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| 1 | Highly expressed BMP9/GDF2 in postnatal mouse liver and lungs may account for its pleiotropic effects on stem cell differentiation,angiogenesis,tumor growth and metabolism显示文摘Bone morphogenetic protein 9(BMP9)(or GDF2)was originally identified from fetal mouse liver cDNA libraries.Emerging evidence indicates BMP9 exerts diverse and pleiotropic functions during postnatal development and in maintaining tissue homeostasis.However,the expression landscape of BMP9 signaling during development and/or in adult tissues remains to be analyzed.Here,we conducted a comprehensive analysis of the expression landscape of BMP9 and its signaling mediators in postnatal mice.By analyzing mouse ENCODE transcriptome datasets we found Bmp9 was highly expressed in the liver and detectable in embryonic brain,adult lungs and adult placenta.We next conducted a comprehensive qPCR analysis of RNAs isolated from major mouse tissues/organs at various ages.We found that Bmp9 was highly expressed in the liver and lung tissues of young adult mice,but decreased in older mice.Interestingly,Bmp9 was only expressed at low to modest levels in developing bones.BMP9-associated TGFβ/BMPR type I receptor Alk1 was highly expressed in the adult lungs.Furthermore,the feedback inhibitor Smads Smad6 and Smad7 were widely expressed in mouse postnatal tissues.However,the BMP signaling antagonist noggin was highly expressed in fat and heart in the older age groups,as well as in kidney,liver and lungs in a biphasic fashion.Thus,our findings indicate that the circulating BMP9 produced in liver and lungs may account for its pleiotropic effects on postnatal tissues/organs although possible roles of BMP9 signaling in liver and lungs remain to be fully understood. | Wei Liu Zhongliang Deng Zongyue Zeng Jiaming Fan Yixiao Feng Xi Wang Daigui Cao Bo Zhang Lijuan Yang Bin Liu Mikhail Pakvasa William Wagstaff Xiaoxing Wu Huaxiu Luo Jing Zhang Meng Zhang Fang He Yukun Mao Huiming Ding Yongtao Zhang Changchun Niu Rex C.Haydon Hue H.Luu Jennifer Moriatis Wolf Michael J.Lee Wei Huang Tong-Chuan He Yulong Zou | 2020 | Genes & Diseases2020，7，2： | 9 |
| 2 | Progress on Continental Scientific Drilling Project of Cretaceous Songliao Basin(SK-1 and SK-2)显示文摘Scientific drilling is a significant exploration tool to better understand earth’s environmental and biological evolution,physical composition and structure,and natural resources and geohazards,through directly sampling on subsurface rock,fluid,living organisms and long-term monitoring of on-going deep processes.It plays a critical role in deciphering earth system dynamics and in solving socio-economic problems currently facing by humans. | Yuan Gao Chengshan Wang Pujun Wang Youfeng Gao Yongjian Huang Changchun Zou | 2019 | Science Bulletin2019，64，2： | 7 |
| 3 | Alterations in DNA methylation and genome structure in two rice mutant lines induced by high pressure显示文摘By using high-pressure treatment, two mutant lines were obtained from a genetically stable japonica rice cultivar Bijing38. Genomic DNA of the mutant lines, together with the original line (Bijing38), was either undigested or digested by Hpa II/Msp I, and then subjected to molecular analy-sis using two markers, ISSR and RAPD. Results indicated that changes in the PCR amplification pro-files of both markers are apparent in the two mutant lines compared with the original rice cultivar, suggesting that there had been both sequence changes and DNA methylation modifications in the mutant lines. Southern blot analysis using diverse sequences, including two cellular genes (S2 and S3), a set of retrotransposons (Osr7, Osr36, Tos19 and more), and a MITE transposon family (mPing and Pong), confirmed the results, and indicated that changes in DNA methylation pattern, genomic structure, and possible activation of some transposons indeed occurred in the mutant lines. Moreover, these changes are stably maintained through selfed generations and in different organs. Thus, our results indicate that it is possible to obtain stable mutants in rice by high pressure treatments, and the molecular basis of the mutants may include both genetic and epigenetic changes. Therefore, high hydrostatic pressure seems a promising approach for plant mutagenesis. | SHEN Sile1,3, WANG Zhenwei3, SHAN Xiaohui2, WANG Hua3, LI Ling3, LIN Xuyun2, LONG Likun2, WENG Kenan4, LIU Bao2 & ZOU Guangtian1 1. National Laboratory of Superhard Materials, Jilin University, Changchun 130012, China 2. Institute of Genetics and Cytology, Northeast Normal University, Changchun 130024, China 3. College of Life Science, Jilin University, Changchun 130012, China 4. Guangzhou Institute of Geochemistry, Chinese Academy of Sciences, Guangzhou 510640, China | 2006 | Science China(Life Sciences)2006，49，2： | 6 |
| 4 | Study of sedimentary sequence cycles by well-seismic calibration显示文摘In order to solve the problems of the fine division of sedimentary sequence cycles and their change in two-dimensional space as well as lateral extension contrast, we developed a method of wavelet depth-frequency analysis. The single signal and composite signal of different Milankovitch cycles are obtained by numerical simulation. The simulated composite signal can be separated into single signals of a single frequency cycle. We also develop a well-seismic calibration insertion technology which helps to realize the calibration from the spectrum characteristics of a single well to the seismic profile. And then we determine the change and distribution characteristics of spectrum cycles in the two-dimensional space. It points out the direction in determining the variations of the regional sedimentary sequence cycles, underground strata structure and the contact relationship. | Xu Jingling Liu Luofu Wang Guiwen Zou Changchun Lai Jin | 2013 | Petroleum Science2013，10，1： | 4 |
| 5 | 联合应用维甲酸和干扰素对膀胱癌细胞生长抑制及诱导凋亡作用的实验研究显示文摘目的 探讨联合应用维甲酸和干扰素对人膀胱癌细胞生长抑制和诱导凋亡的作用机理。 方法 应用全反式维甲酸 (ATRA)、9 顺式维甲酸 (9cRA)、联合干扰素α 2a(IFNα 2a)作用于 4组膀胱癌细胞 ,应用TUNEL、FCM、RT PCR及Western等技术观察维甲酸、干扰素单独或联合应用时对不同膀胱癌细胞株的生长抑制、诱导凋亡作用以及核维甲酸类受体、Stat1蛋白等方面的改变。 结果 ATRA和 9cRA对所有膀胱癌细胞的抑制生长和诱导凋亡作用均不明显 ,而IFNα 2a能增强ATRA和9cRA对膀胱癌的这种作用 ,联合应用ATRA和IFNα 2a能诱导膀胱癌细胞RARβ受体和Statl的表达。 结论 IFNα 2a能协同ATRA和 9cRA对膀胱癌细胞生长抑制和凋亡诱导效应 ,上调Stat1基因表达可能是其主要分子学作用机理。 | 钱立新 Monica Libert Changchun Zou Changping Zou | 2004 | 中华泌尿外科杂志2004，25，6： | 2 |
| 6 | Code red worm propagation modeling and analysis显示文摘 | Cliff Changchun Zou Weibo Gong Don Towsley | 2002 | ACM CCS2002，10，： | 1 |
| 7 | The monitoring and early detection of Internet worms显示文摘 | Zou Cliff Changchun Gong Weibo Towsley Don | 2005 | IEEE/ACM Transactions on Networking2005，13，： | 1 |
| 8 | An Advanced Hybrid Peer-to-Peer Botnet显示文摘 | Wang Ping Sparks S Zou Changchun | 2010 | IEEE Transactions on Dependable and Secure Computing2010，7，2： | 1 |
| 9 | Revision of P-wave Velocity and Thickness of Hydrate Layer in Shenhu Area, South China Sea显示文摘To revise P-wave velocity and thickness of the hydrate layer in the Shenhu area of the South China Sea, acoustic and resistivity logging curves are reanalyzed. The waterlogging phenomenon is found in the shallow sediments of five drilling wells, which causes P-wave velocity to approximate the propagation velocity of sea water(about 1500 m s-1). This also affects the identification of the hydrate layer and results in the underestimate of its thickness. In addition, because there could be about a 5 m thick velocity ramp above or below the hydrate layer as interpreted by acoustic and resistivity logging curves, the recalibrated thickness of this layer is less than the original estimated thickness. The recalibrated P-wave velocity of the hydrate layer is also higher than the original estimated velocity. For the drilling well with a relatively thin hydrate layer, the velocity ramp plays a more important role in identifying and determining the thickness of the layer. | GONG Jianming ZHANG Xunhua ZOU Changchun CHEN Qiang WANG Lichen YUAN Chunfang HU Gaowei JIANG Yubo | 2014 | Journal of Ocean University of China2014，13，5： | 1 |
| 10 | Synthesis and Characterization of Titanosilicate with the Structure of Umbite显示文摘A zeolitic titanosilicate with the composition of K2TiSi3O9·H2O, a structural analogue of natural mineral umbite K2ZrSi3O9·H2O, was hydrothermally synthesized in the SiO2-TiO2-K2O-H2O system and characterized by means of powder X-ray diffraction, SEM, IR and thermal analysis. The effects of TiO2/SiO2 and OH -/SiO2 ratios on the crystallization of the umbite were discussed. The influence of the organic additives on the morphology of the crystal was also investigated and the crystals with different shapes were obtained. | ZHAO Yong-nan 1*, LI Ya-feng 2, ZOU Yong-chun 2, MAI Zhen-hong 1 and PANG Wen-qin 21. Institute of Physics & Center for Condensed Matter Physics, Chinese Academy of Sciences, Beijing 100080, P. R. China 2. Key Laboratory of Inorganic Synthesis and Preparative Chemistry, Jinlin University, Changchun 130023, P. R. China | 2002 | Chemical Research in Chinese Universities2002，18，4： | 1 |
| 11 | Experimental study of the relationship between fluid density and saturation and sonic wave velocity of rock samples from the WXS Depression,South China Sea显示文摘在液体密度和浸透和在华南海从 WXS 消沉拿的岩石样品的声音的波浪速度之间的关系被一个油水代替实验学习在下面在原处模仿了温度和压力条件。二种低密度的油(0.691 和 0.749 g/cm3 ) 和二种高密度的油(0.834 和 0.873 g/cm3 ) 被用来浸透以不同油浸透国家的岩石样品,和浸透的 P 波浪和 S 波浪速度被测量。通过 Gassmanns 方程,理论 P 波浪和 S 波浪速度被液体代替方法也计算。与测量价值和理论价值的比较,这研究来到下列结论。(1 ) 随油浸透的增加和水浸透的减少,岩石样品的 P 波浪速度由低密度的油增加和变化规则浸透了与有效液体理论一致;岩石样品的 P 波浪速度由高密度的油减少和变化规则浸透了反对理论。(2 ) 随油密度的增加(也就是 0.6910.7490.8340.873 g/cm3 ) 当油浸透是未改变的时, P 波浪速度逐渐地增加。(3 )S 波浪速度总是是稳定的并且没被油密度和浸透的变化影响。结果能被用来抑制预先叠地震倒置,和声音的波浪速度的变化规则为在学习区域的烃鉴定是珍贵的。 | Pei Fagen Zou Changchun He Tao Pan Lingzhi Xiao Kun Shi Ge Ren Keying | 2011 | Petroleum Science2011，8，1： | 0 |
| 12 | Genesis and significance of quartz cement in sandstones显示文摘Quartz cement as syntaxial overgrowths is one of the most abundant cements in sandstones. Distribution of quartz cement in time and space indicates that the more younger the stratigraphy is, the more smaller the amount of quartz cement, and the amount of quartz cement increases with increasing of depth and basin type also is a factor which controls the amount of quartz cement. The sources of silica for quartz cement have many different opinions, but there is one or more dominant sources. Temperature and pH of fluid are major factors which influence the precipitation of quartz cement. There exist three hypotheses on the flow of pore fluid and transport and precipitation of silica, that is, the hypothesis of cycle of shallow underground water, the hypothesis of high concentration of fluid driven by compaction and the hypothesis of diffusion and recycle of local fluid. The research of quartz cement is significant for the timing of paleotemperature, heterogeneity of reservoir, physical property of reservoir and the timing of oil immersion, etc. | Yu Junmin, Liu li, Gao Fuhong and Zou Haifeng (Changchun University of Science and Technology, Changchun 130026) Yang Yongchang, Sun Xiaoming and Zhang Liqin (Geology and Development Institute,Dagang Oil Field Group Ltd., Tianjin 300280) | 1999 | Global Geology1999，4，1： | 0 |
| 13 | Pressure effects on the absorption spectra of Na doped in solid Ar显示文摘In this work, the pressure influence on the absorption spectra of Na in solid Ar for various trapping sites is extensively investigated at T = 10 K and in the pressure range from 0 to 2.4 GPa by using Monte Carlo method with a constant pressure ensemble (NPT). For the trapping sites of nv = 1, 2, the absorption spectral widths increase progressively, the absorption peaks and the centroid spectral shift (CSS) tend to have a red shift with pressure increasing, even though there is no local structural symmetry change around Na atom caused by pressure. Highly symmetrical trapping site structure (nv = 1) determines a highly symmetrical triplet absorption feature at a low pressure. With the increase in pressure, the action from the Ar crystal field on the three energy levels of the 3p excited state of Na atom increases, resulting in the overlap of the three peaks. Low symmetrical trapping site structure (nv = 2) yields a low symmetrical triplet absorption pattern in which a large separation between the single?and the double?peaks exists at a low pressure. With the increase in pressure, the splitting between the singlet and the doublet increases, and the doublet merges as the pressure is larger than 2.4 GPa. | CUI Tian1, HE Wenjiong1, YIN Hongwei1, MA Yanming1, CHEN Changbo1, ZOU Guangtian1, WEI Mengfu2 & CHEN Changan2 1. National Laboratory of Superhard Materials, Jilin University, Changchun 130012, China 2. China Academy of Engineering Physics, Box 919-71, Mianyang 621900, China | 2004 | Science China(Physics,Mechanics & Astronomy)2004，47，5： | 0 |
| 14 | Studies on the Gold-Coated Electrode with Grid显示文摘Introduction Thin-layer spectroelectrochemical method has many unique advantages, therefore this method has been widely applied and developed. Recently light transparent thinlayer spectroelectrochemical cells with various types of structures have been reported at home and abroad with gold or platinum minigrids as the working electrode in most | ZOU Ming-zhu, SHENG Gui-hua, ZHENG Guo-dong and ZHFNG Yan-sheng (Department of Chemistry, Jilin University, Changchun, 130023) | 1992 | Chemical Research in Chinese Universities1992，8，4： | 0 |
| 15 | DISLOCATION EMISSION AND EQUATION OF ENERGY BARRIERS AT MODEL I CRACK TIP显示文摘The propagation for the model I crack in aluminum single crystal has been directly studied by in-situ TEM observation.The equation of energy barrier of the dislocation building-up and emission at the model I crack tip has been established by means of Peierls-Nabarro dislocation model and starting from angle of energy.By means of calculation,the critical value of spontaneous emission of the dislocations from tip of the model I crack was obtained. | Zou Hongcheng Dai Shujuan Liu Furong Hu Xiangyang Li Changchun | 1996 | Transactions of Nonferrous Metals Society of China1996，6，1： | 0 |
| 16 | Trimethylsilation of Buckmisterfullerene(C_60)显示文摘Since the initial discovery and subsequent development of the large-scale synthesis of fullerenes, the chemical action of these molecules has been of fundamental interest. Initially detected in the gas phase, there are ongoing attempts to prepare, isolate and characterize fullerenes with metals contained in the interior. Buckmisterfullerene(C60) has been doped with combinations of alkali and other metals to produce high-temperature superconductors. Interaction of C60 with metal surface in | WANG Yue and FAN Yu-guo (Institute of Theoretical Chemistry, Jilin University, Changchun, 130023)YANG Hai-bin, XIAO Peng, ZOU Guang-tian, LI Ming-hui and ZHOU Shu-tang (State Key Laboratory of Superhard Materials, Jilin University, Changchun, 130023) | 1993 | Chemical Research in Chinese Universities1993，9，4： | 0 |
| 17 | Studies on Zeolite Modified Electrode(Ⅰ)─Ascorbic Acid Sensor Based on Carbon Paste Electrode Containing Fe(Ⅲ)Y Zeolite显示文摘A new ascorbic acid sensor constituted of carbon paste and Fe(Ⅲ)Y zeolite was studied.The characters of the sensor such as linear range. potential window、apparen Michaelis constant、response time、stability and accuracy wee investigated. The experimental results indicate that the analytical performance of the sensor is satisfactory. | Ming Zhu ZOU Hong Ding XU Jie LU Qin Hua Ru (a Department of Chemistry, Jilin University, Changchun 130023 b Department of Chemistry, the North-East Normal University, Changchun 130022) (To whom correspondence should be addressed ) | 1997 | Chinese Chemical Letters1997，8，3： | 0 |
| 18 | A Reflectance Thin-layer Spectro-electrochemical Method显示文摘IntroduCtion Speetroeleetroehemieal measurement 15 simultaneously to determine theeleetroehemieal and | ZOU Ming-zhu, ZHENG Yan-sheng, HU Shu and ZHOU Yu-lai (Department of Chemistry, Jilin University, Changchun, 130023) | 1992 | Chemical Research in Chinese Universities1992，8，2： | 0 |
| 19 | Determination of Impurity Silicon in Anticancer Drug (Ge-132) by Electrothermally Atomised Atomic Absorption Spectrometry with Optical Temperature Control Accessory显示文摘The present paper describes the ashing and atomization processes in silicon analysis by electrothermally atomised atomic absorption spectrometry(EAAAS) with an uncoat-ed graphite tube, a pyrolytically coated graphite tube and a tungsten-coated graphitetube. The sensitivity and linear range of three graphite tubes were compared. By using optical temperature control accessory, the signals are enhanced by a factor of 2 and the germanium interferences in the determination of silicon are eliminated. The effects of time constant and carrier gas flow-rate on the determination of silicon were also tested. The sample can be directly analyzed in its aqueous solution without any pretreatment. The measurements of samples containing 0. 2 μg/mL and 0. 4 μg/mL silicon were run ten times and the variation coefficient is 4. 9% and 2.6%, respectively. The recovery tests for carboxyethyl germanium sesquioxide(Ge-132) synthesized and imported were performed, and the recoveries are 97. 0% and 110%, respectively. | Xie Shujuan, Wang Daning and Zou Mingqiang (Jilin I/E Commodity Inspection Bureau, Changchun)Cui Xiaoyuan,Ren Yulin and Zheng Yansheng (Department of Chemistry, Jilin University, Changchun)Wang Jincheng (Dalian Military Medical School, Dalian) | 1991 | Chemical Research in Chinese Universities1991，7，4： | 0 |
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