discuss the condition in which this algorithm can finally reach supply-and-demand balance. Subsequently, the related simulation validates the performance of the algorithm under various conditions. | Yangyang Ming Jie Yang Junwei Cao Ziqiang Zhou Chunxiao Xing | 2018 | Tsinghua Science and Technology2018，23，3： | 3 |
| 11 | Dual-wavelength in-line digital holography with untrained deep neural networks显示文摘Dual-wavelength in-line digital holography(DIDH)is one of the popular methods for quantitative phase imaging of objects with non-contact and high-accuracy features.Two technical challenges in the reconstruction of these objects include suppressing the amplified noise and the twin-image that respectively originate from the phase difference and the phase-conjugated wavefronts.In contrast to the conventional methods,the deep learning network has become a powerful tool for estimating phase information in DIDH with the assistance of noise suppressing or twin-image removing ability.However,most of the current deep learning-based methods rely on supervised learning and training instances,thereby resulting in weakness when it comes to applying this training to practical imaging settings.In this paper,a new DIDH network(DIDH-Net)is proposed,which encapsulates the prior image information and the physical imaging process in an untrained deep neural network.The DIDHNet can effectively suppress the amplified noise and the twin-image of the DIDH simultaneously by automatically adjusting the weights of the network.The obtained results demonstrate that the proposed method with robust phase reconstruction is well suited to improve the imaging performance of DIDH. | CHEN BAI TONG PENG JUNWEI MIN RUNZE LI YUAN ZHOU BAOLI YAO | 2021 | Photonics Research2021，9，12： | 3 |
| 12 | Study on the Influence of Airgun Excitation Conditions on Airgun Signals and Travel Time Variation Measurements显示文摘Because of the different excitation conditions of the airgun source,there will be subtle differences in airgun signals.Travel time variation of airgun signals often mix into source information which can’t fully reflect the evolution of the medium.This article uses the airgun signals from the Binchuan Transmitting Seismic Station to analyze the airgun signal′s characteristics of phase and correlation.We conducted a comparative analysis of the effects of the pair difference method and the deconvolution method on eliminating the influence of the excitation conditions in travel time variation.The results show that:(1)The pressure pulse and its subsequent wave of airgun source wavelet are less affected by excitation conditions that we can use it to obtain high-precision excitation moments.(2)Deconvolution can improve the correlation of the airgun signal.(3)The pair difference method can’t eliminate the influence of excitation conditions in travel time variation.Deconvolution can reduce excitation condition interference and the influence of the excitation condition in the travel time variation after deconvolution of the vertical signal is significantly reduced. | XIANG Ya YANG Runhai WANG Bin ZHOU Yunyao LU Yongqing WU Huan QI Junwei PENG Jing | 2019 | Earthquake Research in China2019，33，2： | 3 |
| 13 | Key point selection in large-scale FBG temperature sensors for thermal error modeling of heavy-duty CNC machine tools显示文摘Thermal error is one of the main factors that influence the machining accuracy of computer numerical control(CNC)machine tools.It is usually reduced by thermal error compensation.Temperature field monitoring and key temperature measurement point(TMP)selection are the bases of thermal error modeling and compensation for CNC machine tools.Compared with small-and medium-sized CNC machine tools,heavy-duty CNC machine tools require the use of more temperature sensors to measure their temperature comprehensively because of their larger size and more complex heat sources.However,the presence of many TMPs counteracts the movement of CNC machine tools due to sensor cables,and too many temperature variables may adversely influence thermal error modeling.Novel temperature sensors based on fiber Bragg grating(FBG)are developed in this study.A total of 128 FBG temperature sensors that are connected in series through a thin optical fiber are mounted on a heavy-duty CNC machine tool to monitor its temperature field.Key TMPs are selected using these large-scale FBG temperature sensors by using the density-based spatial clustering of applications with noise algorithm to reduce the calculation workload and avoid problems in the coupling of TMPs for thermal error modeling.Back propagation neural network thermal error prediction models are established to verify the performance of the proposed TMP selection method.Results show that the number of TMPs is reduced from 128 to 5,and the developed model demonstrates good prediction effects and strong robustness under different working conditions of the heavy-duty CNC machine tool. | Jianmin HU Zude ZHOU Quan LIU Ping LOU Junwei YAN Ruiya LI | 2019 | Frontiers of Mechanical Engineering2019，14，4： | 2 |
| 14 | Effects of injection frequency on the rotor stall margin显示文摘The stall margin of compressor could be improved effectively by rotor tip injection,and the periodic injection is commonly used in the research.The purpose of this work is to investigate the influence of injection frequency on the rotor stall margin.An unsteady CFD code was employed to simulate the flow field of the rotor with injections of different frequencies.Comparing the stall margin of the rotor with injections of different frequencies,it is shown that there is an optimal injection frequency,around which the rotor stability enhancement is the largest.When the injection frequency is away form the optimal frequency,the improvement in stable flow range decreases correspondingly.For the rotor in this paper,the optimal frequency was 1.5 times the frequency of tip leakage vortex(for short,TLV) fluctuation.Time-averaged loading distribution at 98.5% span indicates that the loading of the rotor near the leading edge is decreased through injection with the optimal frequency,and therefore,the stall could be delayed. | ZHOU JunWei,HOU AnPing & ZHOU Sheng National Key Laboratory on Aero-Engines,Beijing University of Aeronautics and Astronautics,Beijing 100191,China | 2010 | Science China(Technological Sciences)2010，53，1： | 2 |
| 15 | Abemaciclib induces apoptosis in cardiomyocytes by activating the Hippo signaling pathway显示文摘Abemaciclib is the newest cyclin-dependent kinase 4/6 inhibitor that has received approval from the US Food and Drug Administration for using in patients with advanced breast cancer. However, its potential adverse effects on cardiomyocytes remain unknown. In this study, we used the cell counting kit-8 assay, western blot analysis, flow cytometry, immunostaining, and quantitative polymerase chain reaction to investigate the role of abemaciclib in inducing apoptosis and in inhibiting the viability and proliferation of AC16 human cardiomyocyte cells. The results revealed that abemaciclib induced apoptosis and inhibited cell proliferation by activating the Hippo signaling pathway. This work demonstrates the molecular basis by which abemaciclib induces cardiac side effects, providing a theoretical basis and effective targets for the treatment of cardiac diseases. | Yajie Zhou Yanfei Li Junwei Shen Jue Li Xinming Li | 2020 | Acta Biochimica et Biophysica Sinica2020，52，8： | 2 |
| 16 | A ratiometric near-infrared naphthalimide-based fluorescent probe with high sensitivity for detecting Fe^(2+)in vivo显示文摘Iron is one of the essential trace elements in the human body.It plays an important role in human biology and pathology.Deregulation of iron levels in cells is associated with disease development.In this work,we synthesized a novel near-infrared intramolecular charge transfer(ICT)based ratiometric fluorescent probe to detect Fe^(2+),by using naphthalimide and indole moieties as building blocks.Our work showed that the radiometric probe has excellent selectivity,sensitivity and rapid response.Moreover,we could successfully perform real-time monitoring of Fe^(2+) in He La cells and C.elegans. | Lina Huang Yu Chen Yuqiang Zhao Yumin Wang Junwei Xiong Junfeng Zhang Xianghua Wu Ying Zhou | 2020 | Chinese Chemical Letters2020，31，11： | 2 |
| 17 | New cooling regulation technology of secondary cooling station in DCS显示文摘 | Zhou Xuan Yan Junwei Zhu Dongsheng | 2008 | Energy and Buildings2008，40，10： | 1 |
| 18 | Olyaniline?grafted graphene hybrid with amide groups and its usein su- percapacitors显示文摘 | An junwei Liu Jianhua Zhou Yecheng et a1 | 2012 | J Phys Chern C2012，116，19： | 1 |
| 19 | RAB-27 and its effector RBF-1 regulate the tethering and docking steps of DCV exocytosis in C.elegans显示文摘The molecular mechanisms by which dense core vesicles(DCVs) translocate,tether,dock and prime are poorly understood.In this study,Caenorhabditis elegans was used as a model organism to study the function of Rab proteins and their effectors in DCV exocytosis.RAB-27/AEX-6,but not RAB-3,was found to be required for peptide release from neurons.By analyzing the movement of DCVs approaching the plasma membrane using total internal reflection fluorescence microscopy,we demonstrated that RAB-27/AEX-6 is involved in the tethering of DCVs and that its effector rabphilin/RBF-1 is required for the initial tethering and subsequent stabilization by docking. | FENG Wan Juan LIANG Tao YU JunWei ZHOU Wei ZHANG YongDeng WU ZhengXing XU Tao | 2012 | Science China(Life Sciences)2012，55，3： | 1 |
| 20 | Synergistic Optimization of Buried Interface by Multifunctional Organic-Inorganic Complexes for Highly Efficient Planar Perovskite Solar Cells显示文摘For the further improvement of the power conversion efficiency(PCE)and stability of perovskite solar cells(PSCs),the buried interface between the perovskite and the electron transport layer is crucial.However,it is challenging to effectively optimize this interface as it is buried beneath the perovskite film.Herein,we have designed and synthesized a series of multifunctional organic-inorganic(OI)complexes as buried interfacial material to promote electron extraction,as well as the crystal growth of the perovskite.The OI complex with BF4−group not only eliminates oxygen vacancies on the SnO_(2) surface but also balances energy level alignment between SnO_(2) and perovskite,providing a favorable environment for charge carrier extraction.Moreover,OI complex with amine(−NH_(2))functional group can regulate the crystallization of the perovskite film via interaction with PbI2,resulting in highly crystallized perovskite film with large grains and low defect density.Consequently,with rational molecular design,the PSCs with optimal OI complex buried interface layer which contains both BF4−and−NH_(2) functional groups yield a champion device efficiency of 23.69%.More importantly,the resulting unencapsulated device performs excellent ambient stability,maintaining over 90%of its initial efficiency after 2000 h storage,and excellent light stability of 91.5%remaining PCE in the maximum power point tracking measurement(under continuous 100 mW cm−2 light illumination in N2 atmosphere)after 500 h. | Heng Liu Zhengyu Lu Weihai Zhang Hongkang Zhou Yu Xia Yueqing Shi Junwei Wang Rui Chen Haiping Xia Hsing-Lin Wang | 2023 | Nano-Micro Letters2023，15，9： | 1 |
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